Rattus norvegicus

375 known processes

Ager

advanced glycosylation end product-specific receptor

(Aliases: RAGE)

Ager biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transcription from rna polymerase ii promoter GO:0006366 252 0.558
transcription dna templated GO:0006351 377 0.359
Human
tissue development GO:0009888 252 0.293
biological adhesion GO:0022610 110 0.288
rna metabolic process GO:0016070 406 0.285
Human
central nervous system development GO:0007417 311 0.282
brain development GO:0007420 247 0.268
regulation of rna metabolic process GO:0051252 391 0.263
Human
negative regulation of cell differentiation GO:0045596 99 0.243
regulation of nucleic acid templated transcription GO:1903506 380 0.239
Human
regulation of cell differentiation GO:0045595 320 0.238
regulation of neuron differentiation GO:0045664 208 0.229
rna biosynthetic process GO:0032774 380 0.225
Human
cell projection organization GO:0030030 302 0.199
regulation of ion transport GO:0043269 245 0.177
positive regulation of multicellular organismal process GO:0051240 387 0.165
response to extracellular stimulus GO:0009991 380 0.165
nucleic acid templated transcription GO:0097659 379 0.164
Human
response to nutrient levels GO:0031667 370 0.161
negative regulation of cell development GO:0010721 82 0.159
cation transport GO:0006812 382 0.158
positive regulation of biosynthetic process GO:0009891 319 0.154
epithelium development GO:0060429 96 0.154
apoptotic process GO:0006915 381 0.149
positive regulation of rna metabolic process GO:0051254 203 0.144
ion transmembrane transport GO:0034220 365 0.134
regulation of rna biosynthetic process GO:2001141 381 0.132
Human
positive regulation of transcription dna templated GO:0045893 197 0.129
positive regulation of rna biosynthetic process GO:1902680 197 0.128
negative regulation of neurogenesis GO:0050768 78 0.127
response to oxygen levels GO:0070482 265 0.126
neuron differentiation GO:0030182 368 0.124
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.121
regulation of neurogenesis GO:0050767 247 0.119
head development GO:0060322 247 0.118
nitrogen compound transport GO:0071705 229 0.118
cardiac ventricle development GO:0003231 1 0.116
negative regulation of transcription dna templated GO:0045892 116 0.113
positive regulation of cellular biosynthetic process GO:0031328 295 0.112
organ morphogenesis GO:0009887 75 0.111
regulation of nervous system development GO:0051960 264 0.105
neuron projection development GO:0031175 273 0.099
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.098
inorganic cation transmembrane transport GO:0098662 202 0.098
negative regulation of developmental process GO:0051093 125 0.094
negative regulation of neuron differentiation GO:0045665 62 0.093
regulation of molecular function GO:0065009 398 0.093
cation transmembrane transport GO:0098655 263 0.090
neuron apoptotic process GO:0051402 88 0.090
homeostatic process GO:0042592 331 0.089
cellular chemical homeostasis GO:0055082 247 0.088
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.088
negative regulation of nervous system development GO:0051961 79 0.088
neuron development GO:0048666 286 0.087
negative regulation of nucleic acid templated transcription GO:1903507 117 0.087
positive regulation of nucleic acid templated transcription GO:1903508 197 0.084
cell morphogenesis GO:0000902 142 0.083
transmembrane transport GO:0055085 412 0.080
multicellular organism reproduction GO:0032504 233 0.079
single organism reproductive process GO:0044702 297 0.079
cellular component biogenesis GO:0044085 368 0.078
regulation of cell development GO:0060284 263 0.076
protein oligomerization GO:0051259 191 0.076
heart morphogenesis GO:0003007 3 0.075
cellular response to endogenous stimulus GO:0071495 377 0.072
response to carbohydrate GO:0009743 183 0.069
regulation of transcription dna templated GO:0006355 374 0.069
Human
positive regulation of molecular function GO:0044093 230 0.067
macromolecular complex assembly GO:0065003 273 0.065
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.065
positive regulation of gene expression GO:0010628 244 0.065
cellular component assembly GO:0022607 360 0.065
positive regulation of developmental process GO:0051094 283 0.063
defecation GO:0030421 1 0.059
s shaped body morphogenesis GO:0072050 2 0.057
response to acid chemical GO:0001101 222 0.057
cellular response to oxygen containing compound GO:1901701 386 0.057
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.056
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.056
