Rattus norvegicus

0 known processes

Ap2a1

adaptor-related protein complex 2, alpha 1 subunit

Ap2a1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
synaptic vesicle endocytosis GO:0048488 4 0.894
vesicle mediated transport GO:0016192 181 0.417
endocytosis GO:0006897 84 0.285
cell cell signaling GO:0007267 335 0.180
nucleotide metabolic process GO:0009117 279 0.172
purine ribonucleotide catabolic process GO:0009154 136 0.171
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.159
synaptic vesicle recycling GO:0036465 5 0.158
macromolecule localization GO:0033036 252 0.157
nucleoside catabolic process GO:0009164 126 0.154
organelle organization GO:0006996 266 0.151
nucleoside triphosphate catabolic process GO:0009143 123 0.140
response to heat GO:0009408 60 0.133
purine nucleoside triphosphate metabolic process GO:0009144 141 0.132
regulation of cellular component organization GO:0051128 368 0.130
purine nucleoside triphosphate catabolic process GO:0009146 122 0.126
cellular catabolic process GO:0044248 295 0.125
carbohydrate derivative metabolic process GO:1901135 346 0.122
nucleobase containing small molecule metabolic process GO:0055086 316 0.120
glycosyl compound metabolic process GO:1901657 182 0.119
purine ribonucleotide metabolic process GO:0009150 227 0.119
olfactory learning GO:0008355 1 0.117
protein localization GO:0008104 191 0.114
ribonucleoside triphosphate catabolic process GO:0009203 122 0.113
nucleoside triphosphate metabolic process GO:0009141 144 0.112
single organism behavior GO:0044708 130 0.111
ribonucleotide metabolic process GO:0009259 231 0.110
organophosphate metabolic process GO:0019637 370 0.109
purine containing compound metabolic process GO:0072521 253 0.108
ribose phosphate metabolic process GO:0019693 235 0.108
nucleotide catabolic process GO:0009166 139 0.107
carbohydrate derivative catabolic process GO:1901136 147 0.107
purine containing compound catabolic process GO:0072523 138 0.102
cellular component assembly GO:0022607 360 0.100
purine nucleotide catabolic process GO:0006195 136 0.098
salivary gland morphogenesis GO:0007435 1 0.098
purine nucleoside metabolic process GO:0042278 169 0.098
purine ribonucleoside metabolic process GO:0046128 168 0.097
gland development GO:0048732 155 0.093
organic cyclic compound catabolic process GO:1901361 175 0.091
gtp catabolic process GO:0006184 71 0.090
vesicle localization GO:0051648 33 0.090
aromatic compound catabolic process GO:0019439 168 0.089
ribonucleotide catabolic process GO:0009261 136 0.088
catabolic process GO:0009056 351 0.087
ribonucleoside triphosphate metabolic process GO:0009199 141 0.087
nucleoside metabolic process GO:0009116 179 0.087
nucleoside phosphate metabolic process GO:0006753 283 0.085
nucleoside phosphate catabolic process GO:1901292 140 0.084
macromolecular complex assembly GO:0065003 273 0.079
glycosyl compound catabolic process GO:1901658 126 0.078
nucleobase containing compound catabolic process GO:0034655 152 0.076
learning or memory GO:0007611 90 0.075
guanosine containing compound metabolic process GO:1901068 74 0.074
cellular component biogenesis GO:0044085 368 0.072
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.072
ribonucleoside metabolic process GO:0009119 174 0.072
purine nucleoside catabolic process GO:0006152 124 0.072
vesicle organization GO:0016050 29 0.072
heterocycle catabolic process GO:0046700 167 0.070
synaptic transmission GO:0007268 235 0.070
organic substance catabolic process GO:1901575 316 0.069
positive regulation of response to stimulus GO:0048584 285 0.068
guanosine containing compound catabolic process GO:1901069 71 0.067
membrane organization GO:0061024 94 0.066
regulation of neurogenesis GO:0050767 247 0.066
positive regulation of signal transduction GO:0009967 175 0.066
response to nutrient GO:0007584 248 0.064
positive regulation of signaling GO:0023056 270 0.064
cell cycle GO:0007049 101 0.063
positive regulation of catalytic activity GO:0043085 184 0.062
purine ribonucleoside catabolic process GO:0046130 124 0.061
regulation of multicellular organismal development GO:2000026 376 0.061
single organism catabolic process GO:0044712 283 0.060
response to extracellular stimulus GO:0009991 380 0.060
positive regulation of nervous system development GO:0051962 178 0.060
chemosensory behavior GO:0007635 2 0.059
cell junction maintenance GO:0034331 1 0.059
response to nutrient levels GO:0031667 370 0.059
synaptic vesicle localization GO:0097479 24 0.059
