Rattus norvegicus

0 known processes

Defb4

defensin beta 4

(Aliases: Defb2,Defb3)

Defb4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
monocarboxylic acid metabolic process GO:0032787 152 0.596
response to glucocorticoid GO:0051384 223 0.359
response to acid chemical GO:0001101 222 0.290
cellular lipid metabolic process GO:0044255 208 0.289
oxoacid metabolic process GO:0043436 290 0.288
central nervous system development GO:0007417 311 0.226
carboxylic acid metabolic process GO:0019752 289 0.218
protein complex assembly GO:0006461 263 0.215
response to ionizing radiation GO:0010212 59 0.201
inorganic ion transmembrane transport GO:0098660 229 0.186
neuron differentiation GO:0030182 368 0.183
organic acid metabolic process GO:0006082 292 0.182
icosanoid metabolic process GO:0006690 38 0.172
carboxylic acid transport GO:0046942 115 0.170
organic acid biosynthetic process GO:0016053 83 0.167
response to inorganic substance GO:0010035 377 0.166
monovalent inorganic cation transport GO:0015672 172 0.158
protein complex biogenesis GO:0070271 263 0.155
response to reactive oxygen species GO:0000302 120 0.152
response to nutrient GO:0007584 248 0.151
cellular response to oxygen containing compound GO:1901701 386 0.147
regulation of molecular function GO:0065009 398 0.144
response to corticosteroid GO:0031960 235 0.141
response to retinoic acid GO:0032526 63 0.138
organic anion transport GO:0015711 132 0.136
response to purine containing compound GO:0014074 126 0.132
response to growth factor GO:0070848 189 0.132
reproductive process GO:0022414 372 0.125
response to radiation GO:0009314 137 0.124
response to extracellular stimulus GO:0009991 380 0.124
response to cytokine GO:0034097 215 0.123
response to peptide hormone GO:0043434 278 0.123
organic acid transport GO:0015849 116 0.119
cellular component biogenesis GO:0044085 368 0.117
fatty acid derivative metabolic process GO:1901568 38 0.116
protein complex subunit organization GO:0071822 302 0.115
response to oxidative stress GO:0006979 186 0.111
inorganic cation transmembrane transport GO:0098662 202 0.109
lipid biosynthetic process GO:0008610 128 0.108
regulation of membrane potential GO:0042391 110 0.104
potassium ion transport GO:0006813 97 0.103
small molecule biosynthetic process GO:0044283 124 0.103
organonitrogen compound biosynthetic process GO:1901566 167 0.099
wound healing GO:0042060 122 0.099
cellular component assembly GO:0022607 360 0.098
ion transmembrane transport GO:0034220 365 0.098
cation transport GO:0006812 382 0.098
fatty acid metabolic process GO:0006631 99 0.097
cellular ketone metabolic process GO:0042180 51 0.096
response to lipopolysaccharide GO:0032496 191 0.096
response to mineralocorticoid GO:0051385 49 0.094
nucleic acid templated transcription GO:0097659 379 0.093
negative regulation of rna metabolic process GO:0051253 123 0.092
regulation of protein metabolic process GO:0051246 289 0.090
negative regulation of metabolic process GO:0009892 331 0.088
chemical homeostasis GO:0048878 292 0.088
carboxylic acid biosynthetic process GO:0046394 83 0.086
glial cell differentiation GO:0010001 65 0.086
single organism reproductive process GO:0044702 297 0.083
protein oligomerization GO:0051259 191 0.081
amine metabolic process GO:0009308 38 0.080
response to molecule of bacterial origin GO:0002237 194 0.079
regulation of potassium ion transport GO:0043266 29 0.078
cellular response to growth factor stimulus GO:0071363 162 0.078
anion transport GO:0006820 178 0.078
proteolysis GO:0006508 175 0.077
forebrain development GO:0030900 98 0.076
cellular response to endogenous stimulus GO:0071495 377 0.075
macromolecular complex assembly GO:0065003 273 0.075
cellular response to abiotic stimulus GO:0071214 85 0.072
monocarboxylic acid transport GO:0015718 52 0.070
metal ion transport GO:0030001 289 0.068
reproductive system development GO:0061458 128 0.068
response to nicotine GO:0035094 51 0.068
brain development GO:0007420 247 0.065
regulation of ion transport GO:0043269 245 0.064
acid secretion GO:0046717 48 0.063
neuron development GO:0048666 286 0.063
response to nutrient levels GO:0031667 370 0.062
lipid localization GO:0010876 62 0.061
protein homooligomerization GO:0051260 91 0.058
lipid transport GO:0006869 61 0.057
cell projection organization GO:0030030 302 0.056
response to peptide GO:1901652 292 0.056
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.056
cellular response to stress GO:0033554 269 0.055
negative regulation of transcription dna templated GO:0045892 116 0.054
