Rattus norvegicus

78 known processes

Ctsb

cathepsin B

Ctsb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell motility GO:0048870 202 0.384
organic substance catabolic process GO:1901575 316 0.371
Human
regulation of cellular component movement GO:0051270 150 0.328
carboxylic acid metabolic process GO:0019752 289 0.293
regulation of programmed cell death GO:0043067 341 0.282
single organism carbohydrate catabolic process GO:0044724 40 0.266
autophagic cell death GO:0048102 4 0.256
Fly
multicellular organism reproduction GO:0032504 233 0.249
single organism catabolic process GO:0044712 283 0.249
Human
dna geometric change GO:0032392 4 0.239
pentose metabolic process GO:0019321 8 0.238
negative regulation of cell death GO:0060548 229 0.233
regulation of blood coagulation GO:0030193 9 0.221
regulation of apoptotic process GO:0042981 335 0.206
response to growth factor GO:0070848 189 0.176
hepaticobiliary system development GO:0061008 90 0.167
oxoacid metabolic process GO:0043436 290 0.161
positive regulation of cell migration GO:0030335 96 0.153
regulation of cell proliferation GO:0042127 359 0.153
monocarboxylic acid metabolic process GO:0032787 152 0.152
keratan sulfate metabolic process GO:0042339 1 0.147
regulation of sperm motility GO:1901317 2 0.142
hepatocyte differentiation GO:0070365 8 0.142
catabolic process GO:0009056 351 0.140
regulation of cell motility GO:2000145 131 0.134
response to peptide GO:1901652 292 0.126
negative regulation of coagulation GO:0050819 7 0.125
response to metal ion GO:0010038 253 0.124
organic acid metabolic process GO:0006082 292 0.121
reproductive process GO:0022414 372 0.117
coagulation GO:0050817 28 0.116
positive regulation of cellular component organization GO:0051130 200 0.114
regulation of body fluid levels GO:0050878 90 0.109
locomotion GO:0040011 237 0.104
positive regulation of cell motility GO:2000147 97 0.102
regulation of neurogenesis GO:0050767 247 0.097
multicellular organismal reproductive process GO:0048609 233 0.095
vesicle mediated transport GO:0016192 181 0.094
organic acid biosynthetic process GO:0016053 83 0.094
pentose phosphate shunt non oxidative branch GO:0009052 4 0.091
lymphocyte activation GO:0046649 43 0.090
positive regulation of cell differentiation GO:0045597 217 0.088
t cell activation GO:0042110 29 0.087
regulation of hormone levels GO:0010817 187 0.087
regulation of cellular component organization GO:0051128 368 0.085
cellular amide metabolic process GO:0043603 44 0.085
regulation of cell projection organization GO:0031344 175 0.084
estrous cycle phase GO:0060206 15 0.083
angiogenesis GO:0001525 53 0.082
positive regulation of cell development GO:0010720 176 0.078
single organism reproductive process GO:0044702 297 0.078
regulation of protein metabolic process GO:0051246 289 0.076
regulation of neuron differentiation GO:0045664 208 0.075
regulation of nervous system development GO:0051960 264 0.074
organonitrogen compound catabolic process GO:1901565 179 0.074
synaptic transmission GO:0007268 235 0.073
multi organism reproductive process GO:0044703 262 0.073
multicellular organismal homeostasis GO:0048871 49 0.072
response to glucocorticoid GO:0051384 223 0.070
rubidium ion transport GO:0035826 1 0.068
carbohydrate derivative metabolic process GO:1901135 346 0.068
negative regulation of hemostasis GO:1900047 6 0.066
sexual reproduction GO:0019953 148 0.066
protein maturation GO:0051604 68 0.064
negative regulation of response to stimulus GO:0048585 155 0.064
programmed cell death GO:0012501 392 0.063
Fly
response to glucose GO:0009749 136 0.062
macrophage chemotaxis GO:0048246 2 0.060
cell projection organization GO:0030030 302 0.058
cellular catabolic process GO:0044248 295 0.058
localization of cell GO:0051674 202 0.057
positive regulation of nervous system development GO:0051962 178 0.057
single organism intracellular transport GO:1902582 166 0.057
positive regulation of signal transduction GO:0009967 175 0.056
negative regulation of cell proliferation GO:0008285 119 0.055
positive regulation of developmental process GO:0051094 283 0.055
regulation of hemostasis GO:1900046 9 0.054