programmed cell death GO:0012501 392 0.055
negative regulation of metabolic process GO:0009892 331 0.055
negative regulation of cellular metabolic process GO:0031324 281 0.055
positive regulation of phosphorus metabolic process GO:0010562 262 0.055
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.053
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.053
regulation of phosphate metabolic process GO:0019220 349 0.052
regulation of multicellular organismal development GO:2000026 376 0.052
protein complex biogenesis GO:0070271 263 0.052
response to inorganic substance GO:0010035 377 0.051
carbohydrate derivative metabolic process GO:1901135 346 0.050
negative regulation of rna biosynthetic process GO:1902679 118 0.050
regulation of cell projection organization GO:0031344 175 0.050
response to glucose GO:0009749 136 0.050
positive regulation of serotonin secretion GO:0014064 1 0.049
response to hexose GO:0009746 144 0.049
negative regulation of cell communication GO:0010648 158 0.049
enzyme linked receptor protein signaling pathway GO:0007167 116 0.049
response to nutrient GO:0007584 248 0.048
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.048
negative regulation of cellular biosynthetic process GO:0031327 161 0.047
anterior posterior pattern specification GO:0009952 1 0.047
regulation of secretion GO:0051046 224 0.046
positive regulation of apoptotic process GO:0043065 154 0.046
purine nucleotide metabolic process GO:0006163 229 0.046
glucose homeostasis GO:0042593 75 0.045
regulation of respiratory gaseous exchange by neurological system process GO:0002087 1 0.044
negative regulation of biosynthetic process GO:0009890 168 0.044
catabolic process GO:0009056 351 0.044
mesoderm development GO:0007498 2 0.044
regulation of cell proliferation GO:0042127 359 0.043
metanephric comma shaped body morphogenesis GO:0072278 2 0.043
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.043
comma shaped body morphogenesis GO:0072049 2 0.042
regulation of cell morphogenesis GO:0022604 77 0.042
motor neuron axon guidance GO:0008045 1 0.042
protein complex assembly GO:0006461 263 0.042
response to decreased oxygen levels GO:0036293 237 0.041
Mouse
cell projection morphogenesis GO:0048858 123 0.041
single organism behavior GO:0044708 130 0.041
cellular amide metabolic process GO:0043603 44 0.041
secretion GO:0046903 307 0.041
regulation of neuron projection development GO:0010975 161 0.040
organic substance catabolic process GO:1901575 316 0.040
immune system process GO:0002376 204 0.040
reproduction GO:0000003 245 0.039
response to growth factor GO:0070848 189 0.039
cellular response to abiotic stimulus GO:0071214 85 0.039
metanephric s shaped body morphogenesis GO:0072284 2 0.039
response to external biotic stimulus GO:0043207 221 0.039
locomotory exploration behavior GO:0035641 1 0.038
protein complex subunit organization GO:0071822 302 0.038
type b pancreatic cell proliferation GO:0044342 3 0.038
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.038
response to biotic stimulus GO:0009607 226 0.037
chemical homeostasis GO:0048878 292 0.037
negative regulation of multicellular organismal process GO:0051241 203 0.037
synaptic growth at neuromuscular junction GO:0051124 1 0.037
positive regulation of signaling GO:0023056 270 0.036
Mouse
regulation of apoptotic process GO:0042981 335 0.035
tube development GO:0035295 89 0.035
muscle structure development GO:0061061 87 0.035
reproductive system development GO:0061458 128 0.035
excretion GO:0007588 24 0.035
multi organism reproductive process GO:0044703 262 0.035
ribonucleotide biosynthetic process GO:0009260 85 0.034
regulation of cytokine production GO:0001817 56 0.034
cell cell signaling GO:0007267 335 0.034
protein homooligomerization GO:0051260 91 0.034
negative regulation of gene expression GO:0010629 199 0.033
ion homeostasis GO:0050801 212 0.033
positive regulation of neurogenesis GO:0050769 165 0.033
negative regulation of macromolecule metabolic process GO:0010605 260 0.033
regulation of synaptic transmission GO:0050804 141 0.033
response to estrogen GO:0043627 232 0.033
cardiovascular system development GO:0072358 134 0.033
regulation of cellular amine metabolic process GO:0033238 8 0.032
ribonucleotide metabolic process GO:0009259 231 0.031
purine nucleotide biosynthetic process GO:0006164 83 0.031
circulatory system development GO:0072359 134 0.031
nucleoside phosphate biosynthetic process GO:1901293 102 0.031
purine ribonucleotide metabolic process GO:0009150 227 0.030
secretion by cell GO:0032940 248 0.030
