Rattus norvegicus

3 known processes

Dkc1

dyskeratosis congenita 1, dyskerin

(Aliases: Nap57)

Dkc1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna metabolic process GO:0016070 406 0.409
regulation of nucleic acid templated transcription GO:1903506 380 0.144
regulation of protein metabolic process GO:0051246 289 0.093
rna biosynthetic process GO:0032774 380 0.091
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.082
protein phosphorylation GO:0006468 345 0.077
regulation of molecular function GO:0065009 398 0.074
negative regulation of macromolecule metabolic process GO:0010605 260 0.070
regulation of rna biosynthetic process GO:2001141 381 0.069
negative regulation of gene expression GO:0010629 199 0.067
programmed cell death GO:0012501 392 0.067
negative regulation of metabolic process GO:0009892 331 0.066
negative regulation of cellular metabolic process GO:0031324 281 0.058
regulation of signal transduction GO:0009966 318 0.057
regulation of cellular protein metabolic process GO:0032268 267 0.054
regulation of rna metabolic process GO:0051252 391 0.052
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.052
nucleic acid templated transcription GO:0097659 379 0.051
intracellular signal transduction GO:0035556 314 0.050
negative regulation of biosynthetic process GO:0009890 168 0.050
positive regulation of gene expression GO:0010628 244 0.049
regulation of cell differentiation GO:0045595 320 0.049
transcription dna templated GO:0006351 377 0.049
regulation of cell proliferation GO:0042127 359 0.047
apoptotic process GO:0006915 381 0.046
response to inorganic substance GO:0010035 377 0.044
negative regulation of rna metabolic process GO:0051253 123 0.042
negative regulation of cell death GO:0060548 229 0.042
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.041
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.041
negative regulation of cellular biosynthetic process GO:0031327 161 0.041
regulation of phosphate metabolic process GO:0019220 349 0.041
negative regulation of response to stimulus GO:0048585 155 0.041
locomotion GO:0040011 237 0.039
cell migration GO:0016477 197 0.039
regulation of multicellular organismal development GO:2000026 376 0.039
positive regulation of cell differentiation GO:0045597 217 0.039
catabolic process GO:0009056 351 0.038
positive regulation of cellular biosynthetic process GO:0031328 295 0.038
cellular catabolic process GO:0044248 295 0.037
regulation of blood circulation GO:1903522 110 0.037
cellular response to stress GO:0033554 269 0.037
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.037
cell type specific apoptotic process GO:0097285 134 0.037
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.035
carbohydrate derivative metabolic process GO:1901135 346 0.035
transcription from rna polymerase ii promoter GO:0006366 252 0.034
negative regulation of protein metabolic process GO:0051248 114 0.034
lymphocyte homeostasis GO:0002260 2 0.034
regulation of ion transport GO:0043269 245 0.034
regulation of catalytic activity GO:0050790 304 0.034
organelle organization GO:0006996 266 0.034
positive regulation of biosynthetic process GO:0009891 319 0.033
nucleobase containing small molecule metabolic process GO:0055086 316 0.033
positive regulation of nucleic acid templated transcription GO:1903508 197 0.033
regulation of phosphorylation GO:0042325 248 0.032
aging GO:0007568 241 0.031
regeneration GO:0031099 163 0.031
cell motility GO:0048870 202 0.031
regulation of immunoglobulin production GO:0002637 4 0.029
regulation of transcription dna templated GO:0006355 374 0.029
cellular response to endogenous stimulus GO:0071495 377 0.029
positive regulation of transcription dna templated GO:0045893 197 0.029
organic cyclic compound catabolic process GO:1901361 175 0.029
regulation of mrna splicing via spliceosome GO:0048024 3 0.028
regulation of programmed cell death GO:0043067 341 0.028
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.028
regulation of phosphorus metabolic process GO:0051174 349 0.028
positive regulation of nervous system development GO:0051962 178 0.027
positive regulation of neurogenesis GO:0050769 165 0.027
regulation of kinase activity GO:0043549 117 0.027
immune response GO:0006955 104 0.027
response to growth factor GO:0070848 189 0.027
macromolecule localization GO:0033036 252 0.027
organic substance catabolic process GO:1901575 316 0.027
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.027
rhythmic process GO:0048511 156 0.026
ion homeostasis GO:0050801 212 0.026
organophosphate metabolic process GO:0019637 370 0.026
localization of cell GO:0051674 202 0.026
cellular calcium ion homeostasis GO:0006874 160 0.026
