Rattus norvegicus

0 known processes

Bik

BCL2-interacting killer (apoptosis-inducing)

(Aliases: Biklk,Blk)

Bik biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
rna biosynthetic process GO:0032774 380 0.167
regulation of rna metabolic process GO:0051252 391 0.092
regulation of cell proliferation GO:0042127 359 0.090
regulation of transcription dna templated GO:0006355 374 0.083
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.080
positive regulation of multicellular organismal process GO:0051240 387 0.079
nucleic acid templated transcription GO:0097659 379 0.078
oxoacid metabolic process GO:0043436 290 0.078
transcription dna templated GO:0006351 377 0.075
transcription from rna polymerase ii promoter GO:0006366 252 0.069
regulation of nucleic acid templated transcription GO:1903506 380 0.064
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.063
regulation of rna biosynthetic process GO:2001141 381 0.063
cation homeostasis GO:0055080 195 0.063
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.063
positive regulation of cell proliferation GO:0008284 249 0.060
rna metabolic process GO:0016070 406 0.055
limb morphogenesis GO:0035108 4 0.054
organophosphate metabolic process GO:0019637 370 0.053
positive regulation of biosynthetic process GO:0009891 319 0.050
positive regulation of cellular biosynthetic process GO:0031328 295 0.049
prostate gland epithelium morphogenesis GO:0060740 2 0.048
regulation of protein metabolic process GO:0051246 289 0.047
chemical homeostasis GO:0048878 292 0.047
divalent inorganic cation homeostasis GO:0072507 165 0.046
regulation of apoptotic process GO:0042981 335 0.045
calcium ion homeostasis GO:0055074 162 0.045
positive regulation of signaling GO:0023056 270 0.045
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.044
gland development GO:0048732 155 0.044
embryonic appendage morphogenesis GO:0035113 4 0.044
single organism reproductive process GO:0044702 297 0.043
cellular response to stress GO:0033554 269 0.042
negative regulation of macromolecule metabolic process GO:0010605 260 0.041
rhythmic process GO:0048511 156 0.040
regulation of cell differentiation GO:0045595 320 0.040
carboxylic acid metabolic process GO:0019752 289 0.039
neuron differentiation GO:0030182 368 0.039
carbohydrate derivative metabolic process GO:1901135 346 0.039
appendage morphogenesis GO:0035107 4 0.039
reproductive process GO:0022414 372 0.038
cellular component movement GO:0006928 248 0.038
positive regulation of developmental process GO:0051094 283 0.037
regulation of epithelial cell proliferation GO:0050678 49 0.037
multi organism reproductive process GO:0044703 262 0.037
cellular divalent inorganic cation homeostasis GO:0072503 162 0.037
cellular chemical homeostasis GO:0055082 247 0.037
nucleobase containing small molecule metabolic process GO:0055086 316 0.037
negative regulation of cell differentiation GO:0045596 99 0.036
response to acid chemical GO:0001101 222 0.036
cellular response to lipid GO:0071396 201 0.036
regulation of multicellular organismal development GO:2000026 376 0.036
negative regulation of developmental process GO:0051093 125 0.036
regulation of cellular amine metabolic process GO:0033238 8 0.036
anatomical structure morphogenesis GO:0009653 298 0.036
cellular ketone metabolic process GO:0042180 51 0.035
cellular homeostasis GO:0019725 252 0.035
organic acid metabolic process GO:0006082 292 0.035
aging GO:0007568 241 0.034
positive regulation of protein modification process GO:0031401 142 0.034
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.034
nucleoside phosphate metabolic process GO:0006753 283 0.034
cellular component biogenesis GO:0044085 368 0.034
cellular cation homeostasis GO:0030003 180 0.033
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.033
cellular amino acid metabolic process GO:0006520 107 0.033
negative regulation of cell death GO:0060548 229 0.033
positive regulation of molecular function GO:0044093 230 0.033
cellular amine metabolic process GO:0044106 38 0.032
localization of cell GO:0051674 202 0.032
