Rattus norvegicus

0 known processes

Akr1b8

aldo-keto reductase family 1, member B8

(Aliases: MGC91427)

Akr1b8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
single organism catabolic process GO:0044712 283 0.264
Human
apoptotic process GO:0006915 381 0.220
regulation of programmed cell death GO:0043067 341 0.219
response to inorganic substance GO:0010035 377 0.194
Rat
regulation of cell proliferation GO:0042127 359 0.180
Rat
regulation of apoptotic process GO:0042981 335 0.179
programmed cell death GO:0012501 392 0.166
response to oxidative stress GO:0006979 186 0.164
Rat
organic acid biosynthetic process GO:0016053 83 0.156
response to extracellular stimulus GO:0009991 380 0.152
response to reactive oxygen species GO:0000302 120 0.147
Rat
response to metal ion GO:0010038 253 0.144
cellular response to organic cyclic compound GO:0071407 202 0.142
oxoacid metabolic process GO:0043436 290 0.116
glutathione metabolic process GO:0006749 15 0.110
response to wounding GO:0009611 254 0.108
response to estrogen GO:0043627 232 0.100
Rat
response to nutrient levels GO:0031667 370 0.094
cellular response to reactive oxygen species GO:0034614 55 0.094
Rat
oxidation reduction process GO:0055114 304 0.092
Human Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.089
response to hydrogen peroxide GO:0042542 89 0.086
Rat
carboxylic acid biosynthetic process GO:0046394 83 0.084
organic acid metabolic process GO:0006082 292 0.083
carboxylic acid metabolic process GO:0019752 289 0.080
response to nutrient GO:0007584 248 0.079
cell type specific apoptotic process GO:0097285 134 0.079
tissue development GO:0009888 252 0.077
regeneration GO:0031099 163 0.077
cellular response to oxygen containing compound GO:1901701 386 0.072
Rat
negative regulation of cell proliferation GO:0008285 119 0.072
transcription dna templated GO:0006351 377 0.070
cellular response to stress GO:0033554 269 0.068
Rat
negative regulation of cell death GO:0060548 229 0.068
response to ethanol GO:0045471 162 0.067
positive regulation of cellular biosynthetic process GO:0031328 295 0.067
catabolic process GO:0009056 351 0.064
Human
response to peptide GO:1901652 292 0.064
Rat
negative regulation of metabolic process GO:0009892 331 0.064
cellular response to steroid hormone stimulus GO:0071383 93 0.060
response to glucocorticoid GO:0051384 223 0.060
positive regulation of cell death GO:0010942 184 0.059
cellular amino acid metabolic process GO:0006520 107 0.059
lipid metabolic process GO:0006629 283 0.058
Human Rat
single organism biosynthetic process GO:0044711 342 0.056
Rat
single organism reproductive process GO:0044702 297 0.055
Rat
ion transmembrane transport GO:0034220 365 0.055
cation transport GO:0006812 382 0.055
cellular response to oxidative stress GO:0034599 76 0.052
Rat
cellular ketone metabolic process GO:0042180 51 0.052
Human
cellular lipid metabolic process GO:0044255 208 0.051
Human Rat
cellular amino acid biosynthetic process GO:0008652 32 0.050
negative regulation of programmed cell death GO:0043069 183 0.049
small molecule biosynthetic process GO:0044283 124 0.049
Rat
positive regulation of programmed cell death GO:0043068 157 0.049
response to hypoxia GO:0001666 231 0.049
positive regulation of biosynthetic process GO:0009891 319 0.049
neuron apoptotic process GO:0051402 88 0.048
blood circulation GO:0008015 183 0.048
rna metabolic process GO:0016070 406 0.047
negative regulation of biosynthetic process GO:0009890 168 0.047
positive regulation of apoptotic process GO:0043065 154 0.047
cell cell signaling GO:0007267 335 0.047
nucleic acid templated transcription GO:0097659 379 0.046
nonribosomal peptide biosynthetic process GO:0019184 3 0.045
response to estradiol GO:0032355 164 0.045
regulation of transcription dna templated GO:0006355 374 0.045
cellular catabolic process GO:0044248 295 0.044
Human
negative regulation of response to stimulus GO:0048585 155 0.044
negative regulation of cellular biosynthetic process GO:0031327 161 0.042
transmembrane transport GO:0055085 412 0.042
divalent inorganic cation transport GO:0072511 134 0.041
