Rattus norvegicus

12 known processes

Ctsd

cathepsin D

Ctsd biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to nutrient levels GO:0031667 370 0.556
Yeast Mouse
response to extracellular stimulus GO:0009991 380 0.360
Yeast Mouse
response to cytokine GO:0034097 215 0.307
response to nutrient GO:0007584 248 0.302
organic acid biosynthetic process GO:0016053 83 0.242
cellular response to external stimulus GO:0071496 118 0.237
Yeast Mouse
response to corticosteroid GO:0031960 235 0.194
single organism catabolic process GO:0044712 283 0.168
Yeast Mouse
regulation of apoptotic process GO:0042981 335 0.167
response to peptide hormone GO:0043434 278 0.154
cell projection organization GO:0030030 302 0.143
response to monosaccharide GO:0034284 159 0.142
response to carbohydrate GO:0009743 183 0.135
response to hypoxia GO:0001666 231 0.131
response to inorganic substance GO:0010035 377 0.128
response to oxygen levels GO:0070482 265 0.127
cellular response to stress GO:0033554 269 0.117
Yeast Mouse
response to reactive oxygen species GO:0000302 120 0.114
oxoacid metabolic process GO:0043436 290 0.112
response to glucocorticoid GO:0051384 223 0.108
monocarboxylic acid metabolic process GO:0032787 152 0.104
response to external biotic stimulus GO:0043207 221 0.095
Zebrafish Rat Fly
lipid metabolic process GO:0006629 283 0.091
cellular response to mechanical stimulus GO:0071260 48 0.089
response to decreased oxygen levels GO:0036293 237 0.088
response to growth factor GO:0070848 189 0.088
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.087
regeneration GO:0031099 163 0.087
regulation of cell proliferation GO:0042127 359 0.086
cellular response to endogenous stimulus GO:0071495 377 0.084
neuron development GO:0048666 286 0.080
cellular response to reactive oxygen species GO:0034614 55 0.080
cellular response to oxygen containing compound GO:1901701 386 0.077
small molecule biosynthetic process GO:0044283 124 0.076
central nervous system development GO:0007417 311 0.076
negative regulation of cell death GO:0060548 229 0.070
cell cell signaling GO:0007267 335 0.069
stress activated protein kinase signaling cascade GO:0031098 37 0.067
regulation of nervous system development GO:0051960 264 0.067
apoptotic process GO:0006915 381 0.065
Fly
response to hexose GO:0009746 144 0.065
carboxylic acid biosynthetic process GO:0046394 83 0.060
response to vitamin GO:0033273 131 0.059
response to mechanical stimulus GO:0009612 134 0.058
positive regulation of transport GO:0051050 245 0.056
catabolic process GO:0009056 351 0.055
protein phosphorylation GO:0006468 345 0.055
cellular response to hormone stimulus GO:0032870 247 0.055
developmental process involved in reproduction GO:0003006 159 0.055
Fly
response to oxidative stress GO:0006979 186 0.054
response to glucose GO:0009749 136 0.053
carboxylic acid metabolic process GO:0019752 289 0.053
regulation of programmed cell death GO:0043067 341 0.052
programmed cell death GO:0012501 392 0.051
Fly
glial cell differentiation GO:0010001 65 0.051
cellular response to nitrogen compound GO:1901699 210 0.051
autophagy GO:0006914 19 0.050
cellular catabolic process GO:0044248 295 0.050
organic acid metabolic process GO:0006082 292 0.049
cellular lipid metabolic process GO:0044255 208 0.049
negative regulation of response to stimulus GO:0048585 155 0.049
reproduction GO:0000003 245 0.048
Fly
gliogenesis GO:0042063 93 0.043
homeostatic process GO:0042592 331 0.043
response to vitamin a GO:0033189 36 0.042
gland development GO:0048732 155 0.042
Fly
regulation of cell differentiation GO:0045595 320 0.041
response to peptide GO:1901652 292 0.040
negative regulation of cell development GO:0010721 82 0.040
metal ion transport GO:0030001 289 0.038
positive regulation of cell projection organization GO:0031346 111 0.036
circadian rhythm GO:0007623 88 0.036
multicellular organism reproduction GO:0032504 233 0.036
