Rattus norvegicus

11 known processes

Col18a1

collagen, type XVIII, alpha 1

Col18a1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to endogenous stimulus GO:0071495 377 0.177
cell projection organization GO:0030030 302 0.144
tissue development GO:0009888 252 0.098
response to glucocorticoid GO:0051384 223 0.097
response to acid chemical GO:0001101 222 0.088
cellular response to hormone stimulus GO:0032870 247 0.085
regulation of cellular protein metabolic process GO:0032268 267 0.077
response to growth factor GO:0070848 189 0.073
epithelium development GO:0060429 96 0.070
defense response GO:0006952 194 0.070
response to wounding GO:0009611 254 0.069
positive regulation of phosphorus metabolic process GO:0010562 262 0.067
response to metal ion GO:0010038 253 0.066
negative regulation of metabolic process GO:0009892 331 0.064
response to inorganic substance GO:0010035 377 0.059
regulation of catalytic activity GO:0050790 304 0.057
neuron development GO:0048666 286 0.055
cellular response to oxygen containing compound GO:1901701 386 0.054
carboxylic acid metabolic process GO:0019752 289 0.052
positive regulation of developmental process GO:0051094 283 0.050
response to glucose GO:0009749 136 0.049
cell morphogenesis involved in differentiation GO:0000904 119 0.049
regulation of multicellular organismal development GO:2000026 376 0.048
response to mechanical stimulus GO:0009612 134 0.047
regulation of fibrinolysis GO:0051917 2 0.046
cation transmembrane transport GO:0098655 263 0.046
brain development GO:0007420 247 0.046
regulation of protein metabolic process GO:0051246 289 0.045
positive regulation of protein metabolic process GO:0051247 178 0.045
formation of primary germ layer GO:0001704 1 0.044
neuron projection development GO:0031175 273 0.044
response to nutrient levels GO:0031667 370 0.043
regulation of phosphorus metabolic process GO:0051174 349 0.043
fibrinolysis GO:0042730 2 0.043
cellular response to lipid GO:0071396 201 0.042
positive regulation of cell differentiation GO:0045597 217 0.041
regulation of phosphorylation GO:0042325 248 0.041
hormone metabolic process GO:0042445 69 0.039
positive regulation of cell projection organization GO:0031346 111 0.039
positive regulation of signal transduction GO:0009967 175 0.039
cation transport GO:0006812 382 0.038
regulation of molecular function GO:0065009 398 0.038
homeostatic process GO:0042592 331 0.038
response to monosaccharide GO:0034284 159 0.038
cell part morphogenesis GO:0032990 123 0.037
mesoderm development GO:0007498 2 0.037
response to corticosteroid GO:0031960 235 0.037
carbohydrate homeostasis GO:0033500 75 0.037
regulation of signal transduction GO:0009966 318 0.037
response to cytokine GO:0034097 215 0.037
cellular response to cytokine stimulus GO:0071345 127 0.037
gland development GO:0048732 155 0.036
cellular homeostasis GO:0019725 252 0.036
skeletal system development GO:0001501 41 0.036
sensory organ development GO:0007423 74 0.036
oxoacid metabolic process GO:0043436 290 0.035
single organism biosynthetic process GO:0044711 342 0.035
amine metabolic process GO:0009308 38 0.034
regulation of anatomical structure morphogenesis GO:0022603 141 0.034
inflammatory response GO:0006954 150 0.034
response to extracellular stimulus GO:0009991 380 0.034
response to oxygen levels GO:0070482 265 0.034
anatomical structure morphogenesis GO:0009653 298 0.033
secretion GO:0046903 307 0.033
regulation of protein modification process GO:0031399 194 0.033
ion transmembrane transport GO:0034220 365 0.032
response to peptide GO:1901652 292 0.032
positive regulation of phosphorylation GO:0042327 177 0.031
negative regulation of macromolecule metabolic process GO:0010605 260 0.031
regulation of secretion by cell GO:1903530 208 0.031
cellular amino acid metabolic process GO:0006520 107 0.031
negative regulation of cellular metabolic process GO:0031324 281 0.031
apoptotic process GO:0006915 381 0.031
cellular response to organonitrogen compound GO:0071417 197 0.030
regulation of neuron differentiation GO:0045664 208 0.029
intracellular signal transduction GO:0035556 314 0.029
cellular response to nitrogen compound GO:1901699 210 0.029
