Rattus norvegicus

36 known processes

Hadha

hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit

(Aliases: RGD1560655,MGC105338)

Hadha biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
fatty acid oxidation GO:0019395 29 0.889
fatty acid metabolic process GO:0006631 99 0.684
monocarboxylic acid metabolic process GO:0032787 152 0.531
lipid oxidation GO:0034440 30 0.493
oxoacid metabolic process GO:0043436 290 0.493
carboxylic acid metabolic process GO:0019752 289 0.468
cellular lipid metabolic process GO:0044255 208 0.445
long chain fatty acid metabolic process GO:0001676 32 0.438
lipid metabolic process GO:0006629 283 0.423
organic acid metabolic process GO:0006082 292 0.363
monocarboxylic acid catabolic process GO:0072329 28 0.281
cellular lipid catabolic process GO:0044242 37 0.241
oxidation reduction process GO:0055114 304 0.226
small molecule catabolic process GO:0044282 59 0.203
lipid catabolic process GO:0016042 46 0.203
cellular catabolic process GO:0044248 295 0.201
carboxylic acid catabolic process GO:0046395 49 0.199
fatty acid catabolic process GO:0009062 26 0.196
catabolic process GO:0009056 351 0.193
lipid modification GO:0030258 52 0.172
programmed cell death GO:0012501 392 0.142
response to nutrient GO:0007584 248 0.141
fatty acid beta oxidation GO:0006635 22 0.129
thioester metabolic process GO:0035383 28 0.127
apoptotic process GO:0006915 381 0.121
regulation of programmed cell death GO:0043067 341 0.118
response to oxygen levels GO:0070482 265 0.117
acetyl coa metabolic process GO:0006084 17 0.117
single organism biosynthetic process GO:0044711 342 0.115
response to nutrient levels GO:0031667 370 0.113
single organism catabolic process GO:0044712 283 0.111
sulfur compound metabolic process GO:0006790 70 0.109
cofactor metabolic process GO:0051186 95 0.100
regulation of apoptotic process GO:0042981 335 0.098
acyl coa metabolic process GO:0006637 28 0.097
cellular ketone metabolic process GO:0042180 51 0.091
organic anion transport GO:0015711 132 0.089
organic acid catabolic process GO:0016054 49 0.086
carboxylic acid transport GO:0046942 115 0.085
negative regulation of apoptotic process GO:0043066 181 0.083
response to extracellular stimulus GO:0009991 380 0.079
regulation of cellular localization GO:0060341 263 0.076
organic acid transport GO:0015849 116 0.073
anion transport GO:0006820 178 0.070
single organism intracellular transport GO:1902582 166 0.069
organic substance catabolic process GO:1901575 316 0.065
regulation of cellular ketone metabolic process GO:0010565 27 0.062
reproductive process GO:0022414 372 0.061
negative regulation of programmed cell death GO:0043069 183 0.060
organelle organization GO:0006996 266 0.059
antral ovarian follicle growth GO:0001547 3 0.056
cellular component assembly GO:0022607 360 0.054
protein oligomerization GO:0051259 191 0.052
cellular response to stress GO:0033554 269 0.052
alcohol metabolic process GO:0006066 77 0.051
negative regulation of cell death GO:0060548 229 0.051
small molecule biosynthetic process GO:0044283 124 0.051
protein phosphorylation GO:0006468 345 0.050
response to hypoxia GO:0001666 231 0.049
response to decreased oxygen levels GO:0036293 237 0.047
cellular response to oxygen containing compound GO:1901701 386 0.047
regulation of lipid metabolic process GO:0019216 68 0.045
regulation of signal transduction GO:0009966 318 0.045
carboxylic acid biosynthetic process GO:0046394 83 0.044
homeostatic process GO:0042592 331 0.044
protein complex biogenesis GO:0070271 263 0.043
coenzyme metabolic process GO:0006732 86 0.043
protein complex subunit organization GO:0071822 302 0.043
nitrogen compound transport GO:0071705 229 0.042
cellular amine metabolic process GO:0044106 38 0.042
amide transport GO:0042886 105 0.041
glycerolipid metabolic process GO:0046486 67 0.041
response to acid chemical GO:0001101 222 0.041
ion transmembrane transport GO:0034220 365 0.041
regulation of cellular component organization GO:0051128 368 0.040
