Rattus norvegicus

12 known processes

Col4a1

collagen, type IV, alpha 1

Col4a1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.846
cellular response to growth factor stimulus GO:0071363 162 0.846
response to transforming growth factor beta GO:0071559 46 0.570
anatomical structure formation involved in morphogenesis GO:0048646 83 0.353
endochondral bone growth GO:0003416 3 0.349
bone development GO:0060348 25 0.325
response to fluoride GO:1902617 3 0.317
tooth eruption GO:0044691 1 0.270
response to growth factor GO:0070848 189 0.239
cellular response to endogenous stimulus GO:0071495 377 0.239
peptide cross linking GO:0018149 1 0.235
cellular response to nicotine GO:0071316 7 0.221
developmental growth GO:0048589 100 0.206
extracellular structure organization GO:0043062 13 0.200
blood vessel morphogenesis GO:0048514 58 0.178
protein complex assembly GO:0006461 263 0.172
response to inorganic substance GO:0010035 377 0.150
response to oxygen levels GO:0070482 265 0.148
pinocytosis GO:0006907 1 0.147
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 10 0.131
vasculature development GO:0001944 70 0.131
response to ionizing radiation GO:0010212 59 0.130
response to estrogen GO:0043627 232 0.117
enzyme linked receptor protein signaling pathway GO:0007167 116 0.109
glycolipid biosynthetic process GO:0009247 6 0.105
cell migration GO:0016477 197 0.105
positive regulation of cell communication GO:0010647 271 0.101
response to nutrient levels GO:0031667 370 0.096
regulation of cell motility GO:2000145 131 0.094
regulation of cell development GO:0060284 263 0.093
single organism biosynthetic process GO:0044711 342 0.092
response to wounding GO:0009611 254 0.089
response to vitamin GO:0033273 131 0.085
endocytosis GO:0006897 84 0.084
protein oligomerization GO:0051259 191 0.082
response to mechanical stimulus GO:0009612 134 0.081
angiogenesis GO:0001525 53 0.081
endochondral ossification GO:0001958 2 0.081
organic acid metabolic process GO:0006082 292 0.079
cellular ketone metabolic process GO:0042180 51 0.077
collagen fibril organization GO:0030199 1 0.077
aging GO:0007568 241 0.076
cellular response to abiotic stimulus GO:0071214 85 0.075
positive regulation of angiogenesis GO:0045766 28 0.075
positive regulation of cell migration GO:0030335 96 0.073
response to tumor necrosis factor GO:0034612 56 0.072
formation of primary germ layer GO:0001704 1 0.072
developmental growth involved in morphogenesis GO:0060560 33 0.071
cellular response to tumor necrosis factor GO:0071356 46 0.071
extracellular matrix organization GO:0030198 13 0.071
tissue development GO:0009888 252 0.070
cellular amine metabolic process GO:0044106 38 0.070
growth GO:0040007 165 0.068
positive regulation of stem cell differentiation GO:2000738 2 0.068
protein localization GO:0008104 191 0.066
extracellular matrix constituent secretion GO:0070278 4 0.062
response to acid chemical GO:0001101 222 0.060
extracellular fibril organization GO:0043206 1 0.060
regulation of epithelial to mesenchymal transition GO:0010717 2 0.058
locomotion GO:0040011 237 0.058
cellular response to vitamin GO:0071295 21 0.057
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.057
protein complex subunit organization GO:0071822 302 0.057
cellular response to organic cyclic compound GO:0071407 202 0.056
positive regulation of signaling GO:0023056 270 0.056
response to extracellular stimulus GO:0009991 380 0.054
protein complex biogenesis GO:0070271 263 0.053
cell matrix adhesion GO:0007160 19 0.053
regulation of multicellular organismal development GO:2000026 376 0.052
positive regulation of locomotion GO:0040017 102 0.052
cartilage development involved in endochondral bone morphogenesis GO:0060351 3 0.051
negative regulation of nervous system development GO:0051961 79 0.051
renal system development GO:0072001 67 0.050
Fly
response to hyperoxia GO:0055093 45 0.050
response to estradiol GO:0032355 164 0.050
macromolecule localization GO:0033036 252 0.049
macromolecular complex assembly GO:0065003 273 0.049
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.049
regulation of cellular component organization GO:0051128 368 0.048
oxoacid metabolic process GO:0043436 290 0.048
regulation of angiogenesis GO:0045765 39 0.047
regulation of apoptotic process GO:0042981 335 0.047
