Rattus norvegicus

0 known processes

Adam6

a disintegrin and metallopeptidase domain 6

(Aliases: TMDCIV)

Adam6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rhythmic process GO:0048511 156 0.490
response to other organism GO:0051707 220 0.229
response to carbohydrate GO:0009743 183 0.226
cellular response to endogenous stimulus GO:0071495 377 0.210
positive regulation of biosynthetic process GO:0009891 319 0.164
transmembrane transport GO:0055085 412 0.161
cellular response to growth factor stimulus GO:0071363 162 0.158
brain development GO:0007420 247 0.153
response to biotic stimulus GO:0009607 226 0.150
secretion by cell GO:0032940 248 0.129
reproductive process GO:0022414 372 0.123
macromolecular complex assembly GO:0065003 273 0.120
positive regulation of cell communication GO:0010647 271 0.116
multi organism reproductive process GO:0044703 262 0.109
protein complex biogenesis GO:0070271 263 0.106
head development GO:0060322 247 0.106
oxidation reduction process GO:0055114 304 0.104
positive regulation of signaling GO:0023056 270 0.101
inorganic ion transmembrane transport GO:0098660 229 0.097
reproduction GO:0000003 245 0.095
regulation of signal transduction GO:0009966 318 0.094
regulation of cell proliferation GO:0042127 359 0.093
response to growth factor GO:0070848 189 0.093
response to radiation GO:0009314 137 0.092
neurological system process GO:0050877 219 0.092
response to decreased oxygen levels GO:0036293 237 0.088
response to cytokine GO:0034097 215 0.088
multicellular organism reproduction GO:0032504 233 0.088
regulation of secretion by cell GO:1903530 208 0.086
carboxylic acid metabolic process GO:0019752 289 0.086
regulation of cellular protein metabolic process GO:0032268 267 0.085
single organism biosynthetic process GO:0044711 342 0.083
cellular chemical homeostasis GO:0055082 247 0.082
response to lipopolysaccharide GO:0032496 191 0.081
positive regulation of cell proliferation GO:0008284 249 0.080
single organism reproductive process GO:0044702 297 0.080
gland development GO:0048732 155 0.079
defense response GO:0006952 194 0.078
response to alkaloid GO:0043279 132 0.077
positive regulation of cell development GO:0010720 176 0.076
cellular component assembly GO:0022607 360 0.075
response to peptide GO:1901652 292 0.074
forebrain development GO:0030900 98 0.074
response to peptide hormone GO:0043434 278 0.072
response to extracellular stimulus GO:0009991 380 0.071
response to inorganic substance GO:0010035 377 0.071
negative regulation of response to stimulus GO:0048585 155 0.069
cellular response to nitrogen compound GO:1901699 210 0.069
positive regulation of nucleic acid templated transcription GO:1903508 197 0.069
telencephalon development GO:0021537 62 0.068
programmed cell death GO:0012501 392 0.068
Rat
cellular lipid metabolic process GO:0044255 208 0.067
response to hypoxia GO:0001666 231 0.065
lipid metabolic process GO:0006629 283 0.064
regulation of transcription dna templated GO:0006355 374 0.063
intracellular signal transduction GO:0035556 314 0.063
developmental process involved in reproduction GO:0003006 159 0.061
organic hydroxy compound metabolic process GO:1901615 115 0.060
regulation of nervous system development GO:0051960 264 0.060
cellular response to stress GO:0033554 269 0.059
negative regulation of metabolic process GO:0009892 331 0.058
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.056
response to bacterium GO:0009617 200 0.056
sex differentiation GO:0007548 113 0.056
organophosphate metabolic process GO:0019637 370 0.055
response to wounding GO:0009611 254 0.054
cation homeostasis GO:0055080 195 0.054
regulation of apoptotic process GO:0042981 335 0.052
Rat
response to estradiol GO:0032355 164 0.051
positive regulation of rna metabolic process GO:0051254 203 0.051
central nervous system development GO:0007417 311 0.049
response to external biotic stimulus GO:0043207 221 0.049
regulation of anatomical structure morphogenesis GO:0022603 141 0.049
regulation of hormone levels GO:0010817 187 0.049