positive regulation of apoptotic process GO:0043065 154 0.032
amine metabolic process GO:0009308 38 0.032
metal ion homeostasis GO:0055065 186 0.031
cellular ion homeostasis GO:0006873 184 0.031
regulation of protein phosphorylation GO:0001932 183 0.031
organ morphogenesis GO:0009887 75 0.030
response to ketone GO:1901654 182 0.030
macromolecular complex assembly GO:0065003 273 0.030
regulation of cellular amino acid metabolic process GO:0006521 2 0.030
regulation of phosphorus metabolic process GO:0051174 349 0.030
regulation of cellular component organization GO:0051128 368 0.030
tube development GO:0035295 89 0.030
cytosolic calcium ion homeostasis GO:0051480 140 0.030
lipid metabolic process GO:0006629 283 0.030
negative regulation of multicellular organismal process GO:0051241 203 0.030
central nervous system development GO:0007417 311 0.029
cell migration GO:0016477 197 0.029
positive regulation of phosphorus metabolic process GO:0010562 262 0.029
regulation of cellular ketone metabolic process GO:0010565 27 0.028
homeostatic process GO:0042592 331 0.028
positive regulation of protein metabolic process GO:0051247 178 0.028
protein phosphorylation GO:0006468 345 0.028
regulation of protein modification process GO:0031399 194 0.027
reproductive structure development GO:0048608 128 0.027
positive regulation of transcription dna templated GO:0045893 197 0.027
regulation of phosphate metabolic process GO:0019220 349 0.026
anatomical structure formation involved in morphogenesis GO:0048646 83 0.026
positive regulation of response to stimulus GO:0048584 285 0.026
anterior posterior pattern specification GO:0009952 1 0.026
ion homeostasis GO:0050801 212 0.026
cellular metal ion homeostasis GO:0006875 172 0.026
intracellular signal transduction GO:0035556 314 0.026
gonad development GO:0008406 104 0.026
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.025
response to ethanol GO:0045471 162 0.025
positive regulation of cell death GO:0010942 184 0.025
metal ion transport GO:0030001 289 0.025
regulation of anatomical structure morphogenesis GO:0022603 141 0.025
positive regulation of cellular protein metabolic process GO:0032270 167 0.025
regulation of cellular protein metabolic process GO:0032268 267 0.025
embryonic limb morphogenesis GO:0030326 4 0.025
response to peptide GO:1901652 292 0.025
response to inorganic substance GO:0010035 377 0.025
positive regulation of cell differentiation GO:0045597 217 0.024
regulation of establishment of planar polarity GO:0090175 2 0.024
response to lipopolysaccharide GO:0032496 191 0.024
positive regulation of phosphorylation GO:0042327 177 0.024
regulation of bmp signaling pathway GO:0030510 2 0.024
cellular calcium ion homeostasis GO:0006874 160 0.024
cell motility GO:0048870 202 0.024
positive regulation of phosphate metabolic process GO:0045937 262 0.024
multicellular organismal reproductive process GO:0048609 233 0.024
cellular response to endogenous stimulus GO:0071495 377 0.024
positive regulation of cell development GO:0010720 176 0.024
intracellular transport GO:0046907 185 0.023
single organism biosynthetic process GO:0044711 342 0.023
programmed cell death GO:0012501 392 0.023
organelle organization GO:0006996 266 0.023
eye morphogenesis GO:0048592 4 0.023
positive regulation of rna biosynthetic process GO:1902680 197 0.023
regulation of nervous system development GO:0051960 264 0.023
negative regulation of metabolic process GO:0009892 331 0.023
negative regulation of programmed cell death GO:0043069 183 0.023
multicellular organism reproduction GO:0032504 233 0.023
negative regulation of cell development GO:0010721 82 0.022
protein complex assembly GO:0006461 263 0.022
regulation of cell development GO:0060284 263 0.022
protein complex subunit organization GO:0071822 302 0.022
negative regulation of nucleic acid templated transcription GO:1903507 117 0.022
calcium ion transport GO:0006816 131 0.022
regulation of programmed cell death GO:0043067 341 0.022
ribose phosphate metabolic process GO:0019693 235 0.022
cell projection organization GO:0030030 302 0.022