macromolecular complex subunit organization GO:0043933 339 0.047
cell motility GO:0048870 202 0.047
cellular amino acid metabolic process GO:0006520 107 0.046
regulation of secretion by cell GO:1903530 208 0.046
response to cytokine GO:0034097 215 0.046
regulation of vesicle mediated transport GO:0060627 81 0.046
regulation of cell differentiation GO:0045595 320 0.046
response to camp GO:0051591 91 0.044
endochondral bone morphogenesis GO:0060350 7 0.044
response to reactive oxygen species GO:0000302 120 0.043
amine metabolic process GO:0009308 38 0.042
positive regulation of epithelial to mesenchymal transition GO:0010718 2 0.042
positive regulation of multicellular organismal process GO:0051240 387 0.042
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.041
cellular response to platelet derived growth factor stimulus GO:0036120 7 0.041
wound healing spreading of epidermal cells GO:0035313 2 0.041
cellular response to nutrient GO:0031670 30 0.040
epiboly GO:0090504 2 0.039
response to carbohydrate GO:0009743 183 0.039
positive regulation of cellular component movement GO:0051272 102 0.039
positive regulation of cell differentiation GO:0045597 217 0.039
epithelial cell differentiation GO:0030855 71 0.038
salivary gland morphogenesis GO:0007435 1 0.037
response to amino acid GO:0043200 75 0.036
skeletal system morphogenesis GO:0048705 12 0.036
response to nutrient GO:0007584 248 0.036
negative regulation of cell development GO:0010721 82 0.034
wound healing spreading of cells GO:0044319 2 0.034
cellular response to hormone stimulus GO:0032870 247 0.034
cellular response to peptide GO:1901653 133 0.034
organophosphate metabolic process GO:0019637 370 0.034
cellular response to glucocorticoid stimulus GO:0071385 68 0.034
response to corticosteroid GO:0031960 235 0.033
negative regulation of developmental process GO:0051093 125 0.033
positive regulation of cellular amine metabolic process GO:0033240 3 0.033
carboxylic acid metabolic process GO:0019752 289 0.033
regulation of signal transduction GO:0009966 318 0.033
cellular response to external stimulus GO:0071496 118 0.032
gastrulation GO:0007369 2 0.032
muscle structure development GO:0061061 87 0.032
Fly
response to decreased oxygen levels GO:0036293 237 0.031
cellular component movement GO:0006928 248 0.031
response to nicotine GO:0035094 51 0.031
ossification GO:0001503 70 0.031
small gtpase mediated signal transduction GO:0007264 36 0.030
positive regulation of protein phosphorylation GO:0001934 135 0.030
positive regulation of developmental process GO:0051094 283 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.030
bone morphogenesis GO:0060349 11 0.030
protein heterooligomerization GO:0051291 89 0.029
cell adhesion GO:0007155 110 0.029
cellular response to mechanical stimulus GO:0071260 48 0.029
response to glucocorticoid GO:0051384 223 0.029
regulation of cell migration GO:0030334 128 0.029
cellular response to thyroid hormone stimulus GO:0097067 5 0.028
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.028
regulation of cellular ketone metabolic process GO:0010565 27 0.028
regulation of stem cell differentiation GO:2000736 2 0.028
regulation of cellular amine metabolic process GO:0033238 8 0.028
epiboly involved in wound healing GO:0090505 2 0.027
ras protein signal transduction GO:0007265 29 0.027
isopeptide cross linking GO:0018262 1 0.027
membrane organization GO:0061024 94 0.027
cellular response to peptide hormone stimulus GO:0071375 120 0.027
collagen metabolic process GO:0032963 21 0.026
muscle organ development GO:0007517 50 0.026
Fly
aorta development GO:0035904 2 0.026
salivary gland development GO:0007431 3 0.026
regulation of programmed cell death GO:0043067 341 0.026
response to monosaccharide GO:0034284 159 0.025
regulation of anatomical structure morphogenesis GO:0022603 141 0.025
negative regulation of calcium ion transport into cytosol GO:0010523 4 0.025
cellular component biogenesis GO:0044085 368 0.025
embryonic skeletal system development GO:0048706 3 0.025
positive regulation of cellular component organization GO:0051130 200 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.025
syncytium formation GO:0006949 4 0.024
coronary vasculature morphogenesis GO:0060977 3 0.024
positive regulation of phosphorus metabolic process GO:0010562 262 0.024
cellular response to extracellular stimulus GO:0031668 73 0.024