protein complex subunit organization GO:0071822 302 0.048
multicellular organismal reproductive process GO:0048609 233 0.047
ion transmembrane transport GO:0034220 365 0.047
neuron death GO:0070997 127 0.047
protein oligomerization GO:0051259 191 0.046
response to ethanol GO:0045471 162 0.046
protein complex assembly GO:0006461 263 0.045
anatomical structure morphogenesis GO:0009653 298 0.045
epithelial cell proliferation GO:0050673 54 0.045
positive regulation of transcription dna templated GO:0045893 197 0.045
negative regulation of cellular metabolic process GO:0031324 281 0.045
inorganic cation transmembrane transport GO:0098662 202 0.045
response to acid chemical GO:0001101 222 0.043
positive regulation of nervous system development GO:0051962 178 0.043
cellular response to organonitrogen compound GO:0071417 197 0.043
response to metal ion GO:0010038 253 0.043
response to hyperoxia GO:0055093 45 0.042
cellular amino acid metabolic process GO:0006520 107 0.042
cellular response to oxygen containing compound GO:1901701 386 0.042
response to increased oxygen levels GO:0036296 45 0.042
negative regulation of programmed cell death GO:0043069 183 0.041
Rat
response to glucocorticoid GO:0051384 223 0.041
positive regulation of cellular component organization GO:0051130 200 0.041
regulation of programmed cell death GO:0043067 341 0.040
Rat
regulation of ion transmembrane transport GO:0034765 121 0.040
response to vitamin GO:0033273 131 0.038
positive regulation of cellular biosynthetic process GO:0031328 295 0.037
negative regulation of gene expression GO:0010629 199 0.037
rna biosynthetic process GO:0032774 380 0.037
response to toxic substance GO:0009636 133 0.037
response to ketone GO:1901654 182 0.037
regulation of transmembrane transport GO:0034762 122 0.036
organic acid metabolic process GO:0006082 292 0.036
cellular ketone metabolic process GO:0042180 51 0.036
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.036
negative regulation of cell death GO:0060548 229 0.036
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.036
lymphocyte migration GO:0072676 3 0.035
cellular metal ion homeostasis GO:0006875 172 0.035
multi multicellular organism process GO:0044706 138 0.034
regulation of phosphorus metabolic process GO:0051174 349 0.034
regulation of protein metabolic process GO:0051246 289 0.034
regulation of vesicle mediated transport GO:0060627 81 0.034
sexual reproduction GO:0019953 148 0.034
regulation of camp biosynthetic process GO:0030817 38 0.033
oxoacid metabolic process GO:0043436 290 0.033
purine nucleotide biosynthetic process GO:0006164 83 0.033
response to glucose GO:0009749 136 0.033
homeostatic process GO:0042592 331 0.033
synaptic transmission GO:0007268 235 0.032
response to mechanical stimulus GO:0009612 134 0.032
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.032
cellular homeostasis GO:0019725 252 0.032
hormone transport GO:0009914 121 0.032
positive regulation of phosphate metabolic process GO:0045937 262 0.031
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.031
regulation of rna biosynthetic process GO:2001141 381 0.031
cellular response to hormone stimulus GO:0032870 247 0.031
neuron development GO:0048666 286 0.031
regulation of neuron death GO:1901214 115 0.030
regulation of epithelial cell proliferation GO:0050678 49 0.030
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
tissue development GO:0009888 252 0.030
protein homooligomerization GO:0051260 91 0.029
cellular response to steroid hormone stimulus GO:0071383 93 0.029
positive regulation of molecular function GO:0044093 230 0.029
cellular component biogenesis GO:0044085 368 0.029
amide transport GO:0042886 105 0.029
response to monosaccharide GO:0034284 159 0.029
development of primary sexual characteristics GO:0045137 107 0.029
amine metabolic process GO:0009308 38 0.028
cellular component movement GO:0006928 248 0.028
neuron differentiation GO:0030182 368 0.027
positive regulation of secretion by cell GO:1903532 128 0.027
neuron projection development GO:0031175 273 0.027
