Rattus norvegicus

0 known processes

Hcn1

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

Hcn1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
head development GO:0060322 247 0.655
Rat
brain development GO:0007420 247 0.599
Rat
behavior GO:0007610 205 0.577
central nervous system development GO:0007417 311 0.286
Rat
protein complex subunit organization GO:0071822 302 0.269
Rat
synaptic transmission GO:0007268 235 0.255
cation transport GO:0006812 382 0.248
Human Mouse Rat
inorganic ion transmembrane transport GO:0098660 229 0.227
Human Mouse
cell cell signaling GO:0007267 335 0.187
macromolecular complex subunit organization GO:0043933 339 0.187
Rat
single organism behavior GO:0044708 130 0.182
g protein coupled receptor signaling pathway GO:0007186 242 0.154
action potential GO:0001508 54 0.146
cellular component assembly GO:0022607 360 0.140
Rat
cellular amino acid biosynthetic process GO:0008652 32 0.126
cellular component biogenesis GO:0044085 368 0.125
Rat
phasic smooth muscle contraction GO:0014821 3 0.124
neurological system process GO:0050877 219 0.121
lipid metabolic process GO:0006629 283 0.119
organic hydroxy compound metabolic process GO:1901615 115 0.107
cellular cation homeostasis GO:0030003 180 0.102
Rat
homeostatic process GO:0042592 331 0.097
Rat
cation transmembrane transport GO:0098655 263 0.095
Human Mouse Rat
regulation of cellular component organization GO:0051128 368 0.094
organic substance catabolic process GO:1901575 316 0.094
oxoacid metabolic process GO:0043436 290 0.093
cation homeostasis GO:0055080 195 0.093
Rat
metal ion transport GO:0030001 289 0.084
Human Mouse
hormone transport GO:0009914 121 0.083
regulation of nervous system development GO:0051960 264 0.081
signal release GO:0023061 145 0.080
forebrain development GO:0030900 98 0.079
carboxylic acid metabolic process GO:0019752 289 0.079
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.078
intracellular signal transduction GO:0035556 314 0.076
regulation of synaptic transmission GO:0050804 141 0.076
learning or memory GO:0007611 90 0.075
macromolecular complex assembly GO:0065003 273 0.072
Rat
single organism biosynthetic process GO:0044711 342 0.070
response to inorganic substance GO:0010035 377 0.070
cellular ketone metabolic process GO:0042180 51 0.070
organophosphate metabolic process GO:0019637 370 0.069
regulation of membrane potential GO:0042391 110 0.068
Human
peristalsis GO:0030432 2 0.068
phototransduction visible light GO:0007603 2 0.067
organic cyclic compound catabolic process GO:1901361 175 0.067
neuron differentiation GO:0030182 368 0.067
Mouse
adult locomotory behavior GO:0008344 4 0.066
glucocorticoid biosynthetic process GO:0006704 5 0.066
reproduction GO:0000003 245 0.066
inorganic cation transmembrane transport GO:0098662 202 0.065
Human Mouse
organic acid metabolic process GO:0006082 292 0.064
urinary bladder smooth muscle contraction GO:0014832 4 0.064
regulation of phosphate metabolic process GO:0019220 349 0.063
negative regulation of signaling GO:0023057 157 0.063
chemical homeostasis GO:0048878 292 0.063
Rat
regulation of hormone secretion GO:0046883 106 0.061
nitrogen compound transport GO:0071705 229 0.060
regulation of peptide hormone secretion GO:0090276 80 0.060
cellular amino acid metabolic process GO:0006520 107 0.059
purine containing compound metabolic process GO:0072521 253 0.058
vesicle mediated transport GO:0016192 181 0.057
regulation of secretion GO:0051046 224 0.056
ion transmembrane transport GO:0034220 365 0.054
Human Mouse Rat
response to reactive oxygen species GO:0000302 120 0.054
protein complex assembly GO:0006461 263 0.054
Rat
monovalent inorganic cation transport GO:0015672 172 0.053
Human Mouse
regulation of hormone levels GO:0010817 187 0.053
amine metabolic process GO:0009308 38 0.052
