Rattus norvegicus

185 known processes

Axl

Axl receptor tyrosine kinase

Axl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of programmed cell death GO:0043067 341 0.344
cellular response to platelet derived growth factor stimulus GO:0036120 7 0.255
blood coagulation GO:0007596 26 0.253
cell migration involved in kidney development GO:0035787 2 0.246
enzyme linked receptor protein signaling pathway GO:0007167 116 0.223
defense response GO:0006952 194 0.220
cellular response to vascular endothelial growth factor stimulus GO:0035924 6 0.200
metanephric glomerulus morphogenesis GO:0072275 1 0.181
regulation of blood coagulation GO:0030193 9 0.164
regulation of apoptotic process GO:0042981 335 0.160
positive regulation of cell communication GO:0010647 271 0.154
cellular component movement GO:0006928 248 0.150
neuron death GO:0070997 127 0.148
positive regulation of phosphate metabolic process GO:0045937 262 0.141
pro t cell differentiation GO:0002572 1 0.139
positive regulation of signaling GO:0023056 270 0.135
positive regulation of mapk cascade GO:0043410 92 0.127
glomerulus morphogenesis GO:0072102 1 0.118
s shaped body morphogenesis GO:0072050 2 0.112
regulation of cellular component movement GO:0051270 150 0.110
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.109
apoptotic process GO:0006915 381 0.106
localization of cell GO:0051674 202 0.103
positive regulation of phosphorylation GO:0042327 177 0.100
locomotion GO:0040011 237 0.100
positive regulation of cell proliferation GO:0008284 249 0.098
cellular response to hormone stimulus GO:0032870 247 0.093
regulation of cell proliferation GO:0042127 359 0.092
regulation of stem cell differentiation GO:2000736 2 0.090
positive regulation of molecular function GO:0044093 230 0.084
response to wounding GO:0009611 254 0.084
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.084
response to biotic stimulus GO:0009607 226 0.084
glomerulus vasculature development GO:0072012 6 0.080
positive regulation of signal transduction GO:0009967 175 0.078
positive regulation of cellular protein metabolic process GO:0032270 167 0.077
tissue remodeling GO:0048771 40 0.077
glomerulus development GO:0032835 10 0.074
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.074
comma shaped body morphogenesis GO:0072049 2 0.074
cell projection organization GO:0030030 302 0.073
carbohydrate derivative metabolic process GO:1901135 346 0.072
positive regulation of cellular biosynthetic process GO:0031328 295 0.071
peptidyl amino acid modification GO:0018193 126 0.071
metanephric mesenchymal cell migration GO:0035789 2 0.071
cell motility GO:0048870 202 0.070
positive regulation of phosphorus metabolic process GO:0010562 262 0.070
lymphoid progenitor cell differentiation GO:0002320 2 0.069
positive regulation of protein metabolic process GO:0051247 178 0.068
vascular endothelial growth factor receptor signaling pathway GO:0048010 8 0.067
vasculature development GO:0001944 70 0.067
single organism reproductive process GO:0044702 297 0.066
single organism cell adhesion GO:0098602 46 0.066
neuron apoptotic process GO:0051402 88 0.065
myeloid progenitor cell differentiation GO:0002318 1 0.064
positive regulation of transport GO:0051050 245 0.063
macromolecular complex subunit organization GO:0043933 339 0.062
coagulation GO:0050817 28 0.062
platelet activation GO:0030168 8 0.061
cellular response to organic cyclic compound GO:0071407 202 0.059
regulation of cell migration GO:0030334 128 0.059
regulation of system process GO:0044057 208 0.058
negative regulation of cell death GO:0060548 229 0.058
embryonic skeletal system development GO:0048706 3 0.058
metanephric glomerulus development GO:0072224 3 0.057
positive regulation of multicellular organismal process GO:0051240 387 0.057
intracellular signal transduction GO:0035556 314 0.056
