Rattus norvegicus

51 known processes

Dpyd

dihydropyrimidine dehydrogenase

Dpyd biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxoacid metabolic process GO:0043436 290 0.719
carboxylic acid metabolic process GO:0019752 289 0.548
organic acid metabolic process GO:0006082 292 0.371
fatty acid metabolic process GO:0006631 99 0.228
monocarboxylic acid metabolic process GO:0032787 152 0.217
aging GO:0007568 241 0.187
cellular lipid metabolic process GO:0044255 208 0.170
lipid metabolic process GO:0006629 283 0.164
cellular hormone metabolic process GO:0034754 49 0.164
cellular amino acid metabolic process GO:0006520 107 0.159
response to extracellular stimulus GO:0009991 380 0.144
response to corticosteroid GO:0031960 235 0.138
response to nutrient levels GO:0031667 370 0.133
response to peptide hormone GO:0043434 278 0.131
response to glucocorticoid GO:0051384 223 0.128
cellular response to organonitrogen compound GO:0071417 197 0.111
halogenated hydrocarbon metabolic process GO:0042197 4 0.108
gland development GO:0048732 155 0.103
response to peptide GO:1901652 292 0.102
organic acid biosynthetic process GO:0016053 83 0.098
cellular response to peptide GO:1901653 133 0.097
cellular ketone metabolic process GO:0042180 51 0.096
organic substance catabolic process GO:1901575 316 0.092
retinal metabolic process GO:0042574 3 0.091
organic hydroxy compound metabolic process GO:1901615 115 0.090
catabolic process GO:0009056 351 0.089
cellular response to peptide hormone stimulus GO:0071375 120 0.089
small molecule biosynthetic process GO:0044283 124 0.088
sulfur compound metabolic process GO:0006790 70 0.085
liver development GO:0001889 90 0.084
alpha amino acid metabolic process GO:1901605 71 0.080
cellular response to oxygen containing compound GO:1901701 386 0.076
single organism catabolic process GO:0044712 283 0.071
cellular response to endogenous stimulus GO:0071495 377 0.071
response to acid chemical GO:0001101 222 0.071
response to insulin GO:0032868 133 0.070
response to inorganic substance GO:0010035 377 0.069
response to xenobiotic stimulus GO:0009410 23 0.067
hormone metabolic process GO:0042445 69 0.064
oxidation reduction process GO:0055114 304 0.063
steroid metabolic process GO:0008202 73 0.063
small molecule catabolic process GO:0044282 59 0.062
lipid biosynthetic process GO:0008610 128 0.062
response to nutrient GO:0007584 248 0.060
response to biotic stimulus GO:0009607 226 0.060
response to metal ion GO:0010038 253 0.058
intracellular signal transduction GO:0035556 314 0.056
chlorinated hydrocarbon metabolic process GO:0042196 4 0.055
naphthalene metabolic process GO:0018931 2 0.055
response to ketone GO:1901654 182 0.054
cellular response to organic cyclic compound GO:0071407 202 0.053
single organism biosynthetic process GO:0044711 342 0.049
hepaticobiliary system development GO:0061008 90 0.048
unsaturated fatty acid metabolic process GO:0033559 39 0.047
regulation of hormone levels GO:0010817 187 0.046
cellular response to xenobiotic stimulus GO:0071466 19 0.046
response to external biotic stimulus GO:0043207 221 0.046
cellular catabolic process GO:0044248 295 0.046
calcitriol biosynthetic process from calciol GO:0036378 2 0.045
blood circulation GO:0008015 183 0.045
phenol containing compound metabolic process GO:0018958 30 0.044
regulation of cellular ketone metabolic process GO:0010565 27 0.044
regulation of signal transduction GO:0009966 318 0.042
cellular response to nitrogen compound GO:1901699 210 0.042
carbohydrate derivative metabolic process GO:1901135 346 0.041
response to bacterium GO:0009617 200 0.041
naphthalene containing compound metabolic process GO:0090420 2 0.041
tube development GO:0035295 89 0.040
response to growth factor GO:0070848 189 0.038
icosanoid metabolic process GO:0006690 38 0.038
reproductive process GO:0022414 372 0.037
fatty acid derivative metabolic process GO:1901568 38 0.037
multicellular organismal reproductive process GO:0048609 233 0.037
central nervous system development GO:0007417 311 0.036
response to carbohydrate GO:0009743 183 0.036
cofactor metabolic process GO:0051186 95 0.035
response to ethanol GO:0045471 162 0.035
response to estrogen GO:0043627 232 0.034
response to toxic substance GO:0009636 133 0.034
cellular response to lipid GO:0071396 201 0.034
positive regulation of signaling GO:0023056 270 0.034
