Rattus norvegicus

21 known processes

Bckdha

branched chain ketoacid dehydrogenase E1, alpha polypeptide

(Aliases: E1a,BCKDA)

Bckdha biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carboxylic acid metabolic process GO:0019752 289 0.445
monocarboxylic acid metabolic process GO:0032787 152 0.370
cellular amino acid metabolic process GO:0006520 107 0.288
organic acid biosynthetic process GO:0016053 83 0.278
oxoacid metabolic process GO:0043436 290 0.255
fatty acid metabolic process GO:0006631 99 0.238
alpha amino acid metabolic process GO:1901605 71 0.199
catabolic process GO:0009056 351 0.159
carboxylic acid biosynthetic process GO:0046394 83 0.152
small molecule catabolic process GO:0044282 59 0.141
alpha amino acid catabolic process GO:1901606 20 0.140
organic acid metabolic process GO:0006082 292 0.133
regulation of cellular ketone metabolic process GO:0010565 27 0.116
lipid metabolic process GO:0006629 283 0.110
pyruvate metabolic process GO:0006090 27 0.104
protein phosphorylation GO:0006468 345 0.102
organelle organization GO:0006996 266 0.102
cellular amino acid biosynthetic process GO:0008652 32 0.101
response to nutrient levels GO:0031667 370 0.094
lipid biosynthetic process GO:0008610 128 0.088
cellular lipid metabolic process GO:0044255 208 0.083
single organism biosynthetic process GO:0044711 342 0.082
acyl coa metabolic process GO:0006637 28 0.081
negative regulation of cellular metabolic process GO:0031324 281 0.080
small molecule biosynthetic process GO:0044283 124 0.079
cellular component assembly GO:0022607 360 0.078
cellular catabolic process GO:0044248 295 0.077
organonitrogen compound biosynthetic process GO:1901566 167 0.076
branched chain amino acid catabolic process GO:0009083 4 0.076
regulation of phosphorylation GO:0042325 248 0.072
thioester metabolic process GO:0035383 28 0.069
regulation of coenzyme metabolic process GO:0051196 1 0.068
sulfur compound biosynthetic process GO:0044272 19 0.068
oxidation reduction process GO:0055114 304 0.067
acetyl coa metabolic process GO:0006084 17 0.063
coenzyme metabolic process GO:0006732 86 0.062
amine metabolic process GO:0009308 38 0.061
programmed cell death GO:0012501 392 0.057
cellular amino acid catabolic process GO:0009063 21 0.056
carboxylic acid catabolic process GO:0046395 49 0.054
regulation of lipid metabolic process GO:0019216 68 0.053
cellular amine metabolic process GO:0044106 38 0.053
organic substance catabolic process GO:1901575 316 0.051
apoptotic process GO:0006915 381 0.050
cellular component biogenesis GO:0044085 368 0.048
response to nutrient GO:0007584 248 0.046
lipid oxidation GO:0034440 30 0.046
cellular response to hormone stimulus GO:0032870 247 0.044
response to oxidative stress GO:0006979 186 0.044
branched chain amino acid metabolic process GO:0009081 4 0.044
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.042
negative regulation of metabolic process GO:0009892 331 0.041
organic acid catabolic process GO:0016054 49 0.039
macromolecular complex subunit organization GO:0043933 339 0.039
cellular ketone metabolic process GO:0042180 51 0.038
reproductive process GO:0022414 372 0.038
response to fatty acid GO:0070542 65 0.037
positive regulation of biosynthetic process GO:0009891 319 0.036
single organism catabolic process GO:0044712 283 0.035
organonitrogen compound catabolic process GO:1901565 179 0.035
rna metabolic process GO:0016070 406 0.035
negative regulation of biosynthetic process GO:0009890 168 0.034
neuron differentiation GO:0030182 368 0.034
response to oxygen levels GO:0070482 265 0.034
sulfur compound metabolic process GO:0006790 70 0.033
regulation of phosphate metabolic process GO:0019220 349 0.032
regulation of molecular function GO:0065009 398 0.032
regulation of cellular amine metabolic process GO:0033238 8 0.031
protein oligomerization GO:0051259 191 0.031
response to organophosphorus GO:0046683 102 0.030
regulation of protein modification process GO:0031399 194 0.030
response to extracellular stimulus GO:0009991 380 0.030
regulation of rna metabolic process GO:0051252 391 0.030