neuron differentiation GO:0030182 368 0.029
cellular amine metabolic process GO:0044106 38 0.029
muscle organ development GO:0007517 50 0.029
regulation of cellular amine metabolic process GO:0033238 8 0.028
response to hexose GO:0009746 144 0.027
response to decreased oxygen levels GO:0036293 237 0.027
head development GO:0060322 247 0.027
regulation of protein phosphorylation GO:0001932 183 0.027
cellular response to steroid hormone stimulus GO:0071383 93 0.027
peptidyl amino acid modification GO:0018193 126 0.026
regulation of cellular component organization GO:0051128 368 0.026
cellular ketone metabolic process GO:0042180 51 0.026
response to hypoxia GO:0001666 231 0.026
positive regulation of phosphate metabolic process GO:0045937 262 0.026
dephosphorylation GO:0016311 98 0.025
regulation of apoptotic process GO:0042981 335 0.025
epithelial cell differentiation GO:0030855 71 0.025
response to carbohydrate GO:0009743 183 0.025
nucleobase containing small molecule metabolic process GO:0055086 316 0.025
establishment of tissue polarity GO:0007164 2 0.025
nucleoside phosphate metabolic process GO:0006753 283 0.024
positive regulation of blood coagulation GO:0030194 4 0.024
macromolecule localization GO:0033036 252 0.024
protein phosphorylation GO:0006468 345 0.024
negative regulation of multicellular organismal process GO:0051241 203 0.024
signal transduction by phosphorylation GO:0023014 144 0.024
cellular chemical homeostasis GO:0055082 247 0.023
reproductive process GO:0022414 372 0.023
organonitrogen compound catabolic process GO:1901565 179 0.023
positive regulation of molecular function GO:0044093 230 0.023
positive regulation of protein phosphorylation GO:0001934 135 0.023
muscle tissue development GO:0060537 58 0.023
regulation of hormone levels GO:0010817 187 0.023
positive regulation of cellular amine metabolic process GO:0033240 3 0.023
regulation of hydrolase activity GO:0051336 143 0.023
positive regulation of nervous system development GO:0051962 178 0.023
positive regulation of immunoglobulin production GO:0002639 4 0.022
response to interleukin 1 GO:0070555 55 0.022
regulation of cell proliferation GO:0042127 359 0.022
multicellular organismal reproductive process GO:0048609 233 0.022
cellular response to organic cyclic compound GO:0071407 202 0.022
central nervous system development GO:0007417 311 0.022
cellular component biogenesis GO:0044085 368 0.022
positive regulation of biosynthetic process GO:0009891 319 0.022
positive regulation of neurogenesis GO:0050769 165 0.021
regulation of cellular ketone metabolic process GO:0010565 27 0.021
positive regulation of bone mineralization GO:0030501 4 0.021
motor neuron axon guidance GO:0008045 1 0.021
cellular component assembly GO:0022607 360 0.021
protein complex assembly GO:0006461 263 0.021
anterior posterior pattern specification GO:0009952 1 0.021
cellular response to growth factor stimulus GO:0071363 162 0.021
eye morphogenesis GO:0048592 4 0.021
cellular response to stress GO:0033554 269 0.021
negative regulation of cell death GO:0060548 229 0.020
regulation of epithelial to mesenchymal transition GO:0010717 2 0.020
cellular amide metabolic process GO:0043603 44 0.020
organic substance catabolic process GO:1901575 316 0.020
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.020
positive regulation of cell development GO:0010720 176 0.020
proteolysis GO:0006508 175 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
cell projection morphogenesis GO:0048858 123 0.020
regulation of cell development GO:0060284 263 0.020
appendage morphogenesis GO:0035107 4 0.019
positive regulation of protein modification process GO:0031401 142 0.019
liver development GO:0001889 90 0.019
protein maturation GO:0051604 68 0.019
positive regulation of cellular component organization GO:0051130 200 0.019
cellular response to abiotic stimulus GO:0071214 85 0.019
regulation of cell projection organization GO:0031344 175 0.019
secretion by cell GO:0032940 248 0.019
regulation of secretion GO:0051046 224 0.019
anion transport GO:0006820 178 0.018
organonitrogen compound biosynthetic process GO:1901566 167 0.018