regeneration GO:0031099 163 0.033
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.033
response to amino acid GO:0043200 75 0.033
cellular response to insulin stimulus GO:0032869 81 0.033
response to reactive oxygen species GO:0000302 120 0.033
regulation of molecular function GO:0065009 398 0.031
cellular response to growth factor stimulus GO:0071363 162 0.031
cellular component biogenesis GO:0044085 368 0.031
heterocycle catabolic process GO:0046700 167 0.030
organic cyclic compound catabolic process GO:1901361 175 0.030
neurological system process GO:0050877 219 0.030
response to oxidative stress GO:0006979 186 0.030
apoptotic process GO:0006915 381 0.029
regulation of cellular amino acid metabolic process GO:0006521 2 0.029
aromatic compound catabolic process GO:0019439 168 0.029
nucleoside metabolic process GO:0009116 179 0.029
response to hypoxia GO:0001666 231 0.028
cellular response to external stimulus GO:0071496 118 0.028
positive regulation of response to stimulus GO:0048584 285 0.028
cellular amine metabolic process GO:0044106 38 0.028
female pregnancy GO:0007565 122 0.028
monocarboxylic acid transport GO:0015718 52 0.027
anion transport GO:0006820 178 0.027
response to vitamin GO:0033273 131 0.027
organic acid catabolic process GO:0016054 49 0.027
response to decreased oxygen levels GO:0036293 237 0.027
organic hydroxy compound biosynthetic process GO:1901617 51 0.026
coenzyme metabolic process GO:0006732 86 0.026
terpenoid metabolic process GO:0006721 37 0.026
carboxylic acid catabolic process GO:0046395 49 0.026
response to other organism GO:0051707 220 0.026
tissue development GO:0009888 252 0.026
positive regulation of cellular amine metabolic process GO:0033240 3 0.026
ribonucleoside metabolic process GO:0009119 174 0.025
response to lipopolysaccharide GO:0032496 191 0.025
organonitrogen compound biosynthetic process GO:1901566 167 0.025
purine ribonucleoside metabolic process GO:0046128 168 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.025
nucleobase containing small molecule metabolic process GO:0055086 316 0.025
organic acid transport GO:0015849 116 0.025
organonitrogen compound catabolic process GO:1901565 179 0.025
circulatory system process GO:0003013 183 0.024
cellular response to extracellular stimulus GO:0031668 73 0.024
reproductive structure development GO:0048608 128 0.024
regulation of cellular amine metabolic process GO:0033238 8 0.024
response to monosaccharide GO:0034284 159 0.024
cellular nitrogen compound catabolic process GO:0044270 163 0.024
cellular response to stress GO:0033554 269 0.024
triglyceride metabolic process GO:0006641 21 0.024
response to molecule of bacterial origin GO:0002237 194 0.024
alkaloid metabolic process GO:0009820 3 0.023
multicellular organism reproduction GO:0032504 233 0.023
behavior GO:0007610 205 0.023
glycosyl compound metabolic process GO:1901657 182 0.023
protein transport GO:0015031 132 0.023
regulation of intracellular signal transduction GO:1902531 218 0.023
regulation of multicellular organismal development GO:2000026 376 0.023
eye morphogenesis GO:0048592 4 0.023
positive regulation of signal transduction GO:0009967 175 0.023
linoleic acid metabolic process GO:0043651 4 0.023
response to cytokine GO:0034097 215 0.022
positive regulation of catalytic activity GO:0043085 184 0.022
cellular chemical homeostasis GO:0055082 247 0.022
isoprenoid metabolic process GO:0006720 45 0.022
purine nucleoside metabolic process GO:0042278 169 0.022
glial cell differentiation GO:0010001 65 0.022
multi organism reproductive process GO:0044703 262 0.022
single organism reproductive process GO:0044702 297 0.022
cellular modified amino acid metabolic process GO:0006575 61 0.022
regulation of cell differentiation GO:0045595 320 0.022
macromolecule localization GO:0033036 252 0.022
reproduction GO:0000003 245 0.022
response to cadmium ion GO:0046686 35 0.022
chemical homeostasis GO:0048878 292 0.021
protein complex biogenesis GO:0070271 263 0.021
purine containing compound metabolic process GO:0072521 253 0.021
regulation of phosphate metabolic process GO:0019220 349 0.021
acylglycerol metabolic process GO:0006639 21 0.021
response to organophosphorus GO:0046683 102 0.021
positive regulation of cell proliferation GO:0008284 249 0.021
alcohol metabolic process GO:0006066 77 0.020
chromosome segregation GO:0007059 2 0.020