positive regulation of cellular biosynthetic process GO:0031328 295 0.029
brain development GO:0007420 247 0.029
hepaticobiliary system development GO:0061008 90 0.029
regulation of cell projection organization GO:0031344 175 0.029
negative regulation of cellular biosynthetic process GO:0031327 161 0.029
gland development GO:0048732 155 0.029
cellular response to stress GO:0033554 269 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.027
regulation of protein metabolic process GO:0051246 289 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.027
fatty acid oxidation GO:0019395 29 0.027
cell projection organization GO:0030030 302 0.027
response to inorganic substance GO:0010035 377 0.027
regulation of programmed cell death GO:0043067 341 0.026
cofactor metabolic process GO:0051186 95 0.026
head development GO:0060322 247 0.026
peptidyl amino acid modification GO:0018193 126 0.026
cellular response to endogenous stimulus GO:0071495 377 0.025
nucleic acid templated transcription GO:0097659 379 0.025
regulation of hormone levels GO:0010817 187 0.025
chemical homeostasis GO:0048878 292 0.025
regulation of neurogenesis GO:0050767 247 0.025
central nervous system development GO:0007417 311 0.025
multi organism reproductive process GO:0044703 262 0.024
negative regulation of macromolecule metabolic process GO:0010605 260 0.024
regulation of cellular amino acid metabolic process GO:0006521 2 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.023
regulation of rna biosynthetic process GO:2001141 381 0.023
multicellular organism reproduction GO:0032504 233 0.023
protein complex assembly GO:0006461 263 0.023
regulation of fatty acid metabolic process GO:0019217 18 0.022
positive regulation of cell differentiation GO:0045597 217 0.022
single organism reproductive process GO:0044702 297 0.022
protein complex subunit organization GO:0071822 302 0.022
regulation of nucleic acid templated transcription GO:1903506 380 0.022
intracellular signal transduction GO:0035556 314 0.022
neuron projection development GO:0031175 273 0.022
regulation of nervous system development GO:0051960 264 0.022
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.022
transcription dna templated GO:0006351 377 0.022
liver development GO:0001889 90 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.021
positive regulation of phosphorylation GO:0042327 177 0.021
purine containing compound metabolic process GO:0072521 253 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
ion homeostasis GO:0050801 212 0.021
fatty acid beta oxidation GO:0006635 22 0.021
positive regulation of phosphate metabolic process GO:0045937 262 0.021
regulation of protein phosphorylation GO:0001932 183 0.020
cofactor biosynthetic process GO:0051188 28 0.020
cellular chemical homeostasis GO:0055082 247 0.020
regulation of cellular component organization GO:0051128 368 0.020
mitotic spindle organization GO:0007052 2 0.020
nitrogen compound transport GO:0071705 229 0.020
response to transition metal nanoparticle GO:1990267 122 0.020
reproduction GO:0000003 245 0.020
spindle organization GO:0007051 2 0.020
cation homeostasis GO:0055080 195 0.020
positive regulation of rna biosynthetic process GO:1902680 197 0.019
response to peptide hormone GO:0043434 278 0.019
protein homooligomerization GO:0051260 91 0.019
positive regulation of cell projection organization GO:0031346 111 0.019
cellular divalent inorganic cation homeostasis GO:0072503 162 0.019
macromolecular complex assembly GO:0065003 273 0.019
regulation of multicellular organismal development GO:2000026 376 0.019
carbohydrate metabolic process GO:0005975 130 0.019
positive regulation of nervous system development GO:0051962 178 0.019
response to peptide GO:1901652 292 0.019
negative regulation of response to stimulus GO:0048585 155 0.019
cellular response to oxygen levels GO:0071453 60 0.018
regulation of signal transduction GO:0009966 318 0.018
cellular carbohydrate metabolic process GO:0044262 72 0.018
positive regulation of protein phosphorylation GO:0001934 135 0.018
response to hyperoxia GO:0055093 45 0.018