anatomical structure morphogenesis GO:0009653 298 0.030
positive regulation of neuron differentiation GO:0045666 126 0.030
negative regulation of rna metabolic process GO:0051253 123 0.030
inorganic ion transmembrane transport GO:0098660 229 0.030
cell part morphogenesis GO:0032990 123 0.030
reproductive process GO:0022414 372 0.030
neurological system process GO:0050877 219 0.029
response to hypoxia GO:0001666 231 0.029
Mouse
developmental growth GO:0048589 100 0.029
regulation of cell cycle GO:0051726 73 0.029
positive regulation of cell development GO:0010720 176 0.028
cell morphogenesis involved in differentiation GO:0000904 119 0.028
retinal ganglion cell axon guidance GO:0031290 1 0.028
response to corticosteroid GO:0031960 235 0.028
response to other organism GO:0051707 220 0.028
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.028
gastrulation GO:0007369 2 0.028
skeletal system development GO:0001501 41 0.028
negative regulation of cell death GO:0060548 229 0.027
regulation of immune system process GO:0002682 123 0.027
learning or memory GO:0007611 90 0.027
circulatory system process GO:0003013 183 0.027
sensory perception GO:0007600 101 0.027
response to cytokine GO:0034097 215 0.027
carbohydrate homeostasis GO:0033500 75 0.027
digestive system development GO:0055123 41 0.027
nerve development GO:0021675 11 0.026
monoamine transport GO:0015844 43 0.026
divalent inorganic cation homeostasis GO:0072507 165 0.026
organic hydroxy compound transport GO:0015850 77 0.026
positive regulation of cell death GO:0010942 184 0.026
multicellular organismal reproductive process GO:0048609 233 0.026
embryo development GO:0009790 49 0.025
macromolecular complex subunit organization GO:0043933 339 0.025
behavior GO:0007610 205 0.024
Mouse
positive regulation of programmed cell death GO:0043068 157 0.024
sexual reproduction GO:0019953 148 0.024
regulation of cellular component organization GO:0051128 368 0.024
single organism organelle organization GO:1902589 180 0.024
locomotion GO:0040011 237 0.024
regulation of programmed cell death GO:0043067 341 0.024
protein localization GO:0008104 191 0.024
Mouse
skeletal muscle cell differentiation GO:0035914 2 0.024
adult locomotory behavior GO:0008344 4 0.024
positive regulation of nucleotide metabolic process GO:0045981 91 0.023
palate development GO:0060021 2 0.023
cyclic purine nucleotide metabolic process GO:0052652 62 0.023
positive regulation of phosphate metabolic process GO:0045937 262 0.023
cellular catabolic process GO:0044248 295 0.023
organelle organization GO:0006996 266 0.023
forebrain development GO:0030900 98 0.023
response to metal ion GO:0010038 253 0.023
regulation of transferase activity GO:0051338 123 0.023
Mouse
sensory perception of pain GO:0019233 73 0.022
cellular homeostasis GO:0019725 252 0.022
organonitrogen compound catabolic process GO:1901565 179 0.022
positive regulation of response to stimulus GO:0048584 285 0.022
single organism biosynthetic process GO:0044711 342 0.022
negative regulation of calcium ion import GO:0090281 2 0.022
cyclic nucleotide metabolic process GO:0009187 80 0.021
proteolysis GO:0006508 175 0.021
morphogenesis of an epithelium GO:0002009 20 0.021
nucleoside phosphate metabolic process GO:0006753 283 0.021
negative regulation of cellular component organization GO:0051129 83 0.021
cellular response to lipid GO:0071396 201 0.021
regulation of ion transmembrane transport GO:0034765 121 0.021
regulation of catecholamine secretion GO:0050433 32 0.021
regulation of defecation GO:2000292 1 0.020
regulation of cellular ketone metabolic process GO:0010565 27 0.020
metal ion transport GO:0030001 289 0.020
positive regulation of cell differentiation GO:0045597 217 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
purine containing compound metabolic process GO:0072521 253 0.020
carboxylic acid transport GO:0046942 115 0.020
negative regulation of signal transduction GO:0009968 83 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
regulation of phosphorus metabolic process GO:0051174 349 0.020
neuron projection morphogenesis GO:0048812 122 0.020
gonadotropin secretion GO:0032274 8 0.019
regulation of follicle stimulating hormone secretion GO:0046880 5 0.019
gamete generation GO:0007276 124 0.019
organophosphate metabolic process GO:0019637 370 0.019
organic acid transport GO:0015849 116 0.019
multicellular organismal water homeostasis GO:0050891 4 0.019
heart development GO:0007507 72 0.019
noradrenergic neuron differentiation GO:0003357 1 0.019
negative regulation of signaling GO:0023057 157 0.019