single organism carbohydrate metabolic process GO:0044723 118 0.020
cellular response to reactive oxygen species GO:0034614 55 0.020
reproductive system development GO:0061458 128 0.020
negative regulation of cell death GO:0060548 229 0.020
defense response GO:0006952 194 0.020
long chain fatty acid metabolic process GO:0001676 32 0.020
negative regulation of metabolic process GO:0009892 331 0.020
neuron development GO:0048666 286 0.020
cellular response to hormone stimulus GO:0032870 247 0.020
head development GO:0060322 247 0.020
positive regulation of intracellular signal transduction GO:1902533 138 0.020
regulation of phosphorylation GO:0042325 248 0.020
transmembrane transport GO:0055085 412 0.020
positive regulation of protein metabolic process GO:0051247 178 0.020
carbohydrate metabolic process GO:0005975 130 0.020
cellular response to steroid hormone stimulus GO:0071383 93 0.020
organophosphate metabolic process GO:0019637 370 0.020
cellular amino acid biosynthetic process GO:0008652 32 0.020
diterpenoid metabolic process GO:0016101 33 0.019
exogenous drug catabolic process GO:0042738 1 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
ras protein signal transduction GO:0007265 29 0.019
regulation of secretion by cell GO:1903530 208 0.019
brain development GO:0007420 247 0.019
positive regulation of phosphorus metabolic process GO:0010562 262 0.019
response to purine containing compound GO:0014074 126 0.019
ion transmembrane transport GO:0034220 365 0.019
positive regulation of cellular protein metabolic process GO:0032270 167 0.018
inner medullary collecting duct development GO:0072061 1 0.018
monosaccharide metabolic process GO:0005996 61 0.018
positive regulation of developmental process GO:0051094 283 0.018
regulation of catabolic process GO:0009894 113 0.018
alditol metabolic process GO:0019400 4 0.018
catechol containing compound metabolic process GO:0009712 19 0.018
cellular component assembly GO:0022607 360 0.018
action potential GO:0001508 54 0.018
response to oxygen levels GO:0070482 265 0.018
positive regulation of protein phosphorylation GO:0001934 135 0.018
neutral lipid metabolic process GO:0006638 21 0.018
regulation of catalytic activity GO:0050790 304 0.018
neuron differentiation GO:0030182 368 0.018
regulation of mapk cascade GO:0043408 116 0.018
positive regulation of phosphate metabolic process GO:0045937 262 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
protein localization GO:0008104 191 0.017
regulation of nervous system development GO:0051960 264 0.017
neuron projection development GO:0031175 273 0.017
regulation of membrane potential GO:0042391 110 0.017
nicotine metabolic process GO:0018933 1 0.017
amine metabolic process GO:0009308 38 0.017
cellular response to alcohol GO:0097306 87 0.017
macromolecular complex assembly GO:0065003 273 0.017
organelle organization GO:0006996 266 0.017
cellular amino acid catabolic process GO:0009063 21 0.017
glycerolipid metabolic process GO:0046486 67 0.017
monocarboxylic acid biosynthetic process GO:0072330 48 0.017
positive regulation of cell development GO:0010720 176 0.017
developmental process involved in reproduction GO:0003006 159 0.017
cellular ion homeostasis GO:0006873 184 0.017
transmission of nerve impulse GO:0019226 42 0.017
protein oligomerization GO:0051259 191 0.017
positive regulation of multicellular organismal process GO:0051240 387 0.017
response to testosterone GO:0033574 55 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
lipid catabolic process GO:0016042 46 0.017
neuronal action potential GO:0019228 35 0.016
arachidonic acid metabolic process GO:0019369 20 0.016
regulation of phosphorus metabolic process GO:0051174 349 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.016
programmed cell death GO:0012501 392 0.016
neuron projection morphogenesis GO:0048812 122 0.016
ion homeostasis GO:0050801 212 0.016
cellular response to ketone GO:1901655 51 0.016
regulation of programmed cell death GO:0043067 341 0.016
cellular response to corticosteroid stimulus GO:0071384 69 0.016
locomotion GO:0040011 237 0.016
negative regulation of cellular metabolic process GO:0031324 281 0.016
positive regulation of transport GO:0051050 245 0.016
anatomical structure morphogenesis GO:0009653 298 0.015
gliogenesis GO:0042063 93 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
