Rattus norvegicus

0 known processes

Cfi

complement factor I

Cfi biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
immune response GO:0006955 104 0.345
inflammatory response GO:0006954 150 0.303
regulation of immune system process GO:0002682 123 0.271
defense response GO:0006952 194 0.267
response to extracellular stimulus GO:0009991 380 0.232
blood coagulation GO:0007596 26 0.214
protein maturation GO:0051604 68 0.209
wound healing GO:0042060 122 0.202
immune system process GO:0002376 204 0.192
coagulation GO:0050817 28 0.191
positive regulation of response to stimulus GO:0048584 285 0.187
response to wounding GO:0009611 254 0.159
proteolysis GO:0006508 175 0.140
regulation of protein metabolic process GO:0051246 289 0.138
response to nutrient levels GO:0031667 370 0.130
regulation of apoptotic process GO:0042981 335 0.129
programmed cell death GO:0012501 392 0.123
protein complex assembly GO:0006461 263 0.118
regulation of cellular localization GO:0060341 263 0.103
response to inorganic substance GO:0010035 377 0.102
protein complex subunit organization GO:0071822 302 0.101
macromolecule localization GO:0033036 252 0.099
positive regulation of immune system process GO:0002684 90 0.096
extracellular matrix constituent secretion GO:0070278 4 0.095
regulation of response to external stimulus GO:0032101 106 0.094
positive regulation of blood coagulation GO:0030194 4 0.091
cell activation GO:0001775 97 0.090
positive regulation of signaling GO:0023056 270 0.089
cellular component assembly GO:0022607 360 0.087
macromolecular complex subunit organization GO:0043933 339 0.085
regulation of immune response GO:0050776 55 0.084
regulation of response to stress GO:0080134 126 0.081
positive regulation of multicellular organismal process GO:0051240 387 0.077
regulation of multicellular organismal development GO:2000026 376 0.077
apoptotic process GO:0006915 381 0.076
homeostatic process GO:0042592 331 0.075
response to vitamin GO:0033273 131 0.074
cell cell signaling GO:0007267 335 0.074
cellular chemical homeostasis GO:0055082 247 0.073
negative regulation of macromolecule metabolic process GO:0010605 260 0.072
regulation of anatomical structure morphogenesis GO:0022603 141 0.069
mapk cascade GO:0000165 140 0.068
positive regulation of cell communication GO:0010647 271 0.068
immune effector process GO:0002252 53 0.066
macromolecular complex assembly GO:0065003 273 0.065
positive regulation of signal transduction GO:0009967 175 0.064
response to external biotic stimulus GO:0043207 221 0.064
regulation of programmed cell death GO:0043067 341 0.063
regulation of protein processing GO:0070613 50 0.061
complement activation GO:0006956 11 0.061
regulation of protein maturation GO:1903317 50 0.060
multicellular organism reproduction GO:0032504 233 0.058
cellular cation homeostasis GO:0030003 180 0.058
regulation of cellular protein metabolic process GO:0032268 267 0.057
regulation of defense response GO:0031347 68 0.057
regulation of body fluid levels GO:0050878 90 0.056
reproduction GO:0000003 245 0.056
humoral immune response GO:0006959 12 0.056
regulation of secretion by cell GO:1903530 208 0.056
acute phase response GO:0006953 20 0.055
cellular metal ion homeostasis GO:0006875 172 0.055
hemostasis GO:0007599 26 0.055
regeneration GO:0031099 163 0.054
neurological system process GO:0050877 219 0.054
response to other organism GO:0051707 220 0.053
reproductive process GO:0022414 372 0.053
negative regulation of gene expression GO:0010629 199 0.052
protein homotrimerization GO:0070207 15 0.052
regulation of molecular function GO:0065009 398 0.051
protein oligomerization GO:0051259 191 0.051
cation transport GO:0006812 382 0.048
protein complex biogenesis GO:0070271 263 0.048
protein homooligomerization GO:0051260 91 0.048
negative regulation of response to stimulus GO:0048585 155 0.047
protein activation cascade GO:0072376 12 0.047
protein processing GO:0016485 68 0.047
positive regulation of immune response GO:0050778 42 0.047
anatomical structure morphogenesis GO:0009653 298 0.046
response to cytokine GO:0034097 215 0.046
reactive oxygen species metabolic process GO:0072593 37 0.046
response to nutrient GO:0007584 248 0.045
response to estrogen GO:0043627 232 0.045
cellular response to mechanical stimulus GO:0071260 48 0.045
positive regulation of secretion GO:0051047 140 0.044
response to mechanical stimulus GO:0009612 134 0.044
regulation of cell proliferation GO:0042127 359 0.043
regulation of epithelial cell proliferation GO:0050678 49 0.043
cellular component biogenesis GO:0044085 368 0.042