wound healing GO:0042060 122 0.054
metanephric s shaped body morphogenesis GO:0072284 2 0.054
cellular response to growth factor stimulus GO:0071363 162 0.054
regulation of response to stress GO:0080134 126 0.054
lipid metabolic process GO:0006629 283 0.053
protein phosphorylation GO:0006468 345 0.052
circulatory system development GO:0072359 134 0.051
cell migration GO:0016477 197 0.050
growth GO:0040007 165 0.050
cellular response to endogenous stimulus GO:0071495 377 0.049
regulation of smooth muscle cell proliferation GO:0048660 75 0.048
inflammatory response GO:0006954 150 0.047
regulation of rna biosynthetic process GO:2001141 381 0.047
regulation of response to external stimulus GO:0032101 106 0.046
reproductive process GO:0022414 372 0.046
regulation of locomotion GO:0040012 148 0.046
positive regulation of developmental process GO:0051094 283 0.046
positive regulation of response to stimulus GO:0048584 285 0.045
regulation of multicellular organismal development GO:2000026 376 0.045
response to growth factor GO:0070848 189 0.045
regulation of platelet activation GO:0010543 2 0.044
salivary gland development GO:0007431 3 0.044
protein complex subunit organization GO:0071822 302 0.043
regulation of hydrolase activity GO:0051336 143 0.043
sensory organ development GO:0007423 74 0.042
platelet derived growth factor receptor alpha signaling pathway GO:0035790 1 0.042
regulation of neuron death GO:1901214 115 0.042
regulation of cellular component organization GO:0051128 368 0.042
cell morphogenesis GO:0000902 142 0.041
positive regulation of myeloid leukocyte differentiation GO:0002763 7 0.041
regulation of response to wounding GO:1903034 69 0.041
response to oxidative stress GO:0006979 186 0.040
positive regulation of catalytic activity GO:0043085 184 0.040
response to mechanical stimulus GO:0009612 134 0.039
heart morphogenesis GO:0003007 3 0.039
regulation of mapk cascade GO:0043408 116 0.039
cellular component assembly GO:0022607 360 0.038
organelle organization GO:0006996 266 0.038
positive regulation of apoptotic process GO:0043065 154 0.038
neuron projection development GO:0031175 273 0.038
cardiovascular system development GO:0072358 134 0.038
response to molecule of bacterial origin GO:0002237 194 0.038
organophosphate metabolic process GO:0019637 370 0.038
positive regulation of protein phosphorylation GO:0001934 135 0.037
response to oxygen levels GO:0070482 265 0.037
immune system process GO:0002376 204 0.037
cell projection assembly GO:0030031 21 0.036
regulation of catalytic activity GO:0050790 304 0.036
regulation of signal transduction GO:0009966 318 0.036
positive regulation of protein kinase activity GO:0045860 73 0.036
regulation of protein metabolic process GO:0051246 289 0.035
positive regulation of cell differentiation GO:0045597 217 0.035
response to glucocorticoid GO:0051384 223 0.034
response to external biotic stimulus GO:0043207 221 0.034
cellular response to steroid hormone stimulus GO:0071383 93 0.034
organonitrogen compound biosynthetic process GO:1901566 167 0.034
negative regulation of b cell differentiation GO:0045578 1 0.034
multicellular organism reproduction GO:0032504 233 0.034
vesicle mediated transport GO:0016192 181 0.034
cell chemotaxis GO:0060326 31 0.034
multicellular organismal homeostasis GO:0048871 49 0.033
regulation of nucleic acid templated transcription GO:1903506 380 0.033
regulation of cell differentiation GO:0045595 320 0.033
signal transduction by phosphorylation GO:0023014 144 0.033
endocytosis GO:0006897 84 0.033
tissue development GO:0009888 252 0.033
nucleic acid templated transcription GO:0097659 379 0.033
regulation of cell projection organization GO:0031344 175 0.032
regulation of cellular protein metabolic process GO:0032268 267 0.032
regulation of phosphorylation GO:0042325 248 0.032
positive regulation of blood coagulation GO:0030194 4 0.031
