Rattus norvegicus

12 known processes

Fen1

flap structure-specific endonuclease 1

(Aliases: FEN-1,MGC94425)

Fen1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular component organization GO:0051128 368 0.109
apoptotic process GO:0006915 381 0.100
histone h3 k9 modification GO:0061647 2 0.091
cellular component assembly GO:0022607 360 0.084
negative regulation of gene expression GO:0010629 199 0.077
macromolecular complex subunit organization GO:0043933 339 0.077
carboxylic acid metabolic process GO:0019752 289 0.075
single organism reproductive process GO:0044702 297 0.067
nucleosome organization GO:0034728 1 0.065
regulation of cell proliferation GO:0042127 359 0.064
cellular component biogenesis GO:0044085 368 0.062
protein phosphorylation GO:0006468 345 0.054
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.054
regulation of programmed cell death GO:0043067 341 0.054
catabolic process GO:0009056 351 0.051
histone serine phosphorylation GO:0035404 1 0.050
chromatin assembly or disassembly GO:0006333 1 0.050
response to nutrient GO:0007584 248 0.049
response to growth factor GO:0070848 189 0.048
cellular response to oxygen containing compound GO:1901701 386 0.047
oxoacid metabolic process GO:0043436 290 0.045
anterior posterior pattern specification GO:0009952 1 0.045
pyrimidine nucleobase metabolic process GO:0006206 8 0.042
organelle organization GO:0006996 266 0.041
negative regulation of metabolic process GO:0009892 331 0.040
alpha amino acid metabolic process GO:1901605 71 0.040
positive regulation of developmental process GO:0051094 283 0.038
cellular catabolic process GO:0044248 295 0.038
cellular amino acid metabolic process GO:0006520 107 0.038
macromolecular complex assembly GO:0065003 273 0.037
positive regulation of multicellular organismal process GO:0051240 387 0.037
protein complex biogenesis GO:0070271 263 0.036
organic acid metabolic process GO:0006082 292 0.036
regulation of molecular function GO:0065009 398 0.036
regulation of proteasomal protein catabolic process GO:0061136 4 0.036
programmed cell death GO:0012501 392 0.036
cellular response to endogenous stimulus GO:0071495 377 0.036
regulation of cellular protein metabolic process GO:0032268 267 0.036
anatomical structure morphogenesis GO:0009653 298 0.035
chromosome segregation GO:0007059 2 0.035
rna biosynthetic process GO:0032774 380 0.034
dna packaging GO:0006323 4 0.034
protein complex assembly GO:0006461 263 0.034
purine containing compound metabolic process GO:0072521 253 0.034
cellular response to stress GO:0033554 269 0.033
protein localization GO:0008104 191 0.033
neuron differentiation GO:0030182 368 0.033
regulation of multicellular organismal development GO:2000026 376 0.032
macromolecule localization GO:0033036 252 0.032
response to nutrient levels GO:0031667 370 0.030
negative regulation of macromolecule metabolic process GO:0010605 260 0.030
regulation of rna biosynthetic process GO:2001141 381 0.030
transcription from rna polymerase ii promoter GO:0006366 252 0.029
protein complex subunit organization GO:0071822 302 0.029
cytoskeleton dependent cytokinesis GO:0061640 2 0.029
regulation of organelle organization GO:0033043 80 0.028
regeneration GO:0031099 163 0.028
regulation of protein metabolic process GO:0051246 289 0.028
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.028
cellular modified amino acid biosynthetic process GO:0042398 18 0.028
regulation of protein modification process GO:0031399 194 0.027
chromosome condensation GO:0030261 3 0.027
multi organism reproductive process GO:0044703 262 0.027
negative regulation of cell cycle phase transition GO:1901988 4 0.026
chromosome organization GO:0051276 36 0.026
positive regulation of phosphorus metabolic process GO:0010562 262 0.026
positive regulation of apoptotic process GO:0043065 154 0.026
positive regulation of protein metabolic process GO:0051247 178 0.026
rhythmic process GO:0048511 156 0.025
organic substance catabolic process GO:1901575 316 0.025
regulation of nucleic acid templated transcription GO:1903506 380 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.025
multicellular organism reproduction GO:0032504 233 0.024
regulation of apoptotic process GO:0042981 335 0.024
reproductive process GO:0022414 372 0.024
single organism biosynthetic process GO:0044711 342 0.024
positive regulation of gene expression GO:0010628 244 0.024
peptidyl amino acid modification GO:0018193 126 0.023
axis specification GO:0009798 4 0.023
gonad development GO:0008406 104 0.023
cell cycle GO:0007049 101 0.023
regulation of protein phosphorylation GO:0001932 183 0.022
response to extracellular stimulus GO:0009991 380 0.022
negative regulation of microtubule depolymerization GO:0007026 3 0.022
