Rattus norvegicus

43 known processes

Cfl1

cofilin 1, non-muscle

Cfl1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
actin filament based process GO:0030029 86 0.524
Yeast Mouse
cellular component biogenesis GO:0044085 368 0.421
cell motility GO:0048870 202 0.405
Mouse
skeletal muscle fiber adaptation GO:0043503 1 0.366
immune response GO:0006955 104 0.286
macromolecular complex assembly GO:0065003 273 0.286
macromolecular complex subunit organization GO:0043933 339 0.285
Yeast Mouse
organic substance catabolic process GO:1901575 316 0.276
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.235
positive regulation of cellular component organization GO:0051130 200 0.211
Mouse
tissue development GO:0009888 252 0.209
Mouse
actin cytoskeleton organization GO:0030036 73 0.208
Yeast Mouse
cellular component assembly GO:0022607 360 0.191
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.190
central nervous system development GO:0007417 311 0.190
protein complex biogenesis GO:0070271 263 0.174
regulation of organelle organization GO:0033043 80 0.167
Mouse
regulation of locomotion GO:0040012 148 0.158
endocytosis GO:0006897 84 0.147
Yeast
protein complex subunit organization GO:0071822 302 0.145
Yeast Mouse
positive regulation of dna metabolic process GO:0051054 39 0.118
anatomical structure morphogenesis GO:0009653 298 0.117
Human Mouse
head development GO:0060322 247 0.109
biological adhesion GO:0022610 110 0.108
chemical homeostasis GO:0048878 292 0.094
regulation of hydrolase activity GO:0051336 143 0.094
macromolecule localization GO:0033036 252 0.093
response to wounding GO:0009611 254 0.093
regulation of cellular component organization GO:0051128 368 0.093
Human Mouse
response to ethanol GO:0045471 162 0.091
purine nucleoside triphosphate metabolic process GO:0009144 141 0.091
response to insulin GO:0032868 133 0.090
histamine secretion by mast cell GO:0002553 3 0.089
purine containing compound metabolic process GO:0072521 253 0.089
heart morphogenesis GO:0003007 3 0.088
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.084
protein complex assembly GO:0006461 263 0.083
negative regulation of nucleic acid templated transcription GO:1903507 117 0.081
dna metabolic process GO:0006259 96 0.081
mast cell mediated immunity GO:0002448 10 0.080
mast cell activation GO:0045576 15 0.076
wound healing GO:0042060 122 0.076
aging GO:0007568 241 0.076
ribose phosphate metabolic process GO:0019693 235 0.076
regulation of actin polymerization or depolymerization GO:0008064 12 0.075
Mouse
response to lithium ion GO:0010226 28 0.071
smad protein complex assembly GO:0007183 1 0.071
guanosine containing compound metabolic process GO:1901068 74 0.070
cardiovascular system development GO:0072358 134 0.066
regulation of dna metabolic process GO:0051052 60 0.066
regulation of rna biosynthetic process GO:2001141 381 0.064
single organism organelle organization GO:1902589 180 0.064
Yeast Mouse
actomyosin structure organization GO:0031032 22 0.063
cellular macromolecule localization GO:0070727 122 0.062
cell projection organization GO:0030030 302 0.059
leukocyte activation GO:0045321 76 0.057
purine nucleoside monophosphate metabolic process GO:0009126 84 0.057
muscle contraction GO:0006936 88 0.057
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.057
carbohydrate catabolic process GO:0016052 40 0.057
protein localization GO:0008104 191 0.057
transmembrane transport GO:0055085 412 0.056
multicellular organismal reproductive process GO:0048609 233 0.055
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.055
cellular cation homeostasis GO:0030003 180 0.055
cellular metal ion homeostasis GO:0006875 172 0.055
cytokinetic process GO:0032506 1 0.054
localization of cell GO:0051674 202 0.054
Mouse
homeostatic process GO:0042592 331 0.053
ribonucleotide catabolic process GO:0009261 136 0.053
secretion GO:0046903 307 0.053
response to glucose GO:0009749 136 0.052
negative regulation of macromolecule metabolic process GO:0010605 260 0.051
neuron projection development GO:0031175 273 0.051
Human
nucleoside monophosphate metabolic process GO:0009123 93 0.050
transcription dna templated GO:0006351 377 0.050
regulation of cell morphogenesis GO:0022604 77 0.049
Human
cytoskeleton dependent cytokinesis GO:0061640 2 0.049
Mouse
organophosphate metabolic process GO:0019637 370 0.048
nucleotide metabolic process GO:0009117 279 0.047
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.047
defense response GO:0006952 194 0.047
