Rattus norvegicus

0 known processes

Egfl6

EGF-like-domain, multiple 6

Egfl6 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of signal transduction GO:0009966 318 0.083
cellular component biogenesis GO:0044085 368 0.075
regulation of multicellular organismal development GO:2000026 376 0.068
regulation of cellular component organization GO:0051128 368 0.064
apoptotic process GO:0006915 381 0.061
intracellular signal transduction GO:0035556 314 0.061
oxoacid metabolic process GO:0043436 290 0.061
regulation of intracellular signal transduction GO:1902531 218 0.055
central nervous system development GO:0007417 311 0.054
organic acid metabolic process GO:0006082 292 0.053
neuron differentiation GO:0030182 368 0.053
cellular component assembly GO:0022607 360 0.052
response to extracellular stimulus GO:0009991 380 0.052
positive regulation of phosphate metabolic process GO:0045937 262 0.051
cellular response to endogenous stimulus GO:0071495 377 0.050
programmed cell death GO:0012501 392 0.050
brain development GO:0007420 247 0.048
ion transmembrane transport GO:0034220 365 0.048
head development GO:0060322 247 0.048
positive regulation of cell communication GO:0010647 271 0.047
cation transport GO:0006812 382 0.047
regulation of cell differentiation GO:0045595 320 0.046
cellular amine metabolic process GO:0044106 38 0.046
carboxylic acid metabolic process GO:0019752 289 0.046
transmembrane transport GO:0055085 412 0.045
chemical homeostasis GO:0048878 292 0.045
neuron development GO:0048666 286 0.045
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.045
regulation of cellular amine metabolic process GO:0033238 8 0.045
catabolic process GO:0009056 351 0.044
regulation of programmed cell death GO:0043067 341 0.044
response to nutrient levels GO:0031667 370 0.043
defense response GO:0006952 194 0.043
nucleic acid templated transcription GO:0097659 379 0.042
organophosphate metabolic process GO:0019637 370 0.042
rna metabolic process GO:0016070 406 0.041
regulation of molecular function GO:0065009 398 0.041
amine metabolic process GO:0009308 38 0.040
cellular chemical homeostasis GO:0055082 247 0.040
g protein coupled receptor signaling pathway GO:0007186 242 0.040
negative regulation of cell communication GO:0010648 158 0.040
lipid metabolic process GO:0006629 283 0.039
negative regulation of signaling GO:0023057 157 0.039
response to wounding GO:0009611 254 0.039
regulation of nervous system development GO:0051960 264 0.039
cellular catabolic process GO:0044248 295 0.039
response to alkaloid GO:0043279 132 0.039
organic substance catabolic process GO:1901575 316 0.038
regulation of phosphorus metabolic process GO:0051174 349 0.038
single organism biosynthetic process GO:0044711 342 0.038
homeostatic process GO:0042592 331 0.038
reproductive process GO:0022414 372 0.037
regulation of apoptotic process GO:0042981 335 0.036
regulation of phosphate metabolic process GO:0019220 349 0.036
macromolecular complex subunit organization GO:0043933 339 0.036
response to nutrient GO:0007584 248 0.036
protein complex subunit organization GO:0071822 302 0.036
reproduction GO:0000003 245 0.036
cellular component movement GO:0006928 248 0.035
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.035
positive regulation of signaling GO:0023056 270 0.035
positive regulation of response to stimulus GO:0048584 285 0.035
negative regulation of response to stimulus GO:0048585 155 0.034
negative regulation of cell death GO:0060548 229 0.034
regulation of cell proliferation GO:0042127 359 0.034
cellular amino acid metabolic process GO:0006520 107 0.034
positive regulation of phosphorus metabolic process GO:0010562 262 0.033
cation transmembrane transport GO:0098655 263 0.032
protein complex assembly GO:0006461 263 0.032
rhythmic process GO:0048511 156 0.032
blood circulation GO:0008015 183 0.032
single organism catabolic process GO:0044712 283 0.032
regulation of cellular amino acid metabolic process GO:0006521 2 0.032
regulation of neurogenesis GO:0050767 247 0.031
regulation of neuron differentiation GO:0045664 208 0.031
negative regulation of metabolic process GO:0009892 331 0.031
regulation of rna metabolic process GO:0051252 391 0.031
regulation of cellular ketone metabolic process GO:0010565 27 0.030
purine nucleotide metabolic process GO:0006163 229 0.030
nucleoside phosphate metabolic process GO:0006753 283 0.030
regulation of catalytic activity GO:0050790 304 0.030
regulation of nucleic acid templated transcription GO:1903506 380 0.030
cellular response to oxygen containing compound GO:1901701 386 0.030
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.030
