Rattus norvegicus

0 known processes

Adam18

ADAM metallopeptidase domain 18

(Aliases: tMDCIII)

Adam18 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
amino acid transport GO:0006865 70 0.146
cation transmembrane transport GO:0098655 263 0.126
positive regulation of transport GO:0051050 245 0.121
response to corticosteroid GO:0031960 235 0.106
organic anion transport GO:0015711 132 0.106
cation transport GO:0006812 382 0.105
ion transmembrane transport GO:0034220 365 0.099
anion transport GO:0006820 178 0.091
amine transport GO:0015837 57 0.090
transmembrane transport GO:0055085 412 0.087
vesicle mediated transport GO:0016192 181 0.085
organic acid transport GO:0015849 116 0.078
cellular response to oxygen containing compound GO:1901701 386 0.076
negative regulation of metabolic process GO:0009892 331 0.076
macromolecule localization GO:0033036 252 0.076
reproduction GO:0000003 245 0.075
regulation of ion transport GO:0043269 245 0.073
response to estrogen GO:0043627 232 0.071
metal ion transport GO:0030001 289 0.070
response to oxidative stress GO:0006979 186 0.069
regulation of secretion GO:0051046 224 0.068
single organism reproductive process GO:0044702 297 0.063
positive regulation of blood circulation GO:1903524 65 0.061
glycosyl compound metabolic process GO:1901657 182 0.060
multicellular organism reproduction GO:0032504 233 0.058
nitrogen compound transport GO:0071705 229 0.057
neurological system process GO:0050877 219 0.056
somatostatin receptor signaling pathway GO:0038169 4 0.055
muscle contraction GO:0006936 88 0.053
cellular catabolic process GO:0044248 295 0.052
response to inorganic substance GO:0010035 377 0.052
carboxylic acid transport GO:0046942 115 0.051
response to alkaloid GO:0043279 132 0.050
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.049
multi organism reproductive process GO:0044703 262 0.048
endocytosis GO:0006897 84 0.047
organonitrogen compound catabolic process GO:1901565 179 0.045
regulation of molecular function GO:0065009 398 0.044
multicellular organismal reproductive process GO:0048609 233 0.044
cellular ketone metabolic process GO:0042180 51 0.043
synaptic transmission GO:0007268 235 0.043
single organism catabolic process GO:0044712 283 0.043
purine nucleotide metabolic process GO:0006163 229 0.042
oxoacid metabolic process GO:0043436 290 0.040
nucleobase containing small molecule metabolic process GO:0055086 316 0.040
purine nucleoside triphosphate metabolic process GO:0009144 141 0.040
positive regulation of molecular function GO:0044093 230 0.038
carboxylic acid metabolic process GO:0019752 289 0.038
response to ammonium ion GO:0060359 71 0.037
g protein coupled receptor signaling pathway GO:0007186 242 0.037
response to biotic stimulus GO:0009607 226 0.037
cellular nitrogen compound catabolic process GO:0044270 163 0.037
chemical homeostasis GO:0048878 292 0.036
reproductive process GO:0022414 372 0.036
catecholamine secretion GO:0050432 33 0.035
cellular chemical homeostasis GO:0055082 247 0.035
single organism behavior GO:0044708 130 0.034
defense response GO:0006952 194 0.034
negative regulation of transport GO:0051051 136 0.033
response to reactive oxygen species GO:0000302 120 0.033
dicarboxylic acid transport GO:0006835 34 0.033
protein transport GO:0015031 132 0.033
purine nucleoside metabolic process GO:0042278 169 0.032
response to toxic substance GO:0009636 133 0.032
catabolic process GO:0009056 351 0.031
cell cell signaling GO:0007267 335 0.031
nucleoside metabolic process GO:0009116 179 0.030
positive regulation of ion transport GO:0043270 94 0.030
protein homooligomerization GO:0051260 91 0.030
response to ethanol GO:0045471 162 0.029
inorganic cation transmembrane transport GO:0098662 202 0.029
regulation of cellular localization GO:0060341 263 0.029
cellular calcium ion homeostasis GO:0006874 160 0.029