formation of primary germ layer GO:0001704 1 0.019
regulation of axonogenesis GO:0050770 37 0.019
muscle tissue morphogenesis GO:0060415 1 0.018
synaptic transmission GO:0007268 235 0.018
gliogenesis GO:0042063 93 0.018
response to transition metal nanoparticle GO:1990267 122 0.018
cellular cation homeostasis GO:0030003 180 0.018
calcium ion transport GO:0006816 131 0.018
regulation of secretion by cell GO:1903530 208 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.018
negative regulation of molecular function GO:0044092 133 0.018
dna metabolic process GO:0006259 96 0.018
response to peptide hormone GO:0043434 278 0.018
chemosensory behavior GO:0007635 2 0.018
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 1 0.018
b cell differentiation GO:0030183 2 0.018
positive regulation of ion transport GO:0043270 94 0.017
regulation of cellular localization GO:0060341 263 0.017
response to fluoride GO:1902617 3 0.017
regulation of signal transduction GO:0009966 318 0.017
Mouse
calcium ion homeostasis GO:0055074 162 0.017
learning GO:0007612 33 0.017
renal system development GO:0072001 67 0.017
peptide biosynthetic process GO:0043043 3 0.017
muscle tissue development GO:0060537 58 0.017
positive regulation of nervous system development GO:0051962 178 0.017
localization of cell GO:0051674 202 0.017
bmp signaling pathway GO:0030509 4 0.017
dendrite development GO:0016358 72 0.017
positive regulation of amine transport GO:0051954 26 0.017
cellular response to acid chemical GO:0071229 75 0.017
response to axon injury GO:0048678 59 0.016
axon development GO:0061564 96 0.016
metanephric part of ureteric bud development GO:0035502 1 0.016
amide transport GO:0042886 105 0.016
positive regulation of cell projection organization GO:0031346 111 0.016
negative regulation of transport GO:0051051 136 0.016
negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 2 0.016
mesoderm formation GO:0001707 1 0.016
muscle organ development GO:0007517 50 0.016
carboxylic acid metabolic process GO:0019752 289 0.016
negative regulation of growth GO:0045926 37 0.016
regulation of growth GO:0040008 105 0.016
negative regulation of cell projection organization GO:0031345 50 0.016
intracellular transport GO:0046907 185 0.016
ribonucleoside triphosphate metabolic process GO:0009199 141 0.016
regulation of purine nucleotide metabolic process GO:1900542 115 0.016
negative regulation of follicle stimulating hormone secretion GO:0046882 3 0.016
growth GO:0040007 165 0.016
axis specification GO:0009798 4 0.016
regulation of cellular protein metabolic process GO:0032268 267 0.015
purine nucleoside catabolic process GO:0006152 124 0.015
regulation of system process GO:0044057 208 0.015
aging GO:0007568 241 0.015
olfactory behavior GO:0042048 2 0.015
regulation of proteasomal protein catabolic process GO:0061136 4 0.015
protein heterooligomerization GO:0051291 89 0.015
response to glucocorticoid GO:0051384 223 0.015
positive regulation of secretion GO:0051047 140 0.015
nucleotide biosynthetic process GO:0009165 98 0.015
organonitrogen compound biosynthetic process GO:1901566 167 0.015
muscle system process GO:0003012 115 0.014
gonad development GO:0008406 104 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
peptide metabolic process GO:0006518 32 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.014
transmission of nerve impulse GO:0019226 42 0.014
negative regulation of neuron projection development GO:0010977 46 0.014
cell fate determination GO:0001709 2 0.014
protein autophosphorylation GO:0046777 66 0.014
regulation of anatomical structure morphogenesis GO:0022603 141 0.014
cell cycle GO:0007049 101 0.014
positive regulation of cell proliferation GO:0008284 249 0.014
regulation of metanephros development GO:0072215 4 0.014
neuron fate commitment GO:0048663 4 0.014
multi multicellular organism process GO:0044706 138 0.014
endochondral bone growth GO:0003416 3 0.014
defense response GO:0006952 194 0.014
regulation of insulin secretion GO:0050796 65 0.014
cardiac chamber development GO:0003205 1 0.014
antigen processing and presentation GO:0019882 2 0.014
action potential GO:0001508 54 0.014
visual perception GO:0007601 3 0.014
apoptotic signaling pathway GO:0097190 27 0.014
regulation of muscle tissue development GO:1901861 25 0.014
norepinephrine secretion GO:0048243 16 0.013
regulation of blood circulation GO:1903522 110 0.013
maintenance of location GO:0051235 17 0.013
response to estradiol GO:0032355 164 0.013
cellular ketone metabolic process GO:0042180 51 0.013
