Rattus norvegicus

39 known processes

Ctss

cathepsin S

Ctss biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of leukocyte chemotaxis GO:0002688 12 0.750
immune system process GO:0002376 204 0.616
programmed cell death GO:0012501 392 0.432
regulation of immune system process GO:0002682 123 0.396
negative regulation of immune system process GO:0002683 39 0.255
regulation of cell proliferation GO:0042127 359 0.216
cell activation GO:0001775 97 0.208
response to glucocorticoid GO:0051384 223 0.203
response to cytokine GO:0034097 215 0.199
cellular response to oxygen containing compound GO:1901701 386 0.186
cellular response to organic cyclic compound GO:0071407 202 0.184
leukocyte chemotaxis GO:0030595 22 0.182
anatomical structure morphogenesis GO:0009653 298 0.172
positive regulation of developmental process GO:0051094 283 0.167
regulation of cell differentiation GO:0045595 320 0.166
tissue remodeling GO:0048771 40 0.162
negative regulation of cell death GO:0060548 229 0.148
positive regulation of cell motility GO:2000147 97 0.146
defense response GO:0006952 194 0.138
vesicle mediated transport GO:0016192 181 0.133
positive regulation of leukocyte differentiation GO:1902107 13 0.132
negative regulation of apoptotic process GO:0043066 181 0.126
positive regulation of multicellular organismal process GO:0051240 387 0.118
negative regulation of neutrophil apoptotic process GO:0033030 3 0.117
neutrophil apoptotic process GO:0001781 4 0.109
cation homeostasis GO:0055080 195 0.108
negative regulation of programmed cell death GO:0043069 183 0.104
behavior GO:0007610 205 0.100
carboxylic acid metabolic process GO:0019752 289 0.097
regulation of locomotion GO:0040012 148 0.095
regulation of apoptotic process GO:0042981 335 0.093
antigen processing and presentation of peptide antigen GO:0048002 2 0.090
cellular response to stress GO:0033554 269 0.084
regulation of myeloid leukocyte differentiation GO:0002761 12 0.081
regulation of cellular component movement GO:0051270 150 0.080
complement activation GO:0006956 11 0.075
response to inorganic substance GO:0010035 377 0.074
cell type specific apoptotic process GO:0097285 134 0.067
regulation of cell activation GO:0050865 50 0.066
b cell mediated immunity GO:0019724 4 0.065
oxoacid metabolic process GO:0043436 290 0.065
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.064
positive regulation of cell differentiation GO:0045597 217 0.064
negative regulation of acute inflammatory response GO:0002674 4 0.062
signal transduction by phosphorylation GO:0023014 144 0.061
regulation of cellular component organization GO:0051128 368 0.060
apoptotic process GO:0006915 381 0.059
muscle cell proliferation GO:0033002 84 0.058
positive regulation of cell development GO:0010720 176 0.056
aging GO:0007568 241 0.055
response to peptide GO:1901652 292 0.055
immunoglobulin mediated immune response GO:0016064 4 0.054
leukocyte activation GO:0045321 76 0.053
response to metal ion GO:0010038 253 0.053
cell projection organization GO:0030030 302 0.052
brain development GO:0007420 247 0.052
mapk cascade GO:0000165 140 0.050
lymphocyte activation GO:0046649 43 0.049
response to wounding GO:0009611 254 0.048
regulation of lymphocyte activation GO:0051249 34 0.048
response to axon injury GO:0048678 59 0.047
positive regulation of immune system process GO:0002684 90 0.045
cellular response to external stimulus GO:0071496 118 0.045
cellular component assembly GO:0022607 360 0.044
intracellular transport GO:0046907 185 0.044
intracellular signal transduction GO:0035556 314 0.043
mononuclear cell proliferation GO:0032943 29 0.043
regulation of programmed cell death GO:0043067 341 0.043
central nervous system development GO:0007417 311 0.042
regulation of neuron differentiation GO:0045664 208 0.042
leukocyte migration GO:0050900 38 0.042
sleep GO:0030431 30 0.041
multicellular organismal homeostasis GO:0048871 49 0.040
positive regulation of response to stimulus GO:0048584 285 0.040
positive regulation of locomotion GO:0040017 102 0.040
negative regulation of multicellular organismal process GO:0051241 203 0.039
regulation of phosphorylation GO:0042325 248 0.037
positive regulation of neurogenesis GO:0050769 165 0.037
regulation of t cell activation GO:0050863 23 0.037
positive regulation of nervous system development GO:0051962 178 0.037
positive regulation of transport GO:0051050 245 0.037
organic hydroxy compound metabolic process GO:1901615 115 0.036