purine nucleoside metabolic process GO:0042278 169 0.047
positive regulation of cellular component movement GO:0051272 102 0.046
brain development GO:0007420 247 0.045
actin filament capping GO:0051693 2 0.045
rna metabolic process GO:0016070 406 0.045
cellular protein complex assembly GO:0043623 44 0.045
growth GO:0040007 165 0.045
response to carbohydrate GO:0009743 183 0.044
negative regulation of signaling GO:0023057 157 0.044
cell cycle process GO:0022402 57 0.044
Mouse
regulation of immune system process GO:0002682 123 0.043
response to inorganic substance GO:0010035 377 0.043
calcium ion homeostasis GO:0055074 162 0.043
cell part morphogenesis GO:0032990 123 0.042
Human
regulation of protein complex assembly GO:0043254 33 0.042
cellular component morphogenesis GO:0032989 155 0.042
Human
cellular ion homeostasis GO:0006873 184 0.042
purine nucleoside catabolic process GO:0006152 124 0.041
negative regulation of actin filament polymerization GO:0030837 4 0.041
response to oxidative stress GO:0006979 186 0.041
sequestering of metal ion GO:0051238 9 0.040
cellular modified amino acid metabolic process GO:0006575 61 0.040
negative regulation of gene expression GO:0010629 199 0.040
heart development GO:0007507 72 0.039
cytoskeleton organization GO:0007010 111 0.039
Human Yeast Mouse
positive regulation of cellular component biogenesis GO:0044089 55 0.039
response to cytokine GO:0034097 215 0.039
nitrogen compound transport GO:0071705 229 0.039
rna biosynthetic process GO:0032774 380 0.039
neuron development GO:0048666 286 0.038
Human
negative regulation of metabolic process GO:0009892 331 0.038
nucleoside metabolic process GO:0009116 179 0.038
negative regulation of programmed cell death GO:0043069 183 0.037
intracellular protein transport GO:0006886 79 0.037
positive regulation of transcription dna templated GO:0045893 197 0.037
regulation of nucleic acid templated transcription GO:1903506 380 0.037
actin filament organization GO:0007015 42 0.036
Yeast Mouse
response to peptide hormone GO:0043434 278 0.035
cellular response to oxygen containing compound GO:1901701 386 0.035
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.035
cell projection morphogenesis GO:0048858 123 0.035
Human
cellular response to cytokine stimulus GO:0071345 127 0.035
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.034
carboxylic acid metabolic process GO:0019752 289 0.034
hormone transport GO:0009914 121 0.033
purine containing compound catabolic process GO:0072523 138 0.033
histamine production involved in inflammatory response GO:0002349 3 0.033
cellular chemical homeostasis GO:0055082 247 0.033
single organism catabolic process GO:0044712 283 0.032
regulation of transcription dna templated GO:0006355 374 0.032
anion transport GO:0006820 178 0.032
catabolic process GO:0009056 351 0.032
regulation of anatomical structure size GO:0090066 135 0.032
cell morphogenesis involved in differentiation GO:0000904 119 0.031
Human
regulation of rna metabolic process GO:0051252 391 0.031
cellular homeostasis GO:0019725 252 0.031
glycosyl compound catabolic process GO:1901658 126 0.030
cell chemotaxis GO:0060326 31 0.029
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.029
reproduction GO:0000003 245 0.029
actin nucleation GO:0045010 2 0.029
reproductive process GO:0022414 372 0.029
regulation of nucleoside metabolic process GO:0009118 66 0.029
response to hypoxia GO:0001666 231 0.029
nucleic acid templated transcription GO:0097659 379 0.029
organic anion transport GO:0015711 132 0.029
barbed end actin filament capping GO:0051016 1 0.028
proteolysis GO:0006508 175 0.028
inflammatory response GO:0006954 150 0.028
purine ribonucleoside metabolic process GO:0046128 168 0.028
nucleoside phosphate metabolic process GO:0006753 283 0.028
generation of precursor metabolites and energy GO:0006091 62 0.027
response to extracellular stimulus GO:0009991 380 0.027
positive regulation of leukocyte migration GO:0002687 21 0.027
regulation of cell migration GO:0030334 128 0.027
response to electrical stimulus GO:0051602 56 0.027
response to glucocorticoid GO:0051384 223 0.026
muscle system process GO:0003012 115 0.026
epithelium development GO:0060429 96 0.026
Mouse
axon development GO:0061564 96 0.026
organic acid metabolic process GO:0006082 292 0.026
organelle organization GO:0006996 266 0.026
Human Yeast Mouse
regulation of programmed cell death GO:0043067 341 0.026
embryo development GO:0009790 49 0.025
Mouse