lipid storage GO:0019915 1 0.015
protein complex assembly GO:0006461 263 0.015
transcription dna templated GO:0006351 377 0.015
regulation of rna biosynthetic process GO:2001141 381 0.015
protein phosphorylation GO:0006468 345 0.015
positive regulation of cell motility GO:2000147 97 0.015
regulation of neurogenesis GO:0050767 247 0.015
homeostatic process GO:0042592 331 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
regulation of nucleic acid templated transcription GO:1903506 380 0.015
retinoid metabolic process GO:0001523 24 0.015
forebrain development GO:0030900 98 0.015
response to insecticide GO:0017085 21 0.015
single organism cellular localization GO:1902580 102 0.015
response to hexose GO:0009746 144 0.015
4 chlorobiphenyl metabolic process GO:0018880 1 0.015
vitamin d3 metabolic process GO:0070640 2 0.015
purine ribonucleotide metabolic process GO:0009150 227 0.015
alpha amino acid catabolic process GO:1901606 20 0.015
carboxylic acid transport GO:0046942 115 0.014
heart morphogenesis GO:0003007 3 0.014
xenobiotic metabolic process GO:0006805 19 0.014
4 nitrophenol metabolic process GO:0018960 1 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
peptidyl tyrosine modification GO:0018212 72 0.014
organophosphate catabolic process GO:0046434 148 0.014
axis specification GO:0009798 4 0.014
fat soluble vitamin biosynthetic process GO:0042362 2 0.014
cellular component movement GO:0006928 248 0.014
cytoplasmic transport GO:0016482 115 0.014
cellular homeostasis GO:0019725 252 0.014
regulation of transcription dna templated GO:0006355 374 0.014
response to hydrogen peroxide GO:0042542 89 0.014
peptidyl amino acid modification GO:0018193 126 0.014
regulation of cell development GO:0060284 263 0.014
cell cell signaling GO:0007267 335 0.014
nucleic acid templated transcription GO:0097659 379 0.014
protein homooligomerization GO:0051260 91 0.014
intracellular transport GO:0046907 185 0.014
response to starvation GO:0042594 59 0.014
protein complex subunit organization GO:0071822 302 0.014
positive regulation of nervous system development GO:0051962 178 0.014
positive regulation of neurogenesis GO:0050769 165 0.014
positive regulation of molecular function GO:0044093 230 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.014
c21 steroid hormone metabolic process GO:0008207 14 0.014
steroid biosynthetic process GO:0006694 48 0.014
secretion GO:0046903 307 0.013
cellular macromolecule localization GO:0070727 122 0.013
regulation of proteasomal protein catabolic process GO:0061136 4 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
rna biosynthetic process GO:0032774 380 0.013
response to temperature stimulus GO:0009266 94 0.013
mesoderm development GO:0007498 2 0.013
maintenance of location GO:0051235 17 0.013
organ regeneration GO:0031100 101 0.013
regulation of cellular protein metabolic process GO:0032268 267 0.013
growth GO:0040007 165 0.013
positive regulation of gene expression GO:0010628 244 0.013
carboxylic acid biosynthetic process GO:0046394 83 0.013
regulation of system process GO:0044057 208 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
kidney development GO:0001822 67 0.013
response to estradiol GO:0032355 164 0.013
positive regulation of biosynthetic process GO:0009891 319 0.013
cell part morphogenesis GO:0032990 123 0.013
regulation of transferase activity GO:0051338 123 0.013
response to sulfur dioxide GO:0010477 3 0.013
cell projection organization GO:0030030 302 0.013
fatty acid catabolic process GO:0009062 26 0.013
regulation of anatomical structure size GO:0090066 135 0.013
protein localization to organelle GO:0033365 57 0.013
drug metabolic process GO:0017144 11 0.013
regulation of protein metabolic process GO:0051246 289 0.013
epoxygenase p450 pathway GO:0019373 1 0.013
salivary gland development GO:0007431 3 0.012
cellular alcohol biosynthetic process GO:0044108 2 0.012
regulation of lipid metabolic process GO:0019216 68 0.012
positive regulation of protein modification process GO:0031401 142 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
cellular protein localization GO:0034613 122 0.012
hormone biosynthetic process GO:0042446 25 0.012
immune system process GO:0002376 204 0.012
secretion by cell GO:0032940 248 0.012
negative regulation of protein import into nucleus translocation GO:0033159 1 0.012