organophosphate catabolic process GO:0046434 148 0.058
anatomical structure morphogenesis GO:0009653 298 0.058
positive regulation of phosphate metabolic process GO:0045937 262 0.057
organonitrogen compound catabolic process GO:1901565 179 0.056
regulation of phosphate metabolic process GO:0019220 349 0.056
macromolecular complex subunit organization GO:0043933 339 0.055
cell projection organization GO:0030030 302 0.054
regulation of cell development GO:0060284 263 0.054
learning GO:0007612 33 0.053
establishment of organelle localization GO:0051656 37 0.053
positive regulation of neurogenesis GO:0050769 165 0.053
feeding behavior GO:0007631 53 0.052
synapse organization GO:0050808 46 0.052
programmed cell death GO:0012501 392 0.052
regulation of cell differentiation GO:0045595 320 0.052
multi organism reproductive process GO:0044703 262 0.051
morphogenesis of a polarized epithelium GO:0001738 1 0.051
organelle localization GO:0051640 55 0.049
apoptotic process GO:0006915 381 0.049
salivary gland development GO:0007431 3 0.048
establishment of vesicle localization GO:0051650 31 0.047
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.047
reproductive process GO:0022414 372 0.047
positive regulation of cell differentiation GO:0045597 217 0.047
positive regulation of phosphorus metabolic process GO:0010562 262 0.046
establishment of synaptic vesicle localization GO:0097480 23 0.046
regulation of nervous system development GO:0051960 264 0.045
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.044
protein complex assembly GO:0006461 263 0.044
response to temperature stimulus GO:0009266 94 0.044
positive regulation of developmental process GO:0051094 283 0.043
single organism organelle organization GO:1902589 180 0.043
synaptic vesicle transport GO:0048489 23 0.041
receptor metabolic process GO:0043112 18 0.040
regulation of apoptotic process GO:0042981 335 0.039
cellular nitrogen compound catabolic process GO:0044270 163 0.039
multicellular organismal reproductive process GO:0048609 233 0.039
regulation of programmed cell death GO:0043067 341 0.038
positive regulation of molecular function GO:0044093 230 0.038
regulation of phosphorus metabolic process GO:0051174 349 0.038
positive regulation of multicellular organismal process GO:0051240 387 0.037
positive regulation of cell development GO:0010720 176 0.037
cell junction organization GO:0034330 21 0.037
regulation of neuron differentiation GO:0045664 208 0.036
protein phosphorylation GO:0006468 345 0.036
cellular response to stress GO:0033554 269 0.036
cytoskeleton dependent cytokinesis GO:0061640 2 0.036
cognition GO:0050890 92 0.036
response to peptide GO:1901652 292 0.036
receptor internalization GO:0031623 14 0.035
regulation of synaptic transmission GO:0050804 141 0.035
regulation of cytoskeleton organization GO:0051493 49 0.034
regulation of signal transduction GO:0009966 318 0.034
gtp metabolic process GO:0046039 72 0.034
metal ion transport GO:0030001 289 0.034
cellular component maintenance GO:0043954 4 0.033
regulation of system process GO:0044057 208 0.033
neuron differentiation GO:0030182 368 0.033
regulation of cellular protein metabolic process GO:0032268 267 0.033
growth GO:0040007 165 0.033
conditioned taste aversion GO:0001661 2 0.032
synapse assembly GO:0007416 29 0.032
transcription dna templated GO:0006351 377 0.032
purine nucleotide metabolic process GO:0006163 229 0.031
regulation of molecular function GO:0065009 398 0.031
negative regulation of cell death GO:0060548 229 0.031
transmembrane transport GO:0055085 412 0.031
regulation of protein metabolic process GO:0051246 289 0.031
single organism membrane organization GO:0044802 74 0.030
cellular amine metabolic process GO:0044106 38 0.030
protein complex biogenesis GO:0070271 263 0.030
establishment of protein localization GO:0045184 141 0.029
regulation of endocytosis GO:0030100 42 0.029
memory GO:0007613 54 0.029
regulation of transcription dna templated GO:0006355 374 0.029
protein complex subunit organization GO:0071822 302 0.029
reproduction GO:0000003 245 0.029
synaptic growth at neuromuscular junction GO:0051124 1 0.029
ribonucleoside catabolic process GO:0042454 126 0.028
rna biosynthetic process GO:0032774 380 0.028
multicellular organism reproduction GO:0032504 233 0.028
cell cycle process GO:0022402 57 0.028
olfactory behavior GO:0042048 2 0.028
cation transport GO:0006812 382 0.028
positive regulation of gtpase activity GO:0043547 47 0.027
amine metabolic process GO:0009308 38 0.026