reproductive system development GO:0061458 128 0.022
female sex differentiation GO:0046660 59 0.021
regulation of synaptic transmission GO:0050804 141 0.021
regulation of neurogenesis GO:0050767 247 0.021
regulation of phosphorylation GO:0042325 248 0.021
positive regulation of protein phosphorylation GO:0001934 135 0.021
prostate gland morphogenesis GO:0060512 2 0.021
negative regulation of rna metabolic process GO:0051253 123 0.021
epithelium development GO:0060429 96 0.021
macromolecular complex subunit organization GO:0043933 339 0.021
negative regulation of biosynthetic process GO:0009890 168 0.021
purine nucleotide metabolic process GO:0006163 229 0.021
regulation of ion transport GO:0043269 245 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
response to extracellular stimulus GO:0009991 380 0.020
epithelial cell proliferation GO:0050673 54 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
circadian rhythm GO:0007623 88 0.020
digestive system development GO:0055123 41 0.020
single organism organelle organization GO:1902589 180 0.020
axis specification GO:0009798 4 0.020
positive regulation of cellular component movement GO:0051272 102 0.020
response to estrogen GO:0043627 232 0.020
heart morphogenesis GO:0003007 3 0.020
locomotion GO:0040011 237 0.020
cation transport GO:0006812 382 0.020
response to estradiol GO:0032355 164 0.020
carbohydrate derivative biosynthetic process GO:1901137 124 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
nucleotide metabolic process GO:0009117 279 0.019
establishment of tissue polarity GO:0007164 2 0.019
cellular catabolic process GO:0044248 295 0.019
multi multicellular organism process GO:0044706 138 0.019
negative regulation of transport GO:0051051 136 0.019
negative regulation of gene expression GO:0010629 199 0.019
immune system process GO:0002376 204 0.019
regeneration GO:0031099 163 0.019
cellular component morphogenesis GO:0032989 155 0.018
cellular response to oxygen containing compound GO:1901701 386 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.018
regulation of hydrolase activity GO:0051336 143 0.018
response to oxygen levels GO:0070482 265 0.018
negative regulation of nervous system development GO:0051961 79 0.018
neurological system process GO:0050877 219 0.018
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.018
response to wounding GO:0009611 254 0.018
divalent inorganic cation transport GO:0072511 134 0.017
negative regulation of transcription dna templated GO:0045892 116 0.017
reproduction GO:0000003 245 0.017
female pregnancy GO:0007565 122 0.017
positive regulation of cell migration GO:0030335 96 0.017
cell cell signaling GO:0007267 335 0.017
cellular component assembly GO:0022607 360 0.017
non canonical wnt signaling pathway GO:0035567 3 0.017
vasculature development GO:0001944 70 0.017
cardiovascular system development GO:0072358 134 0.017
inorganic ion transmembrane transport GO:0098660 229 0.017
brain development GO:0007420 247 0.017
response to retinoic acid GO:0032526 63 0.017
positive regulation of neurogenesis GO:0050769 165 0.017
positive regulation of nucleic acid templated transcription GO:1903508 197 0.016
regulation of cell migration GO:0030334 128 0.016
regulation of cell motility GO:2000145 131 0.016
single organism intracellular transport GO:1902582 166 0.016
ribonucleoside metabolic process GO:0009119 174 0.016
camera type eye development GO:0043010 48 0.016
positive regulation of catalytic activity GO:0043085 184 0.016
growth GO:0040007 165 0.016
regulation of signal transduction GO:0009966 318 0.016
catabolic process GO:0009056 351 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
apoptotic process GO:0006915 381 0.016
regulation of reactive oxygen species metabolic process GO:2000377 26 0.016
b cell differentiation GO:0030183 2 0.016
development of primary female sexual characteristics GO:0046545 56 0.016
cellular protein localization GO:0034613 122 0.016
cellular macromolecule localization GO:0070727 122 0.016
development of primary sexual characteristics GO:0045137 107 0.016
