Rattus norvegicus

0 known processes

Defa

defensin, alpha 5, Paneth cell-specific

Defa biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to hypoxia GO:0001666 231 0.161
response to other organism GO:0051707 220 0.161
Human
cellular response to lipid GO:0071396 201 0.151
positive regulation of cell differentiation GO:0045597 217 0.145
regulation of cell development GO:0060284 263 0.141
regulation of cell differentiation GO:0045595 320 0.141
regulation of rna biosynthetic process GO:2001141 381 0.141
regulation of rna metabolic process GO:0051252 391 0.131
response to biotic stimulus GO:0009607 226 0.125
Human
regulation of transcription dna templated GO:0006355 374 0.125
transcription from rna polymerase ii promoter GO:0006366 252 0.124
response to external biotic stimulus GO:0043207 221 0.121
Human
response to estrogen GO:0043627 232 0.117
rna metabolic process GO:0016070 406 0.115
regulation of nucleic acid templated transcription GO:1903506 380 0.111
response to bacterium GO:0009617 200 0.106
Human
positive regulation of developmental process GO:0051094 283 0.099
cellular response to endogenous stimulus GO:0071495 377 0.097
response to lipopolysaccharide GO:0032496 191 0.090
positive regulation of multicellular organismal process GO:0051240 387 0.088
organ regeneration GO:0031100 101 0.087
positive regulation of nervous system development GO:0051962 178 0.085
negative regulation of multicellular organismal process GO:0051241 203 0.085
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.085
response to mechanical stimulus GO:0009612 134 0.084
regulation of multicellular organismal development GO:2000026 376 0.081
response to oxygen levels GO:0070482 265 0.080
negative regulation of cell proliferation GO:0008285 119 0.077
regulation of neurogenesis GO:0050767 247 0.073
response to nutrient GO:0007584 248 0.073
regulation of nervous system development GO:0051960 264 0.073
reproductive process GO:0022414 372 0.070
immune system process GO:0002376 204 0.068
Human
negative regulation of cellular metabolic process GO:0031324 281 0.068
negative regulation of rna metabolic process GO:0051253 123 0.067
response to extracellular stimulus GO:0009991 380 0.066
response to retinoic acid GO:0032526 63 0.063
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.062
positive regulation of neurogenesis GO:0050769 165 0.061
response to decreased oxygen levels GO:0036293 237 0.059
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.059
nucleotide biosynthetic process GO:0009165 98 0.058
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.058
response to molecule of bacterial origin GO:0002237 194 0.057
ribonucleotide biosynthetic process GO:0009260 85 0.057
negative regulation of biosynthetic process GO:0009890 168 0.055
immune response GO:0006955 104 0.054
Human
gland development GO:0048732 155 0.053
transcription dna templated GO:0006351 377 0.053
positive regulation of cellular component organization GO:0051130 200 0.052
negative regulation of nucleic acid templated transcription GO:1903507 117 0.052
cellular response to steroid hormone stimulus GO:0071383 93 0.052
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.052
neuron differentiation GO:0030182 368 0.051
negative regulation of developmental process GO:0051093 125 0.051
regulation of cytokine production GO:0001817 56 0.048
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.048
response to wounding GO:0009611 254 0.046
nucleoside phosphate biosynthetic process GO:1901293 102 0.046
regulation of cell proliferation GO:0042127 359 0.046
cellular response to organic cyclic compound GO:0071407 202 0.044
response to purine containing compound GO:0014074 126 0.044
response to nutrient levels GO:0031667 370 0.044
hepaticobiliary system development GO:0061008 90 0.044
carboxylic acid metabolic process GO:0019752 289 0.043
memory GO:0007613 54 0.043
cytokine production GO:0001816 61 0.042
cellular response to biotic stimulus GO:0071216 59 0.040
negative regulation of macromolecule metabolic process GO:0010605 260 0.039
regeneration GO:0031099 163 0.037
rna biosynthetic process GO:0032774 380 0.037
organophosphate biosynthetic process GO:0090407 143 0.036
cellular response to nitrogen compound GO:1901699 210 0.036
negative regulation of cellular biosynthetic process GO:0031327 161 0.036
negative regulation of gene expression GO:0010629 199 0.035
response to metal ion GO:0010038 253 0.034