regulation of cellular component movement GO:0051270 150 0.054
regulation of transcription dna templated GO:0006355 374 0.053
macromolecular complex subunit organization GO:0043933 339 0.052
cell cell signaling GO:0007267 335 0.050
regulation of cell proliferation GO:0042127 359 0.049
c21 steroid hormone biosynthetic process GO:0006700 10 0.049
lipid metabolic process GO:0006629 283 0.049
negative regulation of macromolecule metabolic process GO:0010605 260 0.049
regulation of protein modification process GO:0031399 194 0.048
aging GO:0007568 241 0.047
catabolic process GO:0009056 351 0.045
cellular response to nitrogen compound GO:1901699 210 0.045
positive regulation of multicellular organismal process GO:0051240 387 0.044
cellular metal ion homeostasis GO:0006875 172 0.042
multi organism reproductive process GO:0044703 262 0.042
response to mechanical stimulus GO:0009612 134 0.042
response to vitamin GO:0033273 131 0.042
macromolecule localization GO:0033036 252 0.041
regulation of metal ion transport GO:0010959 118 0.041
leydig cell differentiation GO:0033327 8 0.041
neuron projection development GO:0031175 273 0.041
response to estrogen GO:0043627 232 0.040
negative regulation of molecular function GO:0044092 133 0.040
behavior GO:0007610 205 0.040
positive regulation of cellular component organization GO:0051130 200 0.039
positive regulation of nucleic acid templated transcription GO:1903508 197 0.039
regulation of nucleic acid templated transcription GO:1903506 380 0.038
anatomical structure morphogenesis GO:0009653 298 0.038
single organism biosynthetic process GO:0044711 342 0.038
secretion by cell GO:0032940 248 0.037
negative regulation of neuron differentiation GO:0045665 62 0.037
immune system process GO:0002376 204 0.036
organic substance catabolic process GO:1901575 316 0.035
regulation of body fluid levels GO:0050878 90 0.035
cellular homeostasis GO:0019725 252 0.035
circulatory system process GO:0003013 183 0.035
regulation of secretion by cell GO:1903530 208 0.035
regulation of transporter activity GO:0032409 50 0.035
positive regulation of cell communication GO:0010647 271 0.034
cellular calcium ion homeostasis GO:0006874 160 0.034
cellular response to acid chemical GO:0071229 75 0.034
glycerolipid metabolic process GO:0046486 67 0.034
transcription dna templated GO:0006351 377 0.034
regulation of secretion GO:0051046 224 0.033
cell motility GO:0048870 202 0.032
potassium ion transmembrane transport GO:0071805 71 0.032
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.032
androgen biosynthetic process GO:0006702 10 0.032
response to fungicide GO:0060992 20 0.031
divalent inorganic cation homeostasis GO:0072507 165 0.031
regulation of cell migration GO:0030334 128 0.031
diterpenoid metabolic process GO:0016101 33 0.031
muscle system process GO:0003012 115 0.031
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.030
response to ethanol GO:0045471 162 0.030
response to wounding GO:0009611 254 0.030
endocytosis GO:0006897 84 0.030
positive regulation of signaling GO:0023056 270 0.029
monocarboxylic acid biosynthetic process GO:0072330 48 0.029
cellular component movement GO:0006928 248 0.029
cellular response to inorganic substance GO:0071241 65 0.029
negative regulation of gene expression GO:0010629 199 0.029
fatty acid biosynthetic process GO:0006633 33 0.028
tongue morphogenesis GO:0043587 3 0.028
response to hexose GO:0009746 144 0.028
organic hydroxy compound metabolic process GO:1901615 115 0.028
cyclic nucleotide metabolic process GO:0009187 80 0.028
homeostatic process GO:0042592 331 0.028
oxidation reduction process GO:0055114 304 0.028
cellular response to oxidative stress GO:0034599 76 0.027
regulation of multicellular organismal development GO:2000026 376 0.027
positive regulation of protein phosphorylation GO:0001934 135 0.027
ion homeostasis GO:0050801 212 0.027
sodium ion transport GO:0006814 82 0.027
cellular response to biotic stimulus GO:0071216 59 0.027
cellular potassium ion transport GO:0071804 72 0.026
regulation of hormone levels GO:0010817 187 0.026
organophosphate biosynthetic process GO:0090407 143 0.026
positive regulation of transport GO:0051050 245 0.026
carbohydrate derivative metabolic process GO:1901135 346 0.026
negative regulation of nucleic acid templated transcription GO:1903507 117 0.025
negative regulation of catalytic activity GO:0043086 103 0.025
positive regulation of molecular function GO:0044093 230 0.025
regulation of rna biosynthetic process GO:2001141 381 0.025
