Rattus norvegicus

59 known processes

Dhfr

dihydrofolate reductase

(Aliases: Dhfr1)

Dhfr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carboxylic acid metabolic process GO:0019752 289 0.795
oxoacid metabolic process GO:0043436 290 0.741
pteridine containing compound metabolic process GO:0042558 14 0.691
carboxylic acid biosynthetic process GO:0046394 83 0.608
response to inorganic substance GO:0010035 377 0.596
organic acid metabolic process GO:0006082 292 0.584
response to metal ion GO:0010038 253 0.548
response to xenobiotic stimulus GO:0009410 23 0.490
positive regulation of retinal cell programmed cell death GO:0046670 1 0.479
liver development GO:0001889 90 0.477
halogenated hydrocarbon metabolic process GO:0042197 4 0.459
alpha amino acid biosynthetic process GO:1901607 23 0.397
cellular amino acid metabolic process GO:0006520 107 0.369
organonitrogen compound biosynthetic process GO:1901566 167 0.363
chlorinated hydrocarbon metabolic process GO:0042196 4 0.361
response to corticosteroid GO:0031960 235 0.343
response to glucocorticoid GO:0051384 223 0.332
cellular modified amino acid metabolic process GO:0006575 61 0.331
hepaticobiliary system development GO:0061008 90 0.316
tetrahydrofolate metabolic process GO:0046653 9 0.312
response to transition metal nanoparticle GO:1990267 122 0.274
response to toxic substance GO:0009636 133 0.258
response to reactive oxygen species GO:0000302 120 0.254
single organism biosynthetic process GO:0044711 342 0.243
single organism reproductive process GO:0044702 297 0.229
naphthalene metabolic process GO:0018931 2 0.228
cellular catabolic process GO:0044248 295 0.228
response to estrogen GO:0043627 232 0.224
nucleobase containing small molecule metabolic process GO:0055086 316 0.217
response to ketone GO:1901654 182 0.209
catabolic process GO:0009056 351 0.201
dicarboxylic acid metabolic process GO:0043648 42 0.197
cellular response to organic cyclic compound GO:0071407 202 0.191
regulation of retinal cell programmed cell death GO:0046668 1 0.179
response to estradiol GO:0032355 164 0.175
response to nutrient levels GO:0031667 370 0.165
alpha amino acid metabolic process GO:1901605 71 0.164
reproductive process GO:0022414 372 0.161
gland development GO:0048732 155 0.158
response to acid chemical GO:0001101 222 0.155
cellular ketone metabolic process GO:0042180 51 0.150
drug catabolic process GO:0042737 1 0.148
small molecule biosynthetic process GO:0044283 124 0.144
organic acid biosynthetic process GO:0016053 83 0.142
cellular lipid metabolic process GO:0044255 208 0.137
cellular response to stress GO:0033554 269 0.127
positive regulation of interleukin 1 beta secretion GO:0050718 3 0.125
response to cadmium ion GO:0046686 35 0.123
response to extracellular stimulus GO:0009991 380 0.123
response to oxidative stress GO:0006979 186 0.117
aging GO:0007568 241 0.113
response to cobalt ion GO:0032025 12 0.112
regulation of molecular function GO:0065009 398 0.110
head development GO:0060322 247 0.109
response to ionizing radiation GO:0010212 59 0.107
organic substance catabolic process GO:1901575 316 0.107
sulfur amino acid metabolic process GO:0000096 9 0.103
positive regulation of cellular protein metabolic process GO:0032270 167 0.101
multi organism reproductive process GO:0044703 262 0.099
response to nutrient GO:0007584 248 0.096
macromolecule localization GO:0033036 252 0.095
xenobiotic metabolic process GO:0006805 19 0.093
positive regulation of interleukin 1 secretion GO:0050716 3 0.093
negative regulation of cellular metabolic process GO:0031324 281 0.091
single organism catabolic process GO:0044712 283 0.090
response to amino acid GO:0043200 75 0.089
regulation of protein metabolic process GO:0051246 289 0.087
drug metabolic process GO:0017144 11 0.086