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.026
neurological system process GO:0050877 219 0.026
positive regulation of transport GO:0051050 245 0.025
secretion GO:0046903 307 0.025
regulation of notch signaling pathway GO:0008593 3 0.025
regulation of vesicle mediated transport GO:0060627 81 0.025
cellular macromolecular complex assembly GO:0034622 58 0.025
neuron development GO:0048666 286 0.025
oxoacid metabolic process GO:0043436 290 0.025
regulation of cellular amine metabolic process GO:0033238 8 0.025
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
brain development GO:0007420 247 0.025
behavior GO:0007610 205 0.024
cell projection assembly GO:0030031 21 0.024
positive regulation of biosynthetic process GO:0009891 319 0.024
negative regulation of macromolecule metabolic process GO:0010605 260 0.024
transcription from rna polymerase ii promoter GO:0006366 252 0.024
regulation of actin cytoskeleton organization GO:0032956 30 0.024
regulation of cell cycle GO:0051726 73 0.024
positive regulation of protein phosphorylation GO:0001934 135 0.023
small gtpase mediated signal transduction GO:0007264 36 0.023
regulation of catalytic activity GO:0050790 304 0.023
negative regulation of metabolic process GO:0009892 331 0.023
regulation of purine nucleotide metabolic process GO:1900542 115 0.023
negative regulation of programmed cell death GO:0043069 183 0.023
response to estrogen GO:0043627 232 0.023
nucleic acid templated transcription GO:0097659 379 0.023
positive regulation of cellular protein metabolic process GO:0032270 167 0.022
receptor mediated endocytosis GO:0006898 42 0.022
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.022
neuron projection development GO:0031175 273 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.022
signal release GO:0023061 145 0.022
single organism reproductive process GO:0044702 297 0.022
positive regulation of cellular biosynthetic process GO:0031328 295 0.022
regulation of rna biosynthetic process GO:2001141 381 0.022
cytoskeleton organization GO:0007010 111 0.021
rna metabolic process GO:0016070 406 0.021
regulation of kinase activity GO:0043549 117 0.021
positive regulation of rna biosynthetic process GO:1902680 197 0.021
response to radiation GO:0009314 137 0.021
central nervous system development GO:0007417 311 0.021
negative regulation of cellular component organization GO:0051129 83 0.021
sexual reproduction GO:0019953 148 0.021
extracellular matrix organization GO:0030198 13 0.021
gland morphogenesis GO:0022612 12 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
anatomical structure formation involved in morphogenesis GO:0048646 83 0.020
positive regulation of gene expression GO:0010628 244 0.020
regulation of neuron death GO:1901214 115 0.020
adult locomotory behavior GO:0008344 4 0.020
carboxylic acid metabolic process GO:0019752 289 0.020
regulation of transferase activity GO:0051338 123 0.020
secretion by cell GO:0032940 248 0.020
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
regulation of nucleic acid templated transcription GO:1903506 380 0.019
developmental process involved in reproduction GO:0003006 159 0.019
regulation of organelle organization GO:0033043 80 0.019
male gamete generation GO:0048232 99 0.019
positive regulation of cellular component organization GO:0051130 200 0.019
positive regulation of rna metabolic process GO:0051254 203 0.019
negative regulation of apoptotic process GO:0043066 181 0.019
positive regulation of transferase activity GO:0051347 81 0.019
negative regulation of cell communication GO:0010648 158 0.018
negative regulation of rna metabolic process GO:0051253 123 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
cellular lipid metabolic process GO:0044255 208 0.018
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
positive regulation of apoptotic process GO:0043065 154 0.018
neurotransmitter transport GO:0006836 42 0.018
regulation of phosphorylation GO:0042325 248 0.018
negative regulation of biosynthetic process GO:0009890 168 0.017
cellular ketone metabolic process GO:0042180 51 0.017
positive regulation of cell death GO:0010942 184 0.017
positive regulation of protein modification process GO:0031401 142 0.017
regulation of muscle system process GO:0090257 79 0.017
cellular amino acid metabolic process GO:0006520 107 0.017
negative regulation of cellular metabolic process GO:0031324 281 0.017
organic acid metabolic process GO:0006082 292 0.017
positive regulation of cell communication GO:0010647 271 0.017
