Rattus norvegicus

84 known processes

Cd74

Cd74 molecule, major histocompatibility complex, class II invariant chain

(Aliases: INVG34)

Cd74 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 1 0.997
Mouse
antigen processing and presentation of peptide antigen via mhc class ii GO:0002495 1 0.995
Mouse
antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002504 1 0.993
Mouse
cellular response to ammonium ion GO:0071242 17 0.990
negative regulation of t cell activation GO:0050868 7 0.985
Mouse
antigen processing and presentation of peptide antigen GO:0048002 2 0.984
Mouse
regulation of t cell proliferation GO:0042129 17 0.955
t cell proliferation GO:0042098 19 0.944
negative regulation of t cell proliferation GO:0042130 5 0.944
negative regulation of leukocyte proliferation GO:0070664 6 0.934
negative regulation of lymphocyte activation GO:0051250 10 0.930
Mouse
regulation of t cell activation GO:0050863 23 0.873
Mouse
immune system process GO:0002376 204 0.853
Human Mouse
regulation of mononuclear cell proliferation GO:0032944 26 0.836
Human
response to other organism GO:0051707 220 0.828
cellular response to isoquinoline alkaloid GO:0071317 6 0.817
t cell activation GO:0042110 29 0.817
Mouse
immunoglobulin mediated immune response GO:0016064 4 0.809
Mouse
negative regulation of mononuclear cell proliferation GO:0032945 6 0.794
regulation of antigen processing and presentation GO:0002577 1 0.773
Mouse
b cell mediated immunity GO:0019724 4 0.729
Mouse
antigen processing and presentation GO:0019882 2 0.708
Mouse
cellular response to morphine GO:0071315 5 0.635
innate immune response GO:0045087 35 0.599
antigen processing and presentation of exogenous antigen GO:0019884 1 0.576
Mouse
regulation of cell proliferation GO:0042127 359 0.569
Human
antigen processing and presentation of exogenous peptide antigen GO:0002478 1 0.556
Mouse
negative regulation of lymphocyte proliferation GO:0050672 6 0.551
cellular response to corticosteroid stimulus GO:0071384 69 0.548
cellular response to organic cyclic compound GO:0071407 202 0.537
macromolecular complex assembly GO:0065003 273 0.510
Mouse
lymphocyte activation GO:0046649 43 0.498
Human Mouse
negative regulation of immune system process GO:0002683 39 0.458
Mouse
response to interferon gamma GO:0034341 20 0.418
cellular response to dexamethasone stimulus GO:0071549 36 0.393
programmed cell death GO:0012501 392 0.385
Human Mouse
response to corticosteroid GO:0031960 235 0.380
immune response GO:0006955 104 0.378
Mouse
cell activation GO:0001775 97 0.350
Human Mouse
response to dexamethasone GO:0071548 49 0.328
cellular response to endogenous stimulus GO:0071495 377 0.327
response to symbiont GO:0009608 1 0.296
negative regulation of leukocyte activation GO:0002695 14 0.293
Mouse
leukocyte activation GO:0045321 76 0.279
Human Mouse
macromolecular complex subunit organization GO:0043933 339 0.273
Mouse
regulation of lymphocyte proliferation GO:0050670 26 0.238
Human
lymphocyte proliferation GO:0046651 29 0.223
Human
protein complex assembly GO:0006461 263 0.223
Mouse
regulation of cell activation GO:0050865 50 0.223
Human Mouse
cellular response to cytokine stimulus GO:0071345 127 0.220
Human Mouse
positive regulation of antigen processing and presentation GO:0002579 1 0.219
Mouse
response to cytokine GO:0034097 215 0.218
Human Mouse
protein complex biogenesis GO:0070271 263 0.215
Mouse
chemotaxis GO:0006935 66 0.205
Mouse
regulation of leukocyte proliferation GO:0070663 26 0.194
Human
hemopoiesis GO:0030097 34 0.188
Mouse
cellular component assembly GO:0022607 360 0.188
Mouse
b cell differentiation GO:0030183 2 0.171
de novo protein folding GO:0006458 2 0.165
Mouse
response to ammonium ion GO:0060359 71 0.142
positive regulation of immune system process GO:0002684 90 0.141
Human Mouse
regulation of adaptive immune response GO:0002819 8 0.140
protein complex subunit organization GO:0071822 302 0.134
Mouse
regulation of immune system process GO:0002682 123 0.115
Human Mouse
cellular response to stress GO:0033554 269 0.113
Human Mouse
negative regulation of cell proliferation GO:0008285 119 0.110
de novo posttranslational protein folding GO:0051084 2 0.109
Mouse