cellular amine metabolic process GO:0044106 38 0.025
purine ribonucleotide metabolic process GO:0009150 227 0.025
regulation of hormone secretion GO:0046883 106 0.025
hormone transport GO:0009914 121 0.024
cellular chemical homeostasis GO:0055082 247 0.024
cellular amino acid metabolic process GO:0006520 107 0.024
cellular response to organonitrogen compound GO:0071417 197 0.024
cellular response to organic cyclic compound GO:0071407 202 0.024
regulation of neuron differentiation GO:0045664 208 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.023
purine nucleotide biosynthetic process GO:0006164 83 0.023
head development GO:0060322 247 0.023
macromolecule catabolic process GO:0009057 58 0.023
rna metabolic process GO:0016070 406 0.023
response to amino acid GO:0043200 75 0.023
neurological system process GO:0050877 219 0.023
regulation of systemic arterial blood pressure GO:0003073 30 0.023
cellular response to lipopolysaccharide GO:0071222 55 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.023
transcription from rna polymerase ii promoter GO:0006366 252 0.023
cellular response to steroid hormone stimulus GO:0071383 93 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
rna biosynthetic process GO:0032774 380 0.023
cation transmembrane transport GO:0098655 263 0.023
positive regulation of developmental process GO:0051094 283 0.022
positive regulation of cellular component biogenesis GO:0044089 55 0.022
negative regulation of response to stimulus GO:0048585 155 0.022
cellular divalent inorganic cation homeostasis GO:0072503 162 0.022
response to increased oxygen levels GO:0036296 45 0.022
response to alkaloid GO:0043279 132 0.022
telencephalon development GO:0021537 62 0.022
cellular response to molecule of bacterial origin GO:0071219 56 0.022
response to insulin GO:0032868 133 0.022
unsaturated fatty acid metabolic process GO:0033559 39 0.021
hormone biosynthetic process GO:0042446 25 0.021
response to cadmium ion GO:0046686 35 0.021
response to estradiol GO:0032355 164 0.021
response to ketone GO:1901654 182 0.020
negative regulation of multicellular organismal process GO:0051241 203 0.020
response to external biotic stimulus GO:0043207 221 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.020
positive regulation of gene expression GO:0010628 244 0.020
negative regulation of nervous system development GO:0051961 79 0.020
cation homeostasis GO:0055080 195 0.020
cell projection morphogenesis GO:0048858 123 0.020
rhythmic process GO:0048511 156 0.020
reproduction GO:0000003 245 0.020
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
synaptic transmission GO:0007268 235 0.020
transmembrane transport GO:0055085 412 0.019
urogenital system development GO:0001655 78 0.019
organophosphate metabolic process GO:0019637 370 0.019
glutamate secretion GO:0014047 19 0.019
male sex differentiation GO:0046661 64 0.019
long chain fatty acid metabolic process GO:0001676 32 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.019
positive regulation of cell proliferation GO:0008284 249 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
cellular hormone metabolic process GO:0034754 49 0.019
negative regulation of signaling GO:0023057 157 0.019
regulation of transmembrane transport GO:0034762 122 0.019
regulation of nucleotide biosynthetic process GO:0030808 47 0.019
reproductive structure development GO:0048608 128 0.019
organelle organization GO:0006996 266 0.019
regulation of system process GO:0044057 208 0.019
secretion GO:0046903 307 0.019
cellular response to lipid GO:0071396 201 0.019
response to vitamin a GO:0033189 36 0.019
regulation of catalytic activity GO:0050790 304 0.019
nucleotide metabolic process GO:0009117 279 0.018
l glutamate import GO:0051938 2 0.018
regulation of cellular component organization GO:0051128 368 0.018
regulation of cell motility GO:2000145 131 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
isoprenoid metabolic process GO:0006720 45 0.018
negative regulation of vascular permeability GO:0043116 3 0.018
nitrogen compound transport GO:0071705 229 0.018
purine containing compound metabolic process GO:0072521 253 0.018
cellular protein localization GO:0034613 122 0.018
sexual reproduction GO:0019953 148 0.018
response to testosterone GO:0033574 55 0.018
positive regulation of transcription dna templated GO:0045893 197 0.018
negative regulation of innate immune response GO:0045824 4 0.018
signal release GO:0023061 145 0.018
aromatic compound catabolic process GO:0019439 168 0.018
nucleoside phosphate biosynthetic process GO:1901293 102 0.018