sensory perception GO:0007600 101 0.027
regulation of cellular localization GO:0060341 263 0.027
response to nutrient levels GO:0031667 370 0.027
rna metabolic process GO:0016070 406 0.027
regulation of cell differentiation GO:0045595 320 0.027
positive regulation of multicellular organismal process GO:0051240 387 0.027
negative regulation of nucleic acid templated transcription GO:1903507 117 0.027
monovalent inorganic cation transport GO:0015672 172 0.027
response to oxygen levels GO:0070482 265 0.026
positive regulation of protein metabolic process GO:0051247 178 0.026
phospholipid metabolic process GO:0006644 61 0.026
cardiovascular system development GO:0072358 134 0.026
cellular amine metabolic process GO:0044106 38 0.026
synaptic growth at neuromuscular junction GO:0051124 1 0.026
hormone metabolic process GO:0042445 69 0.026
peptide transport GO:0015833 97 0.025
cell cell signaling GO:0007267 335 0.025
neuron neuron synaptic transmission GO:0007270 60 0.025
nucleic acid templated transcription GO:0097659 379 0.024
response to fungicide GO:0060992 20 0.024
negative regulation of signal transduction GO:0009968 83 0.024
transcription dna templated GO:0006351 377 0.024
macromolecular complex subunit organization GO:0043933 339 0.024
regulation of molecular function GO:0065009 398 0.024
localization of cell GO:0051674 202 0.023
regulation of canonical wnt signaling pathway GO:0060828 4 0.023
positive regulation of gene expression GO:0010628 244 0.023
g protein coupled receptor signaling pathway GO:0007186 242 0.023
response to transition metal nanoparticle GO:1990267 122 0.023
calcium ion transport GO:0006816 131 0.023
locomotion GO:0040011 237 0.023
positive regulation of signal transduction GO:0009967 175 0.023
signal release GO:0023061 145 0.023
metal ion transport GO:0030001 289 0.023
regulation of cell development GO:0060284 263 0.023
regulation of neurogenesis GO:0050767 247 0.023
divalent metal ion transport GO:0070838 132 0.023
positive regulation of neurogenesis GO:0050769 165 0.022
cell motility GO:0048870 202 0.022
negative regulation of cellular biosynthetic process GO:0031327 161 0.022
regulation of multicellular organismal development GO:2000026 376 0.022
response to oxidative stress GO:0006979 186 0.022
negative regulation of neuron death GO:1901215 69 0.022
organophosphate biosynthetic process GO:0090407 143 0.022
regulation of nucleic acid templated transcription GO:1903506 380 0.022
peptidyl tyrosine modification GO:0018212 72 0.022
growth GO:0040007 165 0.022
nucleotide biosynthetic process GO:0009165 98 0.022
regulation of intracellular signal transduction GO:1902531 218 0.022
regulation of synaptic transmission GO:0050804 141 0.022
regulation of rna metabolic process GO:0051252 391 0.022
positive regulation of developmental process GO:0051094 283 0.021
regulation of body fluid levels GO:0050878 90 0.021
female pregnancy GO:0007565 122 0.021
signal transduction by phosphorylation GO:0023014 144 0.021
response to nutrient GO:0007584 248 0.021
cellular response to lipid GO:0071396 201 0.020
ossification GO:0001503 70 0.020
positive regulation of response to stimulus GO:0048584 285 0.020
positive regulation of synaptic transmission GO:0050806 62 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
glycerolipid metabolic process GO:0046486 67 0.019
chemical homeostasis GO:0048878 292 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
cation transport GO:0006812 382 0.019
regulation of metal ion transport GO:0010959 118 0.019
response to fibroblast growth factor GO:0071774 29 0.018
negative regulation of transport GO:0051051 136 0.018
negative regulation of molecular function GO:0044092 133 0.018
regulation of leukocyte migration GO:0002685 24 0.018
carbohydrate derivative biosynthetic process GO:1901137 124 0.018
peptidyl tyrosine phosphorylation GO:0018108 72 0.018
immune system process GO:0002376 204 0.018
response to molecule of bacterial origin GO:0002237 194 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