blood circulation GO:0008015 183 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
regulation of synaptic plasticity GO:0048167 70 0.017
regulation of protein kinase activity GO:0045859 105 0.017
regulation of rna metabolic process GO:0051252 391 0.017
carbohydrate metabolic process GO:0005975 130 0.017
regulation of protein modification process GO:0031399 194 0.017
ion homeostasis GO:0050801 212 0.017
spermatogenesis GO:0007283 99 0.017
positive regulation of protein metabolic process GO:0051247 178 0.017
regulation of mrna splicing via spliceosome GO:0048024 3 0.017
regulation of hydrolase activity GO:0051336 143 0.017
negative regulation of gene expression GO:0010629 199 0.017
epithelium development GO:0060429 96 0.016
cellular response to oxygen containing compound GO:1901701 386 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
positive regulation of nucleotide metabolic process GO:0045981 91 0.016
protein oligomerization GO:0051259 191 0.016
negative regulation of cellular biosynthetic process GO:0031327 161 0.016
response to cytokine GO:0034097 215 0.016
positive regulation of gtp catabolic process GO:0033126 48 0.016
intracellular signal transduction GO:0035556 314 0.016
oxidation reduction process GO:0055114 304 0.016
circulatory system process GO:0003013 183 0.016
response to oxygen levels GO:0070482 265 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.015
regulation of gtpase activity GO:0043087 57 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
neuron apoptotic process GO:0051402 88 0.015
adherens junction organization GO:0034332 13 0.015
regulation of gtp catabolic process GO:0033124 58 0.015
single organism biosynthetic process GO:0044711 342 0.015
response to purine containing compound GO:0014074 126 0.015
lipid biosynthetic process GO:0008610 128 0.015
endomembrane system organization GO:0010256 48 0.015
positive regulation of programmed cell death GO:0043068 157 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.015
regulation of cell proliferation GO:0042127 359 0.015
negative regulation of nucleic acid templated transcription GO:1903507 117 0.015
organ morphogenesis GO:0009887 75 0.015
response to ethanol GO:0045471 162 0.014
response to corticosteroid GO:0031960 235 0.014
homeostatic process GO:0042592 331 0.014
response to insulin GO:0032868 133 0.014
cellular response to external stimulus GO:0071496 118 0.014
regulation of intracellular signal transduction GO:1902531 218 0.014
regulation of neuronal synaptic plasticity GO:0048168 31 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
muscle system process GO:0003012 115 0.014
negative regulation of neuron death GO:1901215 69 0.014
anterior posterior pattern specification GO:0009952 1 0.014
cellular chemical homeostasis GO:0055082 247 0.014
cell cell junction organization GO:0045216 20 0.014
regulation of nucleoside metabolic process GO:0009118 66 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
regulation of purine nucleotide catabolic process GO:0033121 65 0.014
regulation of nucleotide catabolic process GO:0030811 65 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
lipid metabolic process GO:0006629 283 0.014
cellular response to unfolded protein GO:0034620 2 0.014
negative regulation of molecular function GO:0044092 133 0.014
rhythmic process GO:0048511 156 0.014
positive regulation of hydrolase activity GO:0051345 86 0.014
cellular component movement GO:0006928 248 0.014
cellular response to cytokine stimulus GO:0071345 127 0.014
negative regulation of transcription dna templated GO:0045892 116 0.014
cellular response to hormone stimulus GO:0032870 247 0.013
regulation of growth GO:0040008 105 0.013
positive regulation of cellular catabolic process GO:0031331 71 0.013
actin cytoskeleton organization GO:0030036 73 0.013
acid secretion GO:0046717 48 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
female pregnancy GO:0007565 122 0.013
associative learning GO:0008306 19 0.013
actin filament based process GO:0030029 86 0.013
response to inorganic substance GO:0010035 377 0.013
response to estradiol GO:0032355 164 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
response to bacterium GO:0009617 200 0.013
axis specification GO:0009798 4 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
negative regulation of rna biosynthetic process GO:1902679 118 0.013
gamete generation GO:0007276 124 0.013
cellular protein complex assembly GO:0043623 44 0.013
chemical homeostasis GO:0048878 292 0.013