nucleotide metabolic process GO:0009117 279 0.041
negative regulation of apoptotic process GO:0043066 181 0.040
response to growth factor GO:0070848 189 0.040
regulation of response to stress GO:0080134 126 0.040
cellular amine metabolic process GO:0044106 38 0.039
response to hexose GO:0009746 144 0.037
multicellular organism reproduction GO:0032504 233 0.037
Rat
sulfur compound metabolic process GO:0006790 70 0.037
rna biosynthetic process GO:0032774 380 0.037
negative regulation of cytokine production GO:0001818 16 0.036
response to toxic substance GO:0009636 133 0.036
response to transition metal nanoparticle GO:1990267 122 0.036
regulation of rna metabolic process GO:0051252 391 0.036
anatomical structure morphogenesis GO:0009653 298 0.035
regulation of molecular function GO:0065009 398 0.035
organophosphate metabolic process GO:0019637 370 0.035
response to monosaccharide GO:0034284 159 0.034
cellular response to glucocorticoid stimulus GO:0071385 68 0.034
cytokine production GO:0001816 61 0.033
cellular response to extracellular stimulus GO:0031668 73 0.033
response to oxygen levels GO:0070482 265 0.033
reactive oxygen species metabolic process GO:0072593 37 0.033
regulation of rna biosynthetic process GO:2001141 381 0.033
cellular response to lipid GO:0071396 201 0.032
localization of cell GO:0051674 202 0.032
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.032
negative regulation of gene expression GO:0010629 199 0.031
cellular response to corticosteroid stimulus GO:0071384 69 0.031
monocarboxylic acid metabolic process GO:0032787 152 0.031
protein homooligomerization GO:0051260 91 0.031
divalent metal ion transport GO:0070838 132 0.030
negative regulation of multicellular organismal process GO:0051241 203 0.030
protein oligomerization GO:0051259 191 0.030
response to peptide hormone GO:0043434 278 0.030
cell projection organization GO:0030030 302 0.029
urogenital system development GO:0001655 78 0.029
Rat
response to amino acid GO:0043200 75 0.029
regulation of neuron apoptotic process GO:0043523 83 0.029
homeostatic process GO:0042592 331 0.029
Rat
response to decreased oxygen levels GO:0036293 237 0.029
central nervous system development GO:0007417 311 0.028
Rat Fly
response to vitamin GO:0033273 131 0.028
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.028
response to corticosteroid GO:0031960 235 0.028
multi multicellular organism process GO:0044706 138 0.027
Rat
reproductive system development GO:0061458 128 0.027
protein complex assembly GO:0006461 263 0.027
organic substance catabolic process GO:1901575 316 0.027
Human
cellular response to endogenous stimulus GO:0071495 377 0.027
Rat
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
response to carbohydrate GO:0009743 183 0.026
negative regulation of transport GO:0051051 136 0.026
cellular component biogenesis GO:0044085 368 0.026
positive regulation of developmental process GO:0051094 283 0.026
brain development GO:0007420 247 0.026
Rat Fly
cellular component assembly GO:0022607 360 0.026
single organism carbohydrate metabolic process GO:0044723 118 0.025
Rat
circulatory system process GO:0003013 183 0.025
cell motility GO:0048870 202 0.025
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
regulation of cellular ketone metabolic process GO:0010565 27 0.025
regulation of ion transmembrane transport GO:0034765 121 0.025
regulation of neuron death GO:1901214 115 0.024
female pregnancy GO:0007565 122 0.024
Rat
regulation of phosphorus metabolic process GO:0051174 349 0.024
response to glucose GO:0009749 136 0.024
response to zinc ion GO:0010043 39 0.024
negative regulation of cellular metabolic process GO:0031324 281 0.024
regulation of response to external stimulus GO:0032101 106 0.024
immune system process GO:0002376 204 0.024
positive regulation of rna biosynthetic process GO:1902680 197 0.024
positive regulation of voltage gated calcium channel activity GO:1901387 1 0.024
growth GO:0040007 165 0.024
regulation of catalytic activity GO:0050790 304 0.023
single organism cellular localization GO:1902580 102 0.023