calcium ion homeostasis GO:0055074 162 0.026
positive regulation of rna biosynthetic process GO:1902680 197 0.026
cellular ion homeostasis GO:0006873 184 0.026
cytoplasmic transport GO:0016482 115 0.026
reproductive process GO:0022414 372 0.026
regulation of locomotion GO:0040012 148 0.026
positive regulation of molecular function GO:0044093 230 0.025
single organism carbohydrate metabolic process GO:0044723 118 0.025
response to bacterium GO:0009617 200 0.025
cellular response to organonitrogen compound GO:0071417 197 0.025
protein localization GO:0008104 191 0.025
single organism intracellular transport GO:1902582 166 0.024
cell projection organization GO:0030030 302 0.024
positive regulation of multicellular organismal process GO:0051240 387 0.024
response to oxidative stress GO:0006979 186 0.024
positive regulation of cell proliferation GO:0008284 249 0.024
ribonucleotide metabolic process GO:0009259 231 0.024
multi organism reproductive process GO:0044703 262 0.024
aromatic compound catabolic process GO:0019439 168 0.024
mrna metabolic process GO:0016071 20 0.024
purine containing compound metabolic process GO:0072521 253 0.024
cellular divalent inorganic cation homeostasis GO:0072503 162 0.023
intracellular transport GO:0046907 185 0.023
ion transmembrane transport GO:0034220 365 0.023
regulation of apoptotic process GO:0042981 335 0.023
single organism catabolic process GO:0044712 283 0.023
head development GO:0060322 247 0.023
amine metabolic process GO:0009308 38 0.023
cellular response to nitrogen compound GO:1901699 210 0.023
positive regulation of rna metabolic process GO:0051254 203 0.023
regulation of protein modification process GO:0031399 194 0.023
ribonucleoside metabolic process GO:0009119 174 0.023
anterior posterior pattern specification GO:0009952 1 0.023
purine nucleoside metabolic process GO:0042278 169 0.022
regulation of catabolic process GO:0009894 113 0.022
cellular amine metabolic process GO:0044106 38 0.022
multicellular organism reproduction GO:0032504 233 0.022
brain development GO:0007420 247 0.022
positive regulation of developmental process GO:0051094 283 0.022
cellular cation homeostasis GO:0030003 180 0.022
purine nucleoside catabolic process GO:0006152 124 0.021
regulation of response to stress GO:0080134 126 0.021
heterocycle catabolic process GO:0046700 167 0.021
cellular amino acid metabolic process GO:0006520 107 0.021
nucleotide metabolic process GO:0009117 279 0.021
regulation of protein phosphorylation GO:0001932 183 0.021
regulation of proteasomal protein catabolic process GO:0061136 4 0.021
response to peptide hormone GO:0043434 278 0.021
transmembrane transport GO:0055085 412 0.021
purine ribonucleotide metabolic process GO:0009150 227 0.021
metal ion transport GO:0030001 289 0.021
response to other organism GO:0051707 220 0.021
regulation of hydrolase activity GO:0051336 143 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.020
regulation of immune system process GO:0002682 123 0.020
regulation of system process GO:0044057 208 0.020
regulation of cellular catabolic process GO:0031329 101 0.020
nucleoside catabolic process GO:0009164 126 0.020
response to toxic substance GO:0009636 133 0.020
response to wounding GO:0009611 254 0.020
negative regulation of signal transduction GO:0009968 83 0.020
ribose phosphate metabolic process GO:0019693 235 0.020
g protein coupled receptor signaling pathway GO:0007186 242 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.020
positive regulation of protein phosphorylation GO:0001934 135 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.020
regulation of cellular component movement GO:0051270 150 0.020
oxidation reduction process GO:0055114 304 0.020
negative regulation of cellular protein metabolic process GO:0032269 106 0.020
metal ion homeostasis GO:0055065 186 0.020
negative regulation of molecular function GO:0044092 133 0.020
regulation of cellular localization GO:0060341 263 0.019
negative regulation of apoptotic process GO:0043066 181 0.019
homeostatic process GO:0042592 331 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
negative regulation of cell communication GO:0010648 158 0.019
positive regulation of signaling GO:0023056 270 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
neuron differentiation GO:0030182 368 0.019
regulation of protein kinase activity GO:0045859 105 0.019
response to lipopolysaccharide GO:0032496 191 0.019
positive regulation of cell development GO:0010720 176 0.019
chemical homeostasis GO:0048878 292 0.019
negative regulation of transcription dna templated GO:0045892 116 0.019
cellular nitrogen compound catabolic process GO:0044270 163 0.019
divalent inorganic cation homeostasis GO:0072507 165 0.019