response to lipopolysaccharide GO:0032496 191 0.013
mitotic sister chromatid separation GO:0051306 1 0.013
response to purine containing compound GO:0014074 126 0.013
regulation of phosphorylation GO:0042325 248 0.013
oxoacid metabolic process GO:0043436 290 0.013
chromosome segregation GO:0007059 2 0.013
cellular component morphogenesis GO:0032989 155 0.013
digestive tract development GO:0048565 39 0.013
spindle organization GO:0007051 2 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.013
organ formation GO:0048645 3 0.013
blood circulation GO:0008015 183 0.013
thigmotaxis GO:0001966 1 0.013
regulation of neuronal synaptic plasticity GO:0048168 31 0.013
embryonic skeletal system development GO:0048706 3 0.013
sex differentiation GO:0007548 113 0.013
dendrite morphogenesis GO:0048813 43 0.013
positive regulation of cellular component organization GO:0051130 200 0.013
cardiac muscle tissue morphogenesis GO:0055008 1 0.012
skeletal system morphogenesis GO:0048705 12 0.012
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.012
positive regulation of peptide secretion GO:0002793 52 0.012
negative regulation of defecation GO:2000293 1 0.012
embryonic morphogenesis GO:0048598 14 0.012
purine containing compound biosynthetic process GO:0072522 85 0.012
ras protein signal transduction GO:0007265 29 0.012
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 2 0.012
male mating behavior GO:0060179 3 0.012
cognition GO:0050890 92 0.012
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.012
regulation of interleukin 6 production GO:0032675 12 0.012
signal release GO:0023061 145 0.012
chromosome organization GO:0051276 36 0.012
cell projection assembly GO:0030031 21 0.012
development of primary sexual characteristics GO:0045137 107 0.012
mesoderm morphogenesis GO:0048332 1 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
behavioral response to ethanol GO:0048149 1 0.012
embryonic pattern specification GO:0009880 1 0.011
reproductive structure development GO:0048608 128 0.011
desensitization of g protein coupled receptor protein signaling pathway GO:0002029 10 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
nucleotide metabolic process GO:0009117 279 0.011
regulation of catabolic process GO:0009894 113 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
regeneration GO:0031099 163 0.011
cellular response to stress GO:0033554 269 0.011
insulin secretion GO:0030073 69 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
diencephalon development GO:0021536 21 0.011
regulation of blood pressure GO:0008217 83 0.011
mapk cascade GO:0000165 140 0.011
Mouse
cytosolic calcium ion homeostasis GO:0051480 140 0.011
regulation of peptide secretion GO:0002791 82 0.011
regulation of respiratory gaseous exchange GO:0043576 2 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
embryonic axis specification GO:0000578 1 0.011
regulation of apoptotic signaling pathway GO:2001233 13 0.011
negative regulation of metanephros development GO:0072217 2 0.011
tissue morphogenesis GO:0048729 22 0.011
muscle organ morphogenesis GO:0048644 1 0.011
cell type specific apoptotic process GO:0097285 134 0.011
protein tetramerization GO:0051262 38 0.011
ribose phosphate metabolic process GO:0019693 235 0.011
negative regulation of developmental growth GO:0048640 15 0.011
embryonic skeletal system morphogenesis GO:0048704 3 0.010
hypothalamus development GO:0021854 11 0.010
protein phosphorylation GO:0006468 345 0.010
positive regulation of cytokine production GO:0001819 42 0.010
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.010
cell adhesion GO:0007155 110 0.010
monovalent inorganic cation transport GO:0015672 172 0.010
male gamete generation GO:0048232 99 0.010
cell differentiation involved in kidney development GO:0061005 4 0.010
tube morphogenesis GO:0035239 23 0.010
cytokine production GO:0001816 61 0.010
regulation of kinase activity GO:0043549 117 0.010
Mouse
organic acid metabolic process GO:0006082 292 0.010
negative regulation of insulin receptor signaling pathway GO:0046627 10 0.010
immune response GO:0006955 104 0.010
cellular ion homeostasis GO:0006873 184 0.010

Ager disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
respiratory system disease DOID:1579 0 0.024
lower respiratory tract disease DOID:0050161 0 0.024
disease of anatomical entity DOID:7 0 0.024
primary ciliary dyskinesia DOID:9562 0 0.018
kidney disease DOID:557 0 0.016
urinary system disease DOID:18 0 0.016
sensory system disease DOID:0050155 0 0.015
nervous system disease DOID:863 0 0.015