positive regulation of intracellular signal transduction GO:1902533 138 0.041
acute inflammatory response GO:0002526 58 0.041
cellular amide metabolic process GO:0043603 44 0.041
regulation of phosphorus metabolic process GO:0051174 349 0.041
regulation of signal transduction GO:0009966 318 0.040
intracellular signal transduction GO:0035556 314 0.039
response to bacterium GO:0009617 200 0.039
secretion GO:0046903 307 0.039
response to hydrogen peroxide GO:0042542 89 0.039
cellular response to external stimulus GO:0071496 118 0.039
protein transport GO:0015031 132 0.039
cellular homeostasis GO:0019725 252 0.038
positive regulation of phosphate metabolic process GO:0045937 262 0.038
protein localization GO:0008104 191 0.038
negative regulation of cell death GO:0060548 229 0.037
regulation of phosphorylation GO:0042325 248 0.037
angiogenesis GO:0001525 53 0.037
cellular response to lipopolysaccharide GO:0071222 55 0.036
rhythmic process GO:0048511 156 0.036
cellular amino acid metabolic process GO:0006520 107 0.036
metal ion transport GO:0030001 289 0.036
positive regulation of phosphorus metabolic process GO:0010562 262 0.036
coenzyme metabolic process GO:0006732 86 0.035
organic acid metabolic process GO:0006082 292 0.035
establishment of protein localization GO:0045184 141 0.035
nitrogen compound transport GO:0071705 229 0.035
regulation of locomotion GO:0040012 148 0.035
negative regulation of protein maturation GO:1903318 47 0.034
divalent inorganic cation transport GO:0072511 134 0.034
monovalent inorganic cation transport GO:0015672 172 0.034
signal transduction by phosphorylation GO:0023014 144 0.034
cellular response to oxygen containing compound GO:1901701 386 0.034
regulation of hydrolase activity GO:0051336 143 0.034
multi multicellular organism process GO:0044706 138 0.034
g protein coupled receptor signaling pathway GO:0007186 242 0.033
negative regulation of protein processing GO:0010955 47 0.033
behavior GO:0007610 205 0.033
cellular component movement GO:0006928 248 0.033
ion homeostasis GO:0050801 212 0.033
negative regulation of endopeptidase activity GO:0010951 36 0.032
cofactor metabolic process GO:0051186 95 0.032
response to transition metal nanoparticle GO:1990267 122 0.032
epithelial cell proliferation GO:0050673 54 0.032
activation of immune response GO:0002253 26 0.032
negative regulation of response to external stimulus GO:0032102 37 0.032
cellular response to biotic stimulus GO:0071216 59 0.032
hepatocyte proliferation GO:0072574 3 0.032
response to biotic stimulus GO:0009607 226 0.032
b cell mediated immunity GO:0019724 4 0.032
amine metabolic process GO:0009308 38 0.031
response to temperature stimulus GO:0009266 94 0.031
biological adhesion GO:0022610 110 0.031
tissue development GO:0009888 252 0.031
negative regulation of programmed cell death GO:0043069 183 0.031
secretion by cell GO:0032940 248 0.030
multicellular organismal reproductive process GO:0048609 233 0.030
negative regulation of developmental process GO:0051093 125 0.030
cellular response to cytokine stimulus GO:0071345 127 0.030
positive regulation of mapk cascade GO:0043410 92 0.030
negative regulation of protein metabolic process GO:0051248 114 0.030
positive regulation of biosynthetic process GO:0009891 319 0.030
single organism reproductive process GO:0044702 297 0.029
response to molecule of bacterial origin GO:0002237 194 0.029
regulation of hormone levels GO:0010817 187 0.029
metal ion homeostasis GO:0055065 186 0.029
regulation of angiogenesis GO:0045765 39 0.029
regulation of ion transport GO:0043269 245 0.029
cellular amine metabolic process GO:0044106 38 0.029
positive regulation of extracellular matrix constituent secretion GO:0003331 2 0.028
regulation of system process GO:0044057 208 0.028
catabolic process GO:0009056 351 0.028
negative regulation of response to wounding GO:1903035 23 0.028
negative regulation of cellular metabolic process GO:0031324 281 0.028
circadian rhythm GO:0007623 88 0.028
response to muscle activity involved in regulation of muscle adaptation GO:0014873 2 0.028
positive regulation of angiogenesis GO:0045766 28 0.028
negative regulation of molecular function GO:0044092 133 0.028
regulation of response to wounding GO:1903034 69 0.028
negative regulation of cellular protein metabolic process GO:0032269 106 0.028
positive regulation of transport GO:0051050 245 0.028
positive regulation of programmed cell death GO:0043068 157 0.027
synaptic transmission GO:0007268 235 0.027
innate immune response GO:0045087 35 0.027
response to ketone GO:1901654 182 0.027
intracellular transport GO:0046907 185 0.027
regulation of calcium ion transport GO:0051924 77 0.027