cellular response to peptide GO:1901653 133 0.038
monocarboxylic acid transport GO:0015718 52 0.038
response to metal ion GO:0010038 253 0.037
cellular response to endogenous stimulus GO:0071495 377 0.037
positive regulation of multicellular organismal process GO:0051240 387 0.037
lipid biosynthetic process GO:0008610 128 0.037
signal release GO:0023061 145 0.036
organic hydroxy compound metabolic process GO:1901615 115 0.036
fatty acid biosynthetic process GO:0006633 33 0.036
gland development GO:0048732 155 0.035
cellular response to lipid GO:0071396 201 0.035
macromolecular complex assembly GO:0065003 273 0.035
intracellular transport GO:0046907 185 0.035
protein homooligomerization GO:0051260 91 0.035
regulation of hormone levels GO:0010817 187 0.035
protein complex assembly GO:0006461 263 0.035
acetate ester biosynthetic process GO:1900620 2 0.034
response to ethanol GO:0045471 162 0.034
cellular component biogenesis GO:0044085 368 0.033
regulation of phosphorylation GO:0042325 248 0.033
multicellular organism reproduction GO:0032504 233 0.033
neutral lipid metabolic process GO:0006638 21 0.033
positive regulation of lipid catabolic process GO:0050996 4 0.032
regulation of organelle organization GO:0033043 80 0.032
behavior GO:0007610 205 0.032
amine metabolic process GO:0009308 38 0.032
response to peptide GO:1901652 292 0.032
positive regulation of cell differentiation GO:0045597 217 0.031
secretion by cell GO:0032940 248 0.031
neurological system process GO:0050877 219 0.031
macromolecule localization GO:0033036 252 0.030
response to peptide hormone GO:0043434 278 0.030
carbohydrate metabolic process GO:0005975 130 0.030
negative regulation of metabolic process GO:0009892 331 0.030
positive regulation of cell communication GO:0010647 271 0.030
positive regulation of fatty acid beta oxidation GO:0032000 4 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.030
lipid localization GO:0010876 62 0.029
organic acid biosynthetic process GO:0016053 83 0.029
multicellular organismal reproductive process GO:0048609 233 0.029
lipid transport GO:0006869 61 0.028
response to inorganic substance GO:0010035 377 0.028
anion transmembrane transport GO:0098656 77 0.028
cell projection organization GO:0030030 302 0.028
regulation of secretion GO:0051046 224 0.028
growth GO:0040007 165 0.027
regulation of multicellular organismal development GO:2000026 376 0.027
macromolecular complex subunit organization GO:0043933 339 0.027
positive regulation of cellular biosynthetic process GO:0031328 295 0.027
secretion GO:0046903 307 0.027
reproduction GO:0000003 245 0.027
positive regulation of fatty acid oxidation GO:0046321 6 0.027
positive regulation of signal transduction GO:0009967 175 0.027
neuron projection development GO:0031175 273 0.027
protein transport GO:0015031 132 0.026
intracellular signal transduction GO:0035556 314 0.026
regulation of phosphate metabolic process GO:0019220 349 0.026
hormone transport GO:0009914 121 0.026
regulation of protein modification process GO:0031399 194 0.025
spindle organization GO:0007051 2 0.025
negative regulation of transport GO:0051051 136 0.025
transmembrane transport GO:0055085 412 0.025
regulation of phosphorus metabolic process GO:0051174 349 0.025
carnitine metabolic process GO:0009437 3 0.024
positive regulation of protein metabolic process GO:0051247 178 0.024
triglyceride metabolic process GO:0006641 21 0.024
regulation of cellular amine metabolic process GO:0033238 8 0.024
regulation of cell proliferation GO:0042127 359 0.024
regulation of protein phosphorylation GO:0001932 183 0.024
cellular response to hormone stimulus GO:0032870 247 0.024
negative regulation of signaling GO:0023057 157 0.024
response to biotic stimulus GO:0009607 226 0.023
cell cycle GO:0007049 101 0.023
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.023
regulation of cellular amino acid metabolic process GO:0006521 2 0.023
