Rattus norvegicus

113 known processes

Chek1

CHK1 checkpoint homolog (S. pombe)

Chek1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to stress GO:0033554 269 0.084
cell cycle GO:0007049 101 0.049
cell projection organization GO:0030030 302 0.048
double strand break repair GO:0006302 1 0.045
Human
macromolecular complex subunit organization GO:0043933 339 0.043
Human Mouse
regulation of protein metabolic process GO:0051246 289 0.043
Mouse
tetrahydrofolate metabolic process GO:0046653 9 0.042
nucleic acid templated transcription GO:0097659 379 0.042
Mouse
response to oxygen levels GO:0070482 265 0.041
cellular component biogenesis GO:0044085 368 0.041
programmed cell death GO:0012501 392 0.039
Zebrafish
negative regulation of metabolic process GO:0009892 331 0.039
macromolecule localization GO:0033036 252 0.038
cellular response to oxygen containing compound GO:1901701 386 0.036
single organism biosynthetic process GO:0044711 342 0.036
apoptotic process GO:0006915 381 0.036
Zebrafish
single organism reproductive process GO:0044702 297 0.035
anatomical structure morphogenesis GO:0009653 298 0.034
cellular component assembly GO:0022607 360 0.034
multicellular organismal reproductive process GO:0048609 233 0.033
multi organism reproductive process GO:0044703 262 0.033
rna metabolic process GO:0016070 406 0.032
Mouse
cell cycle checkpoint GO:0000075 2 0.032
Human Zebrafish Mouse
protein phosphorylation GO:0006468 345 0.031
oxoacid metabolic process GO:0043436 290 0.030
chromosome segregation GO:0007059 2 0.030
cell cycle process GO:0022402 57 0.030
response to inorganic substance GO:0010035 377 0.030
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
neuron differentiation GO:0030182 368 0.030
intracellular signal transduction GO:0035556 314 0.030
Zebrafish
cellular amino acid metabolic process GO:0006520 107 0.029
multicellular organism reproduction GO:0032504 233 0.029
rna biosynthetic process GO:0032774 380 0.029
Mouse
regulation of cellular component organization GO:0051128 368 0.029
Human Mouse
protein complex subunit organization GO:0071822 302 0.029
organelle organization GO:0006996 266 0.028
Human Mouse
response to decreased oxygen levels GO:0036293 237 0.028
response to metal ion GO:0010038 253 0.028
rhythmic process GO:0048511 156 0.028
regulation of transcription dna templated GO:0006355 374 0.027
Mouse
reproductive process GO:0022414 372 0.027
regulation of programmed cell death GO:0043067 341 0.026
response to hypoxia GO:0001666 231 0.026
transcription from rna polymerase ii promoter GO:0006366 252 0.026
Mouse
negative regulation of gene expression GO:0010629 199 0.025
reproduction GO:0000003 245 0.025
regulation of rna metabolic process GO:0051252 391 0.025
Mouse
response to estradiol GO:0032355 164 0.025
head development GO:0060322 247 0.025
regulation of cellular protein metabolic process GO:0032268 267 0.024
Mouse
developmental process involved in reproduction GO:0003006 159 0.024
negative regulation of cellular metabolic process GO:0031324 281 0.024
macromolecular complex assembly GO:0065003 273 0.024
tissue development GO:0009888 252 0.023
regulation of rna biosynthetic process GO:2001141 381 0.023
Mouse
secretion GO:0046903 307 0.023
central nervous system development GO:0007417 311 0.023
locomotion GO:0040011 237 0.023
regulation of cell cycle GO:0051726 73 0.023
cellular amine metabolic process GO:0044106 38 0.023
positive regulation of cell proliferation GO:0008284 249 0.022
homeostatic process GO:0042592 331 0.022
regulation of phosphorylation GO:0042325 248 0.022
regulation of nucleic acid templated transcription GO:1903506 380 0.022
Mouse
aging GO:0007568 241 0.022
neuron development GO:0048666 286 0.021
regulation of phosphorus metabolic process GO:0051174 349 0.021
response to peptide hormone GO:0043434 278 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.021
Mouse
response to estrogen GO:0043627 232 0.020
dna integrity checkpoint GO:0031570 2 0.020
Human Zebrafish Mouse
peptidyl amino acid modification GO:0018193 126 0.020
Human Mouse
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
regulation of cell proliferation GO:0042127 359 0.020
Mouse
folic acid containing compound metabolic process GO:0006760 10 0.020
