Rattus norvegicus

64 known processes

Gclc

glutamate-cysteine ligase, catalytic subunit

(Aliases: MGC93096,Glclc)

Gclc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular modified amino acid metabolic process GO:0006575 61 0.843
cellular amino acid metabolic process GO:0006520 107 0.738
cellular amino acid biosynthetic process GO:0008652 32 0.588
carboxylic acid metabolic process GO:0019752 289 0.576
sulfur compound metabolic process GO:0006790 70 0.528
organic acid metabolic process GO:0006082 292 0.397
glutathione metabolic process GO:0006749 15 0.296
small molecule biosynthetic process GO:0044283 124 0.294
carboxylic acid biosynthetic process GO:0046394 83 0.279
cellular amide metabolic process GO:0043603 44 0.278
alpha amino acid metabolic process GO:1901605 71 0.261
organonitrogen compound biosynthetic process GO:1901566 167 0.247
single organism biosynthetic process GO:0044711 342 0.246
response to inorganic substance GO:0010035 377 0.214
amide biosynthetic process GO:0043604 10 0.196
response to extracellular stimulus GO:0009991 380 0.191
oxoacid metabolic process GO:0043436 290 0.191
cellular modified amino acid biosynthetic process GO:0042398 18 0.188
response to wounding GO:0009611 254 0.184
negative regulation of apoptotic process GO:0043066 181 0.178
peptide metabolic process GO:0006518 32 0.176
cellular response to oxygen containing compound GO:1901701 386 0.165
single organism reproductive process GO:0044702 297 0.152
response to nutrient GO:0007584 248 0.138
response to oxidative stress GO:0006979 186 0.128
response to metal ion GO:0010038 253 0.126
regulation of apoptotic process GO:0042981 335 0.113
organic acid biosynthetic process GO:0016053 83 0.106
negative regulation of cell death GO:0060548 229 0.089
intracellular signal transduction GO:0035556 314 0.084
mesoderm development GO:0007498 2 0.079
response to nutrient levels GO:0031667 370 0.076
apoptotic process GO:0006915 381 0.074
cofactor metabolic process GO:0051186 95 0.074
macromolecular complex assembly GO:0065003 273 0.073
response to carbohydrate GO:0009743 183 0.072
tube development GO:0035295 89 0.071
regulation of organelle organization GO:0033043 80 0.070
coenzyme metabolic process GO:0006732 86 0.067
oxidation reduction process GO:0055114 304 0.063
organelle organization GO:0006996 266 0.063
cellular response to stress GO:0033554 269 0.063
organic hydroxy compound metabolic process GO:1901615 115 0.063
cellular response to organic cyclic compound GO:0071407 202 0.062
cellular lipid metabolic process GO:0044255 208 0.060
response to oxygen levels GO:0070482 265 0.060
protein complex subunit organization GO:0071822 302 0.057
regulation of signal transduction GO:0009966 318 0.056
lipid metabolic process GO:0006629 283 0.054
neuron apoptotic process GO:0051402 88 0.054
central nervous system development GO:0007417 311 0.053
negative regulation of neuron apoptotic process GO:0043524 45 0.052
cellular component assembly GO:0022607 360 0.050
regulation of cellular amine metabolic process GO:0033238 8 0.050
reactive oxygen species metabolic process GO:0072593 37 0.049
response to vitamin GO:0033273 131 0.049
macromolecule localization GO:0033036 252 0.049
regulation of programmed cell death GO:0043067 341 0.049
circulatory system process GO:0003013 183 0.048
positive regulation of developmental process GO:0051094 283 0.048
cellular amine metabolic process GO:0044106 38 0.046
response to acid chemical GO:0001101 222 0.044
protein oligomerization GO:0051259 191 0.044
positive regulation of cell death GO:0010942 184 0.043
amine metabolic process GO:0009308 38 0.043
protein complex biogenesis GO:0070271 263 0.043
organophosphate metabolic process GO:0019637 370 0.042
response to ethanol GO:0045471 162 0.040
cellular ketone metabolic process GO:0042180 51 0.039
macromolecular complex subunit organization GO:0043933 339 0.038
negative regulation of programmed cell death GO:0043069 183 0.038
reproductive process GO:0022414 372 0.038
regulation of phosphorus metabolic process GO:0051174 349 0.038