metal ion transport GO:0030001 289 0.023
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.023
regulation of blood pressure GO:0008217 83 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.023
cellular modified amino acid metabolic process GO:0006575 61 0.023
positive regulation of protein modification process GO:0031401 142 0.022
carbohydrate derivative metabolic process GO:1901135 346 0.022
Human
wound healing GO:0042060 122 0.022
response to alkaloid GO:0043279 132 0.022
cellular response to hypoxia GO:0071456 51 0.022
cellular response to growth factor stimulus GO:0071363 162 0.022
organonitrogen compound biosynthetic process GO:1901566 167 0.022
macromolecular complex subunit organization GO:0043933 339 0.022
cellular response to alcohol GO:0097306 87 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.021
organic anion transport GO:0015711 132 0.021
reproductive structure development GO:0048608 128 0.021
leukocyte proliferation GO:0070661 29 0.021
negative regulation of cell communication GO:0010648 158 0.021
regulation of cytokine production GO:0001817 56 0.021
intracellular signal transduction GO:0035556 314 0.021
Rat
secretion GO:0046903 307 0.021
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.021
regulation of defense response GO:0031347 68 0.021
regulation of leukocyte activation GO:0002694 45 0.021
cellular response to hormone stimulus GO:0032870 247 0.020
regulation of cellular localization GO:0060341 263 0.020
organonitrogen compound catabolic process GO:1901565 179 0.020
cell activation GO:0001775 97 0.020
single organism intracellular transport GO:1902582 166 0.020
response to acid chemical GO:0001101 222 0.020
Rat
amine metabolic process GO:0009308 38 0.020
developmental process involved in reproduction GO:0003006 159 0.020
ossification GO:0001503 70 0.020
regulation of nervous system development GO:0051960 264 0.020
regulation of ion transport GO:0043269 245 0.020
calcium ion import GO:0070509 22 0.020
regulation of calcium ion transport GO:0051924 77 0.020
regulation of multicellular organismal development GO:2000026 376 0.020
unsaturated fatty acid metabolic process GO:0033559 39 0.020
cation transmembrane transport GO:0098655 263 0.020
negative regulation of secretion GO:0051048 82 0.020
positive regulation of gene expression GO:0010628 244 0.019
response to bacterium GO:0009617 200 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.019
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.019
regulation of anatomical structure morphogenesis GO:0022603 141 0.019
organic cyclic compound catabolic process GO:1901361 175 0.019
negative regulation of macromolecule metabolic process GO:0010605 260 0.019
cellular response to nutrient levels GO:0031669 60 0.019
inorganic cation transmembrane transport GO:0098662 202 0.018
vascular process in circulatory system GO:0003018 96 0.018
calcium ion transport GO:0006816 131 0.018
t cell extravasation GO:0072683 1 0.018
cellular homeostasis GO:0019725 252 0.018
rhythmic process GO:0048511 156 0.018
eosinophil migration GO:0072677 3 0.017
lipid biosynthetic process GO:0008610 128 0.017
regulation of skeletal muscle cell differentiation GO:2001014 1 0.017
negative regulation of molecular function GO:0044092 133 0.017
positive regulation of transcription dna templated GO:0045893 197 0.017
regulation of transmembrane transport GO:0034762 122 0.017
cd8 positive alpha beta t cell extravasation GO:0035697 0 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.017
organophosphate biosynthetic process GO:0090407 143 0.017
regulation of protein modification process GO:0031399 194 0.017
nitrogen compound transport GO:0071705 229 0.017
positive regulation of nucleic acid templated transcription GO:1903508 197 0.017
response to purine containing compound GO:0014074 126 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.017
inorganic ion transmembrane transport GO:0098660 229 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
secretion by cell GO:0032940 248 0.016
cellular component movement GO:0006928 248 0.016
