Rattus norvegicus

45 known processes

Ctla4

cytotoxic T-lymphocyte-associated protein 4

(Aliases: Cd152,CTLA-4,sCTLA4)

Ctla4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of cell proliferation GO:0042127 359 0.299
response to nutrient levels GO:0031667 370 0.225
cytokine mediated signaling pathway GO:0019221 43 0.197
homeostatic process GO:0042592 331 0.162
response to food GO:0032094 27 0.146
cellular response to oxygen containing compound GO:1901701 386 0.133
immune response GO:0006955 104 0.129
response to cytokine GO:0034097 215 0.114
cation transport GO:0006812 382 0.108
regulation of programmed cell death GO:0043067 341 0.107
Human
response to other organism GO:0051707 220 0.106
negative regulation of response to external stimulus GO:0032102 37 0.100
response to decreased oxygen levels GO:0036293 237 0.099
response to carbohydrate GO:0009743 183 0.096
regulation of cellular localization GO:0060341 263 0.095
response to corticosteroid GO:0031960 235 0.095
negative regulation of multicellular organismal process GO:0051241 203 0.092
Human
cardiovascular system development GO:0072358 134 0.092
gland development GO:0048732 155 0.092
kidney development GO:0001822 67 0.086
response to reactive oxygen species GO:0000302 120 0.082
response to oxygen levels GO:0070482 265 0.082
regulation of protein transport GO:0051223 68 0.080
g protein coupled receptor signaling pathway GO:0007186 242 0.079
negative regulation of response to stimulus GO:0048585 155 0.077
response to toxic substance GO:0009636 133 0.077
inflammatory response GO:0006954 150 0.075
secretion GO:0046903 307 0.075
organic substance catabolic process GO:1901575 316 0.075
negative regulation of chronic inflammatory response GO:0002677 2 0.074
regulation of secretion GO:0051046 224 0.073
regulation of vasculature development GO:1901342 44 0.073
chemical homeostasis GO:0048878 292 0.072
regulation of immune system process GO:0002682 123 0.070
response to biotic stimulus GO:0009607 226 0.066
macromolecule localization GO:0033036 252 0.064
response to purine containing compound GO:0014074 126 0.064
negative regulation of cellular metabolic process GO:0031324 281 0.063
nucleobase containing small molecule metabolic process GO:0055086 316 0.062
cellular response to lipid GO:0071396 201 0.060
metal ion transport GO:0030001 289 0.058
cellular response to cytokine stimulus GO:0071345 127 0.057
oxoacid metabolic process GO:0043436 290 0.057
secretion by cell GO:0032940 248 0.056
regulation of cytokine production GO:0001817 56 0.055
proteolysis GO:0006508 175 0.055
monovalent inorganic cation transport GO:0015672 172 0.054
feeding behavior GO:0007631 53 0.054
apoptotic process GO:0006915 381 0.053
Human
divalent metal ion transport GO:0070838 132 0.052
regulation of signal transduction GO:0009966 318 0.052
macromolecular complex assembly GO:0065003 273 0.050
positive regulation of biosynthetic process GO:0009891 319 0.050
cellular metal ion homeostasis GO:0006875 172 0.050
blood circulation GO:0008015 183 0.049
cellular homeostasis GO:0019725 252 0.049
dna metabolic process GO:0006259 96 0.047
intracellular transport GO:0046907 185 0.047
organic acid metabolic process GO:0006082 292 0.045
regulation of system process GO:0044057 208 0.044
cellular calcium ion homeostasis GO:0006874 160 0.044
protein complex assembly GO:0006461 263 0.043
intracellular signal transduction GO:0035556 314 0.043
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.043
response to extracellular stimulus GO:0009991 380 0.041
lipid metabolic process GO:0006629 283 0.041
response to inorganic substance GO:0010035 377 0.041
protein localization GO:0008104 191 0.041
response to glucose GO:0009749 136 0.041
response to hexose GO:0009746 144 0.041
vascular process in circulatory system GO:0003018 96 0.040
cellular response to stress GO:0033554 269 0.039
Human
response to antibiotic GO:0046677 39 0.038
protein transport GO:0015031 132 0.038
divalent inorganic cation homeostasis GO:0072507 165 0.037
muscle contraction GO:0006936 88 0.037
regulation of locomotion GO:0040012 148 0.037
regulation of phosphate metabolic process GO:0019220 349 0.037
potassium ion transport GO:0006813 97 0.037
positive regulation of cell death GO:0010942 184 0.037
Human
muscle system process GO:0003012 115 0.037
cellular chemical homeostasis GO:0055082 247 0.036
protein processing GO:0016485 68 0.035
reproductive process GO:0022414 372 0.035
response to glucocorticoid GO:0051384 223 0.035
programmed cell death GO:0012501 392 0.034
Human
cation homeostasis GO:0055080 195 0.034