neuron death GO:0070997 127 0.038
response to axon injury GO:0048678 59 0.036
response to decreased oxygen levels GO:0036293 237 0.036
blood circulation GO:0008015 183 0.036
regulation of neuron death GO:1901214 115 0.035
homeostatic process GO:0042592 331 0.035
response to hydrogen peroxide GO:0042542 89 0.035
negative regulation of molecular function GO:0044092 133 0.035
regulation of transcription dna templated GO:0006355 374 0.034
secretion GO:0046903 307 0.033
response to lipopolysaccharide GO:0032496 191 0.033
response to peptide hormone GO:0043434 278 0.033
regulation of cellular component organization GO:0051128 368 0.033
anatomical structure morphogenesis GO:0009653 298 0.033
gastrulation GO:0007369 2 0.033
cellular component biogenesis GO:0044085 368 0.033
brain development GO:0007420 247 0.033
protein phosphorylation GO:0006468 345 0.032
response to estrogen GO:0043627 232 0.032
mesoderm formation GO:0001707 1 0.032
positive regulation of molecular function GO:0044093 230 0.032
protein complex assembly GO:0006461 263 0.031
benzene containing compound metabolic process GO:0042537 22 0.031
protein homooligomerization GO:0051260 91 0.030
programmed cell death GO:0012501 392 0.030
regulation of cell differentiation GO:0045595 320 0.030
cellular response to oxidative stress GO:0034599 76 0.030
regulation of cell projection organization GO:0031344 175 0.030
growth GO:0040007 165 0.030
reproductive system development GO:0061458 128 0.030
mesoderm morphogenesis GO:0048332 1 0.030
single organism catabolic process GO:0044712 283 0.029
nucleobase containing small molecule metabolic process GO:0055086 316 0.029
cellular response to reactive oxygen species GO:0034614 55 0.029
transcription dna templated GO:0006351 377 0.029
regulation of cell development GO:0060284 263 0.028
aging GO:0007568 241 0.028
dephosphorylation GO:0016311 98 0.027
response to reactive oxygen species GO:0000302 120 0.027
cell growth GO:0016049 104 0.027
response to radiation GO:0009314 137 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
regulation of neuron projection development GO:0010975 161 0.026
head development GO:0060322 247 0.026
nucleoside phosphate metabolic process GO:0006753 283 0.026
neurological system process GO:0050877 219 0.026
reactive oxygen species biosynthetic process GO:1903409 8 0.026
regulation of catalytic activity GO:0050790 304 0.026
response to glucocorticoid GO:0051384 223 0.026
cellular response to nitrogen compound GO:1901699 210 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
nitrogen compound transport GO:0071705 229 0.025
single organism cellular localization GO:1902580 102 0.025
organic acid transport GO:0015849 116 0.025
regulation of transferase activity GO:0051338 123 0.025
negative regulation of cell communication GO:0010648 158 0.025
organic anion transport GO:0015711 132 0.025
inflammatory response GO:0006954 150 0.025
rna biosynthetic process GO:0032774 380 0.025
negative regulation of signaling GO:0023057 157 0.025
response to nitrosative stress GO:0051409 2 0.024
cellular response to lipid GO:0071396 201 0.024
p38mapk cascade GO:0038066 1 0.024
response to peptide GO:1901652 292 0.024
response to monosaccharide GO:0034284 159 0.024
multicellular organism reproduction GO:0032504 233 0.024
negative regulation of cell differentiation GO:0045596 99 0.023
response to retinoic acid GO:0032526 63 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
formation of primary germ layer GO:0001704 1 0.023
protein localization GO:0008104 191 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.023
reactive nitrogen species metabolic process GO:2001057 1 0.023
regulation of cellular ketone metabolic process GO:0010565 27 0.023
regulation of synaptic transmission GO:0050804 141 0.023
cellular response to hormone stimulus GO:0032870 247 0.023
regulation of intracellular signal transduction GO:1902531 218 0.023
carbohydrate derivative biosynthetic process GO:1901137 124 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