cellular response to organonitrogen compound GO:0071417 197 0.085
cellular response to endogenous stimulus GO:0071495 377 0.081
naphthalene containing compound metabolic process GO:0090420 2 0.081
purine containing compound metabolic process GO:0072521 253 0.079
indole containing compound metabolic process GO:0042430 11 0.079
cellular response to peptide hormone stimulus GO:0071375 120 0.077
regulation of catalytic activity GO:0050790 304 0.076
nucleoside metabolic process GO:0009116 179 0.075
defense response GO:0006952 194 0.071
protein complex subunit organization GO:0071822 302 0.070
response to peptide GO:1901652 292 0.070
cellular response to xenobiotic stimulus GO:0071466 19 0.068
protein complex assembly GO:0006461 263 0.067
response to ddt GO:0046680 1 0.067
nucleoside phosphate metabolic process GO:0006753 283 0.067
neuron differentiation GO:0030182 368 0.067
cellular amino acid biosynthetic process GO:0008652 32 0.066
alkaloid metabolic process GO:0009820 3 0.065
regulation of circadian sleep wake cycle sleep GO:0045187 18 0.065
negative regulation of metabolic process GO:0009892 331 0.065
cellular amine metabolic process GO:0044106 38 0.062
gonad development GO:0008406 104 0.062
serine family amino acid catabolic process GO:0009071 3 0.061
coenzyme metabolic process GO:0006732 86 0.061
cell projection organization GO:0030030 302 0.061
multicellular organismal reproductive process GO:0048609 233 0.060
aromatic compound catabolic process GO:0019439 168 0.060
chromosome segregation GO:0007059 2 0.059
cellular nitrogen compound catabolic process GO:0044270 163 0.059
response to peptide hormone GO:0043434 278 0.059
response to vitamin GO:0033273 131 0.058
positive regulation of protein metabolic process GO:0051247 178 0.058
cellular response to steroid hormone stimulus GO:0071383 93 0.058
response to oxygen levels GO:0070482 265 0.058
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.057
macromolecular complex assembly GO:0065003 273 0.057
fatty acid metabolic process GO:0006631 99 0.057
lipid metabolic process GO:0006629 283 0.056
digestive system development GO:0055123 41 0.056
regulation of cellular amino acid metabolic process GO:0006521 2 0.055
positive regulation of rna metabolic process GO:0051254 203 0.055
fatty acid derivative metabolic process GO:1901568 38 0.055
carbohydrate derivative metabolic process GO:1901135 346 0.054
response to iron iii ion GO:0010041 6 0.053
regulation of mitotic sister chromatid separation GO:0010965 1 0.053
reproductive system development GO:0061458 128 0.052
monocarboxylic acid metabolic process GO:0032787 152 0.051
rhythmic process GO:0048511 156 0.051
negative regulation of macromolecule metabolic process GO:0010605 260 0.051
insecticide metabolic process GO:0017143 4 0.050
neutral lipid metabolic process GO:0006638 21 0.049
tube development GO:0035295 89 0.049
reproductive structure development GO:0048608 128 0.049
triglyceride metabolic process GO:0006641 21 0.048
response to wounding GO:0009611 254 0.048
negative regulation of phosphate metabolic process GO:0045936 80 0.048
arachidonic acid metabolic process GO:0019369 20 0.047
response to organophosphorus GO:0046683 102 0.047
pyridine containing compound metabolic process GO:0072524 32 0.047
reproduction GO:0000003 245 0.046
regulation of interleukin 1 secretion GO:0050704 3 0.046
diterpenoid metabolic process GO:0016101 33 0.046
cellular amino acid catabolic process GO:0009063 21 0.045
brain development GO:0007420 247 0.045
cellular response to oxidative stress GO:0034599 76 0.045
protein homooligomerization GO:0051260 91 0.045
biphenyl catabolic process GO:0070980 2 0.044
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.043
organic cyclic compound catabolic process GO:1901361 175 0.043
organonitrogen compound catabolic process GO:1901565 179 0.043
