Rattus norvegicus

27 known processes

Adam17

ADAM metallopeptidase domain 17

(Aliases: TACE)

Adam17 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to biotic stimulus GO:0009607 226 0.721
Human
response to other organism GO:0051707 220 0.574
Human
regulation of cellular component movement GO:0051270 150 0.571
Human Mouse
neuron differentiation GO:0030182 368 0.552
response to external biotic stimulus GO:0043207 221 0.527
Human
cellular response to organic cyclic compound GO:0071407 202 0.521
response to radiation GO:0009314 137 0.517
positive regulation of multicellular organismal process GO:0051240 387 0.514
Human
cellular response to endogenous stimulus GO:0071495 377 0.487
Human Mouse
immune system process GO:0002376 204 0.434
Human Mouse
anatomical structure morphogenesis GO:0009653 298 0.422
Human
intracellular signal transduction GO:0035556 314 0.388
positive regulation of rna metabolic process GO:0051254 203 0.381
regulation of molecular function GO:0065009 398 0.369
Human
oxoacid metabolic process GO:0043436 290 0.367
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.364
response to toxic substance GO:0009636 133 0.363
response to wounding GO:0009611 254 0.357
Human Rat
regulation of catalytic activity GO:0050790 304 0.351
Human
response to oxygen levels GO:0070482 265 0.349
Human
regulation of phosphate metabolic process GO:0019220 349 0.342
Human
regulation of intracellular signal transduction GO:1902531 218 0.330
cell junction organization GO:0034330 21 0.329
cellular ketone metabolic process GO:0042180 51 0.319
regulation of cellular component organization GO:0051128 368 0.311
Human
positive regulation of rna biosynthetic process GO:1902680 197 0.311
peptidyl amino acid modification GO:0018193 126 0.304
Human
positive regulation of cell migration GO:0030335 96 0.302
Human
cell projection organization GO:0030030 302 0.299
positive regulation of cell differentiation GO:0045597 217 0.298
regulation of cellular localization GO:0060341 263 0.294
organelle organization GO:0006996 266 0.293
positive regulation of secretion GO:0051047 140 0.292
regulation of programmed cell death GO:0043067 341 0.283
response to hypoxia GO:0001666 231 0.283
Human
inflammatory response GO:0006954 150 0.281
organic acid metabolic process GO:0006082 292 0.276
regulation of cell differentiation GO:0045595 320 0.273
secretion GO:0046903 307 0.272
neuron development GO:0048666 286 0.272
apoptotic process GO:0006915 381 0.272
defense response GO:0006952 194 0.266
protein localization GO:0008104 191 0.261
positive regulation of interleukin 1 beta production GO:0032731 6 0.256
cellular response to lipid GO:0071396 201 0.252
programmed cell death GO:0012501 392 0.250
positive regulation of protein transport GO:0051222 41 0.247
response to growth factor GO:0070848 189 0.246
Human Mouse
positive regulation of transcription dna templated GO:0045893 197 0.243
regulation of secretion GO:0051046 224 0.242
positive regulation of biosynthetic process GO:0009891 319 0.234
amine metabolic process GO:0009308 38 0.229
positive regulation of retinal cell programmed cell death GO:0046670 1 0.225
positive regulation of cellular biosynthetic process GO:0031328 295 0.224
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.223
positive regulation of protein metabolic process GO:0051247 178 0.222
Human
response to ionizing radiation GO:0010212 59 0.221
regulation of cellular amine metabolic process GO:0033238 8 0.221
regulation of apoptotic process GO:0042981 335 0.221
regulation of cellular ketone metabolic process GO:0010565 27 0.217
regulation of mapk cascade GO:0043408 116 0.217
macromolecule localization GO:0033036 252 0.215
cellular component movement GO:0006928 248 0.210
Human Mouse
macromolecular complex subunit organization GO:0043933 339 0.210
locomotion GO:0040011 237 0.209
Human Mouse
cellular amino acid metabolic process GO:0006520 107 0.209