regulation of protein polymerization GO:0032271 19 0.025
regulation of cellular localization GO:0060341 263 0.025
oxidation reduction process GO:0055114 304 0.025
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.025
cellular response to stress GO:0033554 269 0.025
actin filament polymerization GO:0030041 11 0.025
regulation of actin cytoskeleton organization GO:0032956 30 0.025
Mouse
cellular amino acid metabolic process GO:0006520 107 0.024
negative regulation of cell division GO:0051782 1 0.024
regulation of cell differentiation GO:0045595 320 0.024
Human
actin polymerization or depolymerization GO:0008154 14 0.024
Yeast Mouse
peptidyl lysine acetylation GO:0018394 11 0.024
response to peptide GO:1901652 292 0.023
regulation of multicellular organismal development GO:2000026 376 0.023
Human
ion transmembrane transport GO:0034220 365 0.023
muscle structure development GO:0061061 87 0.023
small gtpase mediated signal transduction GO:0007264 36 0.023
regulation of phosphorus metabolic process GO:0051174 349 0.023
regulation of anatomical structure morphogenesis GO:0022603 141 0.023
Human
positive regulation of cellular biosynthetic process GO:0031328 295 0.022
synaptic growth at neuromuscular junction GO:0051124 1 0.022
aromatic compound catabolic process GO:0019439 168 0.022
calcium ion transport GO:0006816 131 0.022
cellular macromolecular complex assembly GO:0034622 58 0.022
cell activation GO:0001775 97 0.022
protein acetylation GO:0006473 11 0.022
striated muscle tissue development GO:0014706 58 0.022
regulation of molecular function GO:0065009 398 0.021
cellular response to electrical stimulus GO:0071257 8 0.021
nucleobase containing small molecule metabolic process GO:0055086 316 0.021
actin filament bundle organization GO:0061572 19 0.021
neuron projection morphogenesis GO:0048812 122 0.021
Human
cell adhesion GO:0007155 110 0.021
immune system process GO:0002376 204 0.021
regulation of cell development GO:0060284 263 0.021
Human
divalent metal ion transport GO:0070838 132 0.020
male gamete generation GO:0048232 99 0.020
positive regulation of developmental process GO:0051094 283 0.020
regulation of cytoskeleton organization GO:0051493 49 0.020
Mouse
regulation of cell motility GO:2000145 131 0.020
response to oxygen levels GO:0070482 265 0.020
organonitrogen compound catabolic process GO:1901565 179 0.020
nucleobase containing compound catabolic process GO:0034655 152 0.020
regulation of leukocyte migration GO:0002685 24 0.020
regulation of actin filament depolymerization GO:0030834 2 0.020
Mouse
negative regulation of cell communication GO:0010648 158 0.019
circulatory system development GO:0072359 134 0.019
negative regulation of cellular protein metabolic process GO:0032269 106 0.019
cation homeostasis GO:0055080 195 0.019
nucleotide catabolic process GO:0009166 139 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
multicellular organism reproduction GO:0032504 233 0.019
regulation of meiotic cell cycle GO:0051445 3 0.019
cellular nitrogen compound catabolic process GO:0044270 163 0.019
leukocyte degranulation GO:0043299 12 0.018
regulation of actin filament based process GO:0032970 42 0.018
Mouse
positive regulation of rna biosynthetic process GO:1902680 197 0.018
actin filament depolymerization GO:0030042 3 0.018
Yeast Mouse
protein transport GO:0015031 132 0.018
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.018
angiogenesis GO:0001525 53 0.018
ion homeostasis GO:0050801 212 0.018
blood circulation GO:0008015 183 0.018
purine ribonucleotide catabolic process GO:0009154 136 0.018
single organism cell adhesion GO:0098602 46 0.018
spermatogenesis GO:0007283 99 0.018
regulation of peptide hormone secretion GO:0090276 80 0.017
positive regulation of gene expression GO:0010628 244 0.017
cellular protein localization GO:0034613 122 0.017
nucleoside triphosphate catabolic process GO:0009143 123 0.017
metal ion homeostasis GO:0055065 186 0.017
cell migration GO:0016477 197 0.017
Mouse
heart contraction GO:0060047 57 0.017
single organism reproductive process GO:0044702 297 0.017
regulation of purine nucleotide metabolic process GO:1900542 115 0.017
hexose transport GO:0008645 29 0.017
organic cyclic compound catabolic process GO:1901361 175 0.017
cellular response to insulin stimulus GO:0032869 81 0.017
regulation of peptide secretion GO:0002791 82 0.017
ras protein signal transduction GO:0007265 29 0.017
positive regulation of biosynthetic process GO:0009891 319 0.017
purine nucleoside triphosphate catabolic process GO:0009146 122 0.017