protein localization GO:0008104 191 0.016
developmental process involved in reproduction GO:0003006 159 0.016
cell cycle GO:0007049 101 0.016
regulation of growth GO:0040008 105 0.016
organophosphate biosynthetic process GO:0090407 143 0.015
response to decreased oxygen levels GO:0036293 237 0.015
metestrus GO:0060210 1 0.015
blood vessel development GO:0001568 69 0.015
purine ribonucleotide metabolic process GO:0009150 227 0.015
regulation of organelle organization GO:0033043 80 0.015
cell morphogenesis GO:0000902 142 0.015
sensory organ development GO:0007423 74 0.015
embryonic pattern specification GO:0009880 1 0.015
neuron projection development GO:0031175 273 0.015
positive regulation of nervous system development GO:0051962 178 0.015
blood circulation GO:0008015 183 0.015
wound healing GO:0042060 122 0.015
bmp signaling pathway GO:0030509 4 0.015
neuron development GO:0048666 286 0.015
cellular response to lipopolysaccharide GO:0071222 55 0.015
cell morphogenesis involved in differentiation GO:0000904 119 0.015
positive regulation of locomotion GO:0040017 102 0.015
epithelial cell differentiation GO:0030855 71 0.015
response to molecule of bacterial origin GO:0002237 194 0.015
ion transmembrane transport GO:0034220 365 0.015
lung development GO:0030324 43 0.015
negative regulation of cell proliferation GO:0008285 119 0.015
sex differentiation GO:0007548 113 0.015
cellular response to fluid shear stress GO:0071498 4 0.015
negative regulation of neurogenesis GO:0050768 78 0.015
synaptic transmission GO:0007268 235 0.015
cellular response to hormone stimulus GO:0032870 247 0.015
negative regulation of cellular metabolic process GO:0031324 281 0.015
response to peptide hormone GO:0043434 278 0.015
digestive tract development GO:0048565 39 0.015
response to vitamin GO:0033273 131 0.014
circulatory system development GO:0072359 134 0.014
ras protein signal transduction GO:0007265 29 0.014
ensheathment of neurons GO:0007272 40 0.014
positive regulation of epithelial cell proliferation GO:0050679 32 0.014
purine containing compound metabolic process GO:0072521 253 0.014
cellular response to abiotic stimulus GO:0071214 85 0.014
dna metabolic process GO:0006259 96 0.014
positive regulation of gene expression GO:0010628 244 0.014
regulation of neuron differentiation GO:0045664 208 0.014
secretion GO:0046903 307 0.014
negative regulation of apoptotic process GO:0043066 181 0.014
inner ear receptor cell differentiation GO:0060113 2 0.014
gliogenesis GO:0042063 93 0.014
regulation of protein kinase activity GO:0045859 105 0.014
response to indole 3 methanol GO:0071680 2 0.014
head development GO:0060322 247 0.013
sexual reproduction GO:0019953 148 0.013
female gonad development GO:0008585 53 0.013
response to glucose GO:0009749 136 0.013
regulation of molecular function GO:0065009 398 0.013
regulation of cellular localization GO:0060341 263 0.013
multicellular organismal signaling GO:0035637 44 0.013
reactive oxygen species metabolic process GO:0072593 37 0.013
cation transmembrane transport GO:0098655 263 0.013
response to oxidative stress GO:0006979 186 0.013
regulation of catalytic activity GO:0050790 304 0.013
positive regulation of signal transduction GO:0009967 175 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
cell activation GO:0001775 97 0.013
establishment of planar polarity GO:0001736 1 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
multicellular organism growth GO:0035264 1 0.013
mesoderm development GO:0007498 2 0.013
neural crest cell differentiation GO:0014033 2 0.013
negative regulation of cell communication GO:0010648 158 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
small molecule biosynthetic process GO:0044283 124 0.013
cellular response to biotic stimulus GO:0071216 59 0.013
morphogenesis of a polarized epithelium GO:0001738 1 0.013
embryonic hindlimb morphogenesis GO:0035116 2 0.013
regulation of immune system process GO:0002682 123 0.013
regulation of cell cycle GO:0051726 73 0.013
nucleoside metabolic process GO:0009116 179 0.013
potassium ion transport GO:0006813 97 0.013