regulation of molecular function GO:0065009 398 0.023
neuron development GO:0048666 286 0.023
acylglycerol metabolic process GO:0006639 21 0.023
peptide transport GO:0015833 97 0.022
organophosphate biosynthetic process GO:0090407 143 0.022
cellular component morphogenesis GO:0032989 155 0.022
peptide secretion GO:0002790 86 0.022
regulation of cellular protein metabolic process GO:0032268 267 0.022
neuron differentiation GO:0030182 368 0.022
regulation of neurogenesis GO:0050767 247 0.022
regulation of fatty acid metabolic process GO:0019217 18 0.022
anatomical structure morphogenesis GO:0009653 298 0.022
amino acid betaine metabolic process GO:0006577 3 0.021
response to external biotic stimulus GO:0043207 221 0.021
positive regulation of biosynthetic process GO:0009891 319 0.021
negative regulation of response to stimulus GO:0048585 155 0.021
immune system process GO:0002376 204 0.021
cellular response to external stimulus GO:0071496 118 0.021
regulation of intracellular signal transduction GO:1902531 218 0.021
positive regulation of molecular function GO:0044093 230 0.021
response to oxidative stress GO:0006979 186 0.021
steroid metabolic process GO:0008202 73 0.021
tissue development GO:0009888 252 0.021
response to estrogen GO:0043627 232 0.020
regulation of secretion by cell GO:1903530 208 0.020
positive regulation of phosphorylation GO:0042327 177 0.020
response to monosaccharide GO:0034284 159 0.020
aging GO:0007568 241 0.020
positive regulation of protein phosphorylation GO:0001934 135 0.020
apoptotic signaling pathway GO:0097190 27 0.020
organophosphate metabolic process GO:0019637 370 0.020
regulation of cell development GO:0060284 263 0.020
negative regulation of cell communication GO:0010648 158 0.020
regulation of protein metabolic process GO:0051246 289 0.020
positive regulation of response to stimulus GO:0048584 285 0.020
developmental process involved in reproduction GO:0003006 159 0.020
regulation of rna biosynthetic process GO:2001141 381 0.019
response to wounding GO:0009611 254 0.019
response to fatty acid GO:0070542 65 0.019
gonad development GO:0008406 104 0.019
hexose metabolic process GO:0019318 58 0.019
regulation of neuron differentiation GO:0045664 208 0.019
regulation of fatty acid oxidation GO:0046320 10 0.019
positive regulation of developmental process GO:0051094 283 0.019
regulation of cell differentiation GO:0045595 320 0.019
chemical homeostasis GO:0048878 292 0.019
regulation of peptide hormone secretion GO:0090276 80 0.019
single organism membrane organization GO:0044802 74 0.019
regulation of intracellular transport GO:0032386 65 0.019
reproductive system development GO:0061458 128 0.019
protein localization GO:0008104 191 0.018
response to molecule of bacterial origin GO:0002237 194 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
rna metabolic process GO:0016070 406 0.018
cell cell signaling GO:0007267 335 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.018
single organism nuclear import GO:1902593 35 0.018
cellular response to organonitrogen compound GO:0071417 197 0.018
long chain fatty acid transport GO:0015909 14 0.018
regulation of peptide transport GO:0090087 87 0.018
mitotic spindle organization GO:0007052 2 0.018
positive regulation of signaling GO:0023056 270 0.018
central nervous system development GO:0007417 311 0.017
cellular amino acid metabolic process GO:0006520 107 0.017
single organism behavior GO:0044708 130 0.017
response to other organism GO:0051707 220 0.017
regulation of fatty acid beta oxidation GO:0031998 8 0.017
negative regulation of multicellular organismal process GO:0051241 203 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
cellular response to organic cyclic compound GO:0071407 202 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
cytoplasmic transport GO:0016482 115 0.017
organonitrogen compound biosynthetic process GO:1901566 167 0.017
response to carbohydrate GO:0009743 183 0.017
regulation of cellular catabolic process GO:0031329 101 0.017