amine metabolic process GO:0009308 38 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.020
Mouse
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
Mouse
protein complex biogenesis GO:0070271 263 0.019
response to transition metal nanoparticle GO:1990267 122 0.019
carboxylic acid metabolic process GO:0019752 289 0.019
regulation of molecular function GO:0065009 398 0.019
regulation of mrna splicing via spliceosome GO:0048024 3 0.019
positive regulation of response to stimulus GO:0048584 285 0.019
regulation of cell differentiation GO:0045595 320 0.019
positive regulation of protein metabolic process GO:0051247 178 0.018
response to corticosteroid GO:0031960 235 0.018
proteolysis GO:0006508 175 0.018
regulation of apoptotic process GO:0042981 335 0.018
cellular catabolic process GO:0044248 295 0.018
centrosome organization GO:0051297 1 0.018
Human
cellular response to organonitrogen compound GO:0071417 197 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
brain development GO:0007420 247 0.017
reproductive system development GO:0061458 128 0.017
transcription dna templated GO:0006351 377 0.017
Mouse
negative regulation of apoptotic process GO:0043066 181 0.017
positive regulation of gene expression GO:0010628 244 0.017
Mouse
organic substance catabolic process GO:1901575 316 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.017
single organism organelle organization GO:1902589 180 0.017
Human Mouse
regulation of cellular ketone metabolic process GO:0010565 27 0.017
cellular component movement GO:0006928 248 0.016
cellular response to endogenous stimulus GO:0071495 377 0.016
chemical homeostasis GO:0048878 292 0.016
response to nutrient levels GO:0031667 370 0.016
positive regulation of multicellular organismal process GO:0051240 387 0.016
response to carbohydrate GO:0009743 183 0.016
metaphase anaphase transition of cell cycle GO:0044784 1 0.016
negative regulation of programmed cell death GO:0043069 183 0.016
response to growth factor GO:0070848 189 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
response to ketone GO:1901654 182 0.016
centrosome cycle GO:0007098 1 0.016
Human
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
protein complex assembly GO:0006461 263 0.015
negative regulation of cell death GO:0060548 229 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
Mouse
regulation of phosphate metabolic process GO:0019220 349 0.015
cell cell signaling GO:0007267 335 0.015
response to radiation GO:0009314 137 0.015
Mouse
response to acid chemical GO:0001101 222 0.015
pteridine containing compound metabolic process GO:0042558 14 0.015
organic acid metabolic process GO:0006082 292 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
regulation of nervous system development GO:0051960 264 0.015
development of primary sexual characteristics GO:0045137 107 0.015
cellular ketone metabolic process GO:0042180 51 0.015
alpha amino acid biosynthetic process GO:1901607 23 0.015
dna metabolic process GO:0006259 96 0.015
catabolic process GO:0009056 351 0.015
positive regulation of phosphate metabolic process GO:0045937 262 0.015
response to peptide GO:1901652 292 0.015
reproductive structure development GO:0048608 128 0.015
alpha amino acid metabolic process GO:1901605 71 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.015
Mouse
regulation of catalytic activity GO:0050790 304 0.014
regulation of neurogenesis GO:0050767 247 0.014
nucleobase containing small molecule metabolic process GO:0055086 316 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
neuron projection development GO:0031175 273 0.014
sex differentiation GO:0007548 113 0.014
regulation of cell development GO:0060284 263 0.014
rna localization GO:0006403 4 0.014
protein localization GO:0008104 191 0.014
mitotic sister chromatid separation GO:0051306 1 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.014
response to extracellular stimulus GO:0009991 380 0.014
regulation of proteasomal protein catabolic process GO:0061136 4 0.014
regulation of anatomical structure morphogenesis GO:0022603 141 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
response to alkaloid GO:0043279 132 0.014
axis specification GO:0009798 4 0.013
nitrogen compound transport GO:0071705 229 0.013