organ regeneration GO:0031100 101 0.016
biological adhesion GO:0022610 110 0.016
regulation of tube size GO:0035150 89 0.016
synaptic transmission GO:0007268 235 0.016
locomotion GO:0040011 237 0.016
reproductive process GO:0022414 372 0.016
Rat
response to cytokine GO:0034097 215 0.016
protein complex subunit organization GO:0071822 302 0.016
regulation of system process GO:0044057 208 0.016
negative regulation of protein metabolic process GO:0051248 114 0.016
cellular divalent inorganic cation homeostasis GO:0072503 162 0.016
hexose metabolic process GO:0019318 58 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
regulation of phosphate metabolic process GO:0019220 349 0.016
regulation of anatomical structure size GO:0090066 135 0.015
acute inflammatory response GO:0002526 58 0.015
cellular response to metal ion GO:0071248 55 0.015
pyridine containing compound metabolic process GO:0072524 32 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
Human
maternal process involved in female pregnancy GO:0060135 38 0.015
Rat
aromatic compound catabolic process GO:0019439 168 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
carbohydrate homeostasis GO:0033500 75 0.015
response to ketone GO:1901654 182 0.015
Rat
head development GO:0060322 247 0.015
Rat Fly
multicellular organismal reproductive process GO:0048609 233 0.015
Rat
fatty acid metabolic process GO:0006631 99 0.015
regulation of vasculature development GO:1901342 44 0.015
regulation of phosphorylation GO:0042325 248 0.015
neuron death GO:0070997 127 0.015
negative regulation of signaling GO:0023057 157 0.015
hepaticobiliary system development GO:0061008 90 0.015
positive regulation of molecular function GO:0044093 230 0.015
purine containing compound catabolic process GO:0072523 138 0.015
regulation of cell activation GO:0050865 50 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
negative regulation of transcription dna templated GO:0045892 116 0.014
positive regulation of rna metabolic process GO:0051254 203 0.014
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 1 0.014
neuron differentiation GO:0030182 368 0.014
protein complex biogenesis GO:0070271 263 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
anion transport GO:0006820 178 0.014
regulation of cellular component organization GO:0051128 368 0.014
regulation of neurogenesis GO:0050767 247 0.014
inflammatory response GO:0006954 150 0.014
positive regulation of transmembrane transport GO:0034764 25 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
aging GO:0007568 241 0.014
macromolecular complex assembly GO:0065003 273 0.014
development of primary sexual characteristics GO:0045137 107 0.014
sex differentiation GO:0007548 113 0.013
monocarboxylic acid biosynthetic process GO:0072330 48 0.013
cellular response to peptide GO:1901653 133 0.013
Rat
ovulation cycle process GO:0022602 50 0.013
negative regulation of rna biosynthetic process GO:1902679 118 0.013
regulation of protein maturation GO:1903317 50 0.013
cellular modified amino acid biosynthetic process GO:0042398 18 0.013
negative regulation of secretion by cell GO:1903531 72 0.013
gland development GO:0048732 155 0.013
intracellular transport GO:0046907 185 0.013
ribose phosphate biosynthetic process GO:0046390 87 0.013
response to other organism GO:0051707 220 0.013
cellular response to oxygen levels GO:0071453 60 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
regulation of kinase activity GO:0043549 117 0.013
cell adhesion GO:0007155 110 0.013
negative regulation of rna metabolic process GO:0051253 123 0.013
neuronal action potential GO:0019228 35 0.013
cellular response to molecule of bacterial origin GO:0071219 56 0.013
response to insulin GO:0032868 133 0.013
ribonucleoside monophosphate metabolic process GO:0009161 88 0.013
reproduction GO:0000003 245 0.012
Rat
protein phosphorylation GO:0006468 345 0.012
calcium ion transmembrane transport GO:0070588 70 0.012
forebrain development GO:0030900 98 0.012
Rat
multi organism reproductive process GO:0044703 262 0.012
Rat
cellular response to abiotic stimulus GO:0071214 85 0.012