negative regulation of multicellular organismal process GO:0051241 203 0.030
multi organism reproductive process GO:0044703 262 0.030
transcription dna templated GO:0006351 377 0.030
anatomical structure morphogenesis GO:0009653 298 0.029
protein complex biogenesis GO:0070271 263 0.029
response to other organism GO:0051707 220 0.029
positive regulation of cellular biosynthetic process GO:0031328 295 0.029
positive regulation of multicellular organismal process GO:0051240 387 0.029
nucleobase containing small molecule metabolic process GO:0055086 316 0.029
cell projection organization GO:0030030 302 0.029
organonitrogen compound biosynthetic process GO:1901566 167 0.029
positive regulation of developmental process GO:0051094 283 0.029
macromolecular complex assembly GO:0065003 273 0.029
positive regulation of transport GO:0051050 245 0.028
divalent inorganic cation homeostasis GO:0072507 165 0.028
cellular ketone metabolic process GO:0042180 51 0.028
cellular response to stress GO:0033554 269 0.027
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.027
response to acid chemical GO:0001101 222 0.027
cation homeostasis GO:0055080 195 0.027
regulation of cell development GO:0060284 263 0.027
regulation of rna biosynthetic process GO:2001141 381 0.027
metal ion transport GO:0030001 289 0.027
carbohydrate derivative metabolic process GO:1901135 346 0.027
purine ribonucleotide metabolic process GO:0009150 227 0.027
regulation of canonical wnt signaling pathway GO:0060828 4 0.027
inorganic ion transmembrane transport GO:0098660 229 0.027
heart morphogenesis GO:0003007 3 0.027
metal ion homeostasis GO:0055065 186 0.027
cell motility GO:0048870 202 0.027
ion homeostasis GO:0050801 212 0.027
response to biotic stimulus GO:0009607 226 0.027
ribose phosphate metabolic process GO:0019693 235 0.026
positive regulation of cell differentiation GO:0045597 217 0.026
cellular ion homeostasis GO:0006873 184 0.026
response to inorganic substance GO:0010035 377 0.026
nucleotide catabolic process GO:0009166 139 0.026
positive regulation of phosphorylation GO:0042327 177 0.026
cellular divalent inorganic cation homeostasis GO:0072503 162 0.026
cellular lipid metabolic process GO:0044255 208 0.026
locomotion GO:0040011 237 0.026
regulation of transcription dna templated GO:0006355 374 0.026
regulation of phosphorylation GO:0042325 248 0.025
rna biosynthetic process GO:0032774 380 0.025
response to estrogen GO:0043627 232 0.025
response to bacterium GO:0009617 200 0.025
cellular response to lipid GO:0071396 201 0.025
response to external biotic stimulus GO:0043207 221 0.025
regulation of cell projection organization GO:0031344 175 0.024
single organism reproductive process GO:0044702 297 0.024
regulation of ion transport GO:0043269 245 0.024
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
multicellular organismal reproductive process GO:0048609 233 0.024
regulation of response to stress GO:0080134 126 0.024
heterocycle catabolic process GO:0046700 167 0.024
protein phosphorylation GO:0006468 345 0.024
ribonucleotide metabolic process GO:0009259 231 0.024
purine containing compound metabolic process GO:0072521 253 0.024
positive regulation of gene expression GO:0010628 244 0.023
response to glucocorticoid GO:0051384 223 0.023
regulation of cellular localization GO:0060341 263 0.023
calcium ion homeostasis GO:0055074 162 0.023
nucleotide metabolic process GO:0009117 279 0.023
positive regulation of signal transduction GO:0009967 175 0.023
negative regulation of programmed cell death GO:0043069 183 0.023
protein oligomerization GO:0051259 191 0.023
cell migration GO:0016477 197 0.023
circulatory system process GO:0003013 183 0.023
response to oxygen levels GO:0070482 265 0.023
organelle organization GO:0006996 266 0.023
negative regulation of macromolecule metabolic process GO:0010605 260 0.023
positive regulation of cell proliferation GO:0008284 249 0.022
localization of cell GO:0051674 202 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.022
regeneration GO:0031099 163 0.022
secretion GO:0046903 307 0.022
small gtpase mediated signal transduction GO:0007264 36 0.022
response to ethanol GO:0045471 162 0.022
aging GO:0007568 241 0.022
positive regulation of cell death GO:0010942 184 0.021
cellular cation homeostasis GO:0030003 180 0.021
protein homooligomerization GO:0051260 91 0.021
cell cell signaling GO:0007267 335 0.021
regulation of protein modification process GO:0031399 194 0.021
response to metal ion GO:0010038 253 0.021
secretion by cell GO:0032940 248 0.021
carbohydrate metabolic process GO:0005975 130 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.021