single organism biosynthetic process GO:0044711 342 0.031
positive regulation of transferase activity GO:0051347 81 0.031
regulation of molecular function GO:0065009 398 0.030
response to inorganic substance GO:0010035 377 0.030
metanephric comma shaped body morphogenesis GO:0072278 2 0.030
organic acid metabolic process GO:0006082 292 0.030
positive regulation of intracellular signal transduction GO:1902533 138 0.030
leydig cell differentiation GO:0033327 8 0.030
programmed cell death GO:0012501 392 0.030
positive regulation of biosynthetic process GO:0009891 319 0.029
blood vessel development GO:0001568 69 0.029
positive regulation of interleukin 6 production GO:0032755 8 0.029
cellular component biogenesis GO:0044085 368 0.028
positive regulation of locomotion GO:0040017 102 0.028
multicellular organismal reproductive process GO:0048609 233 0.027
organ morphogenesis GO:0009887 75 0.026
cellular response to oxygen containing compound GO:1901701 386 0.026
negative regulation of cell differentiation GO:0045596 99 0.026
mapk cascade GO:0000165 140 0.026
skeletal system development GO:0001501 41 0.026
regulation of coagulation GO:0050818 11 0.026
regulation of chemotaxis GO:0050920 29 0.026
rna biosynthetic process GO:0032774 380 0.026
positive regulation of protein modification process GO:0031401 142 0.025
innate immune response GO:0045087 35 0.025
development of primary female sexual characteristics GO:0046545 56 0.025
response to corticosteroid GO:0031960 235 0.025
kidney development GO:0001822 67 0.025
positive regulation of growth GO:0045927 55 0.025
small gtpase mediated signal transduction GO:0007264 36 0.024
reproduction GO:0000003 245 0.024
regulation of nervous system development GO:0051960 264 0.024
positive regulation of kinase activity GO:0033674 77 0.024
regulation of phosphate metabolic process GO:0019220 349 0.024
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.023
eye development GO:0001654 50 0.023
organ regeneration GO:0031100 101 0.023
response to hypoxia GO:0001666 231 0.023
collagen metabolic process GO:0032963 21 0.023
response to bacterium GO:0009617 200 0.023
regulation of smooth muscle contraction GO:0006940 29 0.023
aminoglycan biosynthetic process GO:0006023 4 0.023
protein transport GO:0015031 132 0.022
positive regulation of gene expression GO:0010628 244 0.022
positive regulation of protein export from nucleus GO:0046827 3 0.022
response to estrogen GO:0043627 232 0.022
tissue homeostasis GO:0001894 28 0.022
positive regulation of cellular component organization GO:0051130 200 0.022
cellular response to lipid GO:0071396 201 0.022
carboxylic acid metabolic process GO:0019752 289 0.022
regulation of transcription dna templated GO:0006355 374 0.022
cellular response to organonitrogen compound GO:0071417 197 0.021
developmental process involved in reproduction GO:0003006 159 0.021
cell activation GO:0001775 97 0.021
regulation of protein modification process GO:0031399 194 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
cellular amine metabolic process GO:0044106 38 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
aging GO:0007568 241 0.020
muscle contraction GO:0006936 88 0.020
response to decreased oxygen levels GO:0036293 237 0.020
ras protein signal transduction GO:0007265 29 0.020
transcription from rna polymerase ii promoter GO:0006366 252 0.020
peptidyl tyrosine phosphorylation GO:0018108 72 0.020
response to reactive oxygen species GO:0000302 120 0.020
negative regulation of programmed cell death GO:0043069 183 0.020
hematopoietic progenitor cell differentiation GO:0002244 2 0.020
kidney mesenchyme development GO:0072074 2 0.020
cellular hormone metabolic process GO:0034754 49 0.020
renal system development GO:0072001 67 0.019
response to glucose GO:0009749 136 0.019
gliogenesis GO:0042063 93 0.019