regulation of reactive oxygen species metabolic process GO:2000377 26 0.043
purine nucleoside metabolic process GO:0042278 169 0.043
limbic system development GO:0021761 38 0.042
isoprenoid metabolic process GO:0006720 45 0.042
eye morphogenesis GO:0048592 4 0.042
female sex differentiation GO:0046660 59 0.040
cellular response to nitrogen compound GO:1901699 210 0.040
protein complex biogenesis GO:0070271 263 0.040
alpha amino acid catabolic process GO:1901606 20 0.040
oxidation reduction process GO:0055114 304 0.040
multi multicellular organism process GO:0044706 138 0.040
cofactor metabolic process GO:0051186 95 0.039
multicellular organism reproduction GO:0032504 233 0.039
regulation of transcription dna templated GO:0006355 374 0.039
regulation of cell development GO:0060284 263 0.039
negative regulation of cell division GO:0051782 1 0.039
protein localization GO:0008104 191 0.038
exogenous drug catabolic process GO:0042738 1 0.038
protein oligomerization GO:0051259 191 0.037
epoxygenase p450 pathway GO:0019373 1 0.037
cellular response to alcohol GO:0097306 87 0.037
heterocycle catabolic process GO:0046700 167 0.037
regulation of phosphorylation GO:0042325 248 0.036
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.036
response to cytokine GO:0034097 215 0.036
regulation of cellular amine metabolic process GO:0033238 8 0.036
regulation of interleukin 1 beta secretion GO:0050706 3 0.035
nucleotide metabolic process GO:0009117 279 0.035
sex differentiation GO:0007548 113 0.035
regulation of protein phosphorylation GO:0001932 183 0.035
cellular response to lipid GO:0071396 201 0.035
benzene containing compound metabolic process GO:0042537 22 0.034
cell cycle checkpoint GO:0000075 2 0.034
regulation of cellular protein metabolic process GO:0032268 267 0.034
central nervous system development GO:0007417 311 0.034
positive regulation of cell communication GO:0010647 271 0.034
cell activation GO:0001775 97 0.034
macromolecular complex subunit organization GO:0043933 339 0.034
negative regulation of neurogenesis GO:0050768 78 0.034
cellular hormone metabolic process GO:0034754 49 0.033
organelle organization GO:0006996 266 0.033
regulation of protein transport GO:0051223 68 0.033
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.033
terpenoid metabolic process GO:0006721 37 0.033
response to ethanol GO:0045471 162 0.032
positive regulation of biosynthetic process GO:0009891 319 0.032
developmental process involved in reproduction GO:0003006 159 0.032
organophosphate metabolic process GO:0019637 370 0.032
regulation of multicellular organismal development GO:2000026 376 0.032
dna metabolic process GO:0006259 96 0.031
amine metabolic process GO:0009308 38 0.031
negative regulation of cell cycle phase transition GO:1901988 4 0.031
negative regulation of nuclear division GO:0051784 1 0.031
luteolysis GO:0001554 5 0.031
androgen metabolic process GO:0008209 14 0.031
purine containing compound biosynthetic process GO:0072522 85 0.030
double strand break repair GO:0006302 1 0.030
circadian sleep wake cycle GO:0042745 23 0.030
oxidative demethylation GO:0070989 2 0.030
purine ribonucleotide metabolic process GO:0009150 227 0.030
female pregnancy GO:0007565 122 0.030
interleukin 1 beta secretion GO:0050702 3 0.030
regulation of cell cycle GO:0051726 73 0.030
regulation of phosphorus metabolic process GO:0051174 349 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.029
positive regulation of response to stimulus GO:0048584 285 0.029
unsaturated fatty acid metabolic process GO:0033559 39 0.029
organ regeneration GO:0031100 101 0.029
telencephalon development GO:0021537 62 0.029
negative regulation of protein metabolic process GO:0051248 114 0.029
folic acid containing compound metabolic process GO:0006760 10 0.028