positive regulation of programmed cell death GO:0043068 157 0.018
embryonic pattern specification GO:0009880 1 0.018
response to biotic stimulus GO:0009607 226 0.018
response to external biotic stimulus GO:0043207 221 0.018
negative regulation of cell differentiation GO:0045596 99 0.018
synaptic growth at neuromuscular junction GO:0051124 1 0.018
nitrogen compound transport GO:0071705 229 0.018
cation transport GO:0006812 382 0.018
response to reactive oxygen species GO:0000302 120 0.018
organonitrogen compound catabolic process GO:1901565 179 0.018
cellular homeostasis GO:0019725 252 0.018
secretion GO:0046903 307 0.018
central nervous system development GO:0007417 311 0.018
anatomical structure formation involved in morphogenesis GO:0048646 83 0.017
response to hydrogen peroxide GO:0042542 89 0.017
negative regulation of developmental process GO:0051093 125 0.017
regulation of transferase activity GO:0051338 123 0.017
response to ketone GO:1901654 182 0.017
biological adhesion GO:0022610 110 0.017
regulation of secretion by cell GO:1903530 208 0.017
positive regulation of intracellular signal transduction GO:1902533 138 0.017
cellular metal ion homeostasis GO:0006875 172 0.017
regulation of secretion GO:0051046 224 0.017
gastrulation GO:0007369 2 0.017
negative regulation of rna biosynthetic process GO:1902679 118 0.017
cytosolic calcium ion homeostasis GO:0051480 140 0.017
cellular macromolecule localization GO:0070727 122 0.017
heart morphogenesis GO:0003007 3 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.017
response to oxygen levels GO:0070482 265 0.017
single organism organelle organization GO:1902589 180 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
lipid metabolic process GO:0006629 283 0.016
negative regulation of catalytic activity GO:0043086 103 0.016
positive regulation of response to stimulus GO:0048584 285 0.016
regulation of cellular ketone metabolic process GO:0010565 27 0.016
protein transport GO:0015031 132 0.016
response to osmotic stress GO:0006970 42 0.016
single organism reproductive process GO:0044702 297 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.016
positive regulation of apoptotic process GO:0043065 154 0.016
circulatory system development GO:0072359 134 0.016
negative regulation of nucleic acid templated transcription GO:1903507 117 0.016
negative regulation of programmed cell death GO:0043069 183 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
oxoacid metabolic process GO:0043436 290 0.016
neuron development GO:0048666 286 0.016
purine ribonucleoside metabolic process GO:0046128 168 0.016
peptidyl amino acid modification GO:0018193 126 0.016
protein localization to organelle GO:0033365 57 0.016
regulation of neurogenesis GO:0050767 247 0.015
positive regulation of cellular component organization GO:0051130 200 0.015
protein autophosphorylation GO:0046777 66 0.015
positive regulation of cellular protein metabolic process GO:0032270 167 0.015
nucleobase containing compound catabolic process GO:0034655 152 0.015
hematopoietic progenitor cell differentiation GO:0002244 2 0.015
cellular ketone metabolic process GO:0042180 51 0.015
organic acid metabolic process GO:0006082 292 0.015
cardiovascular system development GO:0072358 134 0.015
cellular component assembly GO:0022607 360 0.015
regulation of nervous system development GO:0051960 264 0.015
regulation of cell motility GO:2000145 131 0.015
neuron death GO:0070997 127 0.015
cellular response to abiotic stimulus GO:0071214 85 0.015
axis specification GO:0009798 4 0.015
neuron projection development GO:0031175 273 0.014
positive regulation of secretion by cell GO:1903532 128 0.014
regulation of cell development GO:0060284 263 0.014
cellular chemical homeostasis GO:0055082 247 0.014
heart process GO:0003015 57 0.014
ribonucleoside triphosphate catabolic process GO:0009203 122 0.014
reproduction GO:0000003 245 0.014
negative regulation of immune system process GO:0002683 39 0.014
negative regulation of signaling GO:0023057 157 0.014
muscle system process GO:0003012 115 0.014
regulation of canonical wnt signaling pathway GO:0060828 4 0.014
macromolecular complex assembly GO:0065003 273 0.014
cell growth GO:0016049 104 0.014
carbohydrate metabolic process GO:0005975 130 0.014
learning or memory GO:0007611 90 0.014
response to decreased oxygen levels GO:0036293 237 0.014
mechanoreceptor differentiation GO:0042490 2 0.014
secretion by cell GO:0032940 248 0.013
sexual reproduction GO:0019953 148 0.013
insulin like growth factor receptor signaling pathway GO:0048009 3 0.013
response to mechanical stimulus GO:0009612 134 0.013
carboxylic acid metabolic process GO:0019752 289 0.013