cell growth GO:0016049 104 0.019
neurological system process GO:0050877 219 0.019
positive regulation of cell death GO:0010942 184 0.019
smooth muscle cell proliferation GO:0048659 77 0.018
regulation of bmp signaling pathway GO:0030510 2 0.018
positive regulation of cell migration GO:0030335 96 0.018
smooth muscle contraction GO:0006939 37 0.018
bone resorption GO:0045453 18 0.018
establishment of protein localization GO:0045184 141 0.018
neuronal action potential GO:0019228 35 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.018
b cell differentiation GO:0030183 2 0.018
rho protein signal transduction GO:0007266 11 0.018
response to transforming growth factor beta GO:0071559 46 0.018
platelet aggregation GO:0070527 4 0.018
neuron differentiation GO:0030182 368 0.018
positive regulation of rna biosynthetic process GO:1902680 197 0.018
organic substance catabolic process GO:1901575 316 0.018
negative regulation of macromolecule metabolic process GO:0010605 260 0.018
sex differentiation GO:0007548 113 0.018
salivary gland morphogenesis GO:0007435 1 0.018
maternal process involved in female pregnancy GO:0060135 38 0.017
actin cytoskeleton organization GO:0030036 73 0.017
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
metanephros development GO:0001656 14 0.017
multi organism reproductive process GO:0044703 262 0.017
positive regulation of hemostasis GO:1900048 4 0.017
regulation of anatomical structure size GO:0090066 135 0.017
regulation of b cell differentiation GO:0045577 1 0.017
response to nutrient levels GO:0031667 370 0.017
regulation of protein kinase activity GO:0045859 105 0.017
spindle organization GO:0007051 2 0.017
cellular response to cytokine stimulus GO:0071345 127 0.017
muscle system process GO:0003012 115 0.017
cytokine mediated signaling pathway GO:0019221 43 0.017
axis specification GO:0009798 4 0.017
regulation of immune system process GO:0002682 123 0.017
anatomical structure homeostasis GO:0060249 29 0.017
positive regulation of coagulation GO:0050820 5 0.016
regulation of blood vessel size GO:0050880 89 0.016
negative regulation of immune system process GO:0002683 39 0.016
response to other organism GO:0051707 220 0.016
neuron development GO:0048666 286 0.016
urogenital system development GO:0001655 78 0.016
carbohydrate derivative biosynthetic process GO:1901137 124 0.016
regulation of cellular localization GO:0060341 263 0.015
regulation of small gtpase mediated signal transduction GO:0051056 48 0.015
catabolic process GO:0009056 351 0.015
female sex differentiation GO:0046660 59 0.015
homeostasis of number of cells GO:0048872 10 0.015
homeostatic process GO:0042592 331 0.015
cellular component morphogenesis GO:0032989 155 0.015
response to toxic substance GO:0009636 133 0.015
positive regulation of intracellular protein transport GO:0090316 20 0.015
secretion by cell GO:0032940 248 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.015
anatomical structure morphogenesis GO:0009653 298 0.015
positive regulation of cell projection organization GO:0031346 111 0.015
positive regulation of transcription dna templated GO:0045893 197 0.014
regulation of cellular amine metabolic process GO:0033238 8 0.014
central nervous system development GO:0007417 311 0.014
regulation of tube size GO:0035150 89 0.014
cellular component maintenance GO:0043954 4 0.014
regulation of osteoclast differentiation GO:0045670 8 0.014
nephron development GO:0072006 22 0.014
cellular response to glucocorticoid stimulus GO:0071385 68 0.014
negative regulation of apoptotic process GO:0043066 181 0.014
peptidyl tyrosine modification GO:0018212 72 0.014
regulation of neuron projection development GO:0010975 161 0.014
regulation of kinase activity GO:0043549 117 0.014
regulation of catabolic process GO:0009894 113 0.014
response to vitamin GO:0033273 131 0.014