response to other organism GO:0051707 220 0.017
Human
cellular response to interleukin 1 GO:0071347 37 0.017
response to mechanical stimulus GO:0009612 134 0.017
sequestering of calcium ion GO:0051208 8 0.017
nucleotide biosynthetic process GO:0009165 98 0.017
positive regulation of endocytosis GO:0045807 28 0.016
protein polymerization GO:0051258 22 0.016
gtp catabolic process GO:0006184 71 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
regulation of insulin secretion GO:0050796 65 0.016
production of molecular mediator involved in inflammatory response GO:0002532 5 0.016
secretion by cell GO:0032940 248 0.016
cell substrate adhesion GO:0031589 29 0.016
cellular response to endogenous stimulus GO:0071495 377 0.016
dna recombination GO:0006310 3 0.016
oxoacid metabolic process GO:0043436 290 0.016
muscle organ morphogenesis GO:0048644 1 0.016
neuron death GO:0070997 127 0.016
cardiac muscle contraction GO:0060048 27 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
hexose metabolic process GO:0019318 58 0.016
inorganic ion transmembrane transport GO:0098660 229 0.016
cellular response to hormone stimulus GO:0032870 247 0.016
regulation of cellular component biogenesis GO:0044087 86 0.015
regulation of body fluid levels GO:0050878 90 0.015
gastrulation GO:0007369 2 0.015
multi organism reproductive process GO:0044703 262 0.015
single organism cellular localization GO:1902580 102 0.015
histamine secretion involved in inflammatory response GO:0002441 3 0.015
divalent inorganic cation homeostasis GO:0072507 165 0.015
organonitrogen compound biosynthetic process GO:1901566 167 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
regulation of behavior GO:0050795 61 0.015
cellular divalent inorganic cation homeostasis GO:0072503 162 0.015
amine metabolic process GO:0009308 38 0.015
striated muscle cell differentiation GO:0051146 39 0.015
negative regulation of transport GO:0051051 136 0.015
muscle tissue development GO:0060537 58 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.015
internal peptidyl lysine acetylation GO:0018393 9 0.015
positive regulation of phosphate metabolic process GO:0045937 262 0.015
cardiac muscle tissue development GO:0048738 26 0.015
positive regulation of transport GO:0051050 245 0.015
regulation of hormone secretion GO:0046883 106 0.015
multicellular organismal homeostasis GO:0048871 49 0.015
regulation of catalytic activity GO:0050790 304 0.015
regulation of protein heterodimerization activity GO:0043497 1 0.015
cellular catabolic process GO:0044248 295 0.015
carbohydrate derivative catabolic process GO:1901136 147 0.015
regulation of phosphate metabolic process GO:0019220 349 0.015
jump response GO:0007630 1 0.015
cellular response to nitrogen compound GO:1901699 210 0.015
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.014
arp2 3 complex mediated actin nucleation GO:0034314 2 0.014
carbohydrate derivative metabolic process GO:1901135 346 0.014
cytokinesis GO:0000910 5 0.014
Mouse
negative regulation of arp2 3 complex mediated actin nucleation GO:0034316 1 0.014
regulation of cellular protein metabolic process GO:0032268 267 0.014
cellular amine metabolic process GO:0044106 38 0.014
response to hexose GO:0009746 144 0.014
regulation of hormone levels GO:0010817 187 0.014
oligodendrocyte differentiation GO:0048709 32 0.014
regulation of ion homeostasis GO:2000021 63 0.014
response to calcium ion GO:0051592 59 0.014
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 1 0.014
gland development GO:0048732 155 0.014
purine nucleoside monophosphate catabolic process GO:0009128 55 0.014
neuron differentiation GO:0030182 368 0.014
Human
striated muscle contraction GO:0006941 44 0.014
response to corticosteroid GO:0031960 235 0.014
cation transport GO:0006812 382 0.014
sexual reproduction GO:0019953 148 0.014
carbohydrate biosynthetic process GO:0016051 42 0.013
nucleoside triphosphate metabolic process GO:0009141 144 0.013
organelle localization GO:0051640 55 0.013
negative regulation of homeostatic process GO:0032845 47 0.013
epithelial cell differentiation GO:0030855 71 0.013
transcription from rna polymerase ii promoter GO:0006366 252 0.013
regulation of cellular component movement GO:0051270 150 0.013
single organism carbohydrate catabolic process GO:0044724 40 0.013
divalent inorganic cation transport GO:0072511 134 0.013
protein localization to organelle GO:0033365 57 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
