Rattus norvegicus

61 known processes

Gjb2

gap junction protein, beta 2

(Aliases: Cx26,CXN-26,MGC93804)

Gjb2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to metal ion GO:0010038 253 0.227
organic acid biosynthetic process GO:0016053 83 0.214
nitrogen compound transport GO:0071705 229 0.195
Rat
monocarboxylic acid transport GO:0015718 52 0.183
transmembrane transport GO:0055085 412 0.183
cellular response to oxygen containing compound GO:1901701 386 0.182
Rat
response to inorganic substance GO:0010035 377 0.163
Rat
organic anion transport GO:0015711 132 0.157
Rat
anion transport GO:0006820 178 0.150
Rat
carboxylic acid transport GO:0046942 115 0.143
response to transition metal nanoparticle GO:1990267 122 0.131
response to retinoic acid GO:0032526 63 0.130
cellular response to lipid GO:0071396 201 0.128
ion transmembrane transport GO:0034220 365 0.125
response to nutrient levels GO:0031667 370 0.121
amino acid transmembrane transport GO:0003333 33 0.118
organic acid transport GO:0015849 116 0.116
response to camp GO:0051591 91 0.111
secretion GO:0046903 307 0.111
Rat
organic acid metabolic process GO:0006082 292 0.101
choline transport GO:0015871 4 0.099
cellular response to organonitrogen compound GO:0071417 197 0.097
anion transmembrane transport GO:0098656 77 0.097
reproductive process GO:0022414 372 0.096
response to estrogen GO:0043627 232 0.095
carboxylic acid biosynthetic process GO:0046394 83 0.093
response to organophosphorus GO:0046683 102 0.093
response to nutrient GO:0007584 248 0.091
protein complex assembly GO:0006461 263 0.090
Rat
response to purine containing compound GO:0014074 126 0.088
response to extracellular stimulus GO:0009991 380 0.087
central nervous system development GO:0007417 311 0.087
cellular component biogenesis GO:0044085 368 0.087
Rat
amino acid transport GO:0006865 70 0.085
response to acid chemical GO:0001101 222 0.085
carboxylic acid metabolic process GO:0019752 289 0.084
response to toxic substance GO:0009636 133 0.083
oxoacid metabolic process GO:0043436 290 0.079
protein oligomerization GO:0051259 191 0.078
Rat
response to corticosteroid GO:0031960 235 0.077
cellular response to endogenous stimulus GO:0071495 377 0.075
macromolecular complex subunit organization GO:0043933 339 0.073
Rat
protein complex biogenesis GO:0070271 263 0.072
Rat
protein complex subunit organization GO:0071822 302 0.069
Rat
tissue development GO:0009888 252 0.067
response to carbohydrate GO:0009743 183 0.066
Rat
regulation of multicellular organismal development GO:2000026 376 0.065
Rat
regulation of cell proliferation GO:0042127 359 0.063
Rat
protein homooligomerization GO:0051260 91 0.063
macromolecule localization GO:0033036 252 0.061
single organism reproductive process GO:0044702 297 0.060
lipid biosynthetic process GO:0008610 128 0.059
reproduction GO:0000003 245 0.059
cation transport GO:0006812 382 0.058
Rat
multicellular organismal reproductive process GO:0048609 233 0.057
response to biotic stimulus GO:0009607 226 0.057
Rat
cellular response to peptide GO:1901653 133 0.053
multi organism reproductive process GO:0044703 262 0.053
cellular response to nitrogen compound GO:1901699 210 0.051
response to glucocorticoid GO:0051384 223 0.050
regulation of secretion GO:0051046 224 0.050
Rat
lipid transport GO:0006869 61 0.050
cellular amino acid biosynthetic process GO:0008652 32 0.049
gamete generation GO:0007276 124 0.049
response to estradiol GO:0032355 164 0.048
kidney development GO:0001822 67 0.047
organic hydroxy compound transport GO:0015850 77 0.047
multicellular organism reproduction GO:0032504 233 0.046
cellular response to organic cyclic compound GO:0071407 202 0.046
negative regulation of multicellular organismal process GO:0051241 203 0.046
Rat
response to wounding GO:0009611 254 0.045
Rat
cofactor metabolic process GO:0051186 95 0.045
behavior GO:0007610 205 0.045
Rat
negative regulation of nervous system development GO:0051961 79 0.045
regulation of hormone levels GO:0010817 187 0.044
Rat
macromolecular complex assembly GO:0065003 273 0.044
Rat
head development GO:0060322 247 0.043
programmed cell death GO:0012501 392 0.043
Rat
sexual reproduction GO:0019953 148 0.043
cellular amino acid metabolic process GO:0006520 107 0.042
catabolic process GO:0009056 351 0.042
Rat
response to hypoxia GO:0001666 231 0.041
cellular ketone metabolic process GO:0042180 51 0.041
anatomical structure morphogenesis GO:0009653 298 0.040
Rat