sulfur compound metabolic process GO:0006790 70 0.028
regulation of cellular response to stress GO:0080135 49 0.028
peptidyl amino acid modification GO:0018193 126 0.028
response to molecule of bacterial origin GO:0002237 194 0.028
cellular response to peptide GO:1901653 133 0.028
sensory organ development GO:0007423 74 0.028
steroid metabolic process GO:0008202 73 0.028
glycosyl compound metabolic process GO:1901657 182 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.028
positive regulation of circadian rhythm GO:0042753 11 0.027
positive regulation of nucleic acid templated transcription GO:1903508 197 0.027
ribose phosphate metabolic process GO:0019693 235 0.027
eye development GO:0001654 50 0.027
response to glucose GO:0009749 136 0.027
phenol containing compound metabolic process GO:0018958 30 0.027
acylglycerol metabolic process GO:0006639 21 0.027
xenobiotic catabolic process GO:0042178 7 0.026
negative regulation of chromosome organization GO:2001251 1 0.026
negative regulation of molecular function GO:0044092 133 0.026
response to bacterium GO:0009617 200 0.026
cellular response to external stimulus GO:0071496 118 0.026
circadian sleep wake cycle sleep GO:0050802 21 0.026
nicotine metabolic process GO:0018933 1 0.026
neuron projection development GO:0031175 273 0.026
regulation of rna metabolic process GO:0051252 391 0.026
response to axon injury GO:0048678 59 0.026
4 chlorobiphenyl metabolic process GO:0018880 1 0.025
negative regulation of phosphorus metabolic process GO:0010563 80 0.025
organic hydroxy compound metabolic process GO:1901615 115 0.025
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 1 0.025
purine nucleobase metabolic process GO:0006144 4 0.025
regulation of rna biosynthetic process GO:2001141 381 0.025
organic anion transport GO:0015711 132 0.025
positive regulation of rna biosynthetic process GO:1902680 197 0.025
long chain fatty acid metabolic process GO:0001676 32 0.025
ribonucleotide metabolic process GO:0009259 231 0.025
ribonucleoside metabolic process GO:0009119 174 0.025
cellular response to reactive oxygen species GO:0034614 55 0.025
regulation of protein modification process GO:0031399 194 0.025
cellular response to metal ion GO:0071248 55 0.025
response to testosterone GO:0033574 55 0.025
nucleic acid templated transcription GO:0097659 379 0.024
muscle structure development GO:0061061 87 0.024
response to external biotic stimulus GO:0043207 221 0.024
negative regulation of cellular biosynthetic process GO:0031327 161 0.024
intracellular signal transduction GO:0035556 314 0.024
rna metabolic process GO:0016070 406 0.024
nicotinamide nucleotide biosynthetic process GO:0019359 2 0.024
purine ribonucleoside metabolic process GO:0046128 168 0.024
response to lipopolysaccharide GO:0032496 191 0.023
negative regulation of cellular protein metabolic process GO:0032269 106 0.023
ovulation cycle GO:0042698 67 0.023
positive regulation of cellular biosynthetic process GO:0031328 295 0.023
carboxylic acid catabolic process GO:0046395 49 0.023
cellular response to oxygen containing compound GO:1901701 386 0.023
negative regulation of cell proliferation GO:0008285 119 0.023
regulation of hormone levels GO:0010817 187 0.023
circadian rhythm GO:0007623 88 0.023
positive regulation of catalytic activity GO:0043085 184 0.023
striated muscle cell proliferation GO:0014855 9 0.023
response to sulfur dioxide GO:0010477 3 0.022
development of primary sexual characteristics GO:0045137 107 0.022
response to mercury ion GO:0046689 15 0.022
organophosphate biosynthetic process GO:0090407 143 0.022
apoptotic process GO:0006915 381 0.022
cellular component assembly GO:0022607 360 0.022
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.022
purine nucleotide metabolic process GO:0006163 229 0.022
response to insulin GO:0032868 133 0.022