negative regulation of secretion by cell GO:1903531 72 0.052
secretion GO:0046903 307 0.052
lipid biosynthetic process GO:0008610 128 0.052
cellular lipid metabolic process GO:0044255 208 0.052
cellular amine metabolic process GO:0044106 38 0.050
protein complex biogenesis GO:0070271 263 0.050
Rat
single organism reproductive process GO:0044702 297 0.049
neuron development GO:0048666 286 0.048
Mouse
positive regulation of biosynthetic process GO:0009891 319 0.048
aging GO:0007568 241 0.048
Rat
neurotransmitter transport GO:0006836 42 0.048
establishment of organelle localization GO:0051656 37 0.047
carbohydrate derivative metabolic process GO:1901135 346 0.047
nucleobase containing small molecule metabolic process GO:0055086 316 0.045
cellular homeostasis GO:0019725 252 0.045
Rat
rhythmic process GO:0048511 156 0.044
positive regulation of cellular biosynthetic process GO:0031328 295 0.044
cell motility GO:0048870 202 0.044
locomotion GO:0040011 237 0.043
regulation of locomotion GO:0040012 148 0.042
response to ethanol GO:0045471 162 0.042
detection of visible light GO:0009584 3 0.042
regulation of peptide transport GO:0090087 87 0.041
response to growth factor GO:0070848 189 0.041
response to insecticide GO:0017085 21 0.040
regulation of vesicle mediated transport GO:0060627 81 0.040
sensory organ development GO:0007423 74 0.038
Mouse
regulation of cell development GO:0060284 263 0.038
organic acid transport GO:0015849 116 0.038
positive regulation of cell communication GO:0010647 271 0.038
micturition GO:0060073 4 0.037
positive regulation of transcription dna templated GO:0045893 197 0.037
positive regulation of transport GO:0051050 245 0.037
organelle organization GO:0006996 266 0.037
regulation of cellular ketone metabolic process GO:0010565 27 0.037
positive regulation of neurogenesis GO:0050769 165 0.036
nucleic acid templated transcription GO:0097659 379 0.036
regulation of heart contraction GO:0008016 48 0.036
Rat
ribonucleotide catabolic process GO:0009261 136 0.036
response to extracellular stimulus GO:0009991 380 0.035
cellular response to growth factor stimulus GO:0071363 162 0.035
feeding behavior GO:0007631 53 0.035
positive regulation of nervous system development GO:0051962 178 0.035
response to alkaloid GO:0043279 132 0.035
negative regulation of cell communication GO:0010648 158 0.035
positive regulation of saliva secretion GO:0046878 3 0.035
hormone secretion GO:0046879 115 0.035
organic acid biosynthetic process GO:0016053 83 0.035
single organism organelle organization GO:1902589 180 0.034
regulation of cellular amine metabolic process GO:0033238 8 0.034
cognition GO:0050890 92 0.034
reproductive process GO:0022414 372 0.034
neuropeptide signaling pathway GO:0007218 29 0.034
regulation of peptide secretion GO:0002791 82 0.034
ion homeostasis GO:0050801 212 0.034
Rat
response to molecule of bacterial origin GO:0002237 194 0.033
pancreatic a cell differentiation GO:0003310 1 0.033
regulation of ion transport GO:0043269 245 0.033
Human Mouse
glycerolipid metabolic process GO:0046486 67 0.033
multi organism reproductive process GO:0044703 262 0.033
amide transport GO:0042886 105 0.032
cellular chemical homeostasis GO:0055082 247 0.032
Rat
regulation of cellular localization GO:0060341 263 0.032
transmission of nerve impulse GO:0019226 42 0.032
eye morphogenesis GO:0048592 4 0.032
Mouse
adenylate cyclase inhibiting g protein coupled glutamate receptor signaling pathway GO:0007196 5 0.031
cellular response to oxygen containing compound GO:1901701 386 0.031
Human Mouse
somatostatin receptor signaling pathway GO:0038169 4 0.031
cellular response to lipid GO:0071396 201 0.030
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.030
negative regulation of vesicle fusion GO:0031339 2 0.030