regulation of protein modification process GO:0031399 194 0.012
neuron apoptotic process GO:0051402 88 0.012
cell type specific apoptotic process GO:0097285 134 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
sulfur amino acid metabolic process GO:0000096 9 0.012
cellular component morphogenesis GO:0032989 155 0.012
cation transport GO:0006812 382 0.012
ribose phosphate metabolic process GO:0019693 235 0.012
positive regulation of cell communication GO:0010647 271 0.012
sex differentiation GO:0007548 113 0.012
chemosensory behavior GO:0007635 2 0.012
drug catabolic process GO:0042737 1 0.012
epithelium development GO:0060429 96 0.012
regulation of cell proliferation GO:0042127 359 0.012
response to alkaloid GO:0043279 132 0.012
renal system development GO:0072001 67 0.012
negative regulation of macromolecule metabolic process GO:0010605 260 0.012
response to vitamin d GO:0033280 34 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
dicarboxylic acid metabolic process GO:0043648 42 0.012
vitamin d metabolic process GO:0042359 4 0.012
cell morphogenesis GO:0000902 142 0.012
membrane organization GO:0061024 94 0.012
organic anion transport GO:0015711 132 0.011
vitamin d biosynthetic process GO:0042368 2 0.011
gastrulation GO:0007369 2 0.011
cellular response to metal ion GO:0071248 55 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
positive regulation of catabolic process GO:0009896 78 0.011
response to radiation GO:0009314 137 0.011
gonad development GO:0008406 104 0.011
thioester metabolic process GO:0035383 28 0.011
androgen metabolic process GO:0008209 14 0.011
cellular response to nutrient levels GO:0031669 60 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
xenobiotic catabolic process GO:0042178 7 0.011
cellular amide metabolic process GO:0043603 44 0.011
lipid transport GO:0006869 61 0.011
regulation of cellular component organization GO:0051128 368 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
nucleoside catabolic process GO:0009164 126 0.011
negative regulation of cell communication GO:0010648 158 0.011
regulation of neuron differentiation GO:0045664 208 0.011
single organism behavior GO:0044708 130 0.011
response to transforming growth factor beta GO:0071559 46 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.011
alpha amino acid biosynthetic process GO:1901607 23 0.011
regulation of cellular localization GO:0060341 263 0.011
regulation of tube size GO:0035150 89 0.011
regulation of cell migration GO:0030334 128 0.011
cation homeostasis GO:0055080 195 0.011
single organism organelle organization GO:1902589 180 0.011
regulation of cell projection organization GO:0031344 175 0.011
rna metabolic process GO:0016070 406 0.011
sulfation GO:0051923 2 0.011
regulation of blood pressure GO:0008217 83 0.011
olfactory behavior GO:0042048 2 0.011
aromatic amino acid family catabolic process GO:0009074 7 0.011
regulation of cellular catabolic process GO:0031329 101 0.010
negative regulation of cell cycle phase transition GO:1901988 4 0.010
reactive oxygen species metabolic process GO:0072593 37 0.010
ribonucleoside catabolic process GO:0042454 126 0.010
regulation of neuron death GO:1901214 115 0.010
response to wounding GO:0009611 254 0.010
lauric acid metabolic process GO:0048252 4 0.010
positive regulation of neuron differentiation GO:0045666 126 0.010
phthalate metabolic process GO:0018963 8 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
serine family amino acid metabolic process GO:0009069 12 0.010
positive regulation of transcription dna templated GO:0045893 197 0.010
benzene containing compound metabolic process GO:0042537 22 0.010
oligopeptide transport GO:0006857 4 0.010
regulation of cellular component movement GO:0051270 150 0.010
gtp catabolic process GO:0006184 71 0.010
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.010
single organism intracellular transport GO:1902582 166 0.010
cellular lipid catabolic process GO:0044242 37 0.010

Dpyd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.054
inherited metabolic disorder DOID:655 0 0.054
disease of anatomical entity DOID:7 0 0.026
vascular disease DOID:178 0 0.026
cardiovascular system disease DOID:1287 0 0.026
hypertension DOID:10763 0 0.018
artery disease DOID:0050828 0 0.018
nervous system disease DOID:863 0 0.016
disease of cellular proliferation DOID:14566 0 0.011