regulation of vasculature development GO:1901342 44 0.024
response to dexamethasone GO:0071548 49 0.024
positive regulation of response to stimulus GO:0048584 285 0.024
regulation of protein modification process GO:0031399 194 0.024
peptidyl amino acid modification GO:0018193 126 0.024
cellular response to fibroblast growth factor stimulus GO:0044344 24 0.024
smooth muscle cell proliferation GO:0048659 77 0.024
olfactory bulb interneuron differentiation GO:0021889 1 0.024
secretion by cell GO:0032940 248 0.024
response to metal ion GO:0010038 253 0.023
multicellular organism growth GO:0035264 1 0.023
regulation of map kinase activity GO:0043405 53 0.023
respiratory system development GO:0060541 45 0.023
metanephric s shaped body morphogenesis GO:0072284 2 0.023
positive regulation of cell development GO:0010720 176 0.023
skeletal muscle tissue development GO:0007519 31 0.023
Fly
response to peptide hormone GO:0043434 278 0.022
regulation of protein metabolic process GO:0051246 289 0.022
single organism membrane organization GO:0044802 74 0.022
response to peptide GO:1901652 292 0.022
tongue morphogenesis GO:0043587 3 0.022
regulation of endocytosis GO:0030100 42 0.022
endothelium development GO:0003158 12 0.022
apoptotic process GO:0006915 381 0.022
response to norepinephrine GO:0071873 5 0.022
response to oxidative stress GO:0006979 186 0.021
s shaped body morphogenesis GO:0072050 2 0.021
negative regulation of multicellular organismal process GO:0051241 203 0.021
regulation of nervous system development GO:0051960 264 0.021
cellular response to vascular endothelial growth factor stimulus GO:0035924 6 0.021
cellular macromolecule localization GO:0070727 122 0.021
cellular response to vitamin e GO:0071306 3 0.020
cellular response to nitrogen compound GO:1901699 210 0.020
development of primary sexual characteristics GO:0045137 107 0.020
positive regulation of endothelial cell migration GO:0010595 4 0.020
transmembrane transport GO:0055085 412 0.020
regulation of cellular response to growth factor stimulus GO:0090287 15 0.020
tube development GO:0035295 89 0.019
Fly
spindle organization GO:0007051 2 0.019
cellular response to lipid GO:0071396 201 0.019
carbohydrate derivative metabolic process GO:1901135 346 0.018
female pregnancy GO:0007565 122 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.018
response to retinoic acid GO:0032526 63 0.018
cellular response to oxygen containing compound GO:1901701 386 0.018
chylomicron remodeling GO:0034371 1 0.018
positive regulation of phosphate metabolic process GO:0045937 262 0.018
cellular response to corticosteroid stimulus GO:0071384 69 0.018
regeneration GO:0031099 163 0.018
regulation of neuron death GO:1901214 115 0.017
positive regulation of signal transduction GO:0009967 175 0.017
cellular component assembly GO:0022607 360 0.017
response to activity GO:0014823 73 0.017
negative regulation of cell differentiation GO:0045596 99 0.017
regulation of cellular component movement GO:0051270 150 0.017
regulation of phosphorylation GO:0042325 248 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.017
regulation of phosphate metabolic process GO:0019220 349 0.017
myoblast fusion GO:0007520 2 0.017
peptidyl lysine hydroxylation GO:0017185 1 0.017
response to vitamin e GO:0033197 24 0.017
epithelium development GO:0060429 96 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
isopeptide cross linking via n6 l isoglutamyl l lysine GO:0018153 1 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
skeletal muscle organ development GO:0060538 33 0.016
Fly
neuron projection development GO:0031175 273 0.016
programmed cell death GO:0012501 392 0.016
localization of cell GO:0051674 202 0.016
defense response to gram negative bacterium GO:0050829 3 0.016
multicellular organismal macromolecule metabolic process GO:0044259 21 0.015
response to hypoxia GO:0001666 231 0.015
positive regulation of immunoglobulin mediated immune response GO:0002891 2 0.015
behavior GO:0007610 205 0.015
ribonucleotide metabolic process GO:0009259 231 0.015
proteolysis GO:0006508 175 0.015
positive regulation of intracellular protein transport GO:0090316 20 0.015
ion transmembrane transport GO:0034220 365 0.014
reproductive process GO:0022414 372 0.014
response to lead ion GO:0010288 33 0.014