regulation of neuron projection development GO:0010975 161 0.018
cellular calcium ion homeostasis GO:0006874 160 0.018
response to decreased oxygen levels GO:0036293 237 0.018
alpha amino acid biosynthetic process GO:1901607 23 0.018
response to fungicide GO:0060992 20 0.018
cellular cation homeostasis GO:0030003 180 0.018
organophosphate metabolic process GO:0019637 370 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
midgut development GO:0007494 13 0.017
homeostatic process GO:0042592 331 0.017
ion transmembrane transport GO:0034220 365 0.017
signal release GO:0023061 145 0.017
negative regulation of phosphorus metabolic process GO:0010563 80 0.017
anion transport GO:0006820 178 0.017
cellular response to oxygen containing compound GO:1901701 386 0.017
cellular ion homeostasis GO:0006873 184 0.017
positive regulation of cell development GO:0010720 176 0.017
positive regulation of phosphorus metabolic process GO:0010562 262 0.016
protein complex biogenesis GO:0070271 263 0.016
neuron development GO:0048666 286 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
positive regulation of nucleic acid templated transcription GO:1903508 197 0.016
divalent inorganic cation homeostasis GO:0072507 165 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
macromolecule localization GO:0033036 252 0.016
regulation of cell development GO:0060284 263 0.016
regulation of neuron differentiation GO:0045664 208 0.016
cytosolic calcium ion homeostasis GO:0051480 140 0.016
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.016
response to hypoxia GO:0001666 231 0.016
response to ethanol GO:0045471 162 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
protein tetramerization GO:0051262 38 0.015
negative regulation of gene expression GO:0010629 199 0.015
hair follicle development GO:0001942 2 0.015
regulation of cell differentiation GO:0045595 320 0.015
positive regulation of protein modification process GO:0031401 142 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
carboxylic acid transport GO:0046942 115 0.015
heart morphogenesis GO:0003007 3 0.015
positive regulation of molecular function GO:0044093 230 0.015
metal ion homeostasis GO:0055065 186 0.015
regulation of catalytic activity GO:0050790 304 0.015
positive regulation of response to stimulus GO:0048584 285 0.015
negative regulation of cell death GO:0060548 229 0.015
cellular response to oxidative stress GO:0034599 76 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.015
regulation of proteasomal protein catabolic process GO:0061136 4 0.015
regulation of system process GO:0044057 208 0.015
cellular response to acid chemical GO:0071229 75 0.015
regulation of homeostatic process GO:0032844 101 0.015
tissue development GO:0009888 252 0.015
chromosome segregation GO:0007059 2 0.015
negative regulation of signaling GO:0023057 157 0.015
reproductive system development GO:0061458 128 0.014
nucleoside metabolic process GO:0009116 179 0.014
single organism organelle organization GO:1902589 180 0.014
response to estrogen GO:0043627 232 0.014
response to acid chemical GO:0001101 222 0.014
hormone transport GO:0009914 121 0.014
anatomical structure morphogenesis GO:0009653 298 0.014
regulation of cell proliferation GO:0042127 359 0.014
regulation of apoptotic process GO:0042981 335 0.014
positive regulation of rna metabolic process GO:0051254 203 0.014
regulation of gluconeogenesis GO:0006111 4 0.014
secretion GO:0046903 307 0.014
digestive system development GO:0055123 41 0.014
response to vitamin GO:0033273 131 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.014
negative regulation of phosphate metabolic process GO:0045936 80 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
response to molecule of bacterial origin GO:0002237 194 0.014
purine ribonucleotide metabolic process GO:0009150 227 0.014
hormone metabolic process GO:0042445 69 0.014
thioester biosynthetic process GO:0035384 7 0.014
multicellular organismal reproductive process GO:0048609 233 0.013
calcium ion homeostasis GO:0055074 162 0.013
protein homotetramerization GO:0051289 25 0.013
peptidyl serine modification GO:0018209 34 0.013