monocarboxylic acid metabolic process GO:0032787 152 0.036
homeostatic process GO:0042592 331 0.036
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 1 0.035
organic acid metabolic process GO:0006082 292 0.035
regulation of multicellular organismal development GO:2000026 376 0.035
negative regulation of developmental process GO:0051093 125 0.035
response to growth factor GO:0070848 189 0.034
regulation of body fluid levels GO:0050878 90 0.034
cellular metal ion homeostasis GO:0006875 172 0.034
metal ion homeostasis GO:0055065 186 0.034
fatty acid metabolic process GO:0006631 99 0.033
regulation of leukocyte differentiation GO:1902105 20 0.033
sensory organ development GO:0007423 74 0.033
response to retinoic acid GO:0032526 63 0.033
response to estrogen GO:0043627 232 0.033
receptor mediated endocytosis GO:0006898 42 0.033
endocytosis GO:0006897 84 0.032
positive regulation of cellular component movement GO:0051272 102 0.032
smooth muscle cell proliferation GO:0048659 77 0.032
positive regulation of neuron projection development GO:0010976 99 0.031
negative regulation of cell differentiation GO:0045596 99 0.031
regulation of anatomical structure morphogenesis GO:0022603 141 0.031
anatomical structure homeostasis GO:0060249 29 0.031
cellular amine metabolic process GO:0044106 38 0.030
neuron death GO:0070997 127 0.030
regulation of proteasomal protein catabolic process GO:0061136 4 0.030
negative regulation of homeostatic process GO:0032845 47 0.030
regulation of system process GO:0044057 208 0.029
amine metabolic process GO:0009308 38 0.029
regulation of neuron projection development GO:0010975 161 0.029
regulation of phosphate metabolic process GO:0019220 349 0.029
hematopoietic progenitor cell differentiation GO:0002244 2 0.029
cardiovascular system development GO:0072358 134 0.029
cellular cation homeostasis GO:0030003 180 0.029
autophagic cell death GO:0048102 4 0.029
neuron apoptotic process GO:0051402 88 0.028
calcium ion homeostasis GO:0055074 162 0.028
de novo posttranslational protein folding GO:0051084 2 0.028
positive regulation of phosphorus metabolic process GO:0010562 262 0.027
response to nutrient levels GO:0031667 370 0.027
regulation of mononuclear cell proliferation GO:0032944 26 0.027
response to corticosteroid GO:0031960 235 0.027
regulation of smooth muscle cell proliferation GO:0048660 75 0.027
regulation of neurogenesis GO:0050767 247 0.027
negative regulation of cell proliferation GO:0008285 119 0.026
negative regulation of response to stimulus GO:0048585 155 0.026
regulation of lymphocyte proliferation GO:0050670 26 0.026
rna metabolic process GO:0016070 406 0.026
vascular endothelial growth factor signaling pathway GO:0038084 4 0.026
cellular response to vascular endothelial growth factor stimulus GO:0035924 6 0.026
regulation of lymphocyte migration GO:2000401 1 0.026
regulation of signal transduction GO:0009966 318 0.026
cellular response to alcohol GO:0097306 87 0.026
positive regulation of leukocyte migration GO:0002687 21 0.025
neurological system process GO:0050877 219 0.025
cellular response to organonitrogen compound GO:0071417 197 0.025
negative regulation of leukocyte apoptotic process GO:2000107 4 0.025
response to oxidative stress GO:0006979 186 0.025
response to extracellular stimulus GO:0009991 380 0.024
protein phosphorylation GO:0006468 345 0.024
immune response GO:0006955 104 0.024
regulation of ion transport GO:0043269 245 0.024
chemical homeostasis GO:0048878 292 0.023
cation transport GO:0006812 382 0.023
t cell activation GO:0042110 29 0.023
monovalent inorganic cation transport GO:0015672 172 0.023
locomotion GO:0040011 237 0.023
regulation of b cell mediated immunity GO:0002712 2 0.023
comma shaped body morphogenesis GO:0072049 2 0.023
g protein coupled receptor signaling pathway GO:0007186 242 0.023
single organism catabolic process GO:0044712 283 0.022
protein complex biogenesis GO:0070271 263 0.022
salivary gland development GO:0007431 3 0.022
regulation of t cell proliferation GO:0042129 17 0.021
regulation of cellular amino acid metabolic process GO:0006521 2 0.021
macromolecular complex assembly GO:0065003 273 0.021
regulation of myeloid cell differentiation GO:0045637 12 0.021
regulation of mitotic cell cycle phase transition GO:1901990 11 0.021
response to hexose GO:0009746 144 0.021
regulation of immune response GO:0050776 55 0.020
negative regulation of innate immune response GO:0045824 4 0.020
myeloid cell apoptotic process GO:0033028 6 0.020
