Rattus norvegicus

116 known processes

Guk1

guanylate kinase 1

Guk1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
transcription from rna polymerase ii promoter GO:0006366 252 0.159
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.149
central nervous system development GO:0007417 311 0.130
positive regulation of biosynthetic process GO:0009891 319 0.128
protein phosphorylation GO:0006468 345 0.101
nucleotide metabolic process GO:0009117 279 0.097
regulation of phosphorus metabolic process GO:0051174 349 0.096
regulation of phosphate metabolic process GO:0019220 349 0.090
apoptotic process GO:0006915 381 0.086
positive regulation of multicellular organismal process GO:0051240 387 0.084
positive regulation of nucleic acid templated transcription GO:1903508 197 0.084
macromolecular complex subunit organization GO:0043933 339 0.070
positive regulation of cellular biosynthetic process GO:0031328 295 0.068
positive regulation of apoptotic process GO:0043065 154 0.067
regulation of phosphorylation GO:0042325 248 0.065
single organism biosynthetic process GO:0044711 342 0.065
regulation of system process GO:0044057 208 0.062
regulation of protein phosphorylation GO:0001932 183 0.061
rna biosynthetic process GO:0032774 380 0.060
cellular component assembly GO:0022607 360 0.059
protein complex assembly GO:0006461 263 0.059
intracellular signal transduction GO:0035556 314 0.057
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.057
regulation of apoptotic process GO:0042981 335 0.056
purine nucleoside metabolic process GO:0042278 169 0.056
protein complex subunit organization GO:0071822 302 0.055
ribonucleotide biosynthetic process GO:0009260 85 0.053
positive regulation of camp metabolic process GO:0030816 31 0.053
regulation of nucleic acid templated transcription GO:1903506 380 0.051
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.051
aging GO:0007568 241 0.050
response to nutrient levels GO:0031667 370 0.050
regulation of multicellular organismal development GO:2000026 376 0.050
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.050
nucleic acid templated transcription GO:0097659 379 0.048
positive regulation of rna biosynthetic process GO:1902680 197 0.047
positive regulation of transcription dna templated GO:0045893 197 0.047
positive regulation of cellular component organization GO:0051130 200 0.046
positive regulation of rna metabolic process GO:0051254 203 0.046
purine ribonucleotide metabolic process GO:0009150 227 0.045
rna metabolic process GO:0016070 406 0.044
carbohydrate derivative metabolic process GO:1901135 346 0.044
regulation of cellular amine metabolic process GO:0033238 8 0.044
ribose phosphate biosynthetic process GO:0046390 87 0.044
positive regulation of cell death GO:0010942 184 0.043
glycosyl compound metabolic process GO:1901657 182 0.043
positive regulation of gene expression GO:0010628 244 0.043
protein complex biogenesis GO:0070271 263 0.043
programmed cell death GO:0012501 392 0.043
regulation of rna metabolic process GO:0051252 391 0.043
guanosine containing compound metabolic process GO:1901068 74 0.043
positive regulation of neuron apoptotic process GO:0043525 33 0.042
organophosphate metabolic process GO:0019637 370 0.042
cellular component biogenesis GO:0044085 368 0.041
catabolic process GO:0009056 351 0.041
regulation of programmed cell death GO:0043067 341 0.041
cellular response to stress GO:0033554 269 0.040
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.040
response to extracellular stimulus GO:0009991 380 0.040
cellular amine metabolic process GO:0044106 38 0.039
regulation of protein metabolic process GO:0051246 289 0.039
head development GO:0060322 247 0.039
actin filament based process GO:0030029 86 0.038
neuron differentiation GO:0030182 368 0.038
positive regulation of cell communication GO:0010647 271 0.037
regulation of cell differentiation GO:0045595 320 0.037
pyrimidine nucleotide biosynthetic process GO:0006221 9 0.036
protein autophosphorylation GO:0046777 66 0.036
purine containing compound metabolic process GO:0072521 253 0.036
regulation of catalytic activity GO:0050790 304 0.035
regulation of molecular function GO:0065009 398 0.035
carbohydrate derivative biosynthetic process GO:1901137 124 0.035
purine ribonucleoside metabolic process GO:0046128 168 0.035