eye morphogenesis GO:0048592 4 0.013
regulation of cellular localization GO:0060341 263 0.013
response to glucocorticoid GO:0051384 223 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
cellular response to lipid GO:0071396 201 0.013
secretion by cell GO:0032940 248 0.013
positive regulation of developmental process GO:0051094 283 0.013
negative regulation of phosphorus metabolic process GO:0010563 80 0.013
response to nutrient GO:0007584 248 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
regulation of signal transduction GO:0009966 318 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
gonad development GO:0008406 104 0.013
defense response GO:0006952 194 0.013
protein oligomerization GO:0051259 191 0.012
cellular chemical homeostasis GO:0055082 247 0.012
negative regulation of biosynthetic process GO:0009890 168 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
negative regulation of cell communication GO:0010648 158 0.012
cellular modified amino acid biosynthetic process GO:0042398 18 0.012
response to purine containing compound GO:0014074 126 0.012
positive regulation of rna biosynthetic process GO:1902680 197 0.012
Mouse
regulation of sister chromatid segregation GO:0033045 1 0.012
sexual reproduction GO:0019953 148 0.012
cytoplasmic transport GO:0016482 115 0.012
positive regulation of molecular function GO:0044093 230 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
gamete generation GO:0007276 124 0.012
maintenance of location GO:0051235 17 0.012
microtubule organizing center organization GO:0031023 1 0.012
Human
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
regulation of response to stress GO:0080134 126 0.012
Human
response to lipopolysaccharide GO:0032496 191 0.012
positive regulation of phosphorus metabolic process GO:0010562 262 0.012
spermatogenesis GO:0007283 99 0.012
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.012
cellular cation homeostasis GO:0030003 180 0.012
purine containing compound metabolic process GO:0072521 253 0.012
response to oxidative stress GO:0006979 186 0.012
response to molecule of bacterial origin GO:0002237 194 0.011
intracellular transport GO:0046907 185 0.011
response to toxic substance GO:0009636 133 0.011
nucleotide metabolic process GO:0009117 279 0.011
cellular homeostasis GO:0019725 252 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
ovulation cycle GO:0042698 67 0.011
transmembrane transport GO:0055085 412 0.011
response to ethanol GO:0045471 162 0.011
regulation of organelle organization GO:0033043 80 0.011
Human Mouse
regulation of cell projection organization GO:0031344 175 0.011
dna recombination GO:0006310 3 0.011
Human
purine ribonucleotide metabolic process GO:0009150 227 0.011
embryo development GO:0009790 49 0.011
positive regulation of phosphorylation GO:0042327 177 0.011
positive regulation of nucleic acid templated transcription GO:1903508 197 0.011
Mouse
mitotic cell cycle checkpoint GO:0007093 1 0.011
Zebrafish
positive regulation of cellular component organization GO:0051130 200 0.011
chromatin modification GO:0016568 33 0.011
Human Mouse
positive regulation of cell differentiation GO:0045597 217 0.011
mitotic cell cycle phase transition GO:0044772 20 0.011
negative regulation of signaling GO:0023057 157 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
Human
positive regulation of transcription dna templated GO:0045893 197 0.011
Mouse
cofactor metabolic process GO:0051186 95 0.010
sister chromatid segregation GO:0000819 1 0.010
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.010
Mouse
negative regulation of nucleic acid templated transcription GO:1903507 117 0.010
tube development GO:0035295 89 0.010
behavior GO:0007610 205 0.010
positive regulation of biosynthetic process GO:0009891 319 0.010
Mouse
synaptic transmission GO:0007268 235 0.010
regulation of protein modification process GO:0031399 194 0.010
Mouse
male gamete generation GO:0048232 99 0.010
ion homeostasis GO:0050801 212 0.010
anterior posterior pattern specification GO:0009952 1 0.010

Chek1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.017
cancer DOID:162 0 0.017
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012
organ system cancer DOID:0050686 0 0.011