cellular component assembly GO:0022607 360 0.040
Rat
regulation of cellular localization GO:0060341 263 0.040
Rat
negative regulation of cell development GO:0010721 82 0.039
response to oxygen levels GO:0070482 265 0.039
positive regulation of secretion GO:0051047 140 0.039
Rat
neuron differentiation GO:0030182 368 0.039
Rat
defense response GO:0006952 194 0.039
Rat
response to peptide hormone GO:0043434 278 0.038
Rat
cell cell signaling GO:0007267 335 0.038
Rat
response to vitamin GO:0033273 131 0.038
organelle organization GO:0006996 266 0.038
positive regulation of transport GO:0051050 245 0.038
Rat
regulation of programmed cell death GO:0043067 341 0.038
response to hexose GO:0009746 144 0.037
Rat
single organism catabolic process GO:0044712 283 0.037
positive regulation of cell proliferation GO:0008284 249 0.036
positive regulation of phosphorus metabolic process GO:0010562 262 0.036
learning or memory GO:0007611 90 0.036
wound healing GO:0042060 122 0.036
Rat
nucleobase containing small molecule metabolic process GO:0055086 316 0.036
monocarboxylic acid metabolic process GO:0032787 152 0.035
brain development GO:0007420 247 0.034
negative regulation of metabolic process GO:0009892 331 0.034
Rat
neurological system process GO:0050877 219 0.033
Rat
negative regulation of developmental process GO:0051093 125 0.033
Rat
small molecule biosynthetic process GO:0044283 124 0.033
response to lipopolysaccharide GO:0032496 191 0.032
Rat
cellular homeostasis GO:0019725 252 0.032
Rat
liver development GO:0001889 90 0.032
negative regulation of programmed cell death GO:0043069 183 0.032
urogenital system development GO:0001655 78 0.032
intracellular signal transduction GO:0035556 314 0.032
negative regulation of macromolecule metabolic process GO:0010605 260 0.031
Rat
response to ethanol GO:0045471 162 0.031
response to decreased oxygen levels GO:0036293 237 0.031
cellular amine metabolic process GO:0044106 38 0.031
cellular response to peptide hormone stimulus GO:0071375 120 0.031
regulation of cell differentiation GO:0045595 320 0.030
single organism biosynthetic process GO:0044711 342 0.030
response to monosaccharide GO:0034284 159 0.030
Rat
negative regulation of cell differentiation GO:0045596 99 0.030
response to alkaloid GO:0043279 132 0.030
cellular lipid metabolic process GO:0044255 208 0.030
regulation of nervous system development GO:0051960 264 0.029
cellular hormone metabolic process GO:0034754 49 0.029
neuron projection development GO:0031175 273 0.029
Rat
cation transmembrane transport GO:0098655 263 0.029
cellular catabolic process GO:0044248 295 0.028
cellular modified amino acid metabolic process GO:0006575 61 0.028
renal system development GO:0072001 67 0.028
negative regulation of neuron differentiation GO:0045665 62 0.028
drug transmembrane transport GO:0006855 13 0.028
oxidation reduction process GO:0055114 304 0.028
regulation of body fluid levels GO:0050878 90 0.028
Rat
positive regulation of immunoglobulin production GO:0002639 4 0.028
regulation of apoptotic process GO:0042981 335 0.028
aging GO:0007568 241 0.028
Rat
response to molecule of bacterial origin GO:0002237 194 0.027
Rat
regulation of molecular function GO:0065009 398 0.027
negative regulation of cell communication GO:0010648 158 0.027
cellular chemical homeostasis GO:0055082 247 0.027
Rat
developmental growth GO:0048589 100 0.026
Rat
response to peptide GO:1901652 292 0.026
Rat
cellular response to hormone stimulus GO:0032870 247 0.026
response to nicotine GO:0035094 51 0.026
negative regulation of signaling GO:0023057 157 0.026
neurotransmitter uptake GO:0001504 3 0.026
positive regulation of amino acid transport GO:0051957 13 0.026
organic substance catabolic process GO:1901575 316 0.025
Rat
acid secretion GO:0046717 48 0.025
glycerol transport GO:0015793 2 0.025
regulation of cellular component organization GO:0051128 368 0.025
Rat
heterocycle catabolic process GO:0046700 167 0.025
organophosphate catabolic process GO:0046434 148 0.024
amide transport GO:0042886 105 0.024
Rat
aromatic compound catabolic process GO:0019439 168 0.024
response to radiation GO:0009314 137 0.024
regeneration GO:0031099 163 0.024
organic cation transport GO:0015695 11 0.024
positive regulation of protein metabolic process GO:0051247 178 0.024
Rat
regulation of protein metabolic process GO:0051246 289 0.024
Rat
reproductive system development GO:0061458 128 0.023
epithelium development GO:0060429 96 0.023
Rat
cell projection morphogenesis GO:0048858 123 0.023