protein import GO:0017038 37 0.017
regulation of hormone secretion GO:0046883 106 0.017
b cell differentiation GO:0030183 2 0.017
negative regulation of macromolecule metabolic process GO:0010605 260 0.017
negative regulation of cellular metabolic process GO:0031324 281 0.016
transcription dna templated GO:0006351 377 0.016
cellular response to nutrient levels GO:0031669 60 0.016
regulation of nervous system development GO:0051960 264 0.016
positive regulation of phosphate metabolic process GO:0045937 262 0.016
response to bacterium GO:0009617 200 0.016
regulation of catalytic activity GO:0050790 304 0.016
single organism reproductive process GO:0044702 297 0.016
multi organism reproductive process GO:0044703 262 0.016
regulation of nucleic acid templated transcription GO:1903506 380 0.015
positive regulation of intracellular signal transduction GO:1902533 138 0.015
chromosome segregation GO:0007059 2 0.015
hormone secretion GO:0046879 115 0.015
positive regulation of cell development GO:0010720 176 0.015
regulation of establishment of protein localization GO:0070201 69 0.015
establishment of protein localization GO:0045184 141 0.015
cellular response to nitrogen compound GO:1901699 210 0.015
hepaticobiliary system development GO:0061008 90 0.015
monosaccharide metabolic process GO:0005996 61 0.015
positive regulation of nervous system development GO:0051962 178 0.014
reproductive structure development GO:0048608 128 0.014
regulation of catabolic process GO:0009894 113 0.014
positive regulation of cell proliferation GO:0008284 249 0.014
response to glucocorticoid GO:0051384 223 0.014
single organism carbohydrate metabolic process GO:0044723 118 0.014
response to reactive oxygen species GO:0000302 120 0.014
nucleocytoplasmic transport GO:0006913 48 0.014
regulation of peptide secretion GO:0002791 82 0.014
cell morphogenesis involved in differentiation GO:0000904 119 0.014
cell type specific apoptotic process GO:0097285 134 0.014
nucleic acid templated transcription GO:0097659 379 0.014
brain development GO:0007420 247 0.014
response to corticosteroid GO:0031960 235 0.014
regulation of anatomical structure morphogenesis GO:0022603 141 0.014
nuclear transport GO:0051169 49 0.014
positive regulation of protein modification process GO:0031401 142 0.014
negative regulation of biosynthetic process GO:0009890 168 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
protein import into nucleus GO:0006606 35 0.014
cellular response to extracellular stimulus GO:0031668 73 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.014
cellular response to peptide hormone stimulus GO:0071375 120 0.013
cellular macromolecule localization GO:0070727 122 0.013
negative regulation of molecular function GO:0044092 133 0.013
circulatory system process GO:0003013 183 0.013
protein targeting to nucleus GO:0044744 35 0.013
response to insulin GO:0032868 133 0.013
cognition GO:0050890 92 0.013
cation homeostasis GO:0055080 195 0.013
negative regulation of cellular component organization GO:0051129 83 0.013
regulation of cell projection organization GO:0031344 175 0.013
regulation of insulin secretion GO:0050796 65 0.013
transcription from rna polymerase ii promoter GO:0006366 252 0.013
sensory perception of pain GO:0019233 73 0.013
response to growth factor GO:0070848 189 0.013
positive regulation of gene expression GO:0010628 244 0.013
proteolysis GO:0006508 175 0.013
positive regulation of transport GO:0051050 245 0.013
carbohydrate derivative metabolic process GO:1901135 346 0.013
cellular response to acid chemical GO:0071229 75 0.013
developmental growth GO:0048589 100 0.013
cellular glucan metabolic process GO:0006073 23 0.013
axis specification GO:0009798 4 0.013
regulation of apoptotic signaling pathway GO:2001233 13 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
heart morphogenesis GO:0003007 3 0.013
regulation of response to stress GO:0080134 126 0.013
