Rattus norvegicus

22 known processes

Fh1

fumarate hydratase 1

(Aliases: Fh,MGC105468)

Fh1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
coenzyme metabolic process GO:0006732 86 0.816
dicarboxylic acid metabolic process GO:0043648 42 0.741
glycosyl compound metabolic process GO:1901657 182 0.585
generation of precursor metabolites and energy GO:0006091 62 0.568
cofactor metabolic process GO:0051186 95 0.533
purine nucleoside monophosphate metabolic process GO:0009126 84 0.513
oxidation reduction process GO:0055114 304 0.501
oxidative phosphorylation GO:0006119 4 0.474
atp metabolic process GO:0046034 72 0.471
cellular respiration GO:0045333 21 0.457
citrate metabolic process GO:0006101 3 0.448
oxoacid metabolic process GO:0043436 290 0.443
aerobic respiration GO:0009060 13 0.437
nucleobase containing small molecule metabolic process GO:0055086 316 0.409
ribonucleoside monophosphate metabolic process GO:0009161 88 0.364
nucleoside phosphate metabolic process GO:0006753 283 0.342
nucleoside monophosphate metabolic process GO:0009123 93 0.331
carboxylic acid metabolic process GO:0019752 289 0.329
organic acid metabolic process GO:0006082 292 0.318
purine containing compound metabolic process GO:0072521 253 0.278
nucleotide metabolic process GO:0009117 279 0.266
tricarboxylic acid metabolic process GO:0072350 10 0.236
nucleoside metabolic process GO:0009116 179 0.228
nicotinamide nucleotide metabolic process GO:0046496 28 0.220
tricarboxylic acid cycle GO:0006099 11 0.220
electron transport chain GO:0022900 5 0.214
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.204
purine nucleoside metabolic process GO:0042278 169 0.197
purine nucleotide metabolic process GO:0006163 229 0.189
ribonucleoside metabolic process GO:0009119 174 0.165
organelle organization GO:0006996 266 0.165
mitochondrion organization GO:0007005 35 0.152
purine ribonucleoside metabolic process GO:0046128 168 0.152
cofactor biosynthetic process GO:0051188 28 0.150
carbohydrate derivative metabolic process GO:1901135 346 0.147
ribonucleoside triphosphate metabolic process GO:0009199 141 0.133
isocitrate metabolic process GO:0006102 5 0.132
nucleoside triphosphate metabolic process GO:0009141 144 0.126
ribonucleotide metabolic process GO:0009259 231 0.123
growth GO:0040007 165 0.115
nadh metabolic process GO:0006734 10 0.112
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.110
organophosphate metabolic process GO:0019637 370 0.099
single organism biosynthetic process GO:0044711 342 0.098
tetrapyrrole metabolic process GO:0033013 11 0.096
nad metabolic process GO:0019674 15 0.094
transmembrane transport GO:0055085 412 0.092
purine ribonucleotide metabolic process GO:0009150 227 0.090
organic substance catabolic process GO:1901575 316 0.081
energy derivation by oxidation of organic compounds GO:0015980 46 0.077
protein maturation GO:0051604 68 0.076
atp synthesis coupled electron transport GO:0042773 2 0.075
oxidoreduction coenzyme metabolic process GO:0006733 31 0.075
protein transport GO:0015031 132 0.064
apoptotic mitochondrial changes GO:0008637 10 0.062
single organism catabolic process GO:0044712 283 0.059
purine nucleoside triphosphate metabolic process GO:0009144 141 0.059
connective tissue development GO:0061448 33 0.057
acyl coa metabolic process GO:0006637 28 0.048
regulation of molecular function GO:0065009 398 0.044
purine nucleoside biosynthetic process GO:0042451 21 0.044
reproductive process GO:0022414 372 0.043
response to nutrient levels GO:0031667 370 0.041
ribonucleoside biosynthetic process GO:0042455 25 0.041
single organism organelle organization GO:1902589 180 0.040
positive regulation of molecular function GO:0044093 230 0.040
regulation of apoptotic process GO:0042981 335 0.040
sulfur compound metabolic process GO:0006790 70 0.039
protein complex assembly GO:0006461 263 0.039
organonitrogen compound catabolic process GO:1901565 179 0.037
vesicle mediated transport GO:0016192 181 0.037
catabolic process GO:0009056 351 0.035
nucleotide biosynthetic process GO:0009165 98 0.035
regulation of membrane potential GO:0042391 110 0.034
nucleotide catabolic process GO:0009166 139 0.033
response to extracellular stimulus GO:0009991 380 0.033