transcription dna templated GO:0006351 377 0.018
nucleotide metabolic process GO:0009117 279 0.018
negative regulation of catalytic activity GO:0043086 103 0.018
blood vessel morphogenesis GO:0048514 58 0.018
organic acid metabolic process GO:0006082 292 0.018
negative regulation of cell communication GO:0010648 158 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
limb morphogenesis GO:0035108 4 0.018
male sex differentiation GO:0046661 64 0.018
response to peptide hormone GO:0043434 278 0.018
renal system development GO:0072001 67 0.017
positive regulation of neuron projection development GO:0010976 99 0.017
response to nutrient GO:0007584 248 0.017
regulation of cell differentiation GO:0045595 320 0.017
enzyme linked receptor protein signaling pathway GO:0007167 116 0.017
cell motility GO:0048870 202 0.017
response to cobalt ion GO:0032025 12 0.017
ribonucleotide metabolic process GO:0009259 231 0.017
transcription from rna polymerase ii promoter GO:0006366 252 0.017
protein localization GO:0008104 191 0.017
embryonic skeletal system development GO:0048706 3 0.017
negative regulation of gene expression GO:0010629 199 0.017
growth GO:0040007 165 0.017
negative regulation of cellular biosynthetic process GO:0031327 161 0.017
cellular response to external stimulus GO:0071496 118 0.016
multicellular organism reproduction GO:0032504 233 0.016
bone development GO:0060348 25 0.016
response to fatty acid GO:0070542 65 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.016
ribose phosphate metabolic process GO:0019693 235 0.016
embryonic cranial skeleton morphogenesis GO:0048701 2 0.016
chemical homeostasis GO:0048878 292 0.016
response to estradiol GO:0032355 164 0.016
cellular response to metal ion GO:0071248 55 0.016
leukocyte activation GO:0045321 76 0.016
organ regeneration GO:0031100 101 0.016
regulation of programmed cell death GO:0043067 341 0.016
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.016
purine containing compound biosynthetic process GO:0072522 85 0.015
positive regulation of response to stimulus GO:0048584 285 0.015
skeletal muscle tissue development GO:0007519 31 0.015
negative regulation of developmental process GO:0051093 125 0.015
embryonic appendage morphogenesis GO:0035113 4 0.015
protein complex biogenesis GO:0070271 263 0.015
programmed cell death GO:0012501 392 0.015
regulation of cytokine production GO:0001817 56 0.015
protein oligomerization GO:0051259 191 0.015
cellular response to inorganic substance GO:0071241 65 0.015
positive regulation of cellular protein metabolic process GO:0032270 167 0.015
regulation of nervous system development GO:0051960 264 0.015
reproduction GO:0000003 245 0.015
regulation of rna metabolic process GO:0051252 391 0.015
cellular response to alcohol GO:0097306 87 0.015
urogenital system development GO:0001655 78 0.015
cell morphogenesis GO:0000902 142 0.014
rna metabolic process GO:0016070 406 0.014
renal system process GO:0003014 40 0.014
cell matrix adhesion GO:0007160 19 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
multicellular organism growth GO:0035264 1 0.014
negative regulation of molecular function GO:0044092 133 0.014
gastrulation GO:0007369 2 0.014
regulation of developmental growth GO:0048638 45 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
neuron death GO:0070997 127 0.013
divalent metal ion transport GO:0070838 132 0.013
positive regulation of cell proliferation GO:0008284 249 0.013
wound healing GO:0042060 122 0.013
positive regulation of cell death GO:0010942 184 0.013
camera type eye morphogenesis GO:0048593 2 0.013
muscle structure development GO:0061061 87 0.013
regulation of protein kinase activity GO:0045859 105 0.013
embryonic pattern specification GO:0009880 1 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 10 0.013
organ morphogenesis GO:0009887 75 0.013
cell adhesion GO:0007155 110 0.013
regulation of neuron death GO:1901214 115 0.013
cellular response to hexose stimulus GO:0071331 65 0.013
ion homeostasis GO:0050801 212 0.012
cellular response to peptide hormone stimulus GO:0071375 120 0.012
cellular catabolic process GO:0044248 295 0.012
regulation of protein processing GO:0070613 50 0.012