regulation of phosphate metabolic process GO:0019220 349 0.029
sensory perception of pain GO:0019233 73 0.029
immune response GO:0006955 104 0.028
sleep GO:0030431 30 0.028
androgen biosynthetic process GO:0006702 10 0.028
regulation of response to stress GO:0080134 126 0.027
positive regulation of synaptic transmission GO:0050806 62 0.027
negative regulation of cellular biosynthetic process GO:0031327 161 0.027
monoamine transport GO:0015844 43 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.026
muscle structure development GO:0061061 87 0.026
synaptic transmission glycinergic GO:0060012 2 0.026
cellular component assembly GO:0022607 360 0.026
monovalent inorganic cation transport GO:0015672 172 0.026
grooming behavior GO:0007625 4 0.025
negative regulation of gene expression GO:0010629 199 0.025
aromatic compound catabolic process GO:0019439 168 0.025
secretion GO:0046903 307 0.025
immune system process GO:0002376 204 0.025
multi multicellular organism process GO:0044706 138 0.024
purine containing compound metabolic process GO:0072521 253 0.024
organic substance catabolic process GO:1901575 316 0.024
organelle organization GO:0006996 266 0.023
response to external biotic stimulus GO:0043207 221 0.023
circulatory system process GO:0003013 183 0.023
vascular process in circulatory system GO:0003018 96 0.023
organic cyclic compound catabolic process GO:1901361 175 0.022
cellular response to stress GO:0033554 269 0.022
dephosphorylation GO:0016311 98 0.022
response to metal ion GO:0010038 253 0.022
nucleobase containing compound catabolic process GO:0034655 152 0.021
regulation of anatomical structure size GO:0090066 135 0.021
central nervous system development GO:0007417 311 0.021
amide transport GO:0042886 105 0.021
purine ribonucleoside metabolic process GO:0046128 168 0.021
negative regulation of molecular function GO:0044092 133 0.021
response to estradiol GO:0032355 164 0.021
transmission of nerve impulse GO:0019226 42 0.021
nucleotide catabolic process GO:0009166 139 0.021
circulatory system development GO:0072359 134 0.021
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.021
regulation of growth GO:0040008 105 0.021
negative regulation of cell communication GO:0010648 158 0.021
muscle system process GO:0003012 115 0.020
cellular component biogenesis GO:0044085 368 0.020
single organism organelle organization GO:1902589 180 0.020
positive regulation of secretion by cell GO:1903532 128 0.020
negative regulation of membrane potential GO:0045837 5 0.020
regulation of hormone levels GO:0010817 187 0.020
regulation of transmembrane transport GO:0034762 122 0.019
ribonucleoside catabolic process GO:0042454 126 0.019
ribonucleoside metabolic process GO:0009119 174 0.019
programmed cell death GO:0012501 392 0.019
organophosphate catabolic process GO:0046434 148 0.019
organophosphate metabolic process GO:0019637 370 0.019
protein complex biogenesis GO:0070271 263 0.019
hormone metabolic process GO:0042445 69 0.018
regulation of muscle system process GO:0090257 79 0.018
regulation of tube size GO:0035150 89 0.018
sexual reproduction GO:0019953 148 0.018
monocarboxylic acid transport GO:0015718 52 0.018
purine nucleoside catabolic process GO:0006152 124 0.018
protein localization GO:0008104 191 0.018
inorganic ion transmembrane transport GO:0098660 229 0.017
positive regulation of transcription factor import into nucleus GO:0042993 4 0.017
cellular response to nitrogen compound GO:1901699 210 0.017
regulation of membrane potential GO:0042391 110 0.017
purine ribonucleotide metabolic process GO:0009150 227 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
brain development GO:0007420 247 0.017
blood circulation GO:0008015 183 0.017
cellular homeostasis GO:0019725 252 0.017
adenylate cyclase inhibiting serotonin receptor signaling pathway GO:0007198 1 0.017