cellular catabolic process GO:0044248 295 0.033
intracellular transport GO:0046907 185 0.032
negative regulation of programmed cell death GO:0043069 183 0.032
hepaticobiliary system development GO:0061008 90 0.031
2 oxoglutarate metabolic process GO:0006103 6 0.031
cellular component biogenesis GO:0044085 368 0.031
pyridine nucleotide metabolic process GO:0019362 28 0.030
developmental process involved in reproduction GO:0003006 159 0.030
liver development GO:0001889 90 0.029
regulation of transferase activity GO:0051338 123 0.029
programmed cell death GO:0012501 392 0.029
cellular component assembly GO:0022607 360 0.029
metanephric tubule development GO:0072170 4 0.028
protein oligomerization GO:0051259 191 0.027
regulation of signal transduction GO:0009966 318 0.027
response to ethanol GO:0045471 162 0.027
aging GO:0007568 241 0.027
ribonucleotide biosynthetic process GO:0009260 85 0.026
anion transport GO:0006820 178 0.026
homeostatic process GO:0042592 331 0.026
protein processing GO:0016485 68 0.026
purine containing compound biosynthetic process GO:0072522 85 0.026
single organism reproductive process GO:0044702 297 0.026
reproduction GO:0000003 245 0.026
cell redox homeostasis GO:0045454 1 0.025
positive regulation of atp biosynthetic process GO:2001171 2 0.025
protein complex biogenesis GO:0070271 263 0.025
regulation of growth GO:0040008 105 0.024
chemical homeostasis GO:0048878 292 0.024
central nervous system development GO:0007417 311 0.024
synaptic transmission GO:0007268 235 0.024
reproductive structure development GO:0048608 128 0.023
purine nucleotide biosynthetic process GO:0006164 83 0.022
pyridine containing compound metabolic process GO:0072524 32 0.022
response to decreased oxygen levels GO:0036293 237 0.021
purine nucleoside triphosphate catabolic process GO:0009146 122 0.021
single organism intracellular transport GO:1902582 166 0.021
endocytosis GO:0006897 84 0.021
regulation of nucleic acid templated transcription GO:1903506 380 0.021
purine ribonucleoside monophosphate biosynthetic process GO:0009168 20 0.020
brain development GO:0007420 247 0.020
ribose phosphate metabolic process GO:0019693 235 0.020
response to toxic substance GO:0009636 133 0.020
response to external biotic stimulus GO:0043207 221 0.020
apoptotic process GO:0006915 381 0.019
purine nucleoside catabolic process GO:0006152 124 0.019
cellular homeostasis GO:0019725 252 0.019
response to oxygen levels GO:0070482 265 0.019
positive regulation of catalytic activity GO:0043085 184 0.019
multicellular organism reproduction GO:0032504 233 0.019
multicellular organismal reproductive process GO:0048609 233 0.018
negative regulation of apoptotic process GO:0043066 181 0.018
rna biosynthetic process GO:0032774 380 0.018
response to tumor cell GO:0002347 4 0.018
regulation of phosphate metabolic process GO:0019220 349 0.017
aromatic amino acid family metabolic process GO:0009072 9 0.017
mitochondrial transport GO:0006839 19 0.017
regulation of hydrolase activity GO:0051336 143 0.017
organic cyclic compound catabolic process GO:1901361 175 0.017
cellular amino acid metabolic process GO:0006520 107 0.017
immune system process GO:0002376 204 0.017
negative regulation of cell communication GO:0010648 158 0.017
monocarboxylic acid metabolic process GO:0032787 152 0.016
multi organism reproductive process GO:0044703 262 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
macromolecule localization GO:0033036 252 0.016
macromolecular complex assembly GO:0065003 273 0.016
behavior GO:0007610 205 0.016
gamete generation GO:0007276 124 0.016
protein complex subunit organization GO:0071822 302 0.016
regulation of cellular component organization GO:0051128 368 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.015
positive regulation of cell proliferation GO:0008284 249 0.015
regulation of programmed cell death GO:0043067 341 0.015
skeletal system development GO:0001501 41 0.015
purine nucleoside monophosphate biosynthetic process GO:0009127 20 0.015
organophosphate catabolic process GO:0046434 148 0.015
single organism cellular localization GO:1902580 102 0.015
negative regulation of metabolic process GO:0009892 331 0.015