mononuclear cell proliferation GO:0032943 29 0.106
Human
cellular response to hormone stimulus GO:0032870 247 0.105
cellular response to nitrogen compound GO:1901699 210 0.099
cellular protein complex assembly GO:0043623 44 0.099
cellular response to alcohol GO:0097306 87 0.098
response to glucocorticoid GO:0051384 223 0.088
regulation of t cell differentiation GO:0045580 7 0.087
Mouse
positive regulation of cell activation GO:0050867 34 0.084
Human Mouse
response to external biotic stimulus GO:0043207 221 0.081
response to ketone GO:1901654 182 0.080
leukocyte differentiation GO:0002521 30 0.076
Mouse
cellular component biogenesis GO:0044085 368 0.076
Mouse
response to biotic stimulus GO:0009607 226 0.072
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.071
apoptotic process GO:0006915 381 0.068
Human Mouse
response to fungus GO:0009620 8 0.066
cellular response to organonitrogen compound GO:0071417 197 0.065
leukocyte proliferation GO:0070661 29 0.065
Human
response to hexose GO:0009746 144 0.060
positive regulation of cell proliferation GO:0008284 249 0.059
Human
head development GO:0060322 247 0.057
cellular response to steroid hormone stimulus GO:0071383 93 0.053
regulation of programmed cell death GO:0043067 341 0.053
Human Mouse
cytoskeleton organization GO:0007010 111 0.052
negative regulation of apoptotic process GO:0043066 181 0.051
Human Mouse
regulation of cellular ketone metabolic process GO:0010565 27 0.050
cellular response to oxygen containing compound GO:1901701 386 0.049
response to inorganic substance GO:0010035 377 0.048
cellular response to lipid GO:0071396 201 0.045
neuron projection development GO:0031175 273 0.044
negative regulation of cellular metabolic process GO:0031324 281 0.044
immune system development GO:0002520 41 0.043
Mouse
cell junction maintenance GO:0034331 1 0.042
cellular amino acid metabolic process GO:0006520 107 0.041
cellular macromolecular complex assembly GO:0034622 58 0.041
cognition GO:0050890 92 0.040
cellular homeostasis GO:0019725 252 0.039
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 8 0.037
defense response GO:0006952 194 0.036
Mouse
cellular amide metabolic process GO:0043603 44 0.035
catabolic process GO:0009056 351 0.035
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 1 0.034
chaperone mediated protein folding requiring cofactor GO:0051085 2 0.034
Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.034
t helper 1 type immune response GO:0042088 1 0.033
regulation of leukocyte activation GO:0002694 45 0.033
Human Mouse
cell cell signaling GO:0007267 335 0.033
response to isoquinoline alkaloid GO:0014072 28 0.033
gland development GO:0048732 155 0.032
response to starvation GO:0042594 59 0.032
positive regulation of immunoglobulin production GO:0002639 4 0.032
cellular response to starvation GO:0009267 27 0.032
negative regulation of metabolic process GO:0009892 331 0.032
positive regulation of lymphocyte differentiation GO:0045621 6 0.032
Mouse
negative regulation of cell development GO:0010721 82 0.031
cellular ketone metabolic process GO:0042180 51 0.031
response to estradiol GO:0032355 164 0.030
negative regulation of phosphate metabolic process GO:0045936 80 0.030
positive regulation of cell differentiation GO:0045597 217 0.030
Mouse
cation transport GO:0006812 382 0.029
organ regeneration GO:0031100 101 0.029
brain development GO:0007420 247 0.029
regulation of b cell mediated immunity GO:0002712 2 0.028
monovalent inorganic cation transport GO:0015672 172 0.028
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.028
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 6 0.027
positive regulation of signaling GO:0023056 270 0.027
regulation of neurogenesis GO:0050767 247 0.027
regulation of cell differentiation GO:0045595 320 0.027
Mouse
single organism catabolic process GO:0044712 283 0.026
negative regulation of transport GO:0051051 136 0.025
Human
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
negative regulation of biosynthetic process GO:0009890 168 0.025
hematopoietic progenitor cell differentiation GO:0002244 2 0.024
positive regulation of leukocyte activation GO:0002696 30 0.024
Human Mouse
cellular metal ion homeostasis GO:0006875 172 0.024