defense response GO:0006952 194 0.034
Human
positive regulation of endocytosis GO:0045807 28 0.034
regulation of protein metabolic process GO:0051246 289 0.034
negative regulation of transcription dna templated GO:0045892 116 0.033
regulation of inflammatory response GO:0050727 48 0.032
positive regulation of rna metabolic process GO:0051254 203 0.032
positive regulation of cell death GO:0010942 184 0.031
response to acid chemical GO:0001101 222 0.031
inflammatory response GO:0006954 150 0.031
purine nucleotide biosynthetic process GO:0006164 83 0.030
regulation of blood pressure GO:0008217 83 0.030
positive regulation of nucleic acid templated transcription GO:1903508 197 0.029
cellular component assembly GO:0022607 360 0.029
regulation of cellular localization GO:0060341 263 0.028
positive regulation of biosynthetic process GO:0009891 319 0.028
single organism biosynthetic process GO:0044711 342 0.027
positive regulation of response to stimulus GO:0048584 285 0.027
positive regulation of apoptotic process GO:0043065 154 0.027
positive regulation of phagocytosis engulfment GO:0060100 4 0.027
positive regulation of isotype switching GO:0045830 1 0.027
cellular ion homeostasis GO:0006873 184 0.026
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.026
organic acid metabolic process GO:0006082 292 0.026
rhythmic process GO:0048511 156 0.026
oxoacid metabolic process GO:0043436 290 0.026
jak stat cascade GO:0007259 26 0.026
vascular process in circulatory system GO:0003018 96 0.026
anion transmembrane transport GO:0098656 77 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
response to transition metal nanoparticle GO:1990267 122 0.025
epithelial cell proliferation GO:0050673 54 0.025
carbohydrate metabolic process GO:0005975 130 0.025
positive regulation of signaling GO:0023056 270 0.025
negative regulation of metabolic process GO:0009892 331 0.025
regulation of cellular protein metabolic process GO:0032268 267 0.025
regulation of angiogenesis GO:0045765 39 0.025
regulation of immune system process GO:0002682 123 0.025
biological adhesion GO:0022610 110 0.024
negative regulation of cell differentiation GO:0045596 99 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
macromolecular complex subunit organization GO:0043933 339 0.023
positive regulation of cellular protein metabolic process GO:0032270 167 0.023
cellular response to hormone stimulus GO:0032870 247 0.023
liver development GO:0001889 90 0.023
negative regulation of rna biosynthetic process GO:1902679 118 0.023
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.023
positive regulation of cell development GO:0010720 176 0.023
regulation of behavior GO:0050795 61 0.023
behavior GO:0007610 205 0.023
secretion by cell GO:0032940 248 0.022
purine containing compound biosynthetic process GO:0072522 85 0.022
regulation of secretion GO:0051046 224 0.022
neuron projection development GO:0031175 273 0.022
regulation of cellular component organization GO:0051128 368 0.021
response to growth factor GO:0070848 189 0.021
cgmp biosynthetic process GO:0006182 15 0.021
cytosolic calcium ion homeostasis GO:0051480 140 0.021
regulation of anatomical structure morphogenesis GO:0022603 141 0.021
tissue development GO:0009888 252 0.021
neuron development GO:0048666 286 0.021
programmed cell death GO:0012501 392 0.021
regulation of smooth muscle contraction GO:0006940 29 0.020
response to carbohydrate GO:0009743 183 0.020
positive regulation of transcription dna templated GO:0045893 197 0.020
cyclic nucleotide biosynthetic process GO:0009190 63 0.020
response to peptide GO:1901652 292 0.020
regulation of homotypic cell cell adhesion GO:0034110 4 0.020
chemosensory behavior GO:0007635 2 0.020
amine metabolic process GO:0009308 38 0.020
proteolysis GO:0006508 175 0.020
positive regulation of phosphate metabolic process GO:0045937 262 0.020
cellular response to acid chemical GO:0071229 75 0.019
multicellular organismal reproductive process GO:0048609 233 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.019
nitrogen compound transport GO:0071705 229 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
neurological system process GO:0050877 219 0.019
multi organism reproductive process GO:0044703 262 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
single organism reproductive process GO:0044702 297 0.019
positive regulation of secretion GO:0051047 140 0.018