regulation of catalytic activity GO:0050790 304 0.015
cellular response to lipid GO:0071396 201 0.015
cellular metal ion homeostasis GO:0006875 172 0.014
cell cell signaling GO:0007267 335 0.014
cellular response to stress GO:0033554 269 0.014
sexual reproduction GO:0019953 148 0.014
negative regulation of cell death GO:0060548 229 0.014
negative regulation of cellular metabolic process GO:0031324 281 0.014
nucleoside phosphate catabolic process GO:1901292 140 0.014
protein targeting GO:0006605 61 0.014
muscle system process GO:0003012 115 0.014
response to bacterium GO:0009617 200 0.013
macromolecular complex subunit organization GO:0043933 339 0.013
somatic cell dna recombination GO:0016444 2 0.013
response to ketone GO:1901654 182 0.013
positive regulation of hydrolase activity GO:0051345 86 0.013
transcription dna templated GO:0006351 377 0.013
phagocytosis GO:0006909 17 0.013
heme biosynthetic process GO:0006783 4 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
cellular response to oxygen containing compound GO:1901701 386 0.013
regulation of kinase activity GO:0043549 117 0.013
response to molecule of bacterial origin GO:0002237 194 0.012
positive regulation of immune system process GO:0002684 90 0.012
multi multicellular organism process GO:0044706 138 0.012
leukocyte proliferation GO:0070661 29 0.012
negative regulation of protein modification by small protein conjugation or removal GO:1903321 4 0.012
rna metabolic process GO:0016070 406 0.012
lipid storage GO:0019915 1 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
purine containing compound catabolic process GO:0072523 138 0.012
positive regulation of cellular protein metabolic process GO:0032270 167 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
negative regulation of signaling GO:0023057 157 0.012
ion transmembrane transport GO:0034220 365 0.012
proteolysis GO:0006508 175 0.011
aromatic compound catabolic process GO:0019439 168 0.011
amino acid import GO:0043090 7 0.011
regulation of cell differentiation GO:0045595 320 0.011
positive regulation of cell activation GO:0050867 34 0.011
syncytium formation by plasma membrane fusion GO:0000768 3 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
t cell activation GO:0042110 29 0.011
metal ion transport GO:0030001 289 0.011
head development GO:0060322 247 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
cytoplasmic transport GO:0016482 115 0.011
heterocycle catabolic process GO:0046700 167 0.011
positive regulation of viral process GO:0048524 2 0.011
cation transport GO:0006812 382 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
purine ribonucleotide catabolic process GO:0009154 136 0.011
nucleoside monophosphate biosynthetic process GO:0009124 28 0.010
nephron development GO:0072006 22 0.010
cellular response to acid chemical GO:0071229 75 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.010
ribonucleoside catabolic process GO:0042454 126 0.010
spermatogenesis GO:0007283 99 0.010
response to acid chemical GO:0001101 222 0.010
neurotransmitter uptake GO:0001504 3 0.010
lymphocyte activation GO:0046649 43 0.010
response to oxidative stress GO:0006979 186 0.010
response to inorganic substance GO:0010035 377 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
regulation of peptidase activity GO:0052547 55 0.010
cellular chemical homeostasis GO:0055082 247 0.010
positive regulation of lymphocyte activation GO:0051251 25 0.010

Fh1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.164
disease of anatomical entity DOID:7 0 0.164
disease of metabolism DOID:0014667 0 0.053
inherited metabolic disorder DOID:655 0 0.053
central nervous system disease DOID:331 0 0.038
cancer DOID:162 0 0.031
disease of cellular proliferation DOID:14566 0 0.031
gastrointestinal system cancer DOID:3119 0 0.031
organ system cancer DOID:0050686 0 0.031
organic acidemia DOID:0060159 0 0.030
maple syrup urine disease DOID:9269 0 0.030
amino acid metabolic disorder DOID:9252 0 0.030
sensory system disease DOID:0050155 0 0.017
retinal disease DOID:5679 0 0.015
eye disease DOID:5614 0 0.015
eye and adnexa disease DOID:1492 0 0.015
retinitis pigmentosa DOID:10584 0 0.013
retinal degeneration DOID:8466 0 0.013