regulation of apoptotic process GO:0042981 335 0.033
Human
establishment of protein localization GO:0045184 141 0.033
negative regulation of metabolic process GO:0009892 331 0.033
response to oxidative stress GO:0006979 186 0.033
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.033
response to ethanol GO:0045471 162 0.033
inflammatory response to antigenic stimulus GO:0002437 18 0.032
nucleic acid templated transcription GO:0097659 379 0.032
purine ribonucleoside metabolic process GO:0046128 168 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.032
protein maturation GO:0051604 68 0.032
rhythmic process GO:0048511 156 0.031
multi organism reproductive process GO:0044703 262 0.031
ribonucleoside metabolic process GO:0009119 174 0.031
circulatory system process GO:0003013 183 0.031
purine nucleotide biosynthetic process GO:0006164 83 0.031
circulatory system development GO:0072359 134 0.031
response to ionizing radiation GO:0010212 59 0.031
regulation of mononuclear cell proliferation GO:0032944 26 0.031
carbohydrate derivative metabolic process GO:1901135 346 0.030
circadian sleep wake cycle GO:0042745 23 0.030
regulation of homeostatic process GO:0032844 101 0.030
nucleoside phosphate biosynthetic process GO:1901293 102 0.030
regulation of ion transport GO:0043269 245 0.029
positive regulation of transport GO:0051050 245 0.029
negative regulation of immune system process GO:0002683 39 0.029
glycosyl compound metabolic process GO:1901657 182 0.029
protein complex biogenesis GO:0070271 263 0.029
neuron differentiation GO:0030182 368 0.029
circadian rhythm GO:0007623 88 0.029
positive regulation of cell proliferation GO:0008284 249 0.029
sensory organ development GO:0007423 74 0.029
positive regulation of signal transduction GO:0009967 175 0.029
positive regulation of transcription factor import into nucleus GO:0042993 4 0.028
regulation of anatomical structure size GO:0090066 135 0.028
sexual reproduction GO:0019953 148 0.028
response to external biotic stimulus GO:0043207 221 0.027
cellular response to abiotic stimulus GO:0071214 85 0.027
cellular protein localization GO:0034613 122 0.027
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
ribonucleotide biosynthetic process GO:0009260 85 0.025
central nervous system development GO:0007417 311 0.025
purine ribonucleoside catabolic process GO:0046130 124 0.025
ion transmembrane transport GO:0034220 365 0.025
metal ion homeostasis GO:0055065 186 0.025
calcium ion homeostasis GO:0055074 162 0.025
cellular response to hexose stimulus GO:0071331 65 0.025
cellular response to nitrogen compound GO:1901699 210 0.025
nucleoside metabolic process GO:0009116 179 0.025
immune system process GO:0002376 204 0.025
negative regulation of cell proliferation GO:0008285 119 0.025
hormone metabolic process GO:0042445 69 0.024
cellular lipid metabolic process GO:0044255 208 0.024
regulation of protein localization GO:0032880 81 0.024
response to organophosphorus GO:0046683 102 0.024
regulation of dna metabolic process GO:0051052 60 0.024
cytoplasmic transport GO:0016482 115 0.024
cognition GO:0050890 92 0.024
regulation of neurological system process GO:0031644 43 0.023
ribose phosphate metabolic process GO:0019693 235 0.023
nucleoside catabolic process GO:0009164 126 0.023
positive regulation of nervous system development GO:0051962 178 0.023
protein phosphorylation GO:0006468 345 0.023
cellular response to growth factor stimulus GO:0071363 162 0.023
carbohydrate homeostasis GO:0033500 75 0.023
salivary gland development GO:0007431 3 0.023
organic acid transport GO:0015849 116 0.023
carboxylic acid metabolic process GO:0019752 289 0.022
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.022
regulation of response to external stimulus GO:0032101 106 0.022
response to camp GO:0051591 91 0.022
protein secretion GO:0009306 34 0.022
response to starvation GO:0042594 59 0.022
rna biosynthetic process GO:0032774 380 0.022
response to acid chemical GO:0001101 222 0.022
negative regulation of cell communication GO:0010648 158 0.022
response to hypoxia GO:0001666 231 0.022
male sex differentiation GO:0046661 64 0.022
response to growth factor GO:0070848 189 0.022
regulation of protein metabolic process GO:0051246 289 0.022
response to radiation GO:0009314 137 0.021
regulation of phosphorus metabolic process GO:0051174 349 0.021
cell migration GO:0016477 197 0.021
negative regulation of cell death GO:0060548 229 0.021
cellular cation homeostasis GO:0030003 180 0.021
neurological system process GO:0050877 219 0.021