Fly
neuron differentiation GO:0030182 368 0.036
signal release GO:0023061 145 0.036
hepaticobiliary system development GO:0061008 90 0.036
translation GO:0006412 35 0.035
positive regulation of cellular component organization GO:0051130 200 0.035
synaptic transmission GO:0007268 235 0.035
neuron projection development GO:0031175 273 0.035
single organism reproductive process GO:0044702 297 0.035
Fly
positive regulation of cell death GO:0010942 184 0.034
response to metal ion GO:0010038 253 0.034
regulation of neuron differentiation GO:0045664 208 0.034
positive regulation of multicellular organismal process GO:0051240 387 0.034
response to interleukin 1 GO:0070555 55 0.034
response to insulin GO:0032868 133 0.034
positive regulation of developmental process GO:0051094 283 0.033
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.033
response to organophosphorus GO:0046683 102 0.033
Rat
regulation of phosphorylation GO:0042325 248 0.033
cellular chemical homeostasis GO:0055082 247 0.033
negative regulation of neurogenesis GO:0050768 78 0.032
reactive oxygen species biosynthetic process GO:1903409 8 0.031
regulation of cellular component organization GO:0051128 368 0.031
reproductive system development GO:0061458 128 0.031
cellular component biogenesis GO:0044085 368 0.031
Mouse
head development GO:0060322 247 0.031
cation transport GO:0006812 382 0.031
regulation of peptide hormone secretion GO:0090276 80 0.031
positive regulation of apoptotic process GO:0043065 154 0.031
response to lipopolysaccharide GO:0032496 191 0.031
Rat
regulation of cell projection organization GO:0031344 175 0.030
tissue regeneration GO:0042246 36 0.029
cellular response to nutrient levels GO:0031669 60 0.029
Yeast Mouse
ribose phosphate metabolic process GO:0019693 235 0.028
cellular response to abiotic stimulus GO:0071214 85 0.028
positive regulation of peptide hormone secretion GO:0090277 50 0.028
reproductive structure development GO:0048608 128 0.028
cellular response to growth factor stimulus GO:0071363 162 0.028
regulation of cellular amine metabolic process GO:0033238 8 0.027
cellular response to nitric oxide GO:0071732 5 0.027
chemical homeostasis GO:0048878 292 0.027
positive regulation of programmed cell death GO:0043068 157 0.027
protein processing GO:0016485 68 0.026
Rat
multi organism reproductive process GO:0044703 262 0.026
Fly
cellular response to lipid GO:0071396 201 0.025
aging GO:0007568 241 0.025
chemotaxis GO:0006935 66 0.025
secretion GO:0046903 307 0.025
decidualization GO:0046697 14 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
negative regulation of neuron differentiation GO:0045665 62 0.023
positive regulation of nervous system development GO:0051962 178 0.023
membrane fusion GO:0061025 26 0.023
positive regulation of biosynthetic process GO:0009891 319 0.023
multi multicellular organism process GO:0044706 138 0.023
positive regulation of cell development GO:0010720 176 0.023
cellular amino acid metabolic process GO:0006520 107 0.023
multicellular organismal signaling GO:0035637 44 0.023
muscle tissue development GO:0060537 58 0.023
chromatin organization GO:0006325 34 0.023
positive regulation of cellular biosynthetic process GO:0031328 295 0.022
response to transition metal nanoparticle GO:1990267 122 0.022
vesicle mediated transport GO:0016192 181 0.022
hormone transport GO:0009914 121 0.022
male mating behavior GO:0060179 3 0.022
regulation of molecular function GO:0065009 398 0.022
organic substance catabolic process GO:1901575 316 0.022
Yeast
amide transport GO:0042886 105 0.022
reproductive process GO:0022414 372 0.022
Fly
nucleotide metabolic process GO:0009117 279 0.022
growth GO:0040007 165 0.022
negative regulation of cellular component organization GO:0051129 83 0.021
steroid metabolic process GO:0008202 73 0.021
developmental growth GO:0048589 100 0.021