Rat
positive regulation of gamma aminobutyric acid secretion GO:0014054 4 0.023
cellular response to molecule of bacterial origin GO:0071219 56 0.023
lipid localization GO:0010876 62 0.023
organophosphate metabolic process GO:0019637 370 0.022
signal release GO:0023061 145 0.022
Rat
oligopeptide transport GO:0006857 4 0.022
positive regulation of cellular protein metabolic process GO:0032270 167 0.022
peptide biosynthetic process GO:0043043 3 0.022
response to ketone GO:1901654 182 0.022
regulation of secretion by cell GO:1903530 208 0.021
Rat
regulation of protein transport GO:0051223 68 0.021
regulation of phosphorus metabolic process GO:0051174 349 0.021
protein phosphorylation GO:0006468 345 0.021
nucleoside phosphate metabolic process GO:0006753 283 0.021
cellular response to acid chemical GO:0071229 75 0.021
positive regulation of phosphate metabolic process GO:0045937 262 0.021
regulation of cellular ketone metabolic process GO:0010565 27 0.021
lipid metabolic process GO:0006629 283 0.021
chemical homeostasis GO:0048878 292 0.021
Rat
regulation of neuron differentiation GO:0045664 208 0.021
biological adhesion GO:0022610 110 0.020
cellular component movement GO:0006928 248 0.020
response to other organism GO:0051707 220 0.020
Rat
carbohydrate derivative metabolic process GO:1901135 346 0.020
regulation of intracellular signal transduction GO:1902531 218 0.020
regulation of catalytic activity GO:0050790 304 0.020
regulation of phosphate metabolic process GO:0019220 349 0.020
response to growth factor GO:0070848 189 0.020
regulation of membrane potential GO:0042391 110 0.020
nucleotide metabolic process GO:0009117 279 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
response to cytokine GO:0034097 215 0.019
spermatogenesis GO:0007283 99 0.019
regulation of signal transduction GO:0009966 318 0.019
gastrulation GO:0007369 2 0.019
monocarboxylic acid biosynthetic process GO:0072330 48 0.019
positive regulation of phosphorylation GO:0042327 177 0.019
regulation of rna biosynthetic process GO:2001141 381 0.019
response to glucose GO:0009749 136 0.019
Rat
response to external biotic stimulus GO:0043207 221 0.019
Rat
regulation of kinase activity GO:0043549 117 0.019
regulation of anatomical structure size GO:0090066 135 0.019
Rat
organic cyclic compound catabolic process GO:1901361 175 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.018
Rat
negative regulation of cellular metabolic process GO:0031324 281 0.018
Rat
peptide transport GO:0015833 97 0.018
Rat
amine metabolic process GO:0009308 38 0.018
negative regulation of cellular biosynthetic process GO:0031327 161 0.018
Rat
circulatory system process GO:0003013 183 0.018
Rat
protein localization GO:0008104 191 0.018
cell activation GO:0001775 97 0.018
cellular response to insulin stimulus GO:0032869 81 0.018
steroid metabolic process GO:0008202 73 0.018
hepaticobiliary system development GO:0061008 90 0.017
response to ionizing radiation GO:0010212 59 0.017
multi multicellular organism process GO:0044706 138 0.017
cellular response to cgmp GO:0071321 2 0.017
protein transport GO:0015031 132 0.017
tube development GO:0035295 89 0.017
gliogenesis GO:0042063 93 0.017
positive regulation of ion transport GO:0043270 94 0.017
mesoderm development GO:0007498 2 0.017
negative regulation of rna metabolic process GO:0051253 123 0.017
coenzyme metabolic process GO:0006732 86 0.017
regulation of neurogenesis GO:0050767 247 0.017
fatty acid biosynthetic process GO:0006633 33 0.017
rhythmic process GO:0048511 156 0.016
apoptotic process GO:0006915 381 0.016
Rat
purine nucleotide metabolic process GO:0006163 229 0.016
regulation of cellular protein metabolic process GO:0032268 267 0.016
negative regulation of neurogenesis GO:0050768 78 0.016
regulation of cell adhesion GO:0030155 52 0.016
cellular response to lipopolysaccharide GO:0071222 55 0.016
modified amino acid transport GO:0072337 12 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
organonitrogen compound biosynthetic process GO:1901566 167 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
Rat
coagulation GO:0050817 28 0.016
male gamete generation GO:0048232 99 0.016
negative regulation of cell death GO:0060548 229 0.016
cellular response to growth factor stimulus GO:0071363 162 0.016
positive regulation of molecular function GO:0044093 230 0.016
limb morphogenesis GO:0035108 4 0.016
regulation of cell development GO:0060284 263 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