organophosphate biosynthetic process GO:0090407 143 0.034
positive regulation of developmental process GO:0051094 283 0.033
response to decreased oxygen levels GO:0036293 237 0.032
actin cytoskeleton organization GO:0030036 73 0.032
response to corticosteroid GO:0031960 235 0.032
organelle organization GO:0006996 266 0.032
cell fate determination GO:0001709 2 0.032
camp metabolic process GO:0046058 63 0.032
regulation of blood circulation GO:1903522 110 0.031
nucleobase containing small molecule metabolic process GO:0055086 316 0.031
regulation of purine nucleotide metabolic process GO:1900542 115 0.031
regulation of lyase activity GO:0051339 22 0.031
positive regulation of signaling GO:0023056 270 0.031
homeostatic process GO:0042592 331 0.031
ribonucleotide metabolic process GO:0009259 231 0.031
positive regulation of phosphorus metabolic process GO:0010562 262 0.031
positive regulation of nervous system development GO:0051962 178 0.030
regulation of nucleotide metabolic process GO:0006140 117 0.030
blood circulation GO:0008015 183 0.030
regulation of cellular component organization GO:0051128 368 0.029
ribonucleoside metabolic process GO:0009119 174 0.029
cyclic nucleotide metabolic process GO:0009187 80 0.029
regulation of nervous system development GO:0051960 264 0.028
regulation of nucleotide biosynthetic process GO:0030808 47 0.028
circulatory system process GO:0003013 183 0.028
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.028
transcription dna templated GO:0006351 377 0.028
nucleoside catabolic process GO:0009164 126 0.027
regulation of transcription dna templated GO:0006355 374 0.027
cyclic nucleotide biosynthetic process GO:0009190 63 0.027
ribose phosphate metabolic process GO:0019693 235 0.027
response to alkaloid GO:0043279 132 0.027
aromatic compound catabolic process GO:0019439 168 0.026
positive regulation of protein phosphorylation GO:0001934 135 0.026
regulation of cell development GO:0060284 263 0.026
positive regulation of cell development GO:0010720 176 0.026
regulation of rna biosynthetic process GO:2001141 381 0.026
single organism catabolic process GO:0044712 283 0.026
response to estrogen GO:0043627 232 0.026
positive regulation of phosphate metabolic process GO:0045937 262 0.025
brain development GO:0007420 247 0.025
purine nucleoside triphosphate catabolic process GO:0009146 122 0.025
negative regulation of macromolecule metabolic process GO:0010605 260 0.025
positive regulation of molecular function GO:0044093 230 0.025
positive regulation of cell differentiation GO:0045597 217 0.025
macromolecular complex assembly GO:0065003 273 0.025
neuron projection development GO:0031175 273 0.024
negative regulation of metabolic process GO:0009892 331 0.024
cellular chemical homeostasis GO:0055082 247 0.024
positive regulation of cellular protein metabolic process GO:0032270 167 0.024
cell cell signaling GO:0007267 335 0.024
positive regulation of neuron death GO:1901216 43 0.024
nucleoside phosphate metabolic process GO:0006753 283 0.023
response to growth factor GO:0070848 189 0.023
regulation of cellular protein metabolic process GO:0032268 267 0.023
negative regulation of molecular function GO:0044092 133 0.022
amine metabolic process GO:0009308 38 0.022
regulation of neurogenesis GO:0050767 247 0.022
negative regulation of cell death GO:0060548 229 0.022
regulation of transferase activity GO:0051338 123 0.022
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 3 0.022
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.022
negative regulation of protein phosphorylation GO:0001933 44 0.021
regulation of protein modification process GO:0031399 194 0.021
regulation of signal transduction GO:0009966 318 0.021
cellular response to lipid GO:0071396 201 0.021
response to ketone GO:1901654 182 0.021
neuron apoptotic process GO:0051402 88 0.021
negative regulation of phosphate metabolic process GO:0045936 80 0.021
signal transduction by phosphorylation GO:0023014 144 0.021
reproductive process GO:0022414 372 0.020
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.020
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.020
anterior posterior pattern specification GO:0009952 1 0.020
nucleoside metabolic process GO:0009116 179 0.020
immune system process GO:0002376 204 0.019
regulation of cell proliferation GO:0042127 359 0.019