female gonad development GO:0008585 53 0.022
tetrahydrofolate metabolic process GO:0046653 9 0.022
chromatin modification GO:0016568 33 0.022
response to estradiol GO:0032355 164 0.022
positive regulation of phosphorylation GO:0042327 177 0.022
regulation of phosphorylation GO:0042325 248 0.022
multicellular organismal reproductive process GO:0048609 233 0.021
positive regulation of cellular protein metabolic process GO:0032270 167 0.021
dephosphorylation GO:0016311 98 0.021
reproductive system development GO:0061458 128 0.021
single organism organelle organization GO:1902589 180 0.021
double strand break repair GO:0006302 1 0.020
gland development GO:0048732 155 0.020
positive regulation of transcription dna templated GO:0045893 197 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
regulation of phosphorus metabolic process GO:0051174 349 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.020
regulation of phosphate metabolic process GO:0019220 349 0.020
regulation of cell development GO:0060284 263 0.020
regulation of sister chromatid segregation GO:0033045 1 0.020
response to corticosteroid GO:0031960 235 0.020
negative regulation of cellular metabolic process GO:0031324 281 0.019
meiotic cell cycle process GO:1903046 3 0.019
organonitrogen compound biosynthetic process GO:1901566 167 0.019
positive regulation of phosphate metabolic process GO:0045937 262 0.019
gamete generation GO:0007276 124 0.019
regulation of rna metabolic process GO:0051252 391 0.019
pyrimidine nucleotide biosynthetic process GO:0006221 9 0.019
nucleoside phosphate metabolic process GO:0006753 283 0.018
transcription dna templated GO:0006351 377 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
response to glucocorticoid GO:0051384 223 0.018
regulation of cellular ketone metabolic process GO:0010565 27 0.018
intracellular signal transduction GO:0035556 314 0.018
regulation of cell differentiation GO:0045595 320 0.018
embryonic pattern specification GO:0009880 1 0.018
cellular component morphogenesis GO:0032989 155 0.017
pyrimidine containing compound metabolic process GO:0072527 20 0.017
negative regulation of molecular function GO:0044092 133 0.017
mrna metabolic process GO:0016071 20 0.017
cellular amine metabolic process GO:0044106 38 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.017
amine metabolic process GO:0009308 38 0.017
developmental process involved in reproduction GO:0003006 159 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
cell cycle checkpoint GO:0000075 2 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.017
regulation of signal transduction GO:0009966 318 0.016
liver development GO:0001889 90 0.016
rna metabolic process GO:0016070 406 0.016
regulation of transcription dna templated GO:0006355 374 0.016
reproduction GO:0000003 245 0.016
regulation of catalytic activity GO:0050790 304 0.016
response to ketone GO:1901654 182 0.016
positive regulation of protein modification process GO:0031401 142 0.016
central nervous system development GO:0007417 311 0.016
positive regulation of rna metabolic process GO:0051254 203 0.016
positive regulation of programmed cell death GO:0043068 157 0.016
chromatin organization GO:0006325 34 0.016
regulation of kinase activity GO:0043549 117 0.016
cellular macromolecule localization GO:0070727 122 0.016
head development GO:0060322 247 0.016
neuron development GO:0048666 286 0.016
neuron projection development GO:0031175 273 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
metaphase plate congression GO:0051310 1 0.015
dna metabolic process GO:0006259 96 0.015
deoxyribonucleoside monophosphate biosynthetic process GO:0009157 4 0.015
proteolysis GO:0006508 175 0.015
response to purine containing compound GO:0014074 126 0.015
tissue development GO:0009888 252 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
homeostatic process GO:0042592 331 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.015
nucleoside phosphate biosynthetic process GO:1901293 102 0.015
cytoskeleton organization GO:0007010 111 0.015
response to oxygen levels GO:0070482 265 0.015
anion transport GO:0006820 178 0.015
cellular modified amino acid metabolic process GO:0006575 61 0.014
nucleotide metabolic process GO:0009117 279 0.014
positive regulation of neurogenesis GO:0050769 165 0.014
single organism cellular localization GO:1902580 102 0.014
dna integrity checkpoint GO:0031570 2 0.014
embryonic axis specification GO:0000578 1 0.014
ovulation cycle process GO:0022602 50 0.014
centrosome cycle GO:0007098 1 0.014
cellular component movement GO:0006928 248 0.014
transmembrane transport GO:0055085 412 0.014
sex differentiation GO:0007548 113 0.014
response to hypoxia GO:0001666 231 0.014