response to reactive oxygen species GO:0000302 120 0.027
regulation of protein modification process GO:0031399 194 0.027
positive regulation of phosphorylation GO:0042327 177 0.027
blood circulation GO:0008015 183 0.027
vesicle mediated transport GO:0016192 181 0.027
lipid transport GO:0006869 61 0.027
regulation of cell adhesion GO:0030155 52 0.027
regulation of phosphate metabolic process GO:0019220 349 0.026
cell type specific apoptotic process GO:0097285 134 0.026
locomotion GO:0040011 237 0.026
negative regulation of peptidase activity GO:0010466 38 0.026
multi organism reproductive process GO:0044703 262 0.026
positive regulation of secretion by cell GO:1903532 128 0.026
regulation of secretion GO:0051046 224 0.026
calcium ion homeostasis GO:0055074 162 0.026
cellular response to abiotic stimulus GO:0071214 85 0.026
regulation of catalytic activity GO:0050790 304 0.026
growth GO:0040007 165 0.025
response to hexose GO:0009746 144 0.025
positive regulation of apoptotic process GO:0043065 154 0.025
carboxylic acid metabolic process GO:0019752 289 0.025
regulation of mapk cascade GO:0043408 116 0.025
lipid localization GO:0010876 62 0.025
cellular response to stress GO:0033554 269 0.025
regulation of fibrinolysis GO:0051917 2 0.025
neuron differentiation GO:0030182 368 0.024
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
positive regulation of protein metabolic process GO:0051247 178 0.024
regulation of proteolysis GO:0030162 66 0.024
negative regulation of cell proliferation GO:0008285 119 0.024
calcium ion transport GO:0006816 131 0.024
protein phosphorylation GO:0006468 345 0.024
cytokine secretion GO:0050663 15 0.024
blood vessel development GO:0001568 69 0.023
response to metal ion GO:0010038 253 0.023
erk1 and erk2 cascade GO:0070371 48 0.023
cellular response to endogenous stimulus GO:0071495 377 0.023
regulation of cellular component movement GO:0051270 150 0.023
single organism behavior GO:0044708 130 0.023
vasculature development GO:0001944 70 0.023
leukocyte mediated immunity GO:0002443 28 0.023
response to oxygen levels GO:0070482 265 0.022
negative regulation of proteolysis GO:0045861 41 0.022
response to decreased oxygen levels GO:0036293 237 0.022
response to corticosteroid GO:0031960 235 0.022
cardiovascular system development GO:0072358 134 0.022
alcohol metabolic process GO:0006066 77 0.022
cellular ion homeostasis GO:0006873 184 0.022
positive regulation of developmental process GO:0051094 283 0.022
circulatory system development GO:0072359 134 0.022
response to activity GO:0014823 73 0.022
response to lipopolysaccharide GO:0032496 191 0.022
aging GO:0007568 241 0.022
blood vessel morphogenesis GO:0048514 58 0.021
regulation of intracellular signal transduction GO:1902531 218 0.021
fibrinolysis GO:0042730 2 0.021
regulation of cell motility GO:2000145 131 0.021
response to oxidative stress GO:0006979 186 0.021
circulatory system process GO:0003013 183 0.021
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
regulation of peptidase activity GO:0052547 55 0.021
transmembrane transport GO:0055085 412 0.021
plasminogen activation GO:0031639 2 0.021
defense response to gram positive bacterium GO:0050830 2 0.021
cell motility GO:0048870 202 0.020
regulation of blood circulation GO:1903522 110 0.020
gland development GO:0048732 155 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.020
negative regulation of metabolic process GO:0009892 331 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
cellular response to molecule of bacterial origin GO:0071219 56 0.020
regulation of reactive oxygen species metabolic process GO:2000377 26 0.020
chemical homeostasis GO:0048878 292 0.020
regulation of immune effector process GO:0002697 32 0.020
sequestering of calcium ion GO:0051208 8 0.020
positive regulation of response to wounding GO:1903036 34 0.020
reactive nitrogen species metabolic process GO:2001057 1 0.020
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.019
tube development GO:0035295 89 0.019
regulation of cellular amine metabolic process GO:0033238 8 0.019
ion transmembrane transport GO:0034220 365 0.019
organ regeneration GO:0031100 101 0.019
regulation of membrane potential GO:0042391 110 0.019
regulation of extracellular matrix constituent secretion GO:0003330 2 0.019
regulation of metal ion transport GO:0010959 118 0.019
anatomical structure formation involved in morphogenesis GO:0048646 83 0.018
immunoglobulin mediated immune response GO:0016064 4 0.018
cellular response to fluid shear stress GO:0071498 4 0.018
urea cycle GO:0000050 5 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.018