response to peptide hormone GO:0043434 278 0.017
gamete generation GO:0007276 124 0.017
organic hydroxy compound transport GO:0015850 77 0.017
carbohydrate derivative catabolic process GO:1901136 147 0.017
regulation of blood vessel size GO:0050880 89 0.017
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 27 0.016
maternal aggressive behavior GO:0002125 3 0.016
heterocycle catabolic process GO:0046700 167 0.016
neurotransmitter transport GO:0006836 42 0.016
regulation of neurotransmitter levels GO:0001505 42 0.016
regulation of cell proliferation GO:0042127 359 0.016
response to nutrient GO:0007584 248 0.016
striated muscle tissue development GO:0014706 58 0.016
purine containing compound catabolic process GO:0072523 138 0.016
single organism intracellular transport GO:1902582 166 0.016
organic acid metabolic process GO:0006082 292 0.016
nucleoside triphosphate catabolic process GO:0009143 123 0.016
response to decreased oxygen levels GO:0036293 237 0.016
heart process GO:0003015 57 0.015
response to lipopolysaccharide GO:0032496 191 0.015
circadian sleep wake cycle GO:0042745 23 0.015
response to antibiotic GO:0046677 39 0.015
potassium ion transport GO:0006813 97 0.015
regulation of establishment of protein localization GO:0070201 69 0.015
cellular amino acid metabolic process GO:0006520 107 0.015
cognition GO:0050890 92 0.015
skeletal muscle tissue development GO:0007519 31 0.015
negative regulation of biosynthetic process GO:0009890 168 0.015
regulation of protein metabolic process GO:0051246 289 0.015
purine ribonucleoside catabolic process GO:0046130 124 0.015
cellular cation homeostasis GO:0030003 180 0.015
leukocyte mediated immunity GO:0002443 28 0.015
catecholamine transport GO:0051937 37 0.015
regulation of amine transport GO:0051952 54 0.014
nucleotide metabolic process GO:0009117 279 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.014
response to radiation GO:0009314 137 0.014
glycerolipid metabolic process GO:0046486 67 0.014
negative regulation of phosphate metabolic process GO:0045936 80 0.014
ribonucleoside monophosphate metabolic process GO:0009161 88 0.014
negative regulation of macromolecule metabolic process GO:0010605 260 0.014
cellular metal ion homeostasis GO:0006875 172 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
camp metabolic process GO:0046058 63 0.014
response to molecule of bacterial origin GO:0002237 194 0.014
positive regulation of cell differentiation GO:0045597 217 0.014
glycosyl compound catabolic process GO:1901658 126 0.014
regulation of response to wounding GO:1903034 69 0.014
divalent inorganic cation homeostasis GO:0072507 165 0.014
response to anoxia GO:0034059 4 0.014
signal release GO:0023061 145 0.014
regulation of muscle contraction GO:0006937 53 0.014
feeding behavior GO:0007631 53 0.013
exocytosis GO:0006887 60 0.013
dna metabolic process GO:0006259 96 0.013
response to glucocorticoid GO:0051384 223 0.013
negative regulation of cellular metabolic process GO:0031324 281 0.013
regulation of cellular amino acid metabolic process GO:0006521 2 0.013
behavioral response to ethanol GO:0048149 1 0.013
negative regulation of cyclic nucleotide metabolic process GO:0030800 15 0.013
neuronal action potential GO:0019228 35 0.013
immune effector process GO:0002252 53 0.013
actin filament based process GO:0030029 86 0.013
acid secretion GO:0046717 48 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
carbohydrate derivative metabolic process GO:1901135 346 0.013
nucleoside triphosphate metabolic process GO:0009141 144 0.013
positive regulation of immunoglobulin production GO:0002639 4 0.013
regulation of metal ion transport GO:0010959 118 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
regulation of immune system process GO:0002682 123 0.013
regulation of apoptotic process GO:0042981 335 0.013