regulation of multicellular organismal development GO:2000026 376 0.208
neuron death GO:0070997 127 0.205
response to antibiotic GO:0046677 39 0.204
secretion by cell GO:0032940 248 0.202
response to gamma radiation GO:0010332 24 0.201
localization of cell GO:0051674 202 0.197
Human Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.197
regulation of cell development GO:0060284 263 0.197
regulation of cell proliferation GO:0042127 359 0.196
Human
regulation of nervous system development GO:0051960 264 0.194
aging GO:0007568 241 0.193
central nervous system development GO:0007417 311 0.191
cellular component biogenesis GO:0044085 368 0.190
regulation of transcription dna templated GO:0006355 374 0.190
neuron projection development GO:0031175 273 0.189
immune response GO:0006955 104 0.187
Mouse
positive regulation of gene expression GO:0010628 244 0.187
regulation of neuron death GO:1901214 115 0.183
regulation of neuron apoptotic process GO:0043523 83 0.183
digestive system development GO:0055123 41 0.179
response to estrogen GO:0043627 232 0.178
regulation of neurogenesis GO:0050767 247 0.176
nucleic acid templated transcription GO:0097659 379 0.174
response to mechanical stimulus GO:0009612 134 0.172
microglial cell activation GO:0001774 14 0.172
positive regulation of cellular component movement GO:0051272 102 0.172
Human Mouse
response to decreased oxygen levels GO:0036293 237 0.172
Human
positive regulation of cell development GO:0010720 176 0.171
digestive tract development GO:0048565 39 0.171
eye development GO:0001654 50 0.170
signal transduction by phosphorylation GO:0023014 144 0.169
positive regulation of cellular protein metabolic process GO:0032270 167 0.169
Human
positive regulation of nervous system development GO:0051962 178 0.167
regulation of cell motility GO:2000145 131 0.167
Human
positive regulation of response to stimulus GO:0048584 285 0.164
Human Mouse
ovulation cycle process GO:0022602 50 0.161
multicellular organismal reproductive process GO:0048609 233 0.161
Rat
regulation of anatomical structure morphogenesis GO:0022603 141 0.161
positive regulation of secretion by cell GO:1903532 128 0.159
positive regulation of transport GO:0051050 245 0.157
negative regulation of cell proliferation GO:0008285 119 0.156
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.154
Human Mouse
cellular response to nitrogen compound GO:1901699 210 0.151
response to ethanol GO:0045471 162 0.151
cell motility GO:0048870 202 0.150
Human Mouse
axon development GO:0061564 96 0.149
learning or memory GO:0007611 90 0.148
peptidyl tyrosine modification GO:0018212 72 0.146
Human
positive regulation of nucleic acid templated transcription GO:1903508 197 0.146
response to alkaloid GO:0043279 132 0.145
regulation of cellular protein metabolic process GO:0032268 267 0.143
Human
wound healing GO:0042060 122 0.143
Human Rat
leukocyte activation GO:0045321 76 0.142
Mouse
positive regulation of protein modification process GO:0031401 142 0.142
Human
regulation of phosphorylation GO:0042325 248 0.141
Human
regulation of cellular amino acid metabolic process GO:0006521 2 0.141
cell migration GO:0016477 197 0.139
Human
cellular component assembly GO:0022607 360 0.138
eye morphogenesis GO:0048592 4 0.136
protein complex subunit organization GO:0071822 302 0.135
response to carbohydrate GO:0009743 183 0.135
tube development GO:0035295 89 0.134
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.132
regulation of rna biosynthetic process GO:2001141 381 0.132
response to extracellular stimulus GO:0009991 380 0.132
positive regulation of signal transduction GO:0009967 175 0.132
Human Mouse
tissue development GO:0009888 252 0.132
Human Rat
positive regulation of apoptotic process GO:0043065 154 0.132
cellular response to oxygen containing compound GO:1901701 386 0.132
organ morphogenesis GO:0009887 75 0.132
positive regulation of phosphate metabolic process GO:0045937 262 0.130