positive regulation of multicellular organismal process GO:0051240 387 0.054
membrane organization GO:0061024 94 0.054
synaptic vesicle endocytosis GO:0048488 4 0.053
tissue homeostasis GO:0001894 28 0.053
response to hexose GO:0009746 144 0.052
carbohydrate catabolic process GO:0016052 40 0.051
lipid metabolic process GO:0006629 283 0.051
homeostatic process GO:0042592 331 0.050
regulation of cellular protein metabolic process GO:0032268 267 0.050
peptide metabolic process GO:0006518 32 0.050
carbohydrate derivative catabolic process GO:1901136 147 0.049
positive regulation of protein phosphorylation GO:0001934 135 0.049
regulation of cell differentiation GO:0045595 320 0.049
hexose catabolic process GO:0019320 10 0.049
head development GO:0060322 247 0.049
neuron differentiation GO:0030182 368 0.048
pyridine containing compound metabolic process GO:0072524 32 0.048
fatty acid metabolic process GO:0006631 99 0.048
cellular ketone metabolic process GO:0042180 51 0.047
peptide catabolic process GO:0043171 5 0.047
regulation of angiotensin metabolic process GO:0060177 3 0.047
regulation of cell cell adhesion GO:0022407 14 0.047
enzyme linked receptor protein signaling pathway GO:0007167 116 0.046
carboxylic acid biosynthetic process GO:0046394 83 0.045
positive regulation of cell projection organization GO:0031346 111 0.043
hemostasis GO:0007599 26 0.043
antigen processing and presentation GO:0019882 2 0.043
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.043
response to nutrient levels GO:0031667 370 0.043
positive regulation of gene expression GO:0010628 244 0.042
multi multicellular organism process GO:0044706 138 0.042
Mouse
cellular component movement GO:0006928 248 0.042
cell substrate adhesion GO:0031589 29 0.042
positive regulation of angiogenesis GO:0045766 28 0.042
neuron projection development GO:0031175 273 0.042
response to inorganic substance GO:0010035 377 0.041
protein phosphorylation GO:0006468 345 0.041
male mating behavior GO:0060179 3 0.041
negative regulation of cell communication GO:0010648 158 0.041
single organism carbohydrate metabolic process GO:0044723 118 0.040
response to acid chemical GO:0001101 222 0.039
reproduction GO:0000003 245 0.039
sulfur compound catabolic process GO:0044273 3 0.039
t cell proliferation GO:0042098 19 0.039
epithelial cell differentiation GO:0030855 71 0.038
Human
cellular lipid metabolic process GO:0044255 208 0.038
regulation of signal transduction GO:0009966 318 0.038
positive regulation of cellular component movement GO:0051272 102 0.038
response to corticosteroid GO:0031960 235 0.038
regulation of cell migration GO:0030334 128 0.038
regulation of molecular function GO:0065009 398 0.038
positive regulation of neurogenesis GO:0050769 165 0.037
hexose metabolic process GO:0019318 58 0.037
leukocyte proliferation GO:0070661 29 0.037
regulation of locomotion GO:0040012 148 0.036
regulation of response to stress GO:0080134 126 0.036
calcium ion import GO:0070509 22 0.036
chemical homeostasis GO:0048878 292 0.036
sulfur compound metabolic process GO:0006790 70 0.036
negative regulation of response to wounding GO:1903035 23 0.036
regulation of coagulation GO:0050818 11 0.035
regulation of cellular ketone metabolic process GO:0010565 27 0.035
cellular amino acid metabolic process GO:0006520 107 0.035
epithelium development GO:0060429 96 0.034
Human
positive regulation of locomotion GO:0040017 102 0.034
cell activation GO:0001775 97 0.034
regulation of phosphorylation GO:0042325 248 0.034
positive regulation of neuron differentiation GO:0045666 126 0.034
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.034
amine metabolic process GO:0009308 38 0.034
lymphocyte proliferation GO:0046651 29 0.033
cellular response to oxygen containing compound GO:1901701 386 0.032
protein localization to membrane GO:0072657 36 0.032
fatty acid derivative metabolic process GO:1901568 38 0.032
female pregnancy GO:0007565 122 0.032
Mouse
protein autoprocessing GO:0016540 7 0.032
apoptotic process GO:0006915 381 0.031
dna duplex unwinding GO:0032508 3 0.031
monosaccharide catabolic process GO:0046365 10 0.031