protein homotrimerization GO:0070207 15 0.018
purine containing compound metabolic process GO:0072521 253 0.018
positive regulation of rna biosynthetic process GO:1902680 197 0.018
protein oligomerization GO:0051259 191 0.018
apoptotic process GO:0006915 381 0.018
nucleic acid templated transcription GO:0097659 379 0.018
response to fatty acid GO:0070542 65 0.018
cellular amino acid metabolic process GO:0006520 107 0.018
regulation of vasculature development GO:1901342 44 0.018
embryonic pattern specification GO:0009880 1 0.018
negative regulation of nervous system development GO:0051961 79 0.018
positive regulation of cytokine production GO:0001819 42 0.017
head development GO:0060322 247 0.017
anterior posterior pattern specification GO:0009952 1 0.017
response to inorganic substance GO:0010035 377 0.017
positive regulation of cell communication GO:0010647 271 0.017
response to vitamin GO:0033273 131 0.017
cellular response to organonitrogen compound GO:0071417 197 0.017
cell chemotaxis GO:0060326 31 0.017
protein complex biogenesis GO:0070271 263 0.017
protein complex assembly GO:0006461 263 0.017
nucleotide metabolic process GO:0009117 279 0.017
cellular response to vitamin e GO:0071306 3 0.017
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure GO:0001999 1 0.017
secretion GO:0046903 307 0.017
cellular component biogenesis GO:0044085 368 0.017
carbohydrate derivative metabolic process GO:1901135 346 0.017
cellular response to cgmp GO:0071321 2 0.016
cellular response to glucocorticoid stimulus GO:0071385 68 0.016
cell activation GO:0001775 97 0.016
cellular response to ketone GO:1901655 51 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.016
cellular response to stress GO:0033554 269 0.016
regulation of endothelial cell apoptotic process GO:2000351 3 0.016
response to activity GO:0014823 73 0.016
anatomical structure morphogenesis GO:0009653 298 0.016
immunoglobulin mediated immune response GO:0016064 4 0.016
ribose phosphate metabolic process GO:0019693 235 0.016
response to ethanol GO:0045471 162 0.016
innate immune response GO:0045087 35 0.016
Human
macromolecular complex assembly GO:0065003 273 0.016
regulation of apoptotic process GO:0042981 335 0.015
cellular response to corticosteroid stimulus GO:0071384 69 0.015
regulation of tube size GO:0035150 89 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
platelet aggregation GO:0070527 4 0.015
regulation of secretion by cell GO:1903530 208 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
cellular response to peptide hormone stimulus GO:0071375 120 0.015
positive regulation of hydrolase activity GO:0051345 86 0.015
axis specification GO:0009798 4 0.015
muscle system process GO:0003012 115 0.015
ribose phosphate biosynthetic process GO:0046390 87 0.015
response to hyperoxia GO:0055093 45 0.015
positive regulation of cell projection organization GO:0031346 111 0.015
positive regulation of immunoglobulin production GO:0002639 4 0.015
regulation of catalytic activity GO:0050790 304 0.015
regulation of peptide secretion GO:0002791 82 0.015
nucleobase containing small molecule metabolic process GO:0055086 316 0.015
regulation of hormone levels GO:0010817 187 0.015
response to tumor necrosis factor GO:0034612 56 0.014
activation of cysteine type endopeptidase activity GO:0097202 4 0.014
central nervous system development GO:0007417 311 0.014
cellular homeostasis GO:0019725 252 0.014
response to organophosphorus GO:0046683 102 0.014
positive regulation of transport GO:0051050 245 0.014
positive regulation of gene expression GO:0010628 244 0.014
negative regulation of collagen biosynthetic process GO:0032966 4 0.014
response to peptide hormone GO:0043434 278 0.014
spinal cord development GO:0021510 27 0.014
regulation of synaptic plasticity GO:0048167 70 0.014
cell cycle GO:0007049 101 0.014
ovulation cycle GO:0042698 67 0.014
cellular response to cytokine stimulus GO:0071345 127 0.014
regulation of muscle system process GO:0090257 79 0.014
regulation of neuron projection development GO:0010975 161 0.014
smooth muscle cell proliferation GO:0048659 77 0.014
regulation of nucleotide biosynthetic process GO:0030808 47 0.014
regulation of fat cell differentiation GO:0045598 3 0.013
cardiovascular system development GO:0072358 134 0.013
response to vitamin a GO:0033189 36 0.013
regulation of body fluid levels GO:0050878 90 0.013
regulation of proteolysis GO:0030162 66 0.013