response to molecule of bacterial origin GO:0002237 194 0.012
vascular process in circulatory system GO:0003018 96 0.012
regulation of neuron projection development GO:0010975 161 0.012
positive regulation of hemostasis GO:1900048 4 0.012
cation homeostasis GO:0055080 195 0.012
behavior GO:0007610 205 0.012
extracellular matrix constituent secretion GO:0070278 4 0.012
axis specification GO:0009798 4 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
regulation of peptidase activity GO:0052547 55 0.012
aging GO:0007568 241 0.012
positive regulation of protein transport GO:0051222 41 0.012
regulation of blood pressure GO:0008217 83 0.012
regulation of phosphate metabolic process GO:0019220 349 0.012
carbohydrate derivative metabolic process GO:1901135 346 0.012
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.012
locomotion GO:0040011 237 0.012
regulation of response to stress GO:0080134 126 0.012
localization of cell GO:0051674 202 0.012
cellular response to glucose stimulus GO:0071333 65 0.012
cellular response to carbohydrate stimulus GO:0071322 72 0.012
neuron projection morphogenesis GO:0048812 122 0.012
defense response to gram negative bacterium GO:0050829 3 0.011
regulation of map kinase activity GO:0043405 53 0.011
cell differentiation involved in kidney development GO:0061005 4 0.011
peptide cross linking GO:0018149 1 0.011
striated muscle tissue development GO:0014706 58 0.011
peptidyl tyrosine modification GO:0018212 72 0.011
glycosyl compound metabolic process GO:1901657 182 0.011
response to fluoride GO:1902617 3 0.011
response to lipopolysaccharide GO:0032496 191 0.011
regulation of inflammatory response GO:0050727 48 0.011
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.011
collagen metabolic process GO:0032963 21 0.011
cellular component morphogenesis GO:0032989 155 0.011
cellular response to insulin stimulus GO:0032869 81 0.011
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.011
eye development GO:0001654 50 0.011
lipid transport GO:0006869 61 0.011
cellular glucose homeostasis GO:0001678 66 0.011
cellular response to monosaccharide stimulus GO:0071326 67 0.011
cardiovascular system development GO:0072358 134 0.011
cell migration GO:0016477 197 0.011
negative regulation of response to wounding GO:1903035 23 0.011
glucose homeostasis GO:0042593 75 0.011
regulation of body fluid levels GO:0050878 90 0.011
cell cell signaling GO:0007267 335 0.011
regulation of cell motility GO:2000145 131 0.011
peptidyl tyrosine phosphorylation GO:0018108 72 0.011
regulation of canonical wnt signaling pathway GO:0060828 4 0.011
regulation of establishment of planar polarity GO:0090175 2 0.011
positive regulation of transport GO:0051050 245 0.011
purine nucleoside monophosphate metabolic process GO:0009126 84 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
female gonad development GO:0008585 53 0.011
isopeptide cross linking GO:0018262 1 0.010
osteoblast differentiation GO:0001649 26 0.010
coagulation GO:0050817 28 0.010
negative regulation of protein metabolic process GO:0051248 114 0.010
rna biosynthetic process GO:0032774 380 0.010
nucleoside phosphate biosynthetic process GO:1901293 102 0.010
regulation of cellular response to stress GO:0080135 49 0.010
negative regulation of response to stimulus GO:0048585 155 0.010
regeneration GO:0031099 163 0.010
immune system process GO:0002376 204 0.010
bmp signaling pathway GO:0030509 4 0.010
negative regulation of fibrinolysis GO:0051918 2 0.010
purine nucleotide biosynthetic process GO:0006164 83 0.010

Col18a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 0 0.371
disease of anatomical entity DOID:7 0 0.371
nervous system disease DOID:863 0 0.073
connective tissue disease DOID:65 0 0.072
bone development disease DOID:0080006 0 0.072
bone disease DOID:0080001 0 0.072
cardiovascular system disease DOID:1287 0 0.042
sensory system disease DOID:0050155 0 0.031
central nervous system disease DOID:331 0 0.027
essential hypertension DOID:10825 0 0.026
vascular disease DOID:178 0 0.026
artery disease DOID:0050828 0 0.026
hypertension DOID:10763 0 0.026
osteochondrodysplasia DOID:2256 0 0.013