regulation of molecular function GO:0065009 398 0.023
positive regulation of cellular biosynthetic process GO:0031328 295 0.022
glycerolipid metabolic process GO:0046486 67 0.022
regulation of hormone levels GO:0010817 187 0.022
positive regulation of multicellular organismal process GO:0051240 387 0.022
regulation of cell proliferation GO:0042127 359 0.022
positive regulation of cellular component organization GO:0051130 200 0.022
regulation of secretion GO:0051046 224 0.022
digestive system development GO:0055123 41 0.022
cellular response to corticosteroid stimulus GO:0071384 69 0.022
response to hexose GO:0009746 144 0.022
developmental process involved in reproduction GO:0003006 159 0.022
response to corticosteroid GO:0031960 235 0.022
regulation of rna biosynthetic process GO:2001141 381 0.021
vascular process in circulatory system GO:0003018 96 0.021
neuron differentiation GO:0030182 368 0.021
response to ketone GO:1901654 182 0.021
positive regulation of programmed cell death GO:0043068 157 0.021
regulation of anatomical structure morphogenesis GO:0022603 141 0.021
cellular response to metal ion GO:0071248 55 0.021
response to glucose GO:0009749 136 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
transmembrane transport GO:0055085 412 0.021
nucleic acid templated transcription GO:0097659 379 0.020
positive regulation of cell communication GO:0010647 271 0.020
g protein coupled receptor signaling pathway GO:0007186 242 0.020
defense response GO:0006952 194 0.020
retinal metabolic process GO:0042574 3 0.020
catabolic process GO:0009056 351 0.020
response to transition metal nanoparticle GO:1990267 122 0.020
single organism organelle organization GO:1902589 180 0.020
alpha amino acid biosynthetic process GO:1901607 23 0.020
response to cadmium ion GO:0046686 35 0.020
positive regulation of catalytic activity GO:0043085 184 0.020
wound healing GO:0042060 122 0.020
tube formation GO:0035148 3 0.020
response to amino acid GO:0043200 75 0.020
anatomical structure formation involved in morphogenesis GO:0048646 83 0.019
regulation of reactive oxygen species metabolic process GO:2000377 26 0.019
positive regulation of signal transduction GO:0009967 175 0.019
negative regulation of cellular component organization GO:0051129 83 0.019
regulation of anion transport GO:0044070 43 0.019
regeneration GO:0031099 163 0.019
positive regulation of apoptotic process GO:0043065 154 0.019
negative regulation of neuron death GO:1901215 69 0.019
cellular homeostasis GO:0019725 252 0.019
regulation of system process GO:0044057 208 0.019
response to toxic substance GO:0009636 133 0.019
regulation of protein metabolic process GO:0051246 289 0.019
negative regulation of catalytic activity GO:0043086 103 0.019
synaptic transmission GO:0007268 235 0.019
lipid localization GO:0010876 62 0.019
carbohydrate derivative metabolic process GO:1901135 346 0.018
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.018
regulation of multicellular organismal development GO:2000026 376 0.018
regulation of phosphorylation GO:0042325 248 0.018
transcription from rna polymerase ii promoter GO:0006366 252 0.018
lipid biosynthetic process GO:0008610 128 0.018
negative regulation of multicellular organismal process GO:0051241 203 0.018
regulation of rna metabolic process GO:0051252 391 0.017
response to interleukin 1 GO:0070555 55 0.017
cell type specific apoptotic process GO:0097285 134 0.017
positive regulation of signaling GO:0023056 270 0.017
regulation of secretion by cell GO:1903530 208 0.017
peptidyl tyrosine modification GO:0018212 72 0.017
organophosphate biosynthetic process GO:0090407 143 0.017
positive regulation of biosynthetic process GO:0009891 319 0.017
cellular response to alcohol GO:0097306 87 0.017
cellular response to organonitrogen compound GO:0071417 197 0.017
protein tetramerization GO:0051262 38 0.017
reproductive structure development GO:0048608 128 0.017
cellular cation homeostasis GO:0030003 180 0.017
regulation of nervous system development GO:0051960 264 0.017