gamete generation GO:0007276 124 0.018
regulation of system process GO:0044057 208 0.018
circulatory system process GO:0003013 183 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.018
cellular response to acid chemical GO:0071229 75 0.018
neuron projection morphogenesis GO:0048812 122 0.018
positive regulation of transport GO:0051050 245 0.018
synaptic transmission glycinergic GO:0060012 2 0.017
regulation of phosphate metabolic process GO:0019220 349 0.017
tube development GO:0035295 89 0.017
organ regeneration GO:0031100 101 0.017
regulation of hydrolase activity GO:0051336 143 0.017
regulation of ion transport GO:0043269 245 0.017
adult locomotory behavior GO:0008344 4 0.017
divalent inorganic cation homeostasis GO:0072507 165 0.017
alcohol metabolic process GO:0006066 77 0.017
negative regulation of signaling GO:0023057 157 0.017
vesicle mediated transport GO:0016192 181 0.016
negative regulation of rna metabolic process GO:0051253 123 0.016
synapse organization GO:0050808 46 0.016
negative regulation of transcription dna templated GO:0045892 116 0.016
positive regulation of cell differentiation GO:0045597 217 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
Rat
regeneration GO:0031099 163 0.016
somatostatin receptor signaling pathway GO:0038169 4 0.016
cell type specific apoptotic process GO:0097285 134 0.016
wound healing GO:0042060 122 0.016
regulation of hormone secretion GO:0046883 106 0.016
positive regulation of immune system process GO:0002684 90 0.016
terpenoid metabolic process GO:0006721 37 0.016
response to nicotine GO:0035094 51 0.015
regulation of phosphorylation GO:0042325 248 0.015
positive regulation of intracellular signal transduction GO:1902533 138 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
cellular response to hexose stimulus GO:0071331 65 0.015
cellular response to oxidative stress GO:0034599 76 0.015
isoprenoid metabolic process GO:0006720 45 0.015
response to reactive oxygen species GO:0000302 120 0.015
response to hexose GO:0009746 144 0.015
response to light stimulus GO:0009416 52 0.015
regulation of anatomical structure size GO:0090066 135 0.015
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.015
regulation of catalytic activity GO:0050790 304 0.015
reproductive structure development GO:0048608 128 0.015
regulation of cell motility GO:2000145 131 0.015
regulation of insulin secretion GO:0050796 65 0.015
reproductive system development GO:0061458 128 0.015
insecticide metabolic process GO:0017143 4 0.015
regulation of cell adhesion GO:0030155 52 0.014
lymphocyte chemotaxis GO:0048247 3 0.014
protein tetramerization GO:0051262 38 0.014
pallium development GO:0021543 42 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
male gamete generation GO:0048232 99 0.014
positive regulation of protein phosphorylation GO:0001934 135 0.014
regulation of homeostatic process GO:0032844 101 0.014
nitrogen compound transport GO:0071705 229 0.014
circadian rhythm GO:0007623 88 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.014
regulation of defense response GO:0031347 68 0.014
steroid biosynthetic process GO:0006694 48 0.014
synaptic transmission glutamatergic GO:0035249 33 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
regulation of cellular component movement GO:0051270 150 0.014
negative regulation of chronic inflammatory response GO:0002677 2 0.014
cyclic nucleotide biosynthetic process GO:0009190 63 0.014
response to histamine GO:0034776 3 0.014
gliogenesis GO:0042063 93 0.014
organ formation GO:0048645 3 0.014
regulation of kinase activity GO:0043549 117 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
protein heterooligomerization GO:0051291 89 0.013
negative regulation of vesicle fusion GO:0031339 2 0.013
cellular response to biotic stimulus GO:0071216 59 0.013
fertilization GO:0009566 3 0.013
cellular response to histamine GO:0071420 3 0.013
exocytosis GO:0006887 60 0.013
immune response GO:0006955 104 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.013
spermatogenesis GO:0007283 99 0.013