thyroid gland development GO:0030878 1 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
positive regulation of multicellular organismal process GO:0051240 387 0.013
rna metabolic process GO:0016070 406 0.013
female pregnancy GO:0007565 122 0.013
regulation of vesicle mediated transport GO:0060627 81 0.013
homeostatic process GO:0042592 331 0.013
regulation of intracellular signal transduction GO:1902531 218 0.012
negative regulation of signal transduction GO:0009968 83 0.012
sensory perception GO:0007600 101 0.012
intracellular signal transduction GO:0035556 314 0.012
regulation of cell growth GO:0001558 85 0.012
ribonucleoside triphosphate catabolic process GO:0009203 122 0.012
regulation of transcription dna templated GO:0006355 374 0.012
mapk cascade GO:0000165 140 0.012
positive regulation of protein metabolic process GO:0051247 178 0.012
regulation of neuron death GO:1901214 115 0.012
positive regulation of phosphorus metabolic process GO:0010562 262 0.012
positive regulation of immune response GO:0050778 42 0.012
apoptotic process GO:0006915 381 0.012
positive regulation of secretion GO:0051047 140 0.012
calcium ion transport GO:0006816 131 0.012
cellular potassium ion transport GO:0071804 72 0.012
nucleoside catabolic process GO:0009164 126 0.012
regulation of exocytosis GO:0017157 37 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
neuron projection morphogenesis GO:0048812 122 0.012
negative regulation of apoptotic process GO:0043066 181 0.012
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
cation homeostasis GO:0055080 195 0.012
muscle cell differentiation GO:0042692 52 0.012
endocardial cushion development GO:0003197 1 0.012
liver development GO:0001889 90 0.012
synaptic transmission glutamatergic GO:0035249 33 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
response to oxygen levels GO:0070482 265 0.011
anion transmembrane transport GO:0098656 77 0.011
regulation of catabolic process GO:0009894 113 0.011
cellular response to mechanical stimulus GO:0071260 48 0.011
regulation of cell development GO:0060284 263 0.011
adrenal gland development GO:0030325 11 0.011
cellular response to oxidative stress GO:0034599 76 0.011
proteolysis GO:0006508 175 0.011
response to nutrient levels GO:0031667 370 0.011
regulation of cellular protein metabolic process GO:0032268 267 0.011
negative regulation of innate immune response GO:0045824 4 0.011
circadian rhythm GO:0007623 88 0.011
regulation of cell differentiation GO:0045595 320 0.011
sodium ion transport GO:0006814 82 0.011
neuromuscular synaptic transmission GO:0007274 2 0.011
negative regulation of secretion GO:0051048 82 0.011
circadian sleep wake cycle process GO:0022410 21 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.011
neuron development GO:0048666 286 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
regulation of cellular ketone metabolic process GO:0010565 27 0.011
b cell mediated immunity GO:0019724 4 0.011
negative regulation of phosphorus metabolic process GO:0010563 80 0.011
positive regulation of homeostatic process GO:0032846 49 0.010
regulation of blood circulation GO:1903522 110 0.010
antibiotic transport GO:0042891 2 0.010
vasoconstriction GO:0042310 54 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
response to extracellular stimulus GO:0009991 380 0.010
cellular macromolecule localization GO:0070727 122 0.010
response to purine containing compound GO:0014074 126 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.010
positive regulation of developmental process GO:0051094 283 0.010

Adam18 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
congenital adrenal hyperplasia DOID:0050811 0 0.013
disease of metabolism DOID:0014667 0 0.013
lipid metabolism disorder DOID:3146 0 0.013
inherited metabolic disorder DOID:655 0 0.013
steroid inherited metabolic disorder DOID:1701 0 0.013