neuron projection development GO:0031175 273 0.020
positive regulation of signaling GO:0023056 270 0.020
positive regulation of neuron differentiation GO:0045666 126 0.020
positive regulation of cellular component organization GO:0051130 200 0.020
positive regulation of biosynthetic process GO:0009891 319 0.020
cellular response to oxidative stress GO:0034599 76 0.020
head development GO:0060322 247 0.020
response to carbohydrate GO:0009743 183 0.020
cellular calcium ion homeostasis GO:0006874 160 0.020
response to ethanol GO:0045471 162 0.020
amino acid transport GO:0006865 70 0.020
muscle system process GO:0003012 115 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
cellular amino acid metabolic process GO:0006520 107 0.019
regulation of cytokine production GO:0001817 56 0.019
single organism biosynthetic process GO:0044711 342 0.019
cellular response to endogenous stimulus GO:0071495 377 0.019
positive regulation of cell migration GO:0030335 96 0.019
regulation of release of sequestered calcium ion into cytosol GO:0051279 18 0.019
cellular chemical homeostasis GO:0055082 247 0.019
metal ion transport GO:0030001 289 0.019
regulation of leukocyte activation GO:0002694 45 0.018
cellular response to growth factor stimulus GO:0071363 162 0.018
glycerophospholipid metabolic process GO:0006650 47 0.018
regulation of peptide transport GO:0090087 87 0.018
reactive nitrogen species metabolic process GO:2001057 1 0.018
regulation of intracellular signal transduction GO:1902531 218 0.018
reactive oxygen species metabolic process GO:0072593 37 0.018
regulation of neuron death GO:1901214 115 0.018
response to organophosphorus GO:0046683 102 0.018
macromolecular complex subunit organization GO:0043933 339 0.018
immune effector process GO:0002252 53 0.017
protein complex subunit organization GO:0071822 302 0.017
organic substance catabolic process GO:1901575 316 0.017
single organism organelle organization GO:1902589 180 0.017
leukocyte proliferation GO:0070661 29 0.017
response to reactive oxygen species GO:0000302 120 0.017
response to external biotic stimulus GO:0043207 221 0.017
negative regulation of metabolic process GO:0009892 331 0.017
immune system development GO:0002520 41 0.017
positive regulation of lymphocyte migration GO:2000403 1 0.017
divalent inorganic cation homeostasis GO:0072507 165 0.017
respiratory system development GO:0060541 45 0.016
protein polymerization GO:0051258 22 0.016
cell morphogenesis GO:0000902 142 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
negative regulation of macromolecule metabolic process GO:0010605 260 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
cellular response to lipid GO:0071396 201 0.016
endoplasmic reticulum to cytosol transport GO:1903513 4 0.016
response to glucose GO:0009749 136 0.016
leukocyte mediated immunity GO:0002443 28 0.016
negative regulation of neuron death GO:1901215 69 0.015
negative regulation of signal transduction GO:0009968 83 0.015
response to hydrogen peroxide GO:0042542 89 0.015
antigen processing and presentation of peptide antigen via mhc class ii GO:0002495 1 0.015
negative regulation of transport GO:0051051 136 0.015
positive regulation of lymphocyte proliferation GO:0050671 20 0.015
antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002504 1 0.015
localization of cell GO:0051674 202 0.015
erk1 and erk2 cascade GO:0070371 48 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
cytokine production GO:0001816 61 0.015
muscle structure development GO:0061061 87 0.015
response to vitamin GO:0033273 131 0.015
vascular process in circulatory system GO:0003018 96 0.015
cellular response to nutrient GO:0031670 30 0.015
regulation of cellular protein metabolic process GO:0032268 267 0.015
response to camp GO:0051591 91 0.015
inner ear development GO:0048839 21 0.014
pseudopodium assembly GO:0031269 3 0.014
aromatic compound catabolic process GO:0019439 168 0.014
cellular response to molecule of bacterial origin GO:0071219 56 0.014
reproductive structure development GO:0048608 128 0.014
regulation of heart morphogenesis GO:2000826 2 0.014
cellular response to extracellular stimulus GO:0031668 73 0.014
anion transport GO:0006820 178 0.014
regulation of cellular ketone metabolic process GO:0010565 27 0.014
regulation of phosphorus metabolic process GO:0051174 349 0.014
response to interferon gamma GO:0034341 20 0.014
regulation of acute inflammatory response GO:0002673 23 0.014