single organism organelle organization GO:1902589 180 0.013
response to hexose GO:0009746 144 0.013
positive regulation of neurogenesis GO:0050769 165 0.013
response to purine containing compound GO:0014074 126 0.012
learning or memory GO:0007611 90 0.012
response to ketone GO:1901654 182 0.012
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
regulation of rna metabolic process GO:0051252 391 0.012
fatty acid transport GO:0015908 25 0.012
regulation of protein transport GO:0051223 68 0.012
multi multicellular organism process GO:0044706 138 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
development of primary sexual characteristics GO:0045137 107 0.012
protein tetramerization GO:0051262 38 0.012
insulin secretion GO:0030073 69 0.012
negative regulation of cellular biosynthetic process GO:0031327 161 0.012
response to glucose GO:0009749 136 0.012
cardiovascular system development GO:0072358 134 0.012
regulation of transcription dna templated GO:0006355 374 0.012
positive regulation of mitochondrial membrane permeability GO:0035794 1 0.012
mitochondrion organization GO:0007005 35 0.012
cellular protein localization GO:0034613 122 0.012
regulation of system process GO:0044057 208 0.012
positive regulation of cellular component organization GO:0051130 200 0.012
defense response GO:0006952 194 0.012
neurotransmitter biosynthetic process GO:0042136 2 0.012
regulation of neuron projection development GO:0010975 161 0.012
regulation of transferase activity GO:0051338 123 0.012
negative regulation of gene expression GO:0010629 199 0.012
cellular response to oxidative stress GO:0034599 76 0.011
negative regulation of innate immune response GO:0045824 4 0.011
macroautophagy GO:0016236 4 0.011
protein localization to organelle GO:0033365 57 0.011
rna biosynthetic process GO:0032774 380 0.011
sexual reproduction GO:0019953 148 0.011
regeneration GO:0031099 163 0.011
dephosphorylation GO:0016311 98 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
intracellular protein transport GO:0006886 79 0.011
positive regulation of cell death GO:0010942 184 0.011
very long chain fatty acid metabolic process GO:0000038 3 0.011
glucose metabolic process GO:0006006 52 0.011
inflammatory response GO:0006954 150 0.011
gamete generation GO:0007276 124 0.011
cellular homeostasis GO:0019725 252 0.011
sensory perception GO:0007600 101 0.011
gastrulation GO:0007369 2 0.011
cellular response to cytokine stimulus GO:0071345 127 0.011
cellular ion homeostasis GO:0006873 184 0.011
positive regulation of rna metabolic process GO:0051254 203 0.011
hormone metabolic process GO:0042445 69 0.011
regulation of defense response GO:0031347 68 0.011
ion homeostasis GO:0050801 212 0.011
response to cytokine GO:0034097 215 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
locomotion GO:0040011 237 0.011
response to starvation GO:0042594 59 0.011
neuron death GO:0070997 127 0.010
peptidyl amino acid modification GO:0018193 126 0.010
regulation of neurotransmitter levels GO:0001505 42 0.010
female sex differentiation GO:0046660 59 0.010
synaptic transmission GO:0007268 235 0.010
protein targeting GO:0006605 61 0.010
positive regulation of catalytic activity GO:0043085 184 0.010
cellular chemical homeostasis GO:0055082 247 0.010
anterior posterior pattern specification GO:0009952 1 0.010
bmp signaling pathway GO:0030509 4 0.010
regulation of protein localization GO:0032880 81 0.010
neuron projection morphogenesis GO:0048812 122 0.010
positive regulation of nucleic acid templated transcription GO:1903508 197 0.010

Hadha disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.030
nervous system disease DOID:863 0 0.030
musculoskeletal system disease DOID:17 0 0.016
muscular disease DOID:0080000 0 0.014
muscle tissue disease DOID:66 0 0.014
central nervous system disease DOID:331 0 0.013
disease of metabolism DOID:0014667 0 0.012
inherited metabolic disorder DOID:655 0 0.012
myopathy DOID:423 0 0.012
muscular dystrophy DOID:9884 0 0.012