cell projection organization GO:0030030 302 0.016
Rat
blood circulation GO:0008015 183 0.016
Rat
negative regulation of response to stimulus GO:0048585 155 0.015
Rat
embryonic appendage morphogenesis GO:0035113 4 0.015
insecticide metabolic process GO:0017143 4 0.015
purine ribonucleotide metabolic process GO:0009150 227 0.015
eye morphogenesis GO:0048592 4 0.015
cellular response to abiotic stimulus GO:0071214 85 0.015
Rat
purine containing compound metabolic process GO:0072521 253 0.015
negative regulation of nucleic acid templated transcription GO:1903507 117 0.015
regulation of blood vessel size GO:0050880 89 0.015
Rat
single organism behavior GO:0044708 130 0.015
Rat
ribonucleotide metabolic process GO:0009259 231 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
negative regulation of transcription dna templated GO:0045892 116 0.015
positive regulation of apoptotic process GO:0043065 154 0.015
positive regulation of cell differentiation GO:0045597 217 0.014
rna biosynthetic process GO:0032774 380 0.014
small molecule catabolic process GO:0044282 59 0.014
vitamin transport GO:0051180 14 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
transcription dna templated GO:0006351 377 0.014
single organism organelle organization GO:1902589 180 0.014
negative regulation of gene expression GO:0010629 199 0.014
glial cell differentiation GO:0010001 65 0.014
ras protein signal transduction GO:0007265 29 0.014
cell adhesion GO:0007155 110 0.014
reproductive structure development GO:0048608 128 0.014
proteolysis GO:0006508 175 0.014
ribonucleoside triphosphate catabolic process GO:0009203 122 0.014
cognition GO:0050890 92 0.014
intracellular transport GO:0046907 185 0.014
neurotransmitter transport GO:0006836 42 0.014
tripeptide transport GO:0042939 2 0.014
cellular component morphogenesis GO:0032989 155 0.014
Rat
regulation of system process GO:0044057 208 0.014
Rat
regulation of immunoglobulin production GO:0002637 4 0.014
regulation of cellular amine metabolic process GO:0033238 8 0.014
synaptic transmission GO:0007268 235 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
positive regulation of protein phosphorylation GO:0001934 135 0.014
nucleobase containing compound catabolic process GO:0034655 152 0.014
regulation of transcription dna templated GO:0006355 374 0.014
regulation of ion transport GO:0043269 245 0.014
Rat
regulation of rna metabolic process GO:0051252 391 0.014
defense response to gram negative bacterium GO:0050829 3 0.014
inorganic cation transmembrane transport GO:0098662 202 0.014
response to bacterium GO:0009617 200 0.014
Rat
single organismal cell cell adhesion GO:0016337 42 0.014
regulation of response to external stimulus GO:0032101 106 0.014
Rat
regulation of transferase activity GO:0051338 123 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
regulation of response to wounding GO:1903034 69 0.013
Rat
dopamine transport GO:0015872 18 0.013
positive regulation of response to stimulus GO:0048584 285 0.013
Rat
purine ribonucleoside metabolic process GO:0046128 168 0.013
regulation of cell projection organization GO:0031344 175 0.013
neural crest cell differentiation GO:0014033 2 0.013
amide biosynthetic process GO:0043604 10 0.013
muscle tissue development GO:0060537 58 0.013
Rat
positive regulation of programmed cell death GO:0043068 157 0.013
c21 steroid hormone biosynthetic process GO:0006700 10 0.013
positive regulation of cell growth GO:0030307 44 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
regulation of hydrolase activity GO:0051336 143 0.013
neuron neuron synaptic transmission GO:0007270 60 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
Rat
regulation of cell growth GO:0001558 85 0.013
organ regeneration GO:0031100 101 0.013
organonitrogen compound catabolic process GO:1901565 179 0.013
positive regulation of protein modification process GO:0031401 142 0.013
cellular response to hexose stimulus GO:0071331 65 0.013
Rat
regulation of catabolic process GO:0009894 113 0.013
Rat
cellular modified amino acid biosynthetic process GO:0042398 18 0.013
response to mercury ion GO:0046689 15 0.013
metal ion transport GO:0030001 289 0.013
Rat
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 2 0.013
cell part morphogenesis GO:0032990 123 0.012
Rat
regulation of response to stress GO:0080134 126 0.012
Rat
cellular hyperosmotic response GO:0071474 4 0.012
developmental process involved in reproduction GO:0003006 159 0.012