cation homeostasis GO:0055080 195 0.024
cellular protein catabolic process GO:0044257 19 0.024
cell projection organization GO:0030030 302 0.023
regulation of homeostatic process GO:0032844 101 0.023
Mouse
positive regulation of multicellular organismal process GO:0051240 387 0.023
Mouse
response to peptide hormone GO:0043434 278 0.023
negative regulation of cellular biosynthetic process GO:0031327 161 0.023
cellular catabolic process GO:0044248 295 0.023
negative regulation of cell differentiation GO:0045596 99 0.023
Mouse
organic substance catabolic process GO:1901575 316 0.023
response to extracellular stimulus GO:0009991 380 0.022
cell migration GO:0016477 197 0.022
Mouse
negative regulation of macromolecule metabolic process GO:0010605 260 0.022
actin filament based process GO:0030029 86 0.022
regulation of locomotion GO:0040012 148 0.022
Mouse
response to morphine GO:0043278 27 0.022
sodium ion transport GO:0006814 82 0.022
regulation of cellular amino acid metabolic process GO:0006521 2 0.021
neuron differentiation GO:0030182 368 0.021
regulatory t cell differentiation GO:0045066 2 0.021
regulation of cellular amine metabolic process GO:0033238 8 0.021
endocytosis GO:0006897 84 0.021
cellular amine metabolic process GO:0044106 38 0.020
negative regulation of protein metabolic process GO:0051248 114 0.020
maintenance of location GO:0051235 17 0.020
ras protein signal transduction GO:0007265 29 0.019
positive regulation of leukocyte differentiation GO:1902107 13 0.019
Mouse
cytosolic calcium ion homeostasis GO:0051480 140 0.019
carboxylic acid metabolic process GO:0019752 289 0.019
Human
regulation of phosphorylation GO:0042325 248 0.019
axis specification GO:0009798 4 0.018
regulation of phosphate metabolic process GO:0019220 349 0.018
positive regulation of t cell differentiation GO:0045582 6 0.018
Mouse
organelle organization GO:0006996 266 0.018
positive regulation of lymphocyte activation GO:0051251 25 0.018
Human Mouse
negative regulation of neuron differentiation GO:0045665 62 0.018
response to alkaloid GO:0043279 132 0.018
negative regulation of protein modification process GO:0031400 52 0.018
negative regulation of neurogenesis GO:0050768 78 0.018
regulation of apoptotic process GO:0042981 335 0.018
Human Mouse
reactive oxygen species biosynthetic process GO:1903409 8 0.018
response to acid chemical GO:0001101 222 0.018
nucleoside triphosphate catabolic process GO:0009143 123 0.018
positive regulation of cellular component biogenesis GO:0044089 55 0.018
peptide hormone secretion GO:0030072 84 0.018
regulation of histone deacetylation GO:0031063 1 0.018
positive regulation of t cell mediated immunity GO:0002711 4 0.017
positive regulation of apoptotic process GO:0043065 154 0.017
positive regulation of programmed cell death GO:0043068 157 0.017
response to monosaccharide GO:0034284 159 0.017
negative regulation of viral process GO:0048525 4 0.017
signal release GO:0023061 145 0.017
positive regulation of rna metabolic process GO:0051254 203 0.016
actin filament bundle organization GO:0061572 19 0.016
amine metabolic process GO:0009308 38 0.016
triglyceride homeostasis GO:0070328 2 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
negative regulation of innate immune response GO:0045824 4 0.016
purine nucleotide metabolic process GO:0006163 229 0.016
response to nutrient levels GO:0031667 370 0.016
positive regulation of immune response GO:0050778 42 0.016
Mouse
alcohol metabolic process GO:0006066 77 0.016
positive regulation of phosphate metabolic process GO:0045937 262 0.015
positive regulation of cell death GO:0010942 184 0.015
metal ion homeostasis GO:0055065 186 0.015
transcription from rna polymerase ii promoter GO:0006366 252 0.015
cellular response to alkaloid GO:0071312 25 0.015
regulation of body fluid levels GO:0050878 90 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
reactive nitrogen species metabolic process GO:2001057 1 0.015
positive regulation of isotype switching GO:0045830 1 0.015
single organism biosynthetic process GO:0044711 342 0.015
Human
cellular response to abiotic stimulus GO:0071214 85 0.015
positive regulation of gene expression GO:0010628 244 0.014