negative regulation of developmental process GO:0051093 125 0.021
regulation of anatomical structure morphogenesis GO:0022603 141 0.021
cytosolic calcium ion homeostasis GO:0051480 140 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
positive regulation of biosynthetic process GO:0009891 319 0.021
neuron projection development GO:0031175 273 0.020
growth GO:0040007 165 0.020
regulation of neuron projection development GO:0010975 161 0.020
organic anion transport GO:0015711 132 0.020
cellular nitrogen compound catabolic process GO:0044270 163 0.020
positive regulation of nervous system development GO:0051962 178 0.020
cellular homeostasis GO:0019725 252 0.020
positive regulation of cellular component organization GO:0051130 200 0.020
response to growth factor GO:0070848 189 0.020
negative regulation of apoptotic process GO:0043066 181 0.020
anion transport GO:0006820 178 0.020
positive regulation of apoptotic process GO:0043065 154 0.020
positive regulation of programmed cell death GO:0043068 157 0.020
regulation of cellular component movement GO:0051270 150 0.020
organic cyclic compound catabolic process GO:1901361 175 0.020
transcription from rna polymerase ii promoter GO:0006366 252 0.020
female pregnancy GO:0007565 122 0.020
inorganic cation transmembrane transport GO:0098662 202 0.020
negative regulation of biosynthetic process GO:0009890 168 0.020
neurological system process GO:0050877 219 0.020
positive regulation of cell projection organization GO:0031346 111 0.019
cellular metal ion homeostasis GO:0006875 172 0.019
regulation of nucleotide metabolic process GO:0006140 117 0.019
regulation of secretion GO:0051046 224 0.019
positive regulation of nucleic acid templated transcription GO:1903508 197 0.019
organic hydroxy compound metabolic process GO:1901615 115 0.019
cellular response to nitrogen compound GO:1901699 210 0.019
response to peptide GO:1901652 292 0.019
regulation of response to external stimulus GO:0032101 106 0.019
positive regulation of cellular protein metabolic process GO:0032270 167 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.019
nucleobase containing compound catabolic process GO:0034655 152 0.019
positive regulation of protein phosphorylation GO:0001934 135 0.018
learning or memory GO:0007611 90 0.018
response to cytokine GO:0034097 215 0.018
negative regulation of cell differentiation GO:0045596 99 0.018
cell adhesion GO:0007155 110 0.018
Mouse
positive regulation of intracellular signal transduction GO:1902533 138 0.018
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.018
single organism behavior GO:0044708 130 0.018
organic hydroxy compound transport GO:0015850 77 0.018
nucleoside triphosphate metabolic process GO:0009141 144 0.018
response to peptide hormone GO:0043434 278 0.018
regulation of ossification GO:0030278 32 0.017
ras protein signal transduction GO:0007265 29 0.017
cellular response to hormone stimulus GO:0032870 247 0.017
immune system process GO:0002376 204 0.017
positive regulation of rna biosynthetic process GO:1902680 197 0.017
cellular response to organic cyclic compound GO:0071407 202 0.017
response to ketone GO:1901654 182 0.017
negative regulation of transport GO:0051051 136 0.017
gland development GO:0048732 155 0.017
positive regulation of rna metabolic process GO:0051254 203 0.017
positive regulation of molecular function GO:0044093 230 0.017
aromatic compound catabolic process GO:0019439 168 0.017
positive regulation of catalytic activity GO:0043085 184 0.017
positive regulation of protein metabolic process GO:0051247 178 0.017
macromolecule localization GO:0033036 252 0.017
divalent metal ion transport GO:0070838 132 0.017
positive regulation of transcription dna templated GO:0045893 197 0.017
carbohydrate derivative biosynthetic process GO:1901137 124 0.017
regulation of system process GO:0044057 208 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
non canonical wnt signaling pathway GO:0035567 3 0.017
regulation of secretion by cell GO:1903530 208 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
cell morphogenesis GO:0000902 142 0.016
response to ammonium ion GO:0060359 71 0.016
negative regulation of cell proliferation GO:0008285 119 0.016
cellular macromolecule localization GO:0070727 122 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
single organism organelle organization GO:1902589 180 0.016
signal transduction by phosphorylation GO:0023014 144 0.016
regulation of purine nucleotide metabolic process GO:1900542 115 0.016
response to hypoxia GO:0001666 231 0.016
actin filament based process GO:0030029 86 0.016
protein localization GO:0008104 191 0.016