response to hyperoxia GO:0055093 45 0.017
unsaturated fatty acid biosynthetic process GO:0006636 21 0.017
protein localization GO:0008104 191 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
positive regulation of phosphorus metabolic process GO:0010562 262 0.017
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.017
cellular response to mechanical stimulus GO:0071260 48 0.017
regulation of muscle system process GO:0090257 79 0.017
positive regulation of phosphate metabolic process GO:0045937 262 0.017
nucleobase containing small molecule metabolic process GO:0055086 316 0.017
organic hydroxy compound biosynthetic process GO:1901617 51 0.017
metal ion homeostasis GO:0055065 186 0.017
developmental process involved in reproduction GO:0003006 159 0.017
cellular response to metal ion GO:0071248 55 0.017
negative regulation of rna biosynthetic process GO:1902679 118 0.017
positive regulation of protein metabolic process GO:0051247 178 0.017
carbohydrate derivative biosynthetic process GO:1901137 124 0.017
protein tetramerization GO:0051262 38 0.017
multicellular organism reproduction GO:0032504 233 0.017
response to carbohydrate GO:0009743 183 0.017
motor neuron axon guidance GO:0008045 1 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
regulation of catabolic process GO:0009894 113 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.016
cellular response to reactive oxygen species GO:0034614 55 0.016
purine ribonucleotide biosynthetic process GO:0009152 81 0.016
positive regulation of rna metabolic process GO:0051254 203 0.016
positive regulation of catalytic activity GO:0043085 184 0.016
protein maturation GO:0051604 68 0.016
regulation of ion transmembrane transport GO:0034765 121 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
regulation of phosphorylation GO:0042325 248 0.016
regulation of apoptotic process GO:0042981 335 0.016
response to fibroblast growth factor GO:0071774 29 0.016
gonad development GO:0008406 104 0.016
regulation of signal transduction GO:0009966 318 0.016
membrane hyperpolarization GO:0060081 11 0.015
ribose phosphate biosynthetic process GO:0046390 87 0.015
regulation of rna metabolic process GO:0051252 391 0.015
icosanoid biosynthetic process GO:0046456 18 0.015
striated muscle contraction GO:0006941 44 0.015
response to activity GO:0014823 73 0.015
glandular epithelial cell differentiation GO:0002067 4 0.015
ribonucleotide metabolic process GO:0009259 231 0.015
regulation of cell projection organization GO:0031344 175 0.015
gamete generation GO:0007276 124 0.015
ribonucleotide biosynthetic process GO:0009260 85 0.015
cellular response to cytokine stimulus GO:0071345 127 0.015
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.015
regulation of synaptic transmission GO:0050804 141 0.015
multi multicellular organism process GO:0044706 138 0.015
pallium development GO:0021543 42 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.015
fatty acid transport GO:0015908 25 0.015
spermatogenesis GO:0007283 99 0.014
blood circulation GO:0008015 183 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
enzyme linked receptor protein signaling pathway GO:0007167 116 0.014
response to corticosterone GO:0051412 40 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.014
protein heterooligomerization GO:0051291 89 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
regulation of anatomical structure size GO:0090066 135 0.014
positive regulation of potassium ion transport GO:0043268 13 0.014
positive regulation of protein modification process GO:0031401 142 0.014
vesicle mediated transport GO:0016192 181 0.013
apoptotic process GO:0006915 381 0.013
regulation of nervous system development GO:0051960 264 0.013
cell communication by chemical coupling GO:0010643 2 0.013
arachidonic acid metabolic process GO:0019369 20 0.013
regulation of tube size GO:0035150 89 0.013
androgen metabolic process GO:0008209 14 0.013
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.013
negative regulation of neurogenesis GO:0050768 78 0.013
regulation of ion transmembrane transporter activity GO:0032412 48 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.013
specification of organ identity GO:0010092 2 0.013
response to metal ion GO:0010038 253 0.013
regulation of protein phosphorylation GO:0001932 183 0.013
insulin secretion GO:0030073 69 0.013
nucleoside phosphate metabolic process GO:0006753 283 0.013
positive regulation of rna biosynthetic process GO:1902680 197 0.012
negative regulation of cell communication GO:0010648 158 0.012