regulation of cellular component organization GO:0051128 368 0.013
positive regulation of rna biosynthetic process GO:1902680 197 0.013
hepaticobiliary system development GO:0061008 90 0.013
response to corticosteroid GO:0031960 235 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
regulation of neuron apoptotic process GO:0043523 83 0.013
cellular response to organic cyclic compound GO:0071407 202 0.013
development of primary female sexual characteristics GO:0046545 56 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
positive regulation of hormone secretion GO:0046887 65 0.013
gland morphogenesis GO:0022612 12 0.013
peptidyl amino acid modification GO:0018193 126 0.013
hormone secretion GO:0046879 115 0.013
limbic system development GO:0021761 38 0.012
glucose homeostasis GO:0042593 75 0.012
cellular response to insulin stimulus GO:0032869 81 0.012
single fertilization GO:0007338 3 0.012
mast cell migration GO:0097531 4 0.012
positive regulation of secretion GO:0051047 140 0.012
somatostatin signaling pathway GO:0038170 4 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
associative learning GO:0008306 19 0.012
sleep GO:0030431 30 0.012
divalent inorganic cation transport GO:0072511 134 0.012
response to insulin GO:0032868 133 0.012
positive regulation of locomotion GO:0040017 102 0.012
organ morphogenesis GO:0009887 75 0.012
positive regulation of protein modification process GO:0031401 142 0.012
positive regulation of endocytosis GO:0045807 28 0.012
multicellular organism growth GO:0035264 1 0.012
regulation of peptide transport GO:0090087 87 0.012
cellular response to alkaloid GO:0071312 25 0.012
cellular response to reactive oxygen species GO:0034614 55 0.012
regulation of chronic inflammatory response GO:0002676 3 0.012
synapse assembly GO:0007416 29 0.012
anion transmembrane transport GO:0098656 77 0.012
jak stat cascade GO:0007259 26 0.011
secretion GO:0046903 307 0.011
glomerular mesangial cell proliferation GO:0072110 4 0.011
negative regulation of protein maturation GO:1903318 47 0.011
sodium ion transport GO:0006814 82 0.011
parturition GO:0007567 10 0.011
ribonucleotide biosynthetic process GO:0009260 85 0.011
cation transmembrane transport GO:0098655 263 0.011
proteolysis GO:0006508 175 0.011
Rat
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
muscle cell proliferation GO:0033002 84 0.011
carbohydrate derivative metabolic process GO:1901135 346 0.011
response to amino acid GO:0043200 75 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
developmental growth GO:0048589 100 0.011
sequestering of metal ion GO:0051238 9 0.011
negative regulation of luteinizing hormone secretion GO:0033685 4 0.011
detection of stimulus GO:0051606 24 0.011
cell cycle GO:0007049 101 0.011
gonad development GO:0008406 104 0.011
response to estrogen GO:0043627 232 0.011
nucleotide metabolic process GO:0009117 279 0.011
positive regulation of peptide secretion GO:0002793 52 0.011
digestive tract development GO:0048565 39 0.011
single organism organelle organization GO:1902589 180 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
regulation of transferase activity GO:0051338 123 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.010
negative regulation of multicellular organismal process GO:0051241 203 0.010
organelle organization GO:0006996 266 0.010
regulation of cellular amine metabolic process GO:0033238 8 0.010
positive regulation of cellular protein metabolic process GO:0032270 167 0.010
regulation of angiogenesis GO:0045765 39 0.010
intracellular transport GO:0046907 185 0.010
female sex differentiation GO:0046660 59 0.010
transcription from rna polymerase ii promoter GO:0006366 252 0.010
positive regulation of peptide hormone secretion GO:0090277 50 0.010
cellular response to carbohydrate stimulus GO:0071322 72 0.010
regulation of reactive oxygen species metabolic process GO:2000377 26 0.010
hormone biosynthetic process GO:0042446 25 0.010
ribose phosphate metabolic process GO:0019693 235 0.010

Adam6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.014