negative regulation of macromolecule metabolic process GO:0010605 260 0.021
regulation of multicellular organismal development GO:2000026 376 0.021
Human
cellular response to acid chemical GO:0071229 75 0.021
ion homeostasis GO:0050801 212 0.021
leukocyte activation GO:0045321 76 0.021
regulation of anatomical structure morphogenesis GO:0022603 141 0.021
regulation of establishment of protein localization GO:0070201 69 0.021
locomotion GO:0040011 237 0.020
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 3 0.020
response to wounding GO:0009611 254 0.020
divalent inorganic cation transport GO:0072511 134 0.020
positive regulation of programmed cell death GO:0043068 157 0.020
Human
heterocycle catabolic process GO:0046700 167 0.020
positive regulation of molecular function GO:0044093 230 0.020
transmembrane transport GO:0055085 412 0.020
positive regulation of catalytic activity GO:0043085 184 0.020
catabolic process GO:0009056 351 0.020
regulation of neurogenesis GO:0050767 247 0.020
tolerance induction dependent upon immune response GO:0002461 2 0.020
negative regulation of long term synaptic potentiation GO:1900272 1 0.020
acute inflammatory response GO:0002526 58 0.020
nucleoside phosphate metabolic process GO:0006753 283 0.019
regulation of mapk cascade GO:0043408 116 0.019
negative regulation of phosphorus metabolic process GO:0010563 80 0.019
male mating behavior GO:0060179 3 0.019
calcium ion transport GO:0006816 131 0.019
response to hydrogen peroxide GO:0042542 89 0.019
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.019
regulation of cellular extravasation GO:0002691 2 0.019
response to estrogen GO:0043627 232 0.019
response to mineralocorticoid GO:0051385 49 0.019
aromatic compound catabolic process GO:0019439 168 0.019
cellular response to molecule of bacterial origin GO:0071219 56 0.019
protein oligomerization GO:0051259 191 0.018
reactive oxygen species biosynthetic process GO:1903409 8 0.018
cellular divalent inorganic cation homeostasis GO:0072503 162 0.018
purine containing compound metabolic process GO:0072521 253 0.018
developmental process involved in reproduction GO:0003006 159 0.018
response to nutrient GO:0007584 248 0.018
regulation of membrane potential GO:0042391 110 0.018
cellular component movement GO:0006928 248 0.018
regulation of neuron projection development GO:0010975 161 0.018
cellular amino acid metabolic process GO:0006520 107 0.018
cell motility GO:0048870 202 0.018
negative regulation of phosphate metabolic process GO:0045936 80 0.018
learning or memory GO:0007611 90 0.018
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.018
camera type eye development GO:0043010 48 0.018
male gonad development GO:0008584 59 0.018
regulation of nervous system development GO:0051960 264 0.018
regulation of phosphorylation GO:0042325 248 0.018
macromolecular complex subunit organization GO:0043933 339 0.018
purine nucleotide metabolic process GO:0006163 229 0.018
cellular ketone metabolic process GO:0042180 51 0.018
regulation of immunoglobulin secretion GO:0051023 1 0.018
localization of cell GO:0051674 202 0.018
positive regulation of response to stimulus GO:0048584 285 0.018
Human
startle response GO:0001964 2 0.018
regulation of cellular ketone metabolic process GO:0010565 27 0.017
organonitrogen compound catabolic process GO:1901565 179 0.017
regulation of t cell activation GO:0050863 23 0.017
cellular response to organic cyclic compound GO:0071407 202 0.017
regulation of intracellular signal transduction GO:1902531 218 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.017
ribonucleotide metabolic process GO:0009259 231 0.017
tissue remodeling GO:0048771 40 0.017
regulation of neutrophil apoptotic process GO:0033029 4 0.017
regulation of molecular function GO:0065009 398 0.017
response to transition metal nanoparticle GO:1990267 122 0.017
multicellular organism growth GO:0035264 1 0.017
urogenital system development GO:0001655 78 0.017
protein homooligomerization GO:0051260 91 0.017
negative regulation of gene expression GO:0010629 199 0.017
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.017
regulation of cellular protein metabolic process GO:0032268 267 0.017
single organism biosynthetic process GO:0044711 342 0.017
response to monosaccharide GO:0034284 159 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.016
negative regulation of signaling GO:0023057 157 0.016
regulation of protein secretion GO:0050708 28 0.016
sequestering of calcium ion GO:0051208 8 0.016
regulation of rna biosynthetic process GO:2001141 381 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