regulation of neuron projection development GO:0010975 161 0.029
regulation of cell differentiation GO:0045595 320 0.029
saliva secretion GO:0046541 3 0.029
heterocycle catabolic process GO:0046700 167 0.029
response to ammonium ion GO:0060359 71 0.029
organonitrogen compound biosynthetic process GO:1901566 167 0.029
ribonucleotide metabolic process GO:0009259 231 0.029
ribose phosphate metabolic process GO:0019693 235 0.028
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.028
learning GO:0007612 33 0.028
regulation of saliva secretion GO:0046877 3 0.028
cellular metal ion homeostasis GO:0006875 172 0.028
Rat
potassium ion homeostasis GO:0055075 2 0.028
gonad development GO:0008406 104 0.027
secretion by cell GO:0032940 248 0.027
aromatic compound catabolic process GO:0019439 168 0.027
amino acid transport GO:0006865 70 0.027
positive regulation of rna metabolic process GO:0051254 203 0.026
multicellular organismal signaling GO:0035637 44 0.026
cellular catabolic process GO:0044248 295 0.026
sensory perception GO:0007600 101 0.026
regulation of cell migration GO:0030334 128 0.026
protein homooligomerization GO:0051260 91 0.026
cellular response to histamine GO:0071420 3 0.026
urinary tract smooth muscle contraction GO:0014848 4 0.026
negative regulation of response to stimulus GO:0048585 155 0.026
multicellular organism growth GO:0035264 1 0.026
telencephalon development GO:0021537 62 0.025
regulation of phosphorus metabolic process GO:0051174 349 0.025
response to decreased oxygen levels GO:0036293 237 0.025
regulation of neurogenesis GO:0050767 247 0.025
regulation of molecular function GO:0065009 398 0.025
cytoplasmic transport GO:0016482 115 0.025
positive regulation of nucleic acid templated transcription GO:1903508 197 0.024
neuronal action potential GO:0019228 35 0.024
cellular response to ammonium ion GO:0071242 17 0.024
regulation of organelle organization GO:0033043 80 0.024
insulin secretion GO:0030073 69 0.024
cellular calcium ion homeostasis GO:0006874 160 0.023
Rat
rna metabolic process GO:0016070 406 0.023
purine ribonucleotide metabolic process GO:0009150 227 0.023
response to estrogen GO:0043627 232 0.023
neuron projection development GO:0031175 273 0.023
positive regulation of cell differentiation GO:0045597 217 0.023
purine nucleotide metabolic process GO:0006163 229 0.023
peptide transport GO:0015833 97 0.023
locomotory behavior GO:0007626 15 0.023
negative regulation of transport GO:0051051 136 0.023
intracellular transport GO:0046907 185 0.023
blood circulation GO:0008015 183 0.023
Rat
purine nucleoside metabolic process GO:0042278 169 0.023
ovulation cycle GO:0042698 67 0.023
multicellular organism reproduction GO:0032504 233 0.023
cellular response to abiotic stimulus GO:0071214 85 0.023
regulation of system process GO:0044057 208 0.022
Rat
response to acid chemical GO:0001101 222 0.022
response to histamine GO:0034776 3 0.022
phosphatidylinositol dephosphorylation GO:0046856 4 0.022
nucleoside phosphate metabolic process GO:0006753 283 0.022
peptide hormone secretion GO:0030072 84 0.022
nucleoside metabolic process GO:0009116 179 0.022
cellular response to endogenous stimulus GO:0071495 377 0.022
Human Mouse
calcium ion homeostasis GO:0055074 162 0.022
Rat
cell projection organization GO:0030030 302 0.022
regulation of transcription dna templated GO:0006355 374 0.022
peptide secretion GO:0002790 86 0.022
regulation of neurotransmitter levels GO:0001505 42 0.022
organic anion transport GO:0015711 132 0.021
cyclic nucleotide metabolic process GO:0009187 80 0.021
positive regulation of gene expression GO:0010628 244 0.021
single organism intracellular transport GO:1902582 166 0.021
response to nutrient levels GO:0031667 370 0.021
vesicle localization GO:0051648 33 0.021
carboxylic acid transport GO:0046942 115 0.021
apoptotic process GO:0006915 381 0.021