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 2 0.014
striated muscle tissue development GO:0014706 58 0.014
Fly
negative regulation of neuron projection development GO:0010977 46 0.014
cellular catabolic process GO:0044248 295 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
regulation of embryonic development GO:0045995 2 0.013
response to heat GO:0009408 60 0.013
intramembranous ossification GO:0001957 1 0.013
ovulation cycle GO:0042698 67 0.013
skeletal system development GO:0001501 41 0.013
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 2 0.013
cation transmembrane transport GO:0098655 263 0.013
nucleotide metabolic process GO:0009117 279 0.013
negative regulation of cell death GO:0060548 229 0.013
positive regulation of cell motility GO:2000147 97 0.013
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
cellular response to cytokine stimulus GO:0071345 127 0.013
morphogenesis of an epithelium GO:0002009 20 0.013
Fly
cell projection organization GO:0030030 302 0.013
positive regulation of isotype switching GO:0045830 1 0.013
lipid biosynthetic process GO:0008610 128 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.013
negative regulation of cell projection organization GO:0031345 50 0.013
regulation of growth GO:0040008 105 0.013
proline transport GO:0015824 3 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
regulation of response to stress GO:0080134 126 0.012
response to transition metal nanoparticle GO:1990267 122 0.012
cellular response to steroid hormone stimulus GO:0071383 93 0.012
response to external biotic stimulus GO:0043207 221 0.012
multicellular organism reproduction GO:0032504 233 0.012
synaptic growth at neuromuscular junction GO:0051124 1 0.012
response to increased oxygen levels GO:0036296 45 0.012
organic substance catabolic process GO:1901575 316 0.012
reproduction GO:0000003 245 0.012
cellular response to nutrient levels GO:0031669 60 0.012
cardiovascular system development GO:0072358 134 0.012
blood vessel development GO:0001568 69 0.012
dephosphorylation GO:0016311 98 0.012
positive regulation of map kinase activity GO:0043406 46 0.012
positive regulation of transport GO:0051050 245 0.012
regulation of blood pressure GO:0008217 83 0.011
response to toxic substance GO:0009636 133 0.011
head development GO:0060322 247 0.011
regulation of catabolic process GO:0009894 113 0.011
odontogenesis GO:0042476 32 0.011
cellular response to epidermal growth factor stimulus GO:0071364 12 0.011
brain development GO:0007420 247 0.011
positive regulation of response to external stimulus GO:0032103 51 0.011
regulation of system process GO:0044057 208 0.011
cellular response to metal ion GO:0071248 55 0.011
establishment of organelle localization GO:0051656 37 0.011
regulation of protein maturation GO:1903317 50 0.011
triglyceride homeostasis GO:0070328 2 0.011
epithelial cell migration GO:0010631 19 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
cell cell signaling GO:0007267 335 0.011
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.011
skeletal muscle tissue regeneration GO:0043403 10 0.010
response to ketone GO:1901654 182 0.010
plasminogen activation GO:0031639 2 0.010
response to radiation GO:0009314 137 0.010
skin development GO:0043588 17 0.010
regulation of cellular protein metabolic process GO:0032268 267 0.010
positive regulation of cell proliferation GO:0008284 249 0.010
cellular response to alkaloid GO:0071312 25 0.010
response to organophosphorus GO:0046683 102 0.010
regulation of endothelial cell differentiation GO:0045601 4 0.010
response to purine containing compound GO:0014074 126 0.010
multicellular organismal metabolic process GO:0044236 22 0.010

Col4a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.220
musculoskeletal system disease DOID:17 0 0.220
connective tissue disease DOID:65 0 0.152
collagen disease DOID:854 0 0.152
ehlers danlos syndrome DOID:13359 0 0.152
bone disease DOID:0080001 0 0.059
muscle tissue disease DOID:66 0 0.057
muscular dystrophy DOID:9884 0 0.057
myopathy DOID:423 0 0.057
muscular disease DOID:0080000 0 0.057
osteochondrodysplasia DOID:2256 0 0.029
osteogenesis imperfecta DOID:12347 0 0.029
bone development disease DOID:0080006 0 0.029
nervous system disease DOID:863 0 0.027
central nervous system disease DOID:331 0 0.016
sensory system disease DOID:0050155 0 0.014