Human
regulation of cell migration GO:0030334 128 0.130
Human
single organism biosynthetic process GO:0044711 342 0.129
regulation of protein localization GO:0032880 81 0.128
response to molecule of bacterial origin GO:0002237 194 0.127
Human
carboxylic acid metabolic process GO:0019752 289 0.125
development of primary sexual characteristics GO:0045137 107 0.123
response to corticosteroid GO:0031960 235 0.123
cellular response to lipopolysaccharide GO:0071222 55 0.119
cell adhesion GO:0007155 110 0.119
Human
response to lipopolysaccharide GO:0032496 191 0.118
Human
positive regulation of molecular function GO:0044093 230 0.118
Human
cell part morphogenesis GO:0032990 123 0.117
positive regulation of cell motility GO:2000147 97 0.117
Human
cellular response to hormone stimulus GO:0032870 247 0.117
response to light stimulus GO:0009416 52 0.117
female sex differentiation GO:0046660 59 0.115
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.115
Human Mouse
regulation of phosphorus metabolic process GO:0051174 349 0.114
Human
mapk cascade GO:0000165 140 0.113
nitrogen compound transport GO:0071705 229 0.113
positive regulation of intracellular signal transduction GO:1902533 138 0.112
positive regulation of cellular component organization GO:0051130 200 0.112
peptidyl tyrosine phosphorylation GO:0018108 72 0.112
Human
regulation of protein metabolic process GO:0051246 289 0.110
Human
positive regulation of locomotion GO:0040017 102 0.109
Human
positive regulation of phosphorus metabolic process GO:0010562 262 0.108
Human
regulation of signal transduction GO:0009966 318 0.108
Human Mouse
positive regulation of neurogenesis GO:0050769 165 0.108
response to estradiol GO:0032355 164 0.107
interleukin 1 beta secretion GO:0050702 3 0.106
cognition GO:0050890 92 0.106
protein complex assembly GO:0006461 263 0.105
ion homeostasis GO:0050801 212 0.104
organophosphate metabolic process GO:0019637 370 0.104
chemical homeostasis GO:0048878 292 0.104
regulation of rna metabolic process GO:0051252 391 0.103
positive regulation of signaling GO:0023056 270 0.102
Human Mouse
positive regulation of cell proliferation GO:0008284 249 0.102
Human
negative regulation of cell death GO:0060548 229 0.101
cellular homeostasis GO:0019725 252 0.101
vasculogenesis GO:0001570 3 0.100
cellular cation homeostasis GO:0030003 180 0.100
positive regulation of catalytic activity GO:0043085 184 0.100
Human
transcription dna templated GO:0006351 377 0.100
nucleotide metabolic process GO:0009117 279 0.100
neuron projection morphogenesis GO:0048812 122 0.100
cell projection morphogenesis GO:0048858 123 0.098
calcium ion homeostasis GO:0055074 162 0.098
divalent inorganic cation homeostasis GO:0072507 165 0.097
neuron apoptotic process GO:0051402 88 0.097
metal ion homeostasis GO:0055065 186 0.097
single organism reproductive process GO:0044702 297 0.097
Rat
head development GO:0060322 247 0.097
cellular calcium ion homeostasis GO:0006874 160 0.096
regulation of neuron differentiation GO:0045664 208 0.096
homeostatic process GO:0042592 331 0.096
Mouse
response to oxidative stress GO:0006979 186 0.095
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.094
cellular chemical homeostasis GO:0055082 247 0.094
response to ketone GO:1901654 182 0.093
regulation of nucleic acid templated transcription GO:1903506 380 0.093
blood vessel morphogenesis GO:0048514 58 0.092
sensory organ development GO:0007423 74 0.091
negative regulation of programmed cell death GO:0043069 183 0.091
female gonad development GO:0008585 53 0.090
positive regulation of cell communication GO:0010647 271 0.090
Human Mouse
positive regulation of developmental process GO:0051094 283 0.089
positive regulation of programmed cell death GO:0043068 157 0.087
angiogenesis GO:0001525 53 0.087
positive regulation of interleukin 1 beta secretion GO:0050718 3 0.086
enzyme linked receptor protein signaling pathway GO:0007167 116 0.086