regulation of cell development GO:0060284 263 0.018
single organism intracellular transport GO:1902582 166 0.018
oxoacid metabolic process GO:0043436 290 0.018
regulation of cellular component organization GO:0051128 368 0.018
cellular ketone metabolic process GO:0042180 51 0.018
regulation of vasculature development GO:1901342 44 0.018
cell growth GO:0016049 104 0.018
response to carbohydrate GO:0009743 183 0.018
gonad development GO:0008406 104 0.018
negative regulation of cell communication GO:0010648 158 0.017
oxidation reduction process GO:0055114 304 0.017
cellular response to reactive oxygen species GO:0034614 55 0.017
single organism cellular localization GO:1902580 102 0.017
sexual reproduction GO:0019953 148 0.017
response to glucose GO:0009749 136 0.017
female pregnancy GO:0007565 122 0.017
heart growth GO:0060419 20 0.017
negative regulation of multicellular organismal process GO:0051241 203 0.017
response to glucocorticoid GO:0051384 223 0.017
negative regulation of epithelial cell proliferation GO:0050680 16 0.017
cation homeostasis GO:0055080 195 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
embryo development GO:0009790 49 0.017
divalent metal ion transport GO:0070838 132 0.017
renal system development GO:0072001 67 0.017
regulation of wound healing GO:0061041 14 0.017
single organism carbohydrate metabolic process GO:0044723 118 0.017
cell projection organization GO:0030030 302 0.017
inorganic cation transmembrane transport GO:0098662 202 0.016
positive regulation of locomotion GO:0040017 102 0.016
multicellular organismal signaling GO:0035637 44 0.016
positive regulation of cell death GO:0010942 184 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.016
central nervous system development GO:0007417 311 0.016
negative regulation of humoral immune response GO:0002921 4 0.016
regulation of cellular ketone metabolic process GO:0010565 27 0.016
regulation of inflammatory response GO:0050727 48 0.016
cellular macromolecule localization GO:0070727 122 0.016
regulation of cell migration GO:0030334 128 0.016
response to growth factor GO:0070848 189 0.016
cell adhesion GO:0007155 110 0.016
reproductive system development GO:0061458 128 0.015
defense response to other organism GO:0098542 17 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.015
negative regulation of cellular amide metabolic process GO:0034249 1 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.015
organic substance catabolic process GO:1901575 316 0.015
defense response to gram negative bacterium GO:0050829 3 0.015
response to peptide GO:1901652 292 0.015
regulation of homeostatic process GO:0032844 101 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
cellular protein localization GO:0034613 122 0.015
developmental growth GO:0048589 100 0.015
protein heterooligomerization GO:0051291 89 0.015
neuron projection development GO:0031175 273 0.015
response to amino acid GO:0043200 75 0.015
signal release GO:0023061 145 0.015
regulation of hormone secretion GO:0046883 106 0.014
cellular response to oxidative stress GO:0034599 76 0.014
regulation of nervous system development GO:0051960 264 0.014
vasoconstriction GO:0042310 54 0.014
positive regulation of protein phosphorylation GO:0001934 135 0.014
response to vitamin k GO:0032571 4 0.014
response to vitamin a GO:0033189 36 0.014
negative regulation of catalytic activity GO:0043086 103 0.014
regulation of synaptic plasticity GO:0048167 70 0.014
axis specification GO:0009798 4 0.014
organophosphate metabolic process GO:0019637 370 0.014
cytosolic calcium ion homeostasis GO:0051480 140 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.014
endocytosis GO:0006897 84 0.014
cytolysis GO:0019835 4 0.014
liver morphogenesis GO:0072576 3 0.014
action potential GO:0001508 54 0.014
anion transport GO:0006820 178 0.014
neuron development GO:0048666 286 0.014
single organism biosynthetic process GO:0044711 342 0.014
response to monosaccharide GO:0034284 159 0.014
organic hydroxy compound metabolic process GO:1901615 115 0.014
sex differentiation GO:0007548 113 0.014
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.014
cellular response to lipoteichoic acid GO:0071223 1 0.014
response to acid chemical GO:0001101 222 0.013
negative regulation of apoptotic process GO:0043066 181 0.013
localization of cell GO:0051674 202 0.013
response to chromate GO:0046687 3 0.013
embryonic pattern specification GO:0009880 1 0.013
brain development GO:0007420 247 0.013
positive regulation of hemostasis GO:1900048 4 0.013
cell morphogenesis GO:0000902 142 0.013