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 2 0.013
purine ribonucleotide metabolic process GO:0009150 227 0.013
transmembrane transport GO:0055085 412 0.013
cellular response to peptide GO:1901653 133 0.013
cellular response to oxygen containing compound GO:1901701 386 0.013
sexual reproduction GO:0019953 148 0.013
negative regulation of neurogenesis GO:0050768 78 0.013
positive regulation of calcium ion transport GO:0051928 36 0.013
response to zinc ion GO:0010043 39 0.013
regulation of response to wounding GO:1903034 69 0.013
aging GO:0007568 241 0.013
response to interferon gamma GO:0034341 20 0.013
regulation of g protein coupled receptor protein signaling pathway GO:0008277 28 0.013
response to estradiol GO:0032355 164 0.013
cell adhesion GO:0007155 110 0.013
learning or memory GO:0007611 90 0.013
regulation of response to external stimulus GO:0032101 106 0.013
regulation of anatomical structure size GO:0090066 135 0.013
cell type specific apoptotic process GO:0097285 134 0.012
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.012
response to amino acid GO:0043200 75 0.012
regulation of phosphate metabolic process GO:0019220 349 0.012
cell cell signaling GO:0007267 335 0.012
regulation of neuron differentiation GO:0045664 208 0.012
regulation of endocytosis GO:0030100 42 0.012
regulation of vesicle mediated transport GO:0060627 81 0.012
organophosphate metabolic process GO:0019637 370 0.012
positive regulation of cellular amine metabolic process GO:0033240 3 0.012
circadian rhythm GO:0007623 88 0.012
regulation of smooth muscle cell migration GO:0014910 36 0.012
gastric inhibitory peptide signaling pathway GO:0038192 1 0.012
regulation of phagocytosis engulfment GO:0060099 4 0.012
protein heterooligomerization GO:0051291 89 0.012
regulation of peptidase activity GO:0052547 55 0.012
regulation of blood vessel size GO:0050880 89 0.012
regulation of defense response GO:0031347 68 0.012
regulation of synaptic transmission GO:0050804 141 0.011
positive regulation of alpha beta t cell activation GO:0046635 2 0.011
regulation of cellular ketone metabolic process GO:0010565 27 0.011
endothelial cell apoptotic process GO:0072577 3 0.011
wound healing GO:0042060 122 0.011
reproduction GO:0000003 245 0.011
regulation of programmed cell death GO:0043067 341 0.011
positive regulation of behavior GO:0048520 38 0.011
muscle cell migration GO:0014812 36 0.011
cell cycle checkpoint GO:0000075 2 0.011
regulation of anion transport GO:0044070 43 0.011
sequestering of metal ion GO:0051238 9 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
synaptic transmission GO:0007268 235 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
female pregnancy GO:0007565 122 0.011
regulation of immunoglobulin production GO:0002637 4 0.011
response to cytokine GO:0034097 215 0.011
regulation of necroptotic process GO:0060544 2 0.011
positive regulation of smooth muscle cell migration GO:0014911 27 0.011
bmp signaling pathway GO:0030509 4 0.011
rna localization GO:0006403 4 0.011
response to toxic substance GO:0009636 133 0.011
response to cgmp GO:0070305 3 0.010
cytokine mediated signaling pathway GO:0019221 43 0.010
cellular amine metabolic process GO:0044106 38 0.010
regulation of signal transduction GO:0009966 318 0.010
regulation of cell cycle GO:0051726 73 0.010
macromolecule localization GO:0033036 252 0.010
protein transport GO:0015031 132 0.010
protein localization GO:0008104 191 0.010
positive regulation of response to external stimulus GO:0032103 51 0.010
regulation of system process GO:0044057 208 0.010
cellular chemical homeostasis GO:0055082 247 0.010
g protein coupled receptor signaling pathway GO:0007186 242 0.010
positive regulation of molecular function GO:0044093 230 0.010
cellular response to growth factor stimulus GO:0071363 162 0.010
b cell mediated immunity GO:0019724 4 0.010
protein maturation GO:0051604 68 0.010
chemical homeostasis GO:0048878 292 0.010
negative adaptation of signaling pathway GO:0022401 10 0.010
serotonin secretion GO:0001820 6 0.010

Defa disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.051
musculoskeletal system disease DOID:17 0 0.051
connective tissue disease DOID:65 0 0.030
nervous system disease DOID:863 0 0.025
bone disease DOID:0080001 0 0.024
bone development disease DOID:0080006 0 0.016
disease of metabolism DOID:0014667 0 0.013
inherited metabolic disorder DOID:655 0 0.013