Human Mouse
positive regulation of cell death GO:0010942 184 0.085
cell morphogenesis involved in differentiation GO:0000904 119 0.085
protein transport GO:0015031 132 0.084
response to monosaccharide GO:0034284 159 0.084
regulation of immune system process GO:0002682 123 0.084
Human Mouse
cellular response to abiotic stimulus GO:0071214 85 0.084
developmental process involved in reproduction GO:0003006 159 0.084
camera type eye development GO:0043010 48 0.084
response to hexose GO:0009746 144 0.083
response to bacterium GO:0009617 200 0.083
Human
regulation of secretion by cell GO:1903530 208 0.082
biological adhesion GO:0022610 110 0.082
Human
cell cell junction organization GO:0045216 20 0.082
regeneration GO:0031099 163 0.082
Rat
response to nutrient GO:0007584 248 0.081
g protein coupled receptor signaling pathway GO:0007186 242 0.081
Human
cellular response to cytokine stimulus GO:0071345 127 0.081
muscle structure development GO:0061061 87 0.081
transcription from rna polymerase ii promoter GO:0006366 252 0.080
cytoskeleton organization GO:0007010 111 0.080
regulation of interleukin 1 beta secretion GO:0050706 3 0.079
gonad development GO:0008406 104 0.078
germ cell migration GO:0008354 1 0.078
positive regulation of transferase activity GO:0051347 81 0.077
Human
signal release GO:0023061 145 0.077
response to glucocorticoid GO:0051384 223 0.077
multicellular organism reproduction GO:0032504 233 0.076
Rat
positive regulation of chemotaxis GO:0050921 23 0.076
Human
response to acid chemical GO:0001101 222 0.076
circulatory system process GO:0003013 183 0.075
purine containing compound metabolic process GO:0072521 253 0.075
cellular amine metabolic process GO:0044106 38 0.075
cellular response to organonitrogen compound GO:0071417 197 0.075
behavior GO:0007610 205 0.074
Human
rhythmic process GO:0048511 156 0.074
positive regulation of behavior GO:0048520 38 0.073
Human
protein complex biogenesis GO:0070271 263 0.073
response to insulin GO:0032868 133 0.072
rna metabolic process GO:0016070 406 0.072
ribose phosphate metabolic process GO:0019693 235 0.071
regulation of protein modification process GO:0031399 194 0.071
Human
cellular metal ion homeostasis GO:0006875 172 0.070
protein phosphorylation GO:0006468 345 0.070
Human
reproductive process GO:0022414 372 0.069
Rat
positive regulation of interleukin 1 secretion GO:0050716 3 0.069
regulation of response to external stimulus GO:0032101 106 0.069
Human
purine nucleotide metabolic process GO:0006163 229 0.068
positive regulation of protein kinase activity GO:0045860 73 0.068
Human
motor neuron axon guidance GO:0008045 1 0.068
blood circulation GO:0008015 183 0.067
neurological system process GO:0050877 219 0.067
development of primary female sexual characteristics GO:0046545 56 0.067
rna biosynthetic process GO:0032774 380 0.066
reproductive structure development GO:0048608 128 0.066
cell cell signaling GO:0007267 335 0.066
vesicle mediated transport GO:0016192 181 0.066
sexual reproduction GO:0019953 148 0.066
Rat
cellular lipid metabolic process GO:0044255 208 0.066
cation homeostasis GO:0055080 195 0.065
cell morphogenesis GO:0000902 142 0.065
protein heterooligomerization GO:0051291 89 0.065
negative regulation of apoptotic process GO:0043066 181 0.064
response to peptide hormone GO:0043434 278 0.064
gliogenesis GO:0042063 93 0.064
positive regulation of phosphorylation GO:0042327 177 0.063
Human
positive regulation of cytokine production GO:0001819 42 0.063
Human
response to nutrient levels GO:0031667 370 0.062
single organism behavior GO:0044708 130 0.062
regulation of cell adhesion GO:0030155 52 0.062
cellular response to insulin stimulus GO:0032869 81 0.062
cellular response to stress GO:0033554 269 0.061
response to heat GO:0009408 60 0.061
cellular ion homeostasis GO:0006873 184 0.061
sex differentiation GO:0007548 113 0.060
synaptic transmission GO:0007268 235 0.060