nucleotide biosynthetic process GO:0009165 98 0.022
development of primary female sexual characteristics GO:0046545 56 0.022
respiratory system development GO:0060541 45 0.022
inflammatory response GO:0006954 150 0.022
purine nucleoside monophosphate metabolic process GO:0009126 84 0.022
response to decreased oxygen levels GO:0036293 237 0.022
glycoside transport GO:1901656 2 0.021
glycerolipid metabolic process GO:0046486 67 0.021
icosanoid metabolic process GO:0006690 38 0.021
small molecule catabolic process GO:0044282 59 0.021
cellular response to hormone stimulus GO:0032870 247 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.021
trichloroethylene metabolic process GO:0018979 1 0.021
nucleobase biosynthetic process GO:0046112 2 0.021
cellular protein localization GO:0034613 122 0.020
pyrimidine containing compound metabolic process GO:0072527 20 0.020
nucleoside triphosphate metabolic process GO:0009141 144 0.020
regulation of protein kinase activity GO:0045859 105 0.020
cell cycle process GO:0022402 57 0.020
nucleoside phosphate biosynthetic process GO:1901293 102 0.020
negative regulation of biosynthetic process GO:0009890 168 0.020
positive regulation of signaling GO:0023056 270 0.020
regulation of kinase activity GO:0043549 117 0.020
mitotic sister chromatid separation GO:0051306 1 0.020
gamete generation GO:0007276 124 0.020
spermatogenesis GO:0007283 99 0.020
negative regulation of neuron differentiation GO:0045665 62 0.020
cell type specific apoptotic process GO:0097285 134 0.020
digestive tract development GO:0048565 39 0.020
regulation of neuron projection development GO:0010975 161 0.020
hippocampus development GO:0021766 30 0.020
maintenance of location GO:0051235 17 0.020
negative regulation of cellular component organization GO:0051129 83 0.019
metaphase anaphase transition of cell cycle GO:0044784 1 0.019
atp metabolic process GO:0046034 72 0.019
female gonad development GO:0008585 53 0.019
positive regulation of transcription dna templated GO:0045893 197 0.019
regulation of body fluid levels GO:0050878 90 0.019
response to zinc ion GO:0010043 39 0.019
cellular macromolecule localization GO:0070727 122 0.019
rna biosynthetic process GO:0032774 380 0.019
regulation of cell proliferation GO:0042127 359 0.019
microvillus assembly GO:0030033 2 0.019
regulation of protein localization GO:0032880 81 0.019
negative regulation of developmental process GO:0051093 125 0.019
renal system development GO:0072001 67 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.019
small gtpase mediated signal transduction GO:0007264 36 0.019
follicle stimulating hormone signaling pathway GO:0042699 5 0.019
regulation of transferase activity GO:0051338 123 0.019
immune system process GO:0002376 204 0.018
regulation of response to stress GO:0080134 126 0.018
response to hypoxia GO:0001666 231 0.018
negative regulation of phosphorylation GO:0042326 57 0.018
midgut development GO:0007494 13 0.018
response to calcium ion GO:0051592 59 0.018
positive regulation of protein phosphorylation GO:0001934 135 0.018
nucleobase containing compound catabolic process GO:0034655 152 0.018
protein transport GO:0015031 132 0.018
regulation of intracellular signal transduction GO:1902531 218 0.018
negative regulation of nervous system development GO:0051961 79 0.018
protein tetramerization GO:0051262 38 0.018
regulation of chromosome segregation GO:0051983 1 0.018
regulation of cell differentiation GO:0045595 320 0.018
nucleoside monophosphate metabolic process GO:0009123 93 0.018
cellular component biogenesis GO:0044085 368 0.018
nuclear transport GO:0051169 49 0.017
transcription dna templated GO:0006351 377 0.017
cellular response to corticosteroid stimulus GO:0071384 69 0.017
anion transport GO:0006820 178 0.017