positive regulation of protein metabolic process GO:0051247 178 0.031
negative regulation of lipase activity GO:0060192 3 0.030
peptidyl tyrosine phosphorylation GO:0018108 72 0.030
fatty acid biosynthetic process GO:0006633 33 0.030
positive regulation of phosphorus metabolic process GO:0010562 262 0.030
cellular response to stress GO:0033554 269 0.029
cell type specific apoptotic process GO:0097285 134 0.029
ribose phosphate metabolic process GO:0019693 235 0.029
regulation of cellular amine metabolic process GO:0033238 8 0.029
organophosphate metabolic process GO:0019637 370 0.029
spermatogenesis GO:0007283 99 0.029
cellular response to endogenous stimulus GO:0071495 377 0.029
Human
negative regulation of signaling GO:0023057 157 0.029
cellular response to hormone stimulus GO:0032870 247 0.028
Human
response to lead ion GO:0010288 33 0.028
protein localization GO:0008104 191 0.028
positive regulation of neuron projection development GO:0010976 99 0.028
cell growth GO:0016049 104 0.028
metal ion homeostasis GO:0055065 186 0.028
endocytosis GO:0006897 84 0.028
positive regulation of cell communication GO:0010647 271 0.028
macromolecule localization GO:0033036 252 0.028
antigen processing and presentation of peptide antigen GO:0048002 2 0.027
skin morphogenesis GO:0043589 2 0.027
response to estrogen GO:0043627 232 0.027
regulation of blood pressure GO:0008217 83 0.027
liver development GO:0001889 90 0.027
small molecule biosynthetic process GO:0044283 124 0.027
dendritic spine development GO:0060996 20 0.027
cell adhesion GO:0007155 110 0.026
nadp metabolic process GO:0006739 13 0.026
regulation of secretion GO:0051046 224 0.026
male sex differentiation GO:0046661 64 0.026
response to radiation GO:0009314 137 0.026
negative regulation of programmed cell death GO:0043069 183 0.026
response to gonadotropin GO:0034698 34 0.025
peptidyl amino acid modification GO:0018193 126 0.025
response to cytokine GO:0034097 215 0.025
ribose phosphate biosynthetic process GO:0046390 87 0.025
regulation of cellular localization GO:0060341 263 0.025
epithelial cell migration GO:0010631 19 0.025
icosanoid metabolic process GO:0006690 38 0.025
pentose phosphate shunt GO:0006098 8 0.025
carbohydrate metabolic process GO:0005975 130 0.024
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 1 0.024
anatomical structure morphogenesis GO:0009653 298 0.024
Fly
regulation of dendrite development GO:0050773 59 0.024
tissue development GO:0009888 252 0.024
protein targeting to plasma membrane GO:0072661 4 0.023
regulation of cell development GO:0060284 263 0.023
brain development GO:0007420 247 0.023
regulation of epithelial cell proliferation GO:0050678 49 0.023
eosinophil migration GO:0072677 3 0.023
biological phase GO:0044848 17 0.022
gland development GO:0048732 155 0.022
Fly
biological adhesion GO:0022610 110 0.022
negative regulation of signal transduction GO:0009968 83 0.022
ion transmembrane transport GO:0034220 365 0.022
regulation of phosphorus metabolic process GO:0051174 349 0.022
protein processing GO:0016485 68 0.022
regulation of protein modification process GO:0031399 194 0.022
dna metabolic process GO:0006259 96 0.022
proteolysis GO:0006508 175 0.022
regulation of rna biosynthetic process GO:2001141 381 0.021
unsaturated fatty acid biosynthetic process GO:0006636 21 0.021
monosaccharide metabolic process GO:0005996 61 0.021
neuron development GO:0048666 286 0.021
cellular response to nutrient levels GO:0031669 60 0.021
positive regulation of cell death GO:0010942 184 0.021
response to purine containing compound GO:0014074 126 0.021
exocytosis GO:0006887 60 0.021
synaptic vesicle localization GO:0097479 24 0.021
regulation of multicellular organismal development GO:2000026 376 0.021
negative regulation of transport GO:0051051 136 0.020
regulation of angiotensin levels in blood GO:0002002 2 0.020
reproductive structure development GO:0048608 128 0.020
Mouse
response to camp GO:0051591 91 0.020
blood circulation GO:0008015 183 0.020
negative regulation of wound healing GO:0061045 8 0.020
gliogenesis GO:0042063 93 0.020