rna metabolic process GO:0016070 406 0.017
cellular response to peptide GO:1901653 133 0.017
response to growth factor GO:0070848 189 0.017
negative regulation of cell proliferation GO:0008285 119 0.016
hepaticobiliary system development GO:0061008 90 0.016
anterior posterior pattern specification GO:0009952 1 0.016
rhythmic process GO:0048511 156 0.016
regulation of kinase activity GO:0043549 117 0.016
anion transport GO:0006820 178 0.016
cellular response to endogenous stimulus GO:0071495 377 0.016
neuron projection development GO:0031175 273 0.016
purine containing compound metabolic process GO:0072521 253 0.016
circulatory system development GO:0072359 134 0.016
response to hypoxia GO:0001666 231 0.016
response to external biotic stimulus GO:0043207 221 0.016
neuron development GO:0048666 286 0.016
carboxylic acid transport GO:0046942 115 0.016
cellular response to abiotic stimulus GO:0071214 85 0.016
regulation of response to stress GO:0080134 126 0.015
monocarboxylic acid transport GO:0015718 52 0.015
hormone metabolic process GO:0042445 69 0.015
regulation of hormone secretion GO:0046883 106 0.015
regulation of p38mapk cascade GO:1900744 1 0.015
multi organism reproductive process GO:0044703 262 0.015
placenta development GO:0001890 22 0.015
positive regulation of gene expression GO:0010628 244 0.015
cellular response to glucocorticoid stimulus GO:0071385 68 0.015
intracellular transport GO:0046907 185 0.015
positive regulation of intracellular signal transduction GO:1902533 138 0.015
alcohol metabolic process GO:0006066 77 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
establishment of protein localization GO:0045184 141 0.015
amide transport GO:0042886 105 0.015
positive regulation of ligase activity GO:0051351 1 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.015
pyridine containing compound metabolic process GO:0072524 32 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.015
peptidyl tyrosine phosphorylation GO:0018108 72 0.015
response to estradiol GO:0032355 164 0.014
regulation of neuron differentiation GO:0045664 208 0.014
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.014
response to bacterium GO:0009617 200 0.014
epithelium development GO:0060429 96 0.014
prostaglandin secretion GO:0032310 6 0.014
negative regulation of macromolecule metabolic process GO:0010605 260 0.014
embryonic pattern specification GO:0009880 1 0.014
positive regulation of cell proliferation GO:0008284 249 0.014
membrane organization GO:0061024 94 0.014
isoprenoid metabolic process GO:0006720 45 0.014
cell projection organization GO:0030030 302 0.014
spermatogenesis GO:0007283 99 0.013
cation homeostasis GO:0055080 195 0.013
organelle inheritance GO:0048308 2 0.013
response to molecule of bacterial origin GO:0002237 194 0.013
negative regulation of neurogenesis GO:0050768 78 0.013
negative regulation of metabolic process GO:0009892 331 0.013
regulation of peptide transport GO:0090087 87 0.013
regulation of fatty acid transport GO:2000191 10 0.013
cellular response to oxygen levels GO:0071453 60 0.013
regulation of ion transport GO:0043269 245 0.013
protein autophosphorylation GO:0046777 66 0.013
cation transport GO:0006812 382 0.013
behavior GO:0007610 205 0.013
multi multicellular organism process GO:0044706 138 0.013
regulation of embryonic development GO:0045995 2 0.013
actin filament based process GO:0030029 86 0.013
chemical homeostasis GO:0048878 292 0.013
signal release GO:0023061 145 0.013
dna metabolic process GO:0006259 96 0.013
cellular macromolecule localization GO:0070727 122 0.013
carbohydrate homeostasis GO:0033500 75 0.013
negative regulation of phosphorus metabolic process GO:0010563 80 0.013
gland development GO:0048732 155 0.012
regulation of blood circulation GO:1903522 110 0.012
response to nicotine GO:0035094 51 0.012
muscle cell proliferation GO:0033002 84 0.012
regulation of membrane potential GO:0042391 110 0.012
positive regulation of protein modification process GO:0031401 142 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