multi multicellular organism process GO:0044706 138 0.016
vascular process in circulatory system GO:0003018 96 0.016
response to toxic substance GO:0009636 133 0.016
divalent inorganic cation transport GO:0072511 134 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
positive regulation of cellular component movement GO:0051272 102 0.016
vesicle mediated transport GO:0016192 181 0.016
ossification GO:0001503 70 0.016
regulation of membrane potential GO:0042391 110 0.016
regulation of anatomical structure size GO:0090066 135 0.015
peptidyl amino acid modification GO:0018193 126 0.015
cell part morphogenesis GO:0032990 123 0.015
anion transmembrane transport GO:0098656 77 0.015
multicellular organism reproduction GO:0032504 233 0.015
positive regulation of cell development GO:0010720 176 0.015
response to temperature stimulus GO:0009266 94 0.015
positive regulation of neurogenesis GO:0050769 165 0.015
negative regulation of cellular biosynthetic process GO:0031327 161 0.015
regulation of blood vessel size GO:0050880 89 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.015
organophosphate biosynthetic process GO:0090407 143 0.015
organophosphate catabolic process GO:0046434 148 0.015
negative regulation of signal transduction GO:0009968 83 0.015
cognition GO:0050890 92 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
negative regulation of cellular component organization GO:0051129 83 0.015
response to radiation GO:0009314 137 0.015
regulation of catabolic process GO:0009894 113 0.015
purine containing compound catabolic process GO:0072523 138 0.015
biological adhesion GO:0022610 110 0.015
Mouse
establishment of protein localization GO:0045184 141 0.015
oxidation reduction process GO:0055114 304 0.014
liver development GO:0001889 90 0.014
response to oxidative stress GO:0006979 186 0.014
regulation of metal ion transport GO:0010959 118 0.014
nucleoside phosphate biosynthetic process GO:1901293 102 0.014
cardiac chamber development GO:0003205 1 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
cyclic purine nucleotide metabolic process GO:0052652 62 0.014
positive regulation of ion transport GO:0043270 94 0.014
cyclic nucleotide biosynthetic process GO:0009190 63 0.014
mesoderm development GO:0007498 2 0.014
muscle system process GO:0003012 115 0.014
forebrain development GO:0030900 98 0.014
response to glucose GO:0009749 136 0.014
nucleoside triphosphate catabolic process GO:0009143 123 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
response to corticosteroid GO:0031960 235 0.014
organ morphogenesis GO:0009887 75 0.014
nitrogen compound transport GO:0071705 229 0.014
regulation of hydrolase activity GO:0051336 143 0.014
behavior GO:0007610 205 0.014
positive regulation of secretion by cell GO:1903532 128 0.014
regulation of fat cell differentiation GO:0045598 3 0.014
response to carbohydrate GO:0009743 183 0.014
response to vitamin GO:0033273 131 0.014
single organism intracellular transport GO:1902582 166 0.014
regulation of defense response GO:0031347 68 0.014
ribonucleotide catabolic process GO:0009261 136 0.014
negative regulation of neurogenesis GO:0050768 78 0.014
amide transport GO:0042886 105 0.014
cellular component morphogenesis GO:0032989 155 0.014
nucleoside catabolic process GO:0009164 126 0.014
purine containing compound biosynthetic process GO:0072522 85 0.014
synaptic transmission GO:0007268 235 0.013
regulation of neuron death GO:1901214 115 0.013
regulation of protein metabolic process GO:0051246 289 0.013
response to estradiol GO:0032355 164 0.013
muscle contraction GO:0006936 88 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
regulation of immune system process GO:0002682 123 0.013
nucleotide biosynthetic process GO:0009165 98 0.013
cell growth GO:0016049 104 0.013
gastrulation GO:0007369 2 0.013
hormone transport GO:0009914 121 0.013
carboxylic acid transport GO:0046942 115 0.013
membrane organization GO:0061024 94 0.013
negative regulation of cell development GO:0010721 82 0.013
ribose phosphate biosynthetic process GO:0046390 87 0.013
gliogenesis GO:0042063 93 0.013
camp metabolic process GO:0046058 63 0.013
negative regulation of molecular function GO:0044092 133 0.013
nucleoside metabolic process GO:0009116 179 0.013
mapk cascade GO:0000165 140 0.013
cell activation GO:0001775 97 0.013
actin cytoskeleton organization GO:0030036 73 0.013
regulation of cell growth GO:0001558 85 0.013
regulation of synaptic transmission GO:0050804 141 0.013
ribonucleotide biosynthetic process GO:0009260 85 0.013
eye morphogenesis GO:0048592 4 0.013
nucleoside phosphate catabolic process GO:1901292 140 0.013