regulation of growth GO:0040008 105 0.013
response to hypoxia GO:0001666 231 0.013
regulation of synaptic transmission GO:0050804 141 0.013
positive regulation of cell development GO:0010720 176 0.013
response to peptide hormone GO:0043434 278 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
cell migration GO:0016477 197 0.013
urea metabolic process GO:0019627 5 0.013
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.013
single organism cell adhesion GO:0098602 46 0.013
regulation of endopeptidase activity GO:0052548 51 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
negative regulation of signaling GO:0023057 157 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
regulation of hemostasis GO:1900046 9 0.013
development of primary sexual characteristics GO:0045137 107 0.013
positive regulation of tumor necrosis factor production GO:0032760 8 0.012
positive regulation of cell differentiation GO:0045597 217 0.012
single organism catabolic process GO:0044712 283 0.012
spermatogenesis GO:0007283 99 0.012
regulation of cell differentiation GO:0045595 320 0.012
regulation of ion homeostasis GO:2000021 63 0.012
cellular lipid metabolic process GO:0044255 208 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
positive regulation of protein transport GO:0051222 41 0.012
vascular process in circulatory system GO:0003018 96 0.012
regulation of serine type peptidase activity GO:1902571 1 0.012
response to interleukin 1 GO:0070555 55 0.012
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.012
regulation of vesicle mediated transport GO:0060627 81 0.012
protein secretion GO:0009306 34 0.012
positive regulation of extracellular matrix organization GO:1903055 4 0.012
negative regulation of signal transduction GO:0009968 83 0.012
amine transport GO:0015837 57 0.012
negative regulation of wound healing GO:0061045 8 0.011
cellular component morphogenesis GO:0032989 155 0.011
female gonad development GO:0008585 53 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
inorganic ion transmembrane transport GO:0098660 229 0.011
positive regulation of molecular function GO:0044093 230 0.011
regulation of anatomical structure size GO:0090066 135 0.011
negative regulation of transport GO:0051051 136 0.011
positive regulation of protein modification process GO:0031401 142 0.011
hormone secretion GO:0046879 115 0.011
sequestering of metal ion GO:0051238 9 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
tetrapyrrole metabolic process GO:0033013 11 0.011
regulation of transcription dna templated GO:0006355 374 0.011
response to alkaloid GO:0043279 132 0.011
regulation of plasminogen activation GO:0010755 2 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
positive regulation of humoral immune response GO:0002922 2 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
muscle system process GO:0003012 115 0.011
urogenital system development GO:0001655 78 0.011
positive regulation of response to external stimulus GO:0032103 51 0.011
regulation of neurogenesis GO:0050767 247 0.011
limb morphogenesis GO:0035108 4 0.011
macromolecule catabolic process GO:0009057 58 0.010
regulation of tube size GO:0035150 89 0.010
positive regulation of coagulation GO:0050820 5 0.010
rna localization GO:0006403 4 0.010
regulation of cell morphogenesis GO:0022604 77 0.010
male sex differentiation GO:0046661 64 0.010
positive regulation of ion transport GO:0043270 94 0.010
negative regulation of biosynthetic process GO:0009890 168 0.010
nucleic acid templated transcription GO:0097659 379 0.010
positive regulation of behavior GO:0048520 38 0.010
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.010
cellular response to steroid hormone stimulus GO:0071383 93 0.010
platelet aggregation GO:0070527 4 0.010
carboxylic acid transport GO:0046942 115 0.010
response to fatty acid GO:0070542 65 0.010
regulation of neuronal synaptic plasticity GO:0048168 31 0.010
nucleobase containing small molecule metabolic process GO:0055086 316 0.010

Cfi disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.042
cardiovascular system disease DOID:1287 0 0.042
disease of metabolism DOID:0014667 0 0.033
inherited metabolic disorder DOID:655 0 0.033
vascular disease DOID:178 0 0.030
immune system disease DOID:2914 0 0.019
blood coagulation disease DOID:1247 0 0.019
hematopoietic system disease DOID:74 0 0.019
inherited blood coagulation disease DOID:2214 0 0.017
artery disease DOID:0050828 0 0.012
cerebrovascular disease DOID:6713 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011
nervous system disease DOID:863 0 0.011
musculoskeletal system disease DOID:17 0 0.010