response to calcium ion GO:0051592 59 0.012
regulation of insulin secretion GO:0050796 65 0.012
negative regulation of cellular metabolic process GO:0031324 281 0.012
stress activated protein kinase signaling cascade GO:0031098 37 0.012
dna replication GO:0006260 37 0.012
cytoskeleton dependent cytokinesis GO:0061640 2 0.012
carbohydrate metabolic process GO:0005975 130 0.012
regulation of protein modification process GO:0031399 194 0.012
oxidoreduction coenzyme metabolic process GO:0006733 31 0.012
tissue development GO:0009888 252 0.012
cytokine production GO:0001816 61 0.012
response to manganese ion GO:0010042 13 0.012
positive regulation of lipid biosynthetic process GO:0046889 25 0.012
regulation of protein kinase activity GO:0045859 105 0.012
ion homeostasis GO:0050801 212 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
nucleotide metabolic process GO:0009117 279 0.012
cellular response to inorganic substance GO:0071241 65 0.011
immune response GO:0006955 104 0.011
peptide transport GO:0015833 97 0.011
regulation of nucleic acid templated transcription GO:1903506 380 0.011
positive regulation of defense response GO:0031349 37 0.011
digestive tract development GO:0048565 39 0.011
ras protein signal transduction GO:0007265 29 0.011
positive regulation of transcription dna templated GO:0045893 197 0.011
regulation of protein localization GO:0032880 81 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
nicotinamide nucleotide metabolic process GO:0046496 28 0.011
response to alkaloid GO:0043279 132 0.011
regulation of peptide secretion GO:0002791 82 0.011
cellular catabolic process GO:0044248 295 0.011
nucleocytoplasmic transport GO:0006913 48 0.011
liver development GO:0001889 90 0.011
hydrogen peroxide metabolic process GO:0042743 13 0.011
inner ear receptor cell differentiation GO:0060113 2 0.011
single organism behavior GO:0044708 130 0.011
cellular ion homeostasis GO:0006873 184 0.011
morphogenesis of embryonic epithelium GO:0016331 3 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
regulation of lipid metabolic process GO:0019216 68 0.011
cytoskeleton organization GO:0007010 111 0.011
heart morphogenesis GO:0003007 3 0.011
negative regulation of transport GO:0051051 136 0.011
gamete generation GO:0007276 124 0.011
alpha amino acid catabolic process GO:1901606 20 0.011
regulation of tube size GO:0035150 89 0.011
response to osmotic stress GO:0006970 42 0.011
regulation of cell motility GO:2000145 131 0.011
glucose homeostasis GO:0042593 75 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
positive regulation of cellular protein metabolic process GO:0032270 167 0.011
regulation of muscle system process GO:0090257 79 0.011
serine family amino acid metabolic process GO:0009069 12 0.010
acid secretion GO:0046717 48 0.010
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.010
generation of precursor metabolites and energy GO:0006091 62 0.010
steroid biosynthetic process GO:0006694 48 0.010
reproduction GO:0000003 245 0.010
regulation of response to external stimulus GO:0032101 106 0.010
cellular response to steroid hormone stimulus GO:0071383 93 0.010
multicellular organismal homeostasis GO:0048871 49 0.010
positive regulation of endothelial cell migration GO:0010595 4 0.010
negative regulation of muscle cell apoptotic process GO:0010656 21 0.010
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.010
regulation of smoothened signaling pathway GO:0008589 2 0.010
regulation of cellular response to stress GO:0080135 49 0.010
cellular response to lipopolysaccharide GO:0071222 55 0.010
positive regulation of immune system process GO:0002684 90 0.010
chromosome segregation GO:0007059 2 0.010

Gclc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
organ system cancer DOID:0050686 0 0.022
disease of cellular proliferation DOID:14566 0 0.022
cancer DOID:162 0 0.022
disease of metabolism DOID:0014667 0 0.015
disease of anatomical entity DOID:7 0 0.014
nervous system disease DOID:863 0 0.014
inherited metabolic disorder DOID:655 0 0.011