glial cell differentiation GO:0010001 65 0.019
establishment of protein localization GO:0045184 141 0.019
positive regulation of cellular protein metabolic process GO:0032270 167 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
regulation of leukocyte proliferation GO:0070663 26 0.018
ion homeostasis GO:0050801 212 0.018
glutamine family amino acid biosynthetic process GO:0009084 2 0.018
alpha amino acid metabolic process GO:1901605 71 0.018
fibroblast proliferation GO:0048144 22 0.018
regulation of neuron projection development GO:0010975 161 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
single organism membrane organization GO:0044802 74 0.017
positive regulation of response to stimulus GO:0048584 285 0.017
response to hypoxia GO:0001666 231 0.017
cell cell signaling GO:0007267 335 0.017
terpenoid metabolic process GO:0006721 37 0.017
dendrite development GO:0016358 72 0.017
negative regulation of secretion GO:0051048 82 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
organic cyclic compound catabolic process GO:1901361 175 0.017
male gamete generation GO:0048232 99 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
cell migration GO:0016477 197 0.017
nucleic acid templated transcription GO:0097659 379 0.017
protein homooligomerization GO:0051260 91 0.016
regulation of organelle organization GO:0033043 80 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.016
response to estradiol GO:0032355 164 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
positive regulation of phosphorylation GO:0042327 177 0.016
regulation of hydrolase activity GO:0051336 143 0.016
respiratory system development GO:0060541 45 0.016
fatty acid derivative biosynthetic process GO:1901570 18 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.016
regulation of anatomical structure morphogenesis GO:0022603 141 0.016
positive regulation of transport GO:0051050 245 0.016
positive regulation of apoptotic process GO:0043065 154 0.016
cellular macromolecule localization GO:0070727 122 0.016
purine nucleoside monophosphate metabolic process GO:0009126 84 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
positive regulation of cellular biosynthetic process GO:0031328 295 0.016
cytokinetic process GO:0032506 1 0.015
regulation of immune system process GO:0002682 123 0.015
purine nucleoside triphosphate metabolic process GO:0009144 141 0.015
hormone secretion GO:0046879 115 0.015
blood vessel morphogenesis GO:0048514 58 0.015
nitrogen compound transport GO:0071705 229 0.015
single organism biosynthetic process GO:0044711 342 0.015
regulation of phospholipase a2 activity GO:0032429 1 0.015
nucleobase containing small molecule metabolic process GO:0055086 316 0.015
positive regulation of dendritic spine development GO:0060999 9 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.015
cellular protein localization GO:0034613 122 0.015
positive regulation of dendrite development GO:1900006 35 0.014
response to monosaccharide GO:0034284 159 0.014
regulation of dendritic spine development GO:0060998 16 0.014
lipid biosynthetic process GO:0008610 128 0.014
positive regulation of fatty acid metabolic process GO:0045923 14 0.014
cellular amine metabolic process GO:0044106 38 0.014
positive regulation of phosphate metabolic process GO:0045937 262 0.014
erythrocyte aggregation GO:0034117 1 0.014
organelle localization GO:0051640 55 0.014
behavior GO:0007610 205 0.014
vascular endothelial growth factor signaling pathway GO:0038084 4 0.014
regulation of angiogenesis GO:0045765 39 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.014
macromolecule catabolic process GO:0009057 58 0.014
Human
angiotensin maturation GO:0002003 2 0.013
peptide secretion GO:0002790 86 0.013
immune system process GO:0002376 204 0.013
Worm
growth GO:0040007 165 0.013
Zebrafish
mononuclear cell migration GO:0071674 3 0.013
cellular chemical homeostasis GO:0055082 247 0.013
regulation of lipid biosynthetic process GO:0046890 38 0.013
regulation of vesicle mediated transport GO:0060627 81 0.013
response to hyperoxia GO:0055093 45 0.013
signal release GO:0023061 145 0.013
amide transport GO:0042886 105 0.013