growth GO:0040007 165 0.014
regulation of transferase activity GO:0051338 123 0.014
cellular response to acid chemical GO:0071229 75 0.013
hepaticobiliary system development GO:0061008 90 0.013
response to acid chemical GO:0001101 222 0.013
organophosphate metabolic process GO:0019637 370 0.013
organic acid biosynthetic process GO:0016053 83 0.013
negative regulation of cell death GO:0060548 229 0.013
cell projection organization GO:0030030 302 0.013
microtubule organizing center organization GO:0031023 1 0.013
response to decreased oxygen levels GO:0036293 237 0.013
cellular protein localization GO:0034613 122 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
nucleoside metabolic process GO:0009116 179 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.013
carbohydrate derivative metabolic process GO:1901135 346 0.013
meiosis i GO:0007127 2 0.013
negative regulation of cellular component organization GO:0051129 83 0.013
spindle organization GO:0007051 2 0.013
cellular nitrogen compound catabolic process GO:0044270 163 0.013
pteridine containing compound metabolic process GO:0042558 14 0.013
regulation of neurogenesis GO:0050767 247 0.013
positive regulation of molecular function GO:0044093 230 0.013
cell morphogenesis GO:0000902 142 0.012
camera type eye morphogenesis GO:0048593 2 0.012
response to biotic stimulus GO:0009607 226 0.012
brain development GO:0007420 247 0.012
positive regulation of cell death GO:0010942 184 0.012
cellular ketone metabolic process GO:0042180 51 0.012
lipid metabolic process GO:0006629 283 0.012
nucleotide biosynthetic process GO:0009165 98 0.012
positive regulation of response to stimulus GO:0048584 285 0.012
aging GO:0007568 241 0.012
positive regulation of cell development GO:0010720 176 0.011
eye morphogenesis GO:0048592 4 0.011
response to peptide GO:1901652 292 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
histone modification GO:0016570 30 0.011
response to vitamin GO:0033273 131 0.011
cell cycle dna replication GO:0044786 1 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
sexual reproduction GO:0019953 148 0.011
regulation of nervous system development GO:0051960 264 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
response to external biotic stimulus GO:0043207 221 0.011
macromolecule catabolic process GO:0009057 58 0.011
response to inorganic substance GO:0010035 377 0.011
response to vitamin e GO:0033197 24 0.011
chromatin remodeling GO:0006338 3 0.011
response to radiation GO:0009314 137 0.011
negative regulation of signaling GO:0023057 157 0.011
development of primary sexual characteristics GO:0045137 107 0.011
centrosome organization GO:0051297 1 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
cofactor metabolic process GO:0051186 95 0.011
regulation of protein kinase activity GO:0045859 105 0.011
mitotic spindle organization GO:0007052 2 0.011
spermatogenesis GO:0007283 99 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
regulation of microtubule based process GO:0032886 14 0.011
response to monosaccharide GO:0034284 159 0.011
antral ovarian follicle growth GO:0001547 3 0.011
deoxyribonucleotide biosynthetic process GO:0009263 6 0.011
positive regulation of nervous system development GO:0051962 178 0.011
cellular response to lipid GO:0071396 201 0.011
protein dephosphorylation GO:0006470 38 0.011
sister chromatid segregation GO:0000819 1 0.010
positive regulation of protein phosphorylation GO:0001934 135 0.010
cellular response to organonitrogen compound GO:0071417 197 0.010
response to epidermal growth factor GO:0070849 18 0.010
response to molecule of bacterial origin GO:0002237 194 0.010
response to ethanol GO:0045471 162 0.010
synaptic transmission GO:0007268 235 0.010
chemical homeostasis GO:0048878 292 0.010
regulation of ubiquitin protein transferase activity GO:0051438 1 0.010
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 1 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
renal system development GO:0072001 67 0.010
cell cycle process GO:0022402 57 0.010
positive regulation of proteasomal protein catabolic process GO:1901800 3 0.010
regulation of response to stress GO:0080134 126 0.010

Fen1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.022
cancer DOID:162 0 0.022
organ system cancer DOID:0050686 0 0.022
gastrointestinal system cancer DOID:3119 0 0.018
intestinal cancer DOID:10155 0 0.018
nervous system disease DOID:863 0 0.017
disease of anatomical entity DOID:7 0 0.017
colon cancer DOID:219 0 0.015
colorectal cancer DOID:9256 0 0.015
large intestine cancer DOID:5672 0 0.015
sensory system disease DOID:0050155 0 0.012
colon carcinoma DOID:1520 0 0.012
central nervous system disease DOID:331 0 0.010