alcohol metabolic process GO:0006066 77 0.021
neuromuscular process GO:0050905 2 0.021
response to biotic stimulus GO:0009607 226 0.021
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.021
positive regulation of synaptic vesicle exocytosis GO:2000302 3 0.020
protein oligomerization GO:0051259 191 0.020
Rat
transcription dna templated GO:0006351 377 0.020
catabolic process GO:0009056 351 0.020
synaptic transmission glycinergic GO:0060012 2 0.020
angiotensin mediated drinking behavior GO:0003051 2 0.020
response to fungicide GO:0060992 20 0.020
cellular ion homeostasis GO:0006873 184 0.020
Rat
endocytosis GO:0006897 84 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
response to external biotic stimulus GO:0043207 221 0.020
pallium development GO:0021543 42 0.019
nucleotide metabolic process GO:0009117 279 0.019
smooth muscle contraction involved in micturition GO:0060083 1 0.019
muscle system process GO:0003012 115 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
purine ribonucleoside metabolic process GO:0046128 168 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
circadian rhythm GO:0007623 88 0.018
organonitrogen compound catabolic process GO:1901565 179 0.018
glycosyl compound metabolic process GO:1901657 182 0.018
negative regulation of cellular component organization GO:0051129 83 0.018
negative regulation of secretion GO:0051048 82 0.018
regulation of catalytic activity GO:0050790 304 0.018
transcription from rna polymerase ii promoter GO:0006366 252 0.018
divalent inorganic cation transport GO:0072511 134 0.018
cellular response to hormone stimulus GO:0032870 247 0.018
regulation of secretion by cell GO:1903530 208 0.017
regulation of nucleic acid templated transcription GO:1903506 380 0.017
response to amine GO:0014075 46 0.017
positive regulation of phosphorus metabolic process GO:0010562 262 0.017
regulation of multicellular organismal development GO:2000026 376 0.017
brain renin angiotensin system GO:0002035 3 0.017
regulation of cellular amino acid metabolic process GO:0006521 2 0.017
regulation of protein metabolic process GO:0051246 289 0.017
camp metabolic process GO:0046058 63 0.017
phospholipid metabolic process GO:0006644 61 0.017
cell morphogenesis involved in differentiation GO:0000904 119 0.017
anatomical structure morphogenesis GO:0009653 298 0.016
Mouse
protein heterooligomerization GO:0051291 89 0.016
Rat
sodium ion transmembrane transport GO:0035725 67 0.016
Human
carbohydrate derivative catabolic process GO:1901136 147 0.016
positive regulation of cellular component biogenesis GO:0044089 55 0.016
circulatory system process GO:0003013 183 0.016
Rat
cellular nitrogen compound catabolic process GO:0044270 163 0.016
organophosphate biosynthetic process GO:0090407 143 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
response to cytokine GO:0034097 215 0.016
regulation of cellular protein metabolic process GO:0032268 267 0.016
negative regulation of macromolecule metabolic process GO:0010605 260 0.016
negative regulation of cell death GO:0060548 229 0.016
glandular epithelial cell differentiation GO:0002067 4 0.016
cellular macromolecule localization GO:0070727 122 0.016
positive regulation of catalytic activity GO:0043085 184 0.016
macromolecule localization GO:0033036 252 0.016
Mouse
inflammatory response GO:0006954 150 0.016
programmed cell death GO:0012501 392 0.016
positive regulation of somatostatin secretion GO:0090274 4 0.015
monocarboxylic acid metabolic process GO:0032787 152 0.015
protein localization GO:0008104 191 0.015
Mouse
response to carbohydrate GO:0009743 183 0.015
carboxylic acid biosynthetic process GO:0046394 83 0.015
anion transport GO:0006820 178 0.015
divalent inorganic cation homeostasis GO:0072507 165 0.015
Rat
regulation of insulin secretion GO:0050796 