positive regulation of nucleotide metabolic process GO:0045981 91 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
gastrulation GO:0007369 2 0.019
nucleobase containing compound catabolic process GO:0034655 152 0.019
regulation of camp metabolic process GO:0030814 43 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.019
positive regulation of neurogenesis GO:0050769 165 0.019
axis specification GO:0009798 4 0.019
positive regulation of cell proliferation GO:0008284 249 0.018
negative regulation of multicellular organismal process GO:0051241 203 0.018
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.018
cation homeostasis GO:0055080 195 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
response to glucocorticoid GO:0051384 223 0.018
response to acid chemical GO:0001101 222 0.018
negative regulation of cell differentiation GO:0045596 99 0.018
secretion by cell GO:0032940 248 0.018
purine nucleoside triphosphate metabolic process GO:0009144 141 0.018
purine nucleotide biosynthetic process GO:0006164 83 0.018
nucleoside phosphate biosynthetic process GO:1901293 102 0.018
circulatory system development GO:0072359 134 0.018
organonitrogen compound catabolic process GO:1901565 179 0.017
neuron development GO:0048666 286 0.017
response to metal ion GO:0010038 253 0.017
gtp metabolic process GO:0046039 72 0.017
cyclic purine nucleotide metabolic process GO:0052652 62 0.017
regulation of catabolic process GO:0009894 113 0.017
cell migration GO:0016477 197 0.017
positive regulation of intracellular signal transduction GO:1902533 138 0.017
regulation of cellular component movement GO:0051270 150 0.017
response to oxidative stress GO:0006979 186 0.016
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.016
developmental growth GO:0048589 100 0.016
regulation of cell migration GO:0030334 128 0.016
reproduction GO:0000003 245 0.016
ribonucleoside triphosphate catabolic process GO:0009203 122 0.016
cation transport GO:0006812 382 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.016
regulation of kinase activity GO:0043549 117 0.016
nucleotide biosynthetic process GO:0009165 98 0.016
purine containing compound biosynthetic process GO:0072522 85 0.016
developmental process involved in reproduction GO:0003006 159 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
regulation of dna metabolic process GO:0051052 60 0.016
regulation of secretion by cell GO:1903530 208 0.016
camp biosynthetic process GO:0006171 47 0.015
regulation of cyclase activity GO:0031279 21 0.015
response to mineralocorticoid GO:0051385 49 0.015
positive regulation of monooxygenase activity GO:0032770 5 0.015
positive regulation of neuron differentiation GO:0045666 126 0.015
organonitrogen compound biosynthetic process GO:1901566 167 0.015
protein oligomerization GO:0051259 191 0.015
regulation of neuron apoptotic process GO:0043523 83 0.015
positive regulation of cellular component biogenesis GO:0044089 55 0.015
regulation of growth GO:0040008 105 0.015
cell projection organization GO:0030030 302 0.015
response to inorganic substance GO:0010035 377 0.015
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.015
positive regulation of cellular catabolic process GO:0031331 71 0.015
growth GO:0040007 165 0.015
negative regulation of cell communication GO:0010648 158 0.015
positive regulation of response to stimulus GO:0048584 285 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
regulation of locomotion GO:0040012 148 0.014
response to wounding GO:0009611 254 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
negative regulation of developmental process GO:0051093 125 0.014
regulation of erk1 and erk2 cascade GO:0070372 41 0.014
positive regulation of catalytic activity GO:0043085 184 0.014
heart contraction GO:0060047 57 0.014
negative regulation of neuron apoptotic process GO:0043524 45 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
positive regulation of cellular component movement GO:0051272 102 0.014
response to oxygen levels GO:0070482 265 0.014
regulation of secretion GO:0051046 224 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
positive regulation of camp biosynthetic process GO:0030819 28 0.013
chemical homeostasis GO:0048878 292 0.013
cellular amino acid metabolic process GO:0006520 107 0.013
regulation of mapk cascade GO:0043408 116 0.013
multi organism reproductive process GO:0044703 262 0.013