wound healing GO:0042060 122 0.021
cellular component assembly GO:0022607 360 0.021
Mouse
actin filament branching GO:0090135 1 0.020
regulation of protein metabolic process GO:0051246 289 0.020
Rat
response to increased oxygen levels GO:0036296 45 0.020
nitrogen compound transport GO:0071705 229 0.020
negative regulation of cell proliferation GO:0008285 119 0.020
regulation of secretion by cell GO:1903530 208 0.020
reactive nitrogen species metabolic process GO:2001057 1 0.020
endocytosis GO:0006897 84 0.019
cholesterol homeostasis GO:0042632 3 0.019
brain development GO:0007420 247 0.019
insulin secretion GO:0030073 69 0.019
ion homeostasis GO:0050801 212 0.019
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.019
single organism biosynthetic process GO:0044711 342 0.019
placenta development GO:0001890 22 0.019
carbohydrate catabolic process GO:0016052 40 0.019
carbohydrate derivative catabolic process GO:1901136 147 0.019
cell part morphogenesis GO:0032990 123 0.018
enzyme linked receptor protein signaling pathway GO:0007167 116 0.018
regulation of anatomical structure size GO:0090066 135 0.018
regulation of multicellular organismal development GO:2000026 376 0.018
regulation of cell size GO:0008361 37 0.018
regulation of neurogenesis GO:0050767 247 0.018
response to acid chemical GO:0001101 222 0.018
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.018
anatomical structure morphogenesis GO:0009653 298 0.018
Fly
organ regeneration GO:0031100 101 0.018
regulation of ion transport GO:0043269 245 0.018
regulation of reactive oxygen species metabolic process GO:2000377 26 0.017
positive regulation of cell communication GO:0010647 271 0.017
regulation of extent of cell growth GO:0061387 25 0.017
regulation of growth GO:0040008 105 0.017
macroautophagy GO:0016236 4 0.017
Mouse
regulation of hormone secretion GO:0046883 106 0.017
action potential GO:0001508 54 0.017
female pregnancy GO:0007565 122 0.017
cellular ketone metabolic process GO:0042180 51 0.017
cellular homeostasis GO:0019725 252 0.017
protein homooligomerization GO:0051260 91 0.016
hexose metabolic process GO:0019318 58 0.016
organonitrogen compound biosynthetic process GO:1901566 167 0.016
carbohydrate derivative metabolic process GO:1901135 346 0.016
cell morphogenesis GO:0000902 142 0.016
oligodendrocyte differentiation GO:0048709 32 0.016
negative regulation of neuron projection development GO:0010977 46 0.016
biological adhesion GO:0022610 110 0.015
body fluid secretion GO:0007589 41 0.015
cellular response to hypoxia GO:0071456 51 0.015
endocrine system development GO:0035270 30 0.015
regulation of rna metabolic process GO:0051252 391 0.015
neuronal action potential GO:0019228 35 0.015
cell projection morphogenesis GO:0048858 123 0.015
multicellular organism growth GO:0035264 1 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
regulation of hormone levels GO:0010817 187 0.015
Rat
response to ethanol GO:0045471 162 0.015
regulation of axonogenesis GO:0050770 37 0.015
amine metabolic process GO:0009308 38 0.015
regulation of protein modification process GO:0031399 194 0.015
regulation of response to external stimulus GO:0032101 106 0.015
cellular component morphogenesis GO:0032989 155 0.015
response to wounding GO:0009611 254 0.015
transmission of nerve impulse GO:0019226 42 0.014
cellular response to inorganic substance GO:0071241 65 0.014
regulation of neuron projection development GO:0010975 161 0.014
axonogenesis GO:0007409 71 0.014
positive regulation of hormone secretion GO:0046887 65 0.014
regulation of cell growth GO:0001558 85 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
cellular amine metabolic process GO:0044106 38 0.014
locomotion GO:0040011 237 0.014
response to other organism GO:0051707 220 0.014
Zebrafish Rat Fly
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
collagen catabolic process GO:0030574 2 0.014