response to acid chemical GO:0001101 222 0.013
enzyme linked receptor protein signaling pathway GO:0007167 116 0.013
anatomical structure morphogenesis GO:0009653 298 0.013
purine nucleoside triphosphate catabolic process GO:0009146 122 0.013
multicellular organismal reproductive process GO:0048609 233 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
nuclear import GO:0051170 35 0.013
response to peptide GO:1901652 292 0.013
immune system development GO:0002520 41 0.013
macromolecular complex subunit organization GO:0043933 339 0.013
heart development GO:0007507 72 0.013
dna integrity checkpoint GO:0031570 2 0.013
positive regulation of secretion GO:0051047 140 0.013
regulation of cell cycle GO:0051726 73 0.013
epithelium development GO:0060429 96 0.013
leukocyte activation GO:0045321 76 0.013
defense response GO:0006952 194 0.013
cellular response to peptide GO:1901653 133 0.013
reactive nitrogen species metabolic process GO:2001057 1 0.013
hematopoietic or lymphoid organ development GO:0048534 36 0.013
proteolysis GO:0006508 175 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
wound healing GO:0042060 122 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
cell activation GO:0001775 97 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
cellular response to organic cyclic compound GO:0071407 202 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
regulation of cell migration GO:0030334 128 0.012
positive regulation of phosphorus metabolic process GO:0010562 262 0.012
negative regulation of protein phosphorylation GO:0001933 44 0.012
glycosyl compound metabolic process GO:1901657 182 0.012
positive regulation of cellular component movement GO:0051272 102 0.012
nucleoside metabolic process GO:0009116 179 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
lipid biosynthetic process GO:0008610 128 0.012
negative regulation of protein modification process GO:0031400 52 0.012
developmental process involved in reproduction GO:0003006 159 0.012
negative regulation of phosphate metabolic process GO:0045936 80 0.012
regulation of neuron projection development GO:0010975 161 0.012
cellular lipid metabolic process GO:0044255 208 0.012
gonad development GO:0008406 104 0.012
positive regulation of cell communication GO:0010647 271 0.012
histone modification GO:0016570 30 0.011
positive regulation of transport GO:0051050 245 0.011
negative regulation of phosphorus metabolic process GO:0010563 80 0.011
response to camp GO:0051591 91 0.011
somatic stem cell division GO:0048103 2 0.011
regulation of metal ion transport GO:0010959 118 0.011
cell cycle checkpoint GO:0000075 2 0.011
immune system process GO:0002376 204 0.011
heart contraction GO:0060047 57 0.011
purine containing compound catabolic process GO:0072523 138 0.011
cellular component movement GO:0006928 248 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
positive regulation of immune response GO:0050778 42 0.011
regulation of neuron death GO:1901214 115 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
response to extracellular stimulus GO:0009991 380 0.011
cell cycle GO:0007049 101 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
regulation of immune response GO:0050776 55 0.011
regulation of homeostatic process GO:0032844 101 0.011
blood circulation GO:0008015 183 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
single organism biosynthetic process GO:0044711 342 0.011
negative regulation of neuron death GO:1901215 69 0.011
regulation of heart contraction GO:0008016 48 0.011
cell adhesion GO:0007155 110 0.010
dna metabolic process GO:0006259 96 0.010
positive regulation of neuron projection development GO:0010976 99 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010
negative regulation of cell proliferation GO:0008285 119 0.010
organophosphate catabolic process GO:0046434 148 0.010
chromosome segregation GO:0007059 2 0.010
activation of cysteine type endopeptidase activity GO:0097202 4 0.010
cellular response to oxygen containing compound GO:1901701 386 0.010
establishment of protein localization GO:0045184 141 0.010
protein heterooligomerization GO:0051291 89 0.010
gamete generation GO:0007276 124 0.010
artery development GO:0060840 3 0.010
negative regulation of phosphorylation GO:0042326 57 0.010
lymphocyte activation GO:0046649 43 0.010
regulation of cell activation GO:0050865 50 0.010
dna damage checkpoint GO:0000077 2 0.010
regulation of anatomical structure morphogenesis GO:0022603 141 0.010

Dkc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
gastrointestinal system cancer DOID:3119 0 0.016
intestinal cancer DOID:10155 0 0.016
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.016
central nervous system disease DOID:331 0 0.012