regulation of cellular localization GO:0060341 263 0.014
bone development GO:0060348 25 0.014
protein phosphorylation GO:0006468 345 0.014
phagocytosis recognition GO:0006910 1 0.014
negative regulation of nervous system development GO:0051961 79 0.014
response to growth factor GO:0070848 189 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.014
negative regulation of phosphorus metabolic process GO:0010563 80 0.014
carbohydrate derivative catabolic process GO:1901136 147 0.014
regulation of immune response GO:0050776 55 0.014
Mouse
negative regulation of rna metabolic process GO:0051253 123 0.014
positive regulation of response to stimulus GO:0048584 285 0.014
oxidation reduction process GO:0055114 304 0.013
developmental process involved in reproduction GO:0003006 159 0.013
lipid biosynthetic process GO:0008610 128 0.013
Human
multicellular organismal reproductive process GO:0048609 233 0.013
single organism organelle organization GO:1902589 180 0.013
response to bacterium GO:0009617 200 0.013
negative regulation of gene expression GO:0010629 199 0.013
response to radiation GO:0009314 137 0.013
response to vitamin GO:0033273 131 0.013
cellular response to ketone GO:1901655 51 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.013
vesicle mediated transport GO:0016192 181 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
cellular ion homeostasis GO:0006873 184 0.012
lymphocyte differentiation GO:0030098 10 0.012
Mouse
negative regulation of cell activation GO:0050866 15 0.012
Mouse
leukocyte mediated cytotoxicity GO:0001909 10 0.012
regulation of cell development GO:0060284 263 0.012
response to reactive oxygen species GO:0000302 120 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
macromolecule catabolic process GO:0009057 58 0.012
nucleoside phosphate metabolic process GO:0006753 283 0.012
positive regulation of developmental process GO:0051094 283 0.012
Mouse
somatic diversification of immunoglobulins involved in immune response GO:0002208 1 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.012
skeletal system development GO:0001501 41 0.012
gtp catabolic process GO:0006184 71 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.012
positive regulation of cell motility GO:2000147 97 0.012
Mouse
regulation of phosphorus metabolic process GO:0051174 349 0.012
membrane organization GO:0061024 94 0.011
amide transport GO:0042886 105 0.011
Human
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
cellular lipid metabolic process GO:0044255 208 0.011
Human
regulation of t cell differentiation in thymus GO:0033081 1 0.011
sequestering of metal ion GO:0051238 9 0.011
positive regulation of signal transduction GO:0009967 175 0.011
organic acid metabolic process GO:0006082 292 0.011
Human
regulation of neuron projection development GO:0010975 161 0.011
negative regulation of signal transduction GO:0009968 83 0.011
Human Mouse
adaptive immune response GO:0002250 14 0.011
Mouse
defense response to gram negative bacterium GO:0050829 3 0.011
regulation of cellular component organization GO:0051128 368 0.011
circulatory system development GO:0072359 134 0.011
rna biosynthetic process GO:0032774 380 0.011
metal ion transport GO:0030001 289 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.011
aging GO:0007568 241 0.010
regulation of cell morphogenesis GO:0022604 77 0.010
positive regulation of cellular amine metabolic process GO:0033240 3 0.010
nucleic acid templated transcription GO:0097659 379 0.010
spindle organization GO:0007051 2 0.010
actin polymerization or depolymerization GO:0008154 14 0.010
establishment of organelle localization GO:0051656 37 0.010
muscle structure development GO:0061061 87 0.010
localization of cell GO:0051674 202 0.010
Mouse
cell part morphogenesis GO:0032990 123 0.010
nucleobase containing small molecule metabolic process GO:0055086 316 0.010
regulation of multicellular organismal development GO:2000026 376 0.010
Mouse
regulation of cytoskeleton organization GO:0051493 49 0.010
embryonic pattern specification GO:0009880 1 0.010
regulation of intracellular transport GO:0032386 65 0.010
chaperone mediated protein folding GO:0061077 6 0.010
Mouse

Cd74 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011