transcription from rna polymerase ii promoter GO:0006366 252 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.014
positive regulation of gene expression GO:0010628 244 0.014
peptide secretion GO:0002790 86 0.014
macromolecular complex subunit organization GO:0043933 339 0.014
purine containing compound metabolic process GO:0072521 253 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
multicellular organismal catabolic process GO:0044243 2 0.013
carbohydrate metabolic process GO:0005975 130 0.013
carboxylic acid transport GO:0046942 115 0.013
neuron projection regeneration GO:0031102 35 0.013
regulation of vesicle mediated transport GO:0060627 81 0.013
cellular response to extracellular stimulus GO:0031668 73 0.013
Yeast Mouse
positive regulation of neurogenesis GO:0050769 165 0.013
negative regulation of cell communication GO:0010648 158 0.013
cell growth GO:0016049 104 0.013
axon ensheathment GO:0008366 40 0.013
proteolysis GO:0006508 175 0.013
anion transport GO:0006820 178 0.013
response to light stimulus GO:0009416 52 0.013
hormone secretion GO:0046879 115 0.013
positive regulation of insulin secretion GO:0032024 36 0.013
regulation of cell development GO:0060284 263 0.013
salivary gland development GO:0007431 3 0.013
Fly
cell cell signaling involved in cell fate commitment GO:0045168 2 0.012
cellular response to insulin stimulus GO:0032869 81 0.012
cellular amino acid biosynthetic process GO:0008652 32 0.012
negative regulation of nervous system development GO:0051961 79 0.012
nucleoside phosphate metabolic process GO:0006753 283 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
fatty acid metabolic process GO:0006631 99 0.012
multicellular organismal macromolecule metabolic process GO:0044259 21 0.012
negative regulation of apoptotic process GO:0043066 181 0.012
regulation of lipid metabolic process GO:0019216 68 0.012
positive regulation of dna metabolic process GO:0051054 39 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
pattern recognition receptor signaling pathway GO:0002221 9 0.012
response to hyperoxia GO:0055093 45 0.012
generation of precursor metabolites and energy GO:0006091 62 0.012
regulation of peptide secretion GO:0002791 82 0.012
positive regulation of necrotic cell death GO:0010940 4 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.011
positive regulation of peptide secretion GO:0002793 52 0.011
secretion by cell GO:0032940 248 0.011
positive regulation of ion transport GO:0043270 94 0.011
neuron projection morphogenesis GO:0048812 122 0.011
response to estrogen GO:0043627 232 0.011
regulation of dna metabolic process GO:0051052 60 0.011
protein localization GO:0008104 191 0.011
dendrite development GO:0016358 72 0.011
steroid biosynthetic process GO:0006694 48 0.010
single organism intracellular transport GO:1902582 166 0.010
glycogen metabolic process GO:0005977 23 0.010
negative regulation of cell growth GO:0030308 33 0.010
striated muscle tissue development GO:0014706 58 0.010
negative regulation of multicellular organismal process GO:0051241 203 0.010
axon extension GO:0048675 26 0.010
regulation of rna biosynthetic process GO:2001141 381 0.010
peptide hormone secretion GO:0030072 84 0.010
negative regulation of signaling GO:0023057 157 0.010
negative regulation of axon guidance GO:1902668 3 0.010
positive regulation of molecular function GO:0044093 230 0.010
response to camp GO:0051591 91 0.010
Rat
maternal process involved in female pregnancy GO:0060135 38 0.010
response to estradiol GO:0032355 164 0.010
response to fibroblast growth factor GO:0071774 29 0.010
reactive oxygen species metabolic process GO:0072593 37 0.010

Ctsd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027
musculoskeletal system disease DOID:17 0 0.027
nervous system disease DOID:863 0 0.024
bone disease DOID:0080001 0 0.013
connective tissue disease DOID:65 0 0.013