gamete generation GO:0007276 124 0.013
positive regulation of fatty acid biosynthetic process GO:0045723 7 0.012
insulin secretion GO:0030073 69 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
protein localization to plasma membrane GO:0072659 15 0.012
cellular response to external stimulus GO:0071496 118 0.012
establishment of protein localization to membrane GO:0090150 16 0.012
response to ketone GO:1901654 182 0.012
cellular homeostasis GO:0019725 252 0.012
prolactin secretion GO:0070459 2 0.012
establishment of organelle localization GO:0051656 37 0.012
negative regulation of blood coagulation GO:0030195 6 0.012
response to cgmp GO:0070305 3 0.012
positive regulation of dna metabolic process GO:0051054 39 0.012
nucleotide metabolic process GO:0009117 279 0.012
cardiovascular system development GO:0072358 134 0.012
regulation of leukocyte migration GO:0002685 24 0.012
regulation of cell adhesion GO:0030155 52 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
glycosyl compound catabolic process GO:1901658 126 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
central nervous system development GO:0007417 311 0.012
body fluid secretion GO:0007589 41 0.012
tetrapyrrole metabolic process GO:0033013 11 0.012
positive regulation of lipid metabolic process GO:0045834 33 0.012
regulation of fatty acid metabolic process GO:0019217 18 0.012
intracellular transport GO:0046907 185 0.011
positive regulation of epithelial cell migration GO:0010634 13 0.011
anatomical structure homeostasis GO:0060249 29 0.011
regulation of wound healing GO:0061041 14 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
neuronal action potential GO:0019228 35 0.011
epithelium migration GO:0090132 19 0.011
positive regulation of lipid kinase activity GO:0090218 2 0.011
response to starvation GO:0042594 59 0.011
positive regulation of cell adhesion GO:0045785 30 0.011
regulation of nucleic acid templated transcription GO:1903506 380 0.011
cellular component biogenesis GO:0044085 368 0.011
negative regulation of gene expression GO:0010629 199 0.011
circulatory system development GO:0072359 134 0.011
negative regulation of macromolecule metabolic process GO:0010605 260 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
developmental process involved in reproduction GO:0003006 159 0.011
Mouse
mononuclear cell proliferation GO:0032943 29 0.011
ameboidal type cell migration GO:0001667 26 0.011
positive regulation of biosynthetic process GO:0009891 319 0.011
regulation of anatomical structure size GO:0090066 135 0.011
endocrine system development GO:0035270 30 0.011
prostate gland development GO:0030850 9 0.011
regulation of epithelial cell migration GO:0010632 17 0.010
regulation of endocytosis GO:0030100 42 0.010
response to molecule of bacterial origin GO:0002237 194 0.010
negative regulation of molecular function GO:0044092 133 0.010
bone remodeling GO:0046849 23 0.010
regulation of actin cytoskeleton organization GO:0032956 30 0.010
secretion GO:0046903 307 0.010
macroautophagy GO:0016236 4 0.010
epithelial cell proliferation GO:0050673 54 0.010
bradykinin catabolic process GO:0010815 2 0.010
negative regulation of cell projection organization GO:0031345 50 0.010

Ctsb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.434
disease of anatomical entity DOID:7 0 0.238
nervous system disease DOID:863 0 0.238
inherited metabolic disorder DOID:655 0 0.206
lipid storage disease DOID:9455 0 0.192
lysosomal storage disease DOID:3211 0 0.192
hematopoietic system disease DOID:74 0 0.086
immune system disease DOID:2914 0 0.086
blood protein disease DOID:620 0 0.086
primary immunodeficiency disease DOID:612 0 0.046
b cell deficiency DOID:2115 0 0.046
agammaglobulinemia DOID:2583 0 0.046
brain disease DOID:936 0 0.038
central nervous system disease DOID:331 0 0.038
connective tissue disease DOID:65 0 0.035
musculoskeletal system disease DOID:17 0 0.035
sensory system disease DOID:0050155 0 0.022
eye and adnexa disease DOID:1492 0 0.016
epilepsy syndrome DOID:1826 0 0.014
electroclinical syndrome DOID:0050701 0 0.014
acquired metabolic disease DOID:0060158 0 0.013