blood vessel morphogenesis GO:0048514 58 0.014
cellular response to abiotic stimulus GO:0071214 85 0.014
cellular protein complex assembly GO:0043623 44 0.014
response to estradiol GO:0032355 164 0.014
response to ammonium ion GO:0060359 71 0.014
transcription dna templated GO:0006351 377 0.014
sodium ion transport GO:0006814 82 0.014
protein complex assembly GO:0006461 263 0.014
ion homeostasis GO:0050801 212 0.014
regulation of homeostatic process GO:0032844 101 0.014
p38mapk cascade GO:0038066 1 0.014
blood circulation GO:0008015 183 0.014
humoral immune response mediated by circulating immunoglobulin GO:0002455 2 0.013
potassium ion transport GO:0006813 97 0.013
regulation of neuron apoptotic process GO:0043523 83 0.013
inflammatory response GO:0006954 150 0.013
neuron differentiation GO:0030182 368 0.013
negative regulation of neuron apoptotic process GO:0043524 45 0.013
cellular component movement GO:0006928 248 0.013
tube development GO:0035295 89 0.013
secretion by cell GO:0032940 248 0.013
response to peptide hormone GO:0043434 278 0.013
cell motility GO:0048870 202 0.013
adaptive immune response GO:0002250 14 0.013
leukocyte differentiation GO:0002521 30 0.013
circulatory system process GO:0003013 183 0.013
multicellular organismal macromolecule metabolic process GO:0044259 21 0.013
cellular response to nutrient levels GO:0031669 60 0.012
collagen metabolic process GO:0032963 21 0.012
antigen processing and presentation of exogenous peptide antigen GO:0002478 1 0.012
positive regulation of smooth muscle cell migration GO:0014911 27 0.012
ossification GO:0001503 70 0.012
phagocytosis GO:0006909 17 0.012
chemotaxis GO:0006935 66 0.012
glycerolipid metabolic process GO:0046486 67 0.012
nucleotide metabolic process GO:0009117 279 0.012
carboxylic acid biosynthetic process GO:0046394 83 0.012
response to monosaccharide GO:0034284 159 0.012
mitotic cell cycle GO:0000278 49 0.012
blood vessel development GO:0001568 69 0.012
positive regulation of proteasomal protein catabolic process GO:1901800 3 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.012
regulation of interleukin 8 production GO:0032677 2 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
response to decreased oxygen levels GO:0036293 237 0.012
lymphocyte mediated immunity GO:0002449 14 0.012
lymphocyte proliferation GO:0046651 29 0.012
cellular response to peptide GO:1901653 133 0.012
toxin catabolic process GO:0009407 1 0.012
regulation of immunoglobulin production GO:0002637 4 0.012
regulation of nervous system development GO:0051960 264 0.011
organ morphogenesis GO:0009887 75 0.011
response to osmotic stress GO:0006970 42 0.011
bone remodeling GO:0046849 23 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
regulation of vesicle mediated transport GO:0060627 81 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
macromolecule catabolic process GO:0009057 58 0.011
platelet derived growth factor receptor alpha signaling pathway GO:0035790 1 0.011
inorganic cation transmembrane transport GO:0098662 202 0.011
phospholipid metabolic process GO:0006644 61 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
cytoplasmic transport GO:0016482 115 0.011
mitotic cell cycle phase transition GO:0044772 20 0.011
regulation of adaptive immune response GO:0002819 8 0.011
transmembrane transport GO:0055085 412 0.011
negative regulation of myeloid cell differentiation GO:0045638 3 0.011
antigen processing and presentation of exogenous antigen GO:0019884 1 0.011
cellular response to insulin stimulus GO:0032869 81 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
nitrogen compound transport GO:0071705 229 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
positive regulation of chemotaxis GO:0050921 23 0.011
regulation of protein catabolic process GO:0042176 16 0.011
lung development GO:0030324 43 0.011
tissue development GO:0009888 252 0.010
regulation of catabolic process GO:0009894 113 0.010
positive regulation of hormone secretion GO:0046887 65 0.010
metanephric glomerulus morphogenesis GO:0072275 1 0.010
chaperone mediated protein folding requiring cofactor GO:0051085 2 0.010
dorsal ventral pattern formation GO:0009953 4 0.010
catabolic process GO:0009056 351 0.010
hematopoietic or lymphoid organ development GO:0048534 36 0.010
cellular homeostasis GO:0019725 252 0.010
multicellular organismal reproductive process GO:0048609 233 0.010

Ctss disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.013