regulation of blood pressure GO:0008217 83 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.012
response to monosaccharide GO:0034284 159 0.012
regulation of transmembrane transporter activity GO:0022898 49 0.012
chemotaxis GO:0006935 66 0.012
negative regulation of cellular protein metabolic process GO:0032269 106 0.012
positive regulation of response to stimulus GO:0048584 285 0.012
circulatory system development GO:0072359 134 0.012
positive regulation of ion transport GO:0043270 94 0.012
insecticide metabolic process GO:0017143 4 0.012
steroid biosynthetic process GO:0006694 48 0.012
synaptic transmission glutamatergic GO:0035249 33 0.012
protein phosphorylation GO:0006468 345 0.012
taxis GO:0042330 67 0.011
regulation of protein serine threonine kinase activity GO:0071900 64 0.011
phasic smooth muscle contraction GO:0014821 3 0.011
actin filament based process GO:0030029 86 0.011
amino acid transport GO:0006865 70 0.011
vascular process in circulatory system GO:0003018 96 0.011
cellular catabolic process GO:0044248 295 0.011
positive regulation of catabolic process GO:0009896 78 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
circadian rhythm GO:0007623 88 0.011
carboxylic acid catabolic process GO:0046395 49 0.011
male gamete generation GO:0048232 99 0.011
regulation of cell development GO:0060284 263 0.011
calcium ion homeostasis GO:0055074 162 0.011
regulation of proteolysis GO:0030162 66 0.011
locomotion GO:0040011 237 0.011
progesterone biosynthetic process GO:0006701 3 0.011
regulation of programmed cell death GO:0043067 341 0.011
cellular response to alkaloid GO:0071312 25 0.011
response to other organism GO:0051707 220 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
localization of cell GO:0051674 202 0.011
response to oxygen levels GO:0070482 265 0.011
sodium ion transmembrane transport GO:0035725 67 0.011
regulation of transferase activity GO:0051338 123 0.011
long chain fatty acid transport GO:0015909 14 0.011
nucleoside metabolic process GO:0009116 179 0.011
positive regulation of potassium ion transmembrane transport GO:1901381 4 0.011
cell cycle process GO:0022402 57 0.011
response to gamma radiation GO:0010332 24 0.011
multicellular organismal reproductive process GO:0048609 233 0.011
response to light stimulus GO:0009416 52 0.011
programmed cell death GO:0012501 392 0.011
renal system development GO:0072001 67 0.011
single organism catabolic process GO:0044712 283 0.011
limbic system development GO:0021761 38 0.011
response to biotic stimulus GO:0009607 226 0.011
cellular response to external stimulus GO:0071496 118 0.011
hormone secretion GO:0046879 115 0.011
regulation of cell cycle GO:0051726 73 0.011
positive regulation of biosynthetic process GO:0009891 319 0.011
pancreatic a cell differentiation GO:0003310 1 0.011
regulation of cellular localization GO:0060341 263 0.010
neuron neuron synaptic transmission GO:0007270 60 0.010
negative regulation of developmental process GO:0051093 125 0.010
response to bacterium GO:0009617 200 0.010
neuronal action potential GO:0019228 35 0.010
cellular cation homeostasis GO:0030003 180 0.010
cell migration GO:0016477 197 0.010
intracellular transport GO:0046907 185 0.010
ribonucleoside triphosphate metabolic process GO:0009199 141 0.010
regulation of blood circulation GO:1903522 110 0.010
grooming behavior GO:0007625 4 0.010
anterior posterior pattern specification GO:0009952 1 0.010
cytoskeleton organization GO:0007010 111 0.010
male gonad development GO:0008584 59 0.010
cellular response to drug GO:0035690 30 0.010
regulation of cellular protein metabolic process GO:0032268 267 0.010
hormone metabolic process GO:0042445 69 0.010
positive regulation of transferase activity GO:0051347 81 0.010
negative regulation of organ growth GO:0046621 3 0.010

Defb4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.078
respiratory system disease DOID:1579 0 0.078
lower respiratory tract disease DOID:0050161 0 0.078
disease of metabolism DOID:0014667 0 0.032
inherited metabolic disorder DOID:655 0 0.032
steroid inherited metabolic disorder DOID:1701 0 0.032
congenital adrenal hyperplasia DOID:0050811 0 0.032
lipid metabolism disorder DOID:3146 0 0.032
nervous system disease DOID:863 0 0.022
sensory system disease DOID:0050155 0 0.022
retinal disease DOID:5679 0 0.016
eye disease DOID:5614 0 0.016
eye and adnexa disease DOID:1492 0 0.016
retinal degeneration DOID:8466 0 0.014
retinitis pigmentosa DOID:10584 0 0.014
integumentary system disease DOID:16 0 0.011