eye development GO:0001654 50 0.016
tissue development GO:0009888 252 0.016
anion transport GO:0006820 178 0.016
response to dexamethasone GO:0071548 49 0.016
fertilization GO:0009566 3 0.016
leukocyte differentiation GO:0002521 30 0.016
Human
regulation of cell projection organization GO:0031344 175 0.016
prepulse inhibition GO:0060134 1 0.016
response to interleukin 1 GO:0070555 55 0.016
response to peptide GO:1901652 292 0.016
purine nucleoside triphosphate catabolic process GO:0009146 122 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
reactive nitrogen species metabolic process GO:2001057 1 0.016
regulation of hormone levels GO:0010817 187 0.015
cellular response to carbohydrate stimulus GO:0071322 72 0.015
purine ribonucleotide metabolic process GO:0009150 227 0.015
response to molecule of bacterial origin GO:0002237 194 0.015
angioblast cell migration GO:0035476 1 0.015
telencephalon development GO:0021537 62 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
regulation of cellular component movement GO:0051270 150 0.015
anatomical structure morphogenesis GO:0009653 298 0.015
regulation of blood pressure GO:0008217 83 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
protein complex subunit organization GO:0071822 302 0.015
cellular response to external stimulus GO:0071496 118 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
regulation of calcium ion transport GO:0051924 77 0.015
regulation of peptide transport GO:0090087 87 0.015
nucleotide metabolic process GO:0009117 279 0.015
positive regulation of neurogenesis GO:0050769 165 0.015
intracellular protein transport GO:0006886 79 0.015
cellular response to biotic stimulus GO:0071216 59 0.015
regulation of cell migration GO:0030334 128 0.015
gastrulation GO:0007369 2 0.015
camp metabolic process GO:0046058 63 0.015
defense response GO:0006952 194 0.014
positive regulation of developmental process GO:0051094 283 0.014
glucose homeostasis GO:0042593 75 0.014
single organism cellular localization GO:1902580 102 0.014
lymphocyte activation GO:0046649 43 0.014
rna metabolic process GO:0016070 406 0.014
cytokine production GO:0001816 61 0.014
sequestering of metal ion GO:0051238 9 0.014
cellular response to reactive oxygen species GO:0034614 55 0.014
regulation of protein modification process GO:0031399 194 0.014
response to estradiol GO:0032355 164 0.014
blood vessel development GO:0001568 69 0.014
reproduction GO:0000003 245 0.014
aging GO:0007568 241 0.014
dna replication GO:0006260 37 0.014
liver development GO:0001889 90 0.014
response to vitamin GO:0033273 131 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
cellular catabolic process GO:0044248 295 0.014
rhythmic behavior GO:0007622 24 0.013
negative regulation of nucleic acid templated transcription GO:1903507 117 0.013
sensory perception GO:0007600 101 0.013
signal transduction by phosphorylation GO:0023014 144 0.013
lipid localization GO:0010876 62 0.013
forebrain development GO:0030900 98 0.013
regulation of cellular catabolic process GO:0031329 101 0.013
single organism catabolic process GO:0044712 283 0.013
regulation of cellular amino acid metabolic process GO:0006521 2 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.013
myeloid leukocyte migration GO:0097529 20 0.013
oxidation reduction process GO:0055114 304 0.013
adenohypophysis development GO:0021984 2 0.013
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.013
response to fatty acid GO:0070542 65 0.013
organophosphate catabolic process GO:0046434 148 0.013
steroid biosynthetic process GO:0006694 48 0.013
macromolecule catabolic process GO:0009057 58 0.013
negative regulation of fibrinolysis GO:0051918 2 0.013
regulation of nucleic acid templated transcription GO:1903506 380 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
organ formation GO:0048645 3 0.013
positive regulation of potassium ion transport GO:0043268 13 0.013
sodium ion transport GO:0006814 82 0.013
regulation of catalytic activity GO:0050790 304 0.013
reactive oxygen species metabolic process GO:0072593 37 0.012
neuronal action potential GO:0019228 35 0.012
synaptic transmission GO:0007268 235 0.012
neuron projection development GO:0031175 273 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
Human
purine containing compound catabolic process GO:0072523 138 0.012
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.012
epithelial cell differentiation GO:0030855 71 0.012
organophosphate metabolic process GO:0019637 370 0.012
single organism intracellular transport GO:1902582 166 0.012