positive regulation of fibroblast proliferation GO:0048146 15 0.014
positive regulation of cellular component movement GO:0051272 102 0.014
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.014
positive regulation of cell motility GO:2000147 97 0.014
regulation of phosphorus metabolic process GO:0051174 349 0.013
cellular ketone metabolic process GO:0042180 51 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.013
response to cytokine GO:0034097 215 0.013
regulation of hormone levels GO:0010817 187 0.013
amine metabolic process GO:0009308 38 0.013
regulation of body fluid levels GO:0050878 90 0.013
organic anion transport GO:0015711 132 0.013
positive regulation of hydrolase activity GO:0051345 86 0.013
sexual reproduction GO:0019953 148 0.013
mast cell migration GO:0097531 4 0.013
positive regulation of nervous system development GO:0051962 178 0.013
regulation of cell development GO:0060284 263 0.013
regulation of muscle system process GO:0090257 79 0.013
bone development GO:0060348 25 0.013
behavior GO:0007610 205 0.013
embryonic pattern specification GO:0009880 1 0.012
nucleobase containing small molecule metabolic process GO:0055086 316 0.012
smooth muscle cell migration GO:0014909 36 0.012
cell type specific apoptotic process GO:0097285 134 0.012
response to lipopolysaccharide GO:0032496 191 0.012
protein complex assembly GO:0006461 263 0.012
cellular amino acid metabolic process GO:0006520 107 0.012
cell projection morphogenesis GO:0048858 123 0.012
rna metabolic process GO:0016070 406 0.012
hemostasis GO:0007599 26 0.012
response to increased oxygen levels GO:0036296 45 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
secretion GO:0046903 307 0.012
response to fluid shear stress GO:0034405 16 0.012
multicellular organismal macromolecule metabolic process GO:0044259 21 0.012
gamete generation GO:0007276 124 0.012
action potential GO:0001508 54 0.012
cytokine biosynthetic process GO:0042089 3 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
macromolecule localization GO:0033036 252 0.012
anterior posterior pattern specification GO:0009952 1 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
oxoacid metabolic process GO:0043436 290 0.011
cation homeostasis GO:0055080 195 0.011
reproductive structure development GO:0048608 128 0.011
cell adhesion GO:0007155 110 0.011
anatomical structure maturation GO:0071695 2 0.011
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 2 0.011
eye morphogenesis GO:0048592 4 0.011
muscle cell proliferation GO:0033002 84 0.011
single organism catabolic process GO:0044712 283 0.011
palate development GO:0060021 2 0.011
developmental growth GO:0048589 100 0.011
vascular endothelial growth factor signaling pathway GO:0038084 4 0.011
cellular homeostasis GO:0019725 252 0.011
negative regulation of metabolic process GO:0009892 331 0.010
transmembrane transport GO:0055085 412 0.010
protein localization GO:0008104 191 0.010
response to hexose GO:0009746 144 0.010
regulation of cell adhesion GO:0030155 52 0.010
cell migration involved in metanephros development GO:0035788 2 0.010
retina development in camera type eye GO:0060041 27 0.010
phospholipid metabolic process GO:0006644 61 0.010
positive regulation of rna metabolic process GO:0051254 203 0.010
positive regulation of neuron death GO:1901216 43 0.010
blood vessel morphogenesis GO:0048514 58 0.010
cytoskeleton organization GO:0007010 111 0.010

Axl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027
eye and adnexa disease DOID:1492 0 0.027
nervous system disease DOID:863 0 0.027
eye disease DOID:5614 0 0.027
retinal degeneration DOID:8466 0 0.027
retinal disease DOID:5679 0 0.027
sensory system disease DOID:0050155 0 0.027
musculoskeletal system disease DOID:17 0 0.019
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011
cancer DOID:162 0 0.011
gastrointestinal system cancer DOID:3119 0 0.011