positive regulation of mapk cascade GO:0043410 92 0.060
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.060
response to reactive oxygen species GO:0000302 120 0.059
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.059
reproduction GO:0000003 245 0.059
Rat
multi organism reproductive process GO:0044703 262 0.059
Rat
macromolecular complex assembly GO:0065003 273 0.058
acute inflammatory response to non antigenic stimulus GO:0002525 2 0.058
lipid metabolic process GO:0006629 283 0.057
cellular response to growth factor stimulus GO:0071363 162 0.057
Human Mouse
regulation of retinal cell programmed cell death GO:0046668 1 0.057
cellular response to peptide GO:1901653 133 0.057
cellular component morphogenesis GO:0032989 155 0.056
cellular response to ketone GO:1901655 51 0.056
actin cytoskeleton organization GO:0030036 73 0.055
regulation of anatomical structure size GO:0090066 135 0.055
negative regulation of organ growth GO:0046621 3 0.054
ovulation cycle GO:0042698 67 0.054
hormone secretion GO:0046879 115 0.054
cellular response to peptide hormone stimulus GO:0071375 120 0.054
single organism cellular localization GO:1902580 102 0.053
purine ribonucleotide catabolic process GO:0009154 136 0.053
cellular divalent inorganic cation homeostasis GO:0072503 162 0.053
positive regulation of immune response GO:0050778 42 0.052
nucleoside phosphate catabolic process GO:1901292 140 0.052
regulation of map kinase activity GO:0043405 53 0.051
single organism organelle organization GO:1902589 180 0.051
response to glucose GO:0009749 136 0.051
actin filament based process GO:0030029 86 0.051
protein oligomerization GO:0051259 191 0.051
regulation of neuron projection development GO:0010975 161 0.051
anatomical structure formation involved in morphogenesis GO:0048646 83 0.051
response to hydrogen peroxide GO:0042542 89 0.051
positive regulation of cytokine secretion GO:0050715 9 0.050
cellular response to tumor necrosis factor GO:0071356 46 0.050
regulation of protein kinase activity GO:0045859 105 0.048
Human
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.048
cytosolic calcium ion homeostasis GO:0051480 140 0.048
negative regulation of transcription dna templated GO:0045892 116 0.047
regulation of interleukin 1 secretion GO:0050704 3 0.047
positive regulation of map kinase activity GO:0043406 46 0.047
nucleoside phosphate metabolic process GO:0006753 283 0.047
nucleobase containing small molecule metabolic process GO:0055086 316 0.046
positive regulation of protein phosphorylation GO:0001934 135 0.046
Human
hormone transport GO:0009914 121 0.046
regulation of hormone levels GO:0010817 187 0.046
interleukin 1 secretion GO:0050701 3 0.045
reproductive system development GO:0061458 128 0.045
brain development GO:0007420 247 0.045
forebrain development GO:0030900 98 0.045
regulation of cell projection organization GO:0031344 175 0.045
myeloid cell homeostasis GO:0002262 6 0.045
Mouse
reactive oxygen species metabolic process GO:0072593 37 0.045
nucleotide catabolic process GO:0009166 139 0.045
epithelium development GO:0060429 96 0.044
Human
regulation of response to stress GO:0080134 126 0.044
positive regulation of neuron apoptotic process GO:0043525 33 0.044
purine ribonucleoside catabolic process GO:0046130 124 0.044
protein autophosphorylation GO:0046777 66 0.043
response to amino acid GO:0043200 75 0.043
regulation of hormone secretion GO:0046883 106 0.043
anion transport GO:0006820 178 0.042
single organism intracellular transport GO:1902582 166 0.042
organic cyclic compound catabolic process GO:1901361 175 0.042
positive regulation of intracellular protein transport GO:0090316 20 0.041
cellular response to steroid hormone stimulus GO:0071383 93 0.041
regulation of ion transport GO:0043269 245 0.041
regulation of protein phosphorylation GO:0001932 183 0.041
Human
negative regulation of gene expression GO:0010629 199 0.040