protein heterooligomerization GO:0051291 89 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
response to lipopolysaccharide GO:0032496 191 0.013
regulation of hydrolase activity GO:0051336 143 0.013
positive regulation of signal transduction GO:0009967 175 0.013
positive regulation of small gtpase mediated signal transduction GO:0051057 9 0.013
regulation of cell projection organization GO:0031344 175 0.013
negative regulation of cell cycle phase transition GO:1901988 4 0.013
response to hypoxia GO:0001666 231 0.013
heart morphogenesis GO:0003007 3 0.013
muscle system process GO:0003012 115 0.013
mapk cascade GO:0000165 140 0.013
response to corticosterone GO:0051412 40 0.012
regulation of anatomical structure size GO:0090066 135 0.012
single organism carbohydrate metabolic process GO:0044723 118 0.012
response to bacterium GO:0009617 200 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
negative regulation of phosphorus metabolic process GO:0010563 80 0.012
regulation of cell motility GO:2000145 131 0.012
cellular ion homeostasis GO:0006873 184 0.012
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 24 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
cellular ketone metabolic process GO:0042180 51 0.012
cellular cation homeostasis GO:0030003 180 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
apoptotic signaling pathway GO:0097190 27 0.012
single organism reproductive process GO:0044702 297 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
positive regulation of neuron projection development GO:0010976 99 0.012
protein localization GO:0008104 191 0.012
positive regulation of kinase activity GO:0033674 77 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
cellular response to oxygen containing compound GO:1901701 386 0.012
heart development GO:0007507 72 0.012
regulation of neuron differentiation GO:0045664 208 0.012
cell type specific apoptotic process GO:0097285 134 0.012
gtp catabolic process GO:0006184 71 0.012
secretion GO:0046903 307 0.012
divalent metal ion transport GO:0070838 132 0.011
regulation of muscle system process GO:0090257 79 0.011
metal ion transport GO:0030001 289 0.011
negative regulation of gene expression GO:0010629 199 0.011
cellular catabolic process GO:0044248 295 0.011
response to nutrient GO:0007584 248 0.011
regulation of nucleoside metabolic process GO:0009118 66 0.011
cell growth GO:0016049 104 0.011
regulation of cellular ketone metabolic process GO:0010565 27 0.011
peptide secretion GO:0002790 86 0.011
regulation of gtp catabolic process GO:0033124 58 0.011
regulation of heart contraction GO:0008016 48 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
sequestering of metal ion GO:0051238 9 0.011
response to external biotic stimulus GO:0043207 221 0.011
negative regulation of signaling GO:0023057 157 0.011
protein dephosphorylation GO:0006470 38 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
erk1 and erk2 cascade GO:0070371 48 0.011
response to estradiol GO:0032355 164 0.011
response to temperature stimulus GO:0009266 94 0.011
sex differentiation GO:0007548 113 0.011
regulation of immune system process GO:0002682 123 0.011
negative regulation of neurogenesis GO:0050768 78 0.011
ion homeostasis GO:0050801 212 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
guanosine containing compound catabolic process GO:1901069 71 0.011
positive regulation of organelle organization GO:0010638 48 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
oxoacid metabolic process GO:0043436 290 0.011
regulation of dna methylation GO:0044030 6 0.010
cellular nitrogen compound catabolic process GO:0044270 163 0.010
single organism organelle organization GO:1902589 180 0.010
mitotic cell cycle checkpoint GO:0007093 1 0.010
positive regulation of ruffle assembly GO:1900029 1 0.010
regulation of protein kinase activity GO:0045859 105 0.010
regulation of neuron death GO:1901214 115 0.010
response to activity GO:0014823 73 0.010
regulation of camp biosynthetic process GO:0030817 38 0.010
calcium ion transport GO:0006816 131 0.010
reproductive structure development GO:0048608 128 0.010
carboxylic acid metabolic process GO:0019752 289 0.010
dna methylation or demethylation GO:0044728 8 0.010
carbohydrate derivative catabolic process GO:1901136 147 0.010

Guk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org