purine ribonucleoside catabolic process GO:0046130 124 0.013
monovalent inorganic cation transport GO:0015672 172 0.013
negative regulation of neuron differentiation GO:0045665 62 0.013
response to lipopolysaccharide GO:0032496 191 0.013
ribonucleoside metabolic process GO:0009119 174 0.013
regulation of peptide transport GO:0090087 87 0.013
positive regulation of protein modification process GO:0031401 142 0.012
cellular response to external stimulus GO:0071496 118 0.012
axis specification GO:0009798 4 0.012
negative regulation of response to external stimulus GO:0032102 37 0.012
organ regeneration GO:0031100 101 0.012
regulation of cell motility GO:2000145 131 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
positive regulation of nucleotide metabolic process GO:0045981 91 0.012
cyclic nucleotide metabolic process GO:0009187 80 0.012
cellular response to organonitrogen compound GO:0071417 197 0.012
monocarboxylic acid metabolic process GO:0032787 152 0.012
calcium ion transport GO:0006816 131 0.012
cell type specific apoptotic process GO:0097285 134 0.012
negative regulation of gene expression GO:0010629 199 0.012
regulation of homeostatic process GO:0032844 101 0.012
cell cell signaling involved in cell fate commitment GO:0045168 2 0.012
regulation of body fluid levels GO:0050878 90 0.012
cytoskeleton organization GO:0007010 111 0.012
regulation of hormone levels GO:0010817 187 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
regulation of blood circulation GO:1903522 110 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
amino acid transport GO:0006865 70 0.012
inflammatory response GO:0006954 150 0.012
regulation of growth GO:0040008 105 0.012
intracellular transport GO:0046907 185 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
regulation of tube size GO:0035150 89 0.012
cytoplasmic transport GO:0016482 115 0.011
cellular response to cytokine stimulus GO:0071345 127 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
peptide transport GO:0015833 97 0.011
regulation of mapk cascade GO:0043408 116 0.011
coagulation GO:0050817 28 0.011
cellular response to alcohol GO:0097306 87 0.011
cellular protein localization GO:0034613 122 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
regulation of cell migration GO:0030334 128 0.011
negative regulation of nervous system development GO:0051961 79 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
transmission of nerve impulse GO:0019226 42 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.011
negative regulation of innate immune response GO:0045824 4 0.011
proteolysis GO:0006508 175 0.011
organic acid transport GO:0015849 116 0.011
hepaticobiliary system development GO:0061008 90 0.011
purine nucleotide biosynthetic process GO:0006164 83 0.011
regulation of epithelial cell proliferation GO:0050678 49 0.011
lipid biosynthetic process GO:0008610 128 0.011
purine nucleoside triphosphate catabolic process GO:0009146 122 0.011
response to hexose GO:0009746 144 0.011
response to decreased oxygen levels GO:0036293 237 0.011
cell projection morphogenesis GO:0048858 123 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
chemosensory behavior GO:0007635 2 0.011
establishment of tissue polarity GO:0007164 2 0.011
negative regulation of secretion by cell GO:1903531 72 0.011
salivary gland development GO:0007431 3 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.010
tissue development GO:0009888 252 0.010
purine nucleoside triphosphate metabolic process GO:0009144 141 0.010
taxis GO:0042330 67 0.010
regulation of stem cell differentiation GO:2000736 2 0.010
hormone secretion GO:0046879 115 0.010
developmental process involved in reproduction GO:0003006 159 0.010
glycosyl compound catabolic process GO:1901658 126 0.010
muscle cell proliferation GO:0033002 84 0.010
cellular response to extracellular stimulus GO:0031668 73 0.010
carbohydrate derivative catabolic process GO:1901136 147 0.010
regulation of cellular response to stress GO:0080135 49 0.010
sexual reproduction GO:0019953 148 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
regulation of proteasomal protein catabolic process GO:0061136 4 0.010
smooth muscle cell proliferation GO:0048659 77 0.010

Egfl6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
nervous system disease DOID:863 0 0.028
musculoskeletal system disease DOID:17 0 0.017
disease of metabolism DOID:0014667 0 0.013
inherited metabolic disorder DOID:655 0 0.013
sensory system disease DOID:0050155 0 0.012
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012
disease of cellular proliferation DOID:14566 0 0.011
central nervous system disease DOID:331 0 0.010