taxis GO:0042330 67 0.013
cytoplasmic transport GO:0016482 115 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
regulation of ion transport GO:0043269 245 0.013
regulation of nitric oxide synthase activity GO:0050999 8 0.013
heart process GO:0003015 57 0.013
rna localization GO:0006403 4 0.013
positive regulation of organelle organization GO:0010638 48 0.013
Mouse
anatomical structure formation involved in morphogenesis GO:0048646 83 0.013
Mouse
negative regulation of response to stimulus GO:0048585 155 0.013
platelet aggregation GO:0070527 4 0.013
cell morphogenesis GO:0000902 142 0.013
Human
cell aging GO:0007569 14 0.013
regulation of homeostatic process GO:0032844 101 0.013
ribonucleoside monophosphate metabolic process GO:0009161 88 0.013
negative regulation of cell death GO:0060548 229 0.013
organophosphate catabolic process GO:0046434 148 0.013
regulation of ion transmembrane transporter activity GO:0032412 48 0.013
response to decreased oxygen levels GO:0036293 237 0.012
regulation of sequestering of calcium ion GO:0051282 26 0.012
regulation of nucleotide catabolic process GO:0030811 65 0.012
purine ribonucleotide metabolic process GO:0009150 227 0.012
renal system process GO:0003014 40 0.012
negative regulation of signal transduction GO:0009968 83 0.012
viral gene expression GO:0019080 2 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
axonogenesis GO:0007409 71 0.012
camera type eye development GO:0043010 48 0.012
cardiocyte differentiation GO:0035051 22 0.012
atp metabolic process GO:0046034 72 0.012
cellular component assembly involved in morphogenesis GO:0010927 17 0.012
myeloid cell differentiation GO:0030099 22 0.012
regulation of cellular catabolic process GO:0031329 101 0.012
regulation of secretion by cell GO:1903530 208 0.012
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.012
calcium ion transport into cytosol GO:0060402 38 0.012
response to interleukin 1 GO:0070555 55 0.012
regulation of embryonic development GO:0045995 2 0.012
muscle cell differentiation GO:0042692 52 0.011
positive regulation of rna metabolic process GO:0051254 203 0.011
positive regulation of immune system process GO:0002684 90 0.011
positive regulation of response to stimulus GO:0048584 285 0.011
behavioral response to ethanol GO:0048149 1 0.011
behavior GO:0007610 205 0.011
heterocycle catabolic process GO:0046700 167 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
striated muscle cell development GO:0055002 26 0.011
regulation of actin nucleation GO:0051125 2 0.011
eye development GO:0001654 50 0.011
response to caffeine GO:0031000 18 0.011
circulatory system process GO:0003013 183 0.011
viral transcription GO:0019083 2 0.011
nicotinamide nucleotide biosynthetic process GO:0019359 2 0.011
regulation of actin filament length GO:0030832 12 0.011
Mouse
negative regulation of apoptotic process GO:0043066 181 0.011
fertilization GO:0009566 3 0.011
adult locomotory behavior GO:0008344 4 0.011
carbohydrate metabolic process GO:0005975 130 0.011
stress fiber assembly GO:0043149 13 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
actin filament bundle assembly GO:0051017 19 0.011
muscle tissue morphogenesis GO:0060415 1 0.011
polysaccharide metabolic process GO:0005976 25 0.010
muscle organ development GO:0007517 50 0.010
programmed cell death GO:0012501 392 0.010
cellular component movement GO:0006928 248 0.010
Mouse
positive regulation of chemotaxis GO:0050921 23 0.010
organic acid biosynthetic process GO:0016053 83 0.010
cell growth GO:0016049 104 0.010
positive regulation of cellular amine metabolic process GO:0033240 3 0.010
response to metal ion GO:0010038 253 0.010
regulation of metal ion transport GO:0010959 118 0.010
cellular ketone metabolic process GO:0042180 51 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.010
Human
myeloid leukocyte activation GO:0002274 36 0.010
nucleic acid transport GO:0050657 3 0.010
negative regulation of catalytic activity GO:0043086 103 0.010
single fertilization GO:0007338 3 0.010
negative regulation of hydrolase activity GO:0051346 52 0.010

Cfl1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.192
disease of anatomical entity DOID:7 0 0.192
sensory system disease DOID:0050155 0 0.167
organ system cancer DOID:0050686 0 0.026
disease of cellular proliferation DOID:14566 0 0.026
cancer DOID:162 0 0.026
autosomal dominant nonsyndromic deafness DOID:0050564 0 0.012
nonsyndromic deafness DOID:0050563 0 0.012
auditory system disease DOID:2742 0 0.012