purine ribonucleoside metabolic process GO:0046128 168 0.013
negative regulation of nucleic acid templated transcription GO:1903507 117 0.013
ribonucleoside metabolic process GO:0009119 174 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
response to purine containing compound GO:0014074 126 0.013
rna biosynthetic process GO:0032774 380 0.013
carbohydrate derivative metabolic process GO:1901135 346 0.013
nucleotide metabolic process GO:0009117 279 0.013
acetate metabolic process GO:0006083 2 0.013
hormone secretion GO:0046879 115 0.013
transcription from rna polymerase ii promoter GO:0006366 252 0.013
cellular response to external stimulus GO:0071496 118 0.013
positive regulation of gene expression GO:0010628 244 0.013
microtubule organizing center organization GO:0031023 1 0.013
regulation of transcription dna templated GO:0006355 374 0.012
response to glucocorticoid GO:0051384 223 0.012
organic anion transport GO:0015711 132 0.012
cellular response to peptide hormone stimulus GO:0071375 120 0.012
forebrain development GO:0030900 98 0.012
developmental process involved in reproduction GO:0003006 159 0.012
positive regulation of cell communication GO:0010647 271 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.012
positive regulation of transport GO:0051050 245 0.012
salivary gland development GO:0007431 3 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
purine nucleoside catabolic process GO:0006152 124 0.012
rna localization GO:0006403 4 0.012
receptor localization to synapse GO:0097120 2 0.012
regulation of transferase activity GO:0051338 123 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
nucleobase containing small molecule metabolic process GO:0055086 316 0.012
centrosome organization GO:0051297 1 0.012
negative regulation of molecular function GO:0044092 133 0.012
cellular response to peptide GO:1901653 133 0.012
cellular homeostasis GO:0019725 252 0.012
cellular response to hypoxia GO:0071456 51 0.012
negative regulation of programmed cell death GO:0043069 183 0.011
glucose metabolic process GO:0006006 52 0.011
regulation of muscle system process GO:0090257 79 0.011
regulation of immune system process GO:0002682 123 0.011
regulation of secretion by cell GO:1903530 208 0.011
centrosome cycle GO:0007098 1 0.011
multicellular organismal signaling GO:0035637 44 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
monosaccharide metabolic process GO:0005996 61 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
cellular response to drug GO:0035690 30 0.011
cytoskeleton organization GO:0007010 111 0.011
cellular response to reactive oxygen species GO:0034614 55 0.011
cation transport GO:0006812 382 0.011
ras protein signal transduction GO:0007265 29 0.011
gastrulation GO:0007369 2 0.011
neuronal action potential GO:0019228 35 0.011
purine nucleoside diphosphate metabolic process GO:0009135 9 0.011
response to external biotic stimulus GO:0043207 221 0.011
sequestering of calcium ion GO:0051208 8 0.011
neurological system process GO:0050877 219 0.011
ribose phosphate metabolic process GO:0019693 235 0.011
cellular response to lipid GO:0071396 201 0.011
positive regulation of signal transduction GO:0009967 175 0.011
kidney development GO:0001822 67 0.011
circulatory system process GO:0003013 183 0.011
nucleoside catabolic process GO:0009164 126 0.010
positive regulation of developmental process GO:0051094 283 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.010
axis specification GO:0009798 4 0.010
muscle contraction GO:0006936 88 0.010
biological adhesion GO:0022610 110 0.010
male gamete generation GO:0048232 99 0.010
nucleoside phosphate metabolic process GO:0006753 283 0.010
cellular response to fatty acid GO:0071398 29 0.010
regulation of catabolic process GO:0009894 113 0.010
cellular response to nutrient levels GO:0031669 60 0.010

Bckdha disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
inherited metabolic disorder DOID:655 0 0.178
disease of metabolism DOID:0014667 0 0.178
amino acid metabolic disorder DOID:9252 0 0.105
organic acidemia DOID:0060159 0 0.015