behavior GO:0007610 205 0.012
cellular response to endogenous stimulus GO:0071495 377 0.012
memory GO:0007613 54 0.012
cardiac muscle contraction GO:0060048 27 0.012
positive regulation of nucleotide metabolic process GO:0045981 91 0.012
single organism reproductive process GO:0044702 297 0.012
reproductive structure development GO:0048608 128 0.012
calcium ion import GO:0070509 22 0.012
single organism behavior GO:0044708 130 0.012
multicellular organismal reproductive process GO:0048609 233 0.012
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.012
cellular nitrogen compound catabolic process GO:0044270 163 0.012
regulation of reactive oxygen species metabolic process GO:2000377 26 0.012
cellular ion homeostasis GO:0006873 184 0.012
brain development GO:0007420 247 0.012
response to peptide hormone GO:0043434 278 0.012
positive regulation of long term synaptic potentiation GO:1900273 4 0.012
mapk cascade GO:0000165 140 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
positive regulation of ion transport GO:0043270 94 0.012
isoprenoid metabolic process GO:0006720 45 0.012
cellular response to peptide GO:1901653 133 0.012
organic anion transport GO:0015711 132 0.011
protein targeting GO:0006605 61 0.011
insulin secretion GO:0030073 69 0.011
carboxylic acid transport GO:0046942 115 0.011
neuromuscular process GO:0050905 2 0.011
positive regulation of rna metabolic process GO:0051254 203 0.011
metanephric tubule morphogenesis GO:0072173 2 0.011
regulation of cell development GO:0060284 263 0.011
striated muscle contraction GO:0006941 44 0.011
cellular response to dexamethasone stimulus GO:0071549 36 0.011
neutrophil apoptotic process GO:0001781 4 0.011
regulation of immune effector process GO:0002697 32 0.011
negative regulation of protein phosphorylation GO:0001933 44 0.011
cellular response to monosaccharide stimulus GO:0071326 67 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
regulation of protein processing GO:0070613 50 0.011
sleep GO:0030431 30 0.011
response to metal ion GO:0010038 253 0.011
negative regulation of transport GO:0051051 136 0.011
purine ribonucleotide catabolic process GO:0009154 136 0.011
response to ph GO:0009268 27 0.011
regulation of lipid biosynthetic process GO:0046890 38 0.011
cellular glucose homeostasis GO:0001678 66 0.011
regulation of chronic inflammatory response GO:0002676 3 0.011
c21 steroid hormone metabolic process GO:0008207 14 0.011
positive regulation of protein transport GO:0051222 41 0.011
regulation of vascular smooth muscle contraction GO:0003056 3 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
regulation of hydrolase activity GO:0051336 143 0.011
cellular amine metabolic process GO:0044106 38 0.011
regulation of metal ion transport GO:0010959 118 0.011
positive regulation of lymphocyte activation GO:0051251 25 0.011
Rat
regulation of lymphocyte activation GO:0051249 34 0.011
gamete generation GO:0007276 124 0.011
eosinophil migration GO:0072677 3 0.011
response to cgmp GO:0070305 3 0.011
cellular response to mechanical stimulus GO:0071260 48 0.010
positive regulation of immune system process GO:0002684 90 0.010
Human Rat
regulation of transmembrane transport GO:0034762 122 0.010
negative regulation of circadian rhythm GO:0042754 5 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
n methyl d aspartate receptor clustering GO:0097114 2 0.010
cellular response to starvation GO:0009267 27 0.010
response to amine GO:0014075 46 0.010
regulation of neuron differentiation GO:0045664 208 0.010
cytosolic calcium ion homeostasis GO:0051480 140 0.010
negative regulation of cellular biosynthetic process GO:0031327 161 0.010
hepaticobiliary system development GO:0061008 90 0.010
ras protein signal transduction GO:0007265 29 0.010
regulation of intracellular transport GO:0032386 65 0.010
metanephric tubule development GO:0072170 4 0.010
amine metabolic process GO:0009308 38 0.010
activation of mapkk activity GO:0000186 18 0.010
negative regulation of phosphorylation GO:0042326 57 0.010
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.010
response to ketone GO:1901654 182 0.010
transcription from rna polymerase ii promoter GO:0006366 252 0.010
ribonucleoside triphosphate metabolic process GO:0009199 141 0.010

Ctla4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
Human
nervous system disease DOID:863 0 0.028
disease of metabolism DOID:0014667 0 0.014
sensory system disease DOID:0050155 0 0.012
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012
disease of cellular proliferation DOID:14566 0 0.010