transcription from rna polymerase ii promoter GO:0006366 252 0.017
dendrite development GO:0016358 72 0.017
response to insecticide GO:0017085 21 0.016
protein phosphorylation GO:0006468 345 0.016
cellular response to glucocorticoid stimulus GO:0071385 68 0.016
regulation of establishment of protein localization GO:0070201 69 0.016
reactive oxygen species metabolic process GO:0072593 37 0.016
lens development in camera type eye GO:0002088 13 0.016
regulation of cell projection organization GO:0031344 175 0.016
regulation of phosphate metabolic process GO:0019220 349 0.016
ribonucleoside triphosphate metabolic process GO:0009199 141 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.016
mapk cascade GO:0000165 140 0.016
positive regulation of cytokine production GO:0001819 42 0.016
metaphase plate congression GO:0051310 1 0.016
ribonucleoside monophosphate metabolic process GO:0009161 88 0.016
regulation of cellular component organization GO:0051128 368 0.016
negative regulation of protein phosphorylation GO:0001933 44 0.016
nucleotide catabolic process GO:0009166 139 0.016
positive regulation of protein modification process GO:0031401 142 0.015
regulation of neuron differentiation GO:0045664 208 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.015
programmed cell death GO:0012501 392 0.015
glycosyl compound catabolic process GO:1901658 126 0.015
urea cycle GO:0000050 5 0.015
nicotinamide nucleotide metabolic process GO:0046496 28 0.015
muscle cell proliferation GO:0033002 84 0.015
positive regulation of multicellular organismal process GO:0051240 387 0.015
positive regulation of phosphate metabolic process GO:0045937 262 0.015
lipid transport GO:0006869 61 0.015
regulation of mitotic sister chromatid segregation GO:0033047 1 0.015
negative regulation of apoptotic process GO:0043066 181 0.015
muscle organ development GO:0007517 50 0.014
cellular response to cytokine stimulus GO:0071345 127 0.014
positive regulation of phosphorus metabolic process GO:0010562 262 0.014
pallium development GO:0021543 42 0.014
regulation of mapk cascade GO:0043408 116 0.014
hormone metabolic process GO:0042445 69 0.014
negative regulation of gene expression GO:0010629 199 0.014
retinoid metabolic process GO:0001523 24 0.014
axis specification GO:0009798 4 0.014
regulation of dna metabolic process GO:0051052 60 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
positive regulation of molecular function GO:0044093 230 0.014
cellular response to inorganic substance GO:0071241 65 0.014
glial cell apoptotic process GO:0034349 8 0.014
neuron development GO:0048666 286 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
biphenyl metabolic process GO:0018879 10 0.014
response to biotic stimulus GO:0009607 226 0.014
regulation of apoptotic process GO:0042981 335 0.014
camera type eye development GO:0043010 48 0.014
centrosome cycle GO:0007098 1 0.014
response to cesium ion GO:0010164 2 0.014
mitotic cell cycle checkpoint GO:0007093 1 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
regulation of cellular localization GO:0060341 263 0.013
negative regulation of reactive oxygen species metabolic process GO:2000378 7 0.013
nucleoside phosphate catabolic process GO:1901292 140 0.013
histone h3 k9 methylation GO:0051567 1 0.013
dna integrity checkpoint GO:0031570 2 0.013
fat cell proliferation GO:0070341 2 0.013
negative regulation of cell communication GO:0010648 158 0.013
peptide biosynthetic process GO:0043043 3 0.013
regulation of circadian sleep wake cycle GO:0042749 18 0.013
cell fate determination GO:0001709 2 0.013
retinal cell programmed cell death GO:0046666 1 0.013
pyrimidine deoxyribonucleotide biosynthetic process GO:0009221 5 0.013
circulatory system development GO:0072359 134 0.013
response to monosaccharide GO:0034284 159 0.013
mitotic cell cycle process GO:1903047 35 0.013