lipid storage GO:0019915 1 0.013
response to decreased oxygen levels GO:0036293 237 0.013
cellular process involved in reproduction in multicellular organism GO:0022412 35 0.013
cellular response to extracellular stimulus GO:0031668 73 0.013
cell part morphogenesis GO:0032990 123 0.013
positive regulation of immune system process GO:0002684 90 0.013
positive regulation of intracellular signal transduction GO:1902533 138 0.013
limb morphogenesis GO:0035108 4 0.013
negative regulation of neuron apoptotic process GO:0043524 45 0.013
regulation of cellular catabolic process GO:0031329 101 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
protein transport GO:0015031 132 0.012
head development GO:0060322 247 0.012
negative regulation of signaling GO:0023057 157 0.012
regulation of cellular localization GO:0060341 263 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
ras protein signal transduction GO:0007265 29 0.012
positive regulation of kinase activity GO:0033674 77 0.012
cellular homeostasis GO:0019725 252 0.012
peptidyl amino acid modification GO:0018193 126 0.012
cellular response to nitrogen compound GO:1901699 210 0.012
response to acid chemical GO:0001101 222 0.012
eye morphogenesis GO:0048592 4 0.012
gastrulation GO:0007369 2 0.012
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.012
regulation of hormone levels GO:0010817 187 0.012
response to hypoxia GO:0001666 231 0.012
inorganic ion transmembrane transport GO:0098660 229 0.012
response to peptide hormone GO:0043434 278 0.012
response to vitamin GO:0033273 131 0.012
cellular protein localization GO:0034613 122 0.012
neuron neuron synaptic transmission GO:0007270 60 0.012
axon development GO:0061564 96 0.011
single organism intracellular transport GO:1902582 166 0.011
negative regulation of innate immune response GO:0045824 4 0.011
regeneration GO:0031099 163 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
positive regulation of cellular component movement GO:0051272 102 0.011
regulation of muscle contraction GO:0006937 53 0.011
response to wounding GO:0009611 254 0.011
regulation of catabolic process GO:0009894 113 0.011
muscle contraction GO:0006936 88 0.011
cell motility GO:0048870 202 0.011
regulation of neuron apoptotic process GO:0043523 83 0.011
localization of cell GO:0051674 202 0.011
regulation of actin filament based process GO:0032970 42 0.011
cell projection morphogenesis GO:0048858 123 0.011
response to lipopolysaccharide GO:0032496 191 0.011
embryonic pattern specification GO:0009880 1 0.011
dna metabolic process GO:0006259 96 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.011
cell morphogenesis GO:0000902 142 0.011
locomotion GO:0040011 237 0.011
cytoplasmic transport GO:0016482 115 0.011
positive regulation of t cell mediated cytotoxicity GO:0001916 4 0.011
glial cell differentiation GO:0010001 65 0.011
response to glucocorticoid GO:0051384 223 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
divalent metal ion transport GO:0070838 132 0.011
toxin transport GO:1901998 3 0.011
positive regulation of protein kinase activity GO:0045860 73 0.011
neuron projection morphogenesis GO:0048812 122 0.011
muscle structure development GO:0061061 87 0.011
organic hydroxy compound metabolic process GO:1901615 115 0.010
cortical actin cytoskeleton organization GO:0030866 2 0.010
ribose phosphate biosynthetic process GO:0046390 87 0.010
endoplasmic reticulum unfolded protein response GO:0030968 2 0.010
neuromuscular process GO:0050905 2 0.010
negative regulation of transport GO:0051051 136 0.010
regulation of ion transport GO:0043269 245 0.010
membrane budding GO:0006900 8 0.010
response to external biotic stimulus GO:0043207 221 0.010
regulation of membrane potential GO:0042391 110 0.010
regulation of protein localization GO:0032880 81 0.010
response to oxidative stress GO:0006979 186 0.010
regulation of secretion by cell GO:1903530 208 0.010
cellular response to growth factor stimulus GO:0071363 162 0.010
carboxylic acid transport GO:0046942 115 0.010
embryonic limb morphogenesis GO:0030326 4 0.010
aging GO:0007568 241 0.010

Ap2a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.079
musculoskeletal system disease DOID:17 0 0.079
myopathy DOID:423 0 0.051
muscle tissue disease DOID:66 0 0.051
muscular disease DOID:0080000 0 0.051
nervous system disease DOID:863 0 0.026
disease of metabolism DOID:0014667 0 0.012
sensory system disease DOID:0050155 0 0.011
central nervous system disease DOID:331 0 0.010