negative regulation of synaptic transmission dopaminergic GO:0032227 4 0.012
positive regulation of cell communication GO:0010647 271 0.012
Rat
reactive oxygen species biosynthetic process GO:1903409 8 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.012
anterior posterior pattern specification GO:0009952 1 0.012
response to antibiotic GO:0046677 39 0.012
homeostatic process GO:0042592 331 0.012
Rat
cell proliferation in external granule layer GO:0021924 1 0.012
negative regulation of molecular function GO:0044092 133 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.012
nucleoside metabolic process GO:0009116 179 0.012
response to lead ion GO:0010288 33 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
cell morphogenesis GO:0000902 142 0.012
Rat
positive regulation of isotype switching GO:0045830 1 0.012
cell migration GO:0016477 197 0.012
cell type specific apoptotic process GO:0097285 134 0.012
cellular macromolecule localization GO:0070727 122 0.012
axis specification GO:0009798 4 0.012
positive regulation of immune system process GO:0002684 90 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
Rat
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
porphyrin containing compound metabolic process GO:0006778 8 0.012
response to testosterone GO:0033574 55 0.012
establishment of protein localization GO:0045184 141 0.012
regulation of protein modification process GO:0031399 194 0.012
response to mechanical stimulus GO:0009612 134 0.012
Rat
response to cgmp GO:0070305 3 0.012
cell motility GO:0048870 202 0.012
regulation of immunoglobulin secretion GO:0051023 1 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
memory GO:0007613 54 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
non canonical wnt signaling pathway GO:0035567 3 0.011
cellular response to external stimulus GO:0071496 118 0.011
Rat
t cell activation GO:0042110 29 0.011
regulation of immune system process GO:0002682 123 0.011
cellular response to stress GO:0033554 269 0.011
rna metabolic process GO:0016070 406 0.011
positive regulation of cell death GO:0010942 184 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
bile acid and bile salt transport GO:0015721 12 0.011
glial cell development GO:0021782 19 0.011
positive regulation of developmental process GO:0051094 283 0.011
locomotion GO:0040011 237 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
cofactor biosynthetic process GO:0051188 28 0.011
cellular response to steroid hormone stimulus GO:0071383 93 0.011
organ morphogenesis GO:0009887 75 0.011
regulation of tube size GO:0035150 89 0.011
Rat
embryo development GO:0009790 49 0.011
Rat
neuron development GO:0048666 286 0.011
Rat
hormone metabolic process GO:0042445 69 0.011
nucleoside phosphate catabolic process GO:1901292 140 0.011
regulation of peptide secretion GO:0002791 82 0.011
Rat
alpha amino acid metabolic process GO:1901605 71 0.011
positive regulation of secretion by cell GO:1903532 128 0.011
Rat
hormone transport GO:0009914 121 0.011
Rat
b cell differentiation GO:0030183 2 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
negative regulation of transport GO:0051051 136 0.011
canalicular bile acid transport GO:0015722 5 0.011
regulation of synaptic plasticity GO:0048167 70 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
regulation of cellular component movement GO:0051270 150 0.011
regulation of developmental growth GO:0048638 45 0.010
Rat
fatty acid metabolic process GO:0006631 99 0.010
cell growth GO:0016049 104 0.010
immune system process GO:0002376 204 0.010
embryonic limb morphogenesis GO:0030326 4 0.010
gland development GO:0048732 155 0.010
positive regulation of intracellular signal transduction GO:1902533 138 0.010
purine containing compound catabolic process GO:0072523 138 0.010
glutathione transport GO:0034635 2 0.010
response to oxidative stress GO:0006979 186 0.010
negative regulation of biosynthetic process GO:0009890 168 0.010
Rat
dna metabolic process GO:0006259 96 0.010
Rat
axon development GO:0061564 96 0.010
single organism cellular localization GO:1902580 102 0.010
alcohol metabolic process GO:0006066 77 0.010
astrocyte development GO:0014002 4 0.010

Gjb2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.027
disease of anatomical entity DOID:7 0 0.023
Human
nervous system disease DOID:863 0 0.023
Human
inherited metabolic disorder DOID:655 0 0.013
gastrointestinal system disease DOID:77 0 0.011
central nervous system disease DOID:331 0 0.011