response to radiation GO:0009314 137 0.013
lipid storage GO:0019915 1 0.013
growth GO:0040007 165 0.013
regulation of cell cycle g2 m phase transition GO:1902749 4 0.013
circadian sleep wake cycle process GO:0022410 21 0.013
regulation of protein serine threonine kinase activity GO:0071900 64 0.013
positive regulation of hydrolase activity GO:0051345 86 0.013
protein processing GO:0016485 68 0.013
nucleoside catabolic process GO:0009164 126 0.012
regulation of intracellular transport GO:0032386 65 0.012
angiogenesis GO:0001525 53 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.012
dna recombination GO:0006310 3 0.012
cell cycle GO:0007049 101 0.012
nucleoside monophosphate biosynthetic process GO:0009124 28 0.012
drug transport GO:0015893 18 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.012
retinoic acid receptor signaling pathway GO:0048384 7 0.012
sexual reproduction GO:0019953 148 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
negative regulation of rna metabolic process GO:0051253 123 0.012
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.012
positive regulation of interleukin 1 beta production GO:0032731 6 0.012
cellular chemical homeostasis GO:0055082 247 0.012
regeneration GO:0031099 163 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
pyridine nucleotide biosynthetic process GO:0019363 2 0.012
toxin catabolic process GO:0009407 1 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
organic hydroxy compound biosynthetic process GO:1901617 51 0.012
lipid biosynthetic process GO:0008610 128 0.012
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
protein homotetramerization GO:0051289 25 0.012
positive regulation of mapk cascade GO:0043410 92 0.012
cell adhesion GO:0007155 110 0.012
cytoskeleton organization GO:0007010 111 0.012
sister chromatid segregation GO:0000819 1 0.011
immune response GO:0006955 104 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
response to carbohydrate GO:0009743 183 0.011
regulation of protein targeting GO:1903533 28 0.011
regulation of interleukin 1 beta production GO:0032651 7 0.011
organophosphate catabolic process GO:0046434 148 0.011
androgen biosynthetic process GO:0006702 10 0.011
linoleic acid metabolic process GO:0043651 4 0.011
cellular response to ketone GO:1901655 51 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
ovulation cycle process GO:0022602 50 0.011
secondary metabolic process GO:0019748 15 0.011
serine family amino acid metabolic process GO:0009069 12 0.011
negative regulation of transcription dna templated GO:0045892 116 0.011
single organism intracellular transport GO:1902582 166 0.011
regulation of nervous system development GO:0051960 264 0.011
rhythmic behavior GO:0007622 24 0.011
proteolysis GO:0006508 175 0.011
protein localization to organelle GO:0033365 57 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
lipid localization GO:0010876 62 0.011
serine family amino acid biosynthetic process GO:0009070 4 0.011
positive regulation of mitochondrion organization GO:0010822 4 0.011
muscle tissue development GO:0060537 58 0.011
response to alkaloid GO:0043279 132 0.011
dna packaging GO:0006323 4 0.011
response to growth factor GO:0070848 189 0.011
regulation of neurogenesis GO:0050767 247 0.011
developmental programmed cell death GO:0010623 2 0.011
deoxyribose phosphate metabolic process GO:0019692 9 0.011
negative regulation of mapk cascade GO:0043409 20 0.011
negative regulation of rna biosynthetic process GO:1902679 118 0.011
carbohydrate biosynthetic process GO:0016051 42 0.010
regulation of heart growth GO:0060420 12 0.010
regulation of behavior GO:0050795 61 0.010

Dhfr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.044
vascular disease DOID:178 0 0.044
cardiovascular system disease DOID:1287 0 0.044