regulation of locomotion GO:0040012 148 0.040
Human
response to transition metal nanoparticle GO:1990267 122 0.040
lens development in camera type eye GO:0002088 13 0.040
retinal cell programmed cell death GO:0046666 1 0.039
regulation of circadian sleep wake cycle GO:0042749 18 0.039
glial cell apoptotic process GO:0034349 8 0.038
negative regulation of response to stimulus GO:0048585 155 0.038
Human
regulation of catabolic process GO:0009894 113 0.038
exocytosis GO:0006887 60 0.038
axis specification GO:0009798 4 0.038
response to transforming growth factor beta GO:0071559 46 0.037
Human Mouse
response to cobalt ion GO:0032025 12 0.037
negative regulation of cellular component organization GO:0051129 83 0.037
establishment of protein localization GO:0045184 141 0.036
dna metabolic process GO:0006259 96 0.036
ribonucleoside triphosphate catabolic process GO:0009203 122 0.036
cellular response to alcohol GO:0097306 87 0.036
cellular response to molecule of bacterial origin GO:0071219 56 0.035
positive regulation of hydrolase activity GO:0051345 86 0.035
carbohydrate derivative metabolic process GO:1901135 346 0.035
regulation of peptide transport GO:0090087 87 0.035
regulation of membrane potential GO:0042391 110 0.035
regulation of establishment of protein localization GO:0070201 69 0.034
carbohydrate derivative catabolic process GO:1901136 147 0.034
erythrocyte differentiation GO:0030218 1 0.034
regulation of system process GO:0044057 208 0.034
carboxylic acid transport GO:0046942 115 0.034
response to vitamin GO:0033273 131 0.034
organophosphate catabolic process GO:0046434 148 0.034
organonitrogen compound catabolic process GO:1901565 179 0.034
organic substance catabolic process GO:1901575 316 0.033
immune response activating signal transduction GO:0002757 15 0.033
intracellular transport GO:0046907 185 0.032
small gtpase mediated signal transduction GO:0007264 36 0.032
heterotypic cell cell adhesion GO:0034113 2 0.032
regulation of vesicle mediated transport GO:0060627 81 0.032
negative regulation of developmental process GO:0051093 125 0.032
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.032
Human
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.032
purine ribonucleoside metabolic process GO:0046128 168 0.031
telencephalon development GO:0021537 62 0.031
cation transport GO:0006812 382 0.031
regulation of hydrolase activity GO:0051336 143 0.031
aromatic compound catabolic process GO:0019439 168 0.031
regulation of cytokine production GO:0001817 56 0.030
Human
single organism catabolic process GO:0044712 283 0.030
regulation of protein secretion GO:0050708 28 0.030
single organismal cell cell adhesion GO:0016337 42 0.030
regulation of transferase activity GO:0051338 123 0.029
Human
ribonucleoside metabolic process GO:0009119 174 0.029
positive regulation of neuron death GO:1901216 43 0.029
proteolysis GO:0006508 175 0.029
cardiovascular system development GO:0072358 134 0.029
positive regulation of kinase activity GO:0033674 77 0.029
Human
regulation of nucleotide metabolic process GO:0006140 117 0.029
regulation of peptide secretion GO:0002791 82 0.028
purine ribonucleotide metabolic process GO:0009150 227 0.028
response to inorganic substance GO:0010035 377 0.028
neuronal action potential GO:0019228 35 0.028
lipid biosynthetic process GO:0008610 128 0.028
response to nicotine GO:0035094 51 0.028
negative regulation of rna biosynthetic process GO:1902679 118 0.028
ribonucleotide catabolic process GO:0009261 136 0.028
pallium development GO:0021543 42 0.027
response to axon injury GO:0048678 59 0.027
vascular process in circulatory system GO:0003018 96 0.027
regulation of cellular component biogenesis GO:0044087 86 0.027
catabolic process GO:0009056 351 0.027
cytokine secretion GO:0050663 15 0.027
ribonucleotide metabolic process GO:0009259 231 0.027
blood vessel development GO:0001568 69 0.027
myeloid cell differentiation GO:0030099 22 0.027