regulation of homeostatic process GO:0032844 101 0.012
cytoplasmic transport GO:0016482 115 0.012
nucleoside phosphate biosynthetic process GO:1901293 102 0.012
transmission of nerve impulse GO:0019226 42 0.012
establishment of protein localization GO:0045184 141 0.012
neuron fate commitment GO:0048663 4 0.012
response to cytokine GO:0034097 215 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
regulation of vasculature development GO:1901342 44 0.012
response to metal ion GO:0010038 253 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
gastrulation GO:0007369 2 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.012
response to reactive oxygen species GO:0000302 120 0.012
regulation of transferase activity GO:0051338 123 0.012
response to glucocorticoid GO:0051384 223 0.012
negative regulation of neuron differentiation GO:0045665 62 0.012
response to growth factor GO:0070848 189 0.012
response to insulin GO:0032868 133 0.012
mechanoreceptor differentiation GO:0042490 2 0.012
response to nutrient levels GO:0031667 370 0.012
spermatogenesis GO:0007283 99 0.012
organonitrogen compound biosynthetic process GO:1901566 167 0.012
purine nucleoside catabolic process GO:0006152 124 0.012
morphogenesis of embryonic epithelium GO:0016331 3 0.011
neural crest cell development GO:0014032 2 0.011
maintenance of location GO:0051235 17 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
lipid storage GO:0019915 1 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
vasculogenesis GO:0001570 3 0.011
response to testosterone GO:0033574 55 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
sequestering of metal ion GO:0051238 9 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
response to hypoxia GO:0001666 231 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
positive regulation of hepatocyte differentiation GO:0070368 2 0.011
regulation of membrane potential GO:0042391 110 0.011
regulation of cell growth GO:0001558 85 0.011
sodium ion transport GO:0006814 82 0.011
inner ear morphogenesis GO:0042472 1 0.011
male sex differentiation GO:0046661 64 0.011
cellular response to external stimulus GO:0071496 118 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
protein complex biogenesis GO:0070271 263 0.011
cell growth GO:0016049 104 0.011
camera type eye morphogenesis GO:0048593 2 0.011
cell differentiation involved in kidney development GO:0061005 4 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
regulation of fat cell differentiation GO:0045598 3 0.011
tissue development GO:0009888 252 0.011
purine ribonucleoside catabolic process GO:0046130 124 0.011
response to external biotic stimulus GO:0043207 221 0.011
proteolysis GO:0006508 175 0.011
regulation of cell morphogenesis GO:0022604 77 0.011
negative regulation of homeostatic process GO:0032845 47 0.011
regulation of tube size GO:0035150 89 0.010
negative regulation of molecular function GO:0044092 133 0.010
hepaticobiliary system development GO:0061008 90 0.010
negative regulation of cellular component organization GO:0051129 83 0.010
peptidyl amino acid modification GO:0018193 126 0.010
ovulation cycle process GO:0022602 50 0.010
negative regulation of signaling GO:0023057 157 0.010
palate development GO:0060021 2 0.010
ribonucleoside catabolic process GO:0042454 126 0.010
organic substance catabolic process GO:1901575 316 0.010
regulation of canonical wnt signaling pathway GO:0060828 4 0.010
regulation of developmental growth GO:0048638 45 0.010
negative regulation of rna biosynthetic process GO:1902679 118 0.010
cellular response to alcohol GO:0097306 87 0.010
tube formation GO:0035148 3 0.010
negative regulation of cellular biosynthetic process GO:0031327 161 0.010
eye development GO:0001654 50 0.010
regulation of system process GO:0044057 208 0.010

Bik disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.023
sensory system disease DOID:0050155 0 0.018
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.011
gastrointestinal system cancer DOID:3119 0 0.010
vascular disease DOID:178 0 0.010
cardiovascular system disease DOID:1287 0 0.010