positive regulation of lipid catabolic process GO:0050996 4 0.012
peptide metabolic process GO:0006518 32 0.012
protein maturation GO:0051604 68 0.012
chemical homeostasis GO:0048878 292 0.012
neuron projection development GO:0031175 273 0.012
mononuclear cell migration GO:0071674 3 0.012
fatty acid derivative metabolic process GO:1901568 38 0.012
cell migration GO:0016477 197 0.012
regulation of secretion by cell GO:1903530 208 0.012
cell growth GO:0016049 104 0.012
positive regulation of defense response GO:0031349 37 0.012
ribonucleotide metabolic process GO:0009259 231 0.012
regulation of reactive oxygen species metabolic process GO:2000377 26 0.012
heterocycle catabolic process GO:0046700 167 0.012
response to molecule of bacterial origin GO:0002237 194 0.012
cardiovascular system development GO:0072358 134 0.012
erythrocyte differentiation GO:0030218 1 0.012
cellular response to inorganic substance GO:0071241 65 0.012
macromolecule localization GO:0033036 252 0.012
response to external biotic stimulus GO:0043207 221 0.012
glutathione biosynthetic process GO:0006750 3 0.012
purine ribonucleotide catabolic process GO:0009154 136 0.012
cellular response to external stimulus GO:0071496 118 0.012
carboxylic acid transport GO:0046942 115 0.012
multicellular organism growth GO:0035264 1 0.012
positive regulation of inflammatory response GO:0050729 24 0.012
cellular amide metabolic process GO:0043603 44 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
cellular component morphogenesis GO:0032989 155 0.011
response to activity GO:0014823 73 0.011
gonad development GO:0008406 104 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
transcription from rna polymerase ii promoter GO:0006366 252 0.011
regulation of cell development GO:0060284 263 0.011
positive regulation of transport GO:0051050 245 0.011
cellular protein localization GO:0034613 122 0.011
regulation of blood circulation GO:1903522 110 0.011
developmental growth GO:0048589 100 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
cellular response to ketone GO:1901655 51 0.011
Rat
regulation of response to wounding GO:1903034 69 0.011
regulation of endothelial cell apoptotic process GO:2000351 3 0.011
circulatory system development GO:0072359 134 0.011
signal release GO:0023061 145 0.011
nicotinamide nucleotide metabolic process GO:0046496 28 0.011
response to lipopolysaccharide GO:0032496 191 0.011
purine ribonucleoside catabolic process GO:0046130 124 0.011
regulation of cell motility GO:2000145 131 0.011
defense response GO:0006952 194 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
cellular response to fluid shear stress GO:0071498 4 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
cellular response to nutrient GO:0031670 30 0.011
icosanoid metabolic process GO:0006690 38 0.011
skeletal muscle cell differentiation GO:0035914 2 0.011
ribose phosphate metabolic process GO:0019693 235 0.011
negative regulation of response to external stimulus GO:0032102 37 0.011
glucose homeostasis GO:0042593 75 0.011
positive regulation of signaling GO:0023056 270 0.011
Rat
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
regulation of protein localization GO:0032880 81 0.010
regulation of cellular component size GO:0032535 51 0.010
regulation of cell morphogenesis GO:0022604 77 0.010
icosanoid biosynthetic process GO:0046456 18 0.010
response to nicotine GO:0035094 51 0.010
negative regulation of signal transduction GO:0009968 83 0.010
macrophage chemotaxis GO:0048246 2 0.010
regulation of vesicle mediated transport GO:0060627 81 0.010
regulation of cell projection organization GO:0031344 175 0.010
regulation of synaptic plasticity GO:0048167 70 0.010
synaptic growth at neuromuscular junction GO:0051124 1 0.010
negative regulation of neuron death GO:1901215 69 0.010
organic acid transport GO:0015849 116 0.010
positive regulation of protein metabolic process GO:0051247 178 0.010

Akr1b8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027
nervous system disease DOID:863 0 0.027
central nervous system disease DOID:331 0 0.015