positive regulation of immune system process GO:0002684 90 0.027
Human
regulation of response to wounding GO:1903034 69 0.027
response to organophosphorus GO:0046683 102 0.027
regulation of inflammatory response GO:0050727 48 0.026
leukocyte migration GO:0050900 38 0.026
Human
embryonic pattern specification GO:0009880 1 0.026
transmission of nerve impulse GO:0019226 42 0.026
transmembrane transport GO:0055085 412 0.025
purine nucleoside triphosphate catabolic process GO:0009146 122 0.025
embryonic skeletal system morphogenesis GO:0048704 3 0.025
response to testosterone GO:0033574 55 0.025
sensory perception of pain GO:0019233 73 0.025
negative regulation of neuron death GO:1901215 69 0.025
regulation of cell morphogenesis GO:0022604 77 0.025
cell activation GO:0001775 97 0.025
Mouse
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.025
glial cell differentiation GO:0010001 65 0.025
negative regulation of metabolic process GO:0009892 331 0.025
regulation of synaptic transmission GO:0050804 141 0.025
negative regulation of neurogenesis GO:0050768 78 0.025
embryonic skeletal system development GO:0048706 3 0.025
respiratory system development GO:0060541 45 0.025
ribonucleoside triphosphate metabolic process GO:0009199 141 0.025
organic acid transport GO:0015849 116 0.024
gamete generation GO:0007276 124 0.024
Rat
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.024
erythrocyte homeostasis GO:0034101 2 0.024
positive regulation of neuron differentiation GO:0045666 126 0.024
organonitrogen compound biosynthetic process GO:1901566 167 0.024
chemotaxis GO:0006935 66 0.024
Human
inorganic ion transmembrane transport GO:0098660 229 0.024
action potential GO:0001508 54 0.024
regulation of protein transport GO:0051223 68 0.024
nucleobase containing compound catabolic process GO:0034655 152 0.024
cellular response to mechanical stimulus GO:0071260 48 0.024
glycosyl compound metabolic process GO:1901657 182 0.024
muscle contraction GO:0006936 88 0.023
cellular catabolic process GO:0044248 295 0.023
purine nucleotide catabolic process GO:0006195 136 0.023
response to cytokine GO:0034097 215 0.023
positive regulation of cell projection organization GO:0031346 111 0.023
nucleoside triphosphate catabolic process GO:0009143 123 0.023
macrophage activation GO:0042116 15 0.023
defense response to other organism GO:0098542 17 0.023
glycosyl compound catabolic process GO:1901658 126 0.023
cellular macromolecule localization GO:0070727 122 0.023
regulation of peptide hormone secretion GO:0090276 80 0.023
response to x ray GO:0010165 15 0.022
cellular response to external stimulus GO:0071496 118 0.022
amide transport GO:0042886 105 0.022
myeloid leukocyte activation GO:0002274 36 0.022
intracellular protein transport GO:0006886 79 0.022
response to purine containing compound GO:0014074 126 0.022
regulation of nucleocytoplasmic transport GO:0046822 28 0.022
organic hydroxy compound metabolic process GO:1901615 115 0.022
positive regulation of neuron projection development GO:0010976 99 0.022
negative regulation of cell communication GO:0010648 158 0.022
Human
negative regulation of biosynthetic process GO:0009890 168 0.022
negative regulation of cellular biosynthetic process GO:0031327 161 0.022
acute inflammatory response GO:0002526 58 0.022
negative regulation of neuron apoptotic process GO:0043524 45 0.022
negative regulation of signaling GO:0023057 157 0.022
Human
regulation of immune response GO:0050776 55 0.022
cell matrix adhesion GO:0007160 19 0.021
tube morphogenesis GO:0035239 23 0.021
positive regulation of synaptic transmission GO:0050806 62 0.021
positive regulation of peptide secretion GO:0002793 52 0.021

Adam17 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.032
disease of cellular proliferation DOID:14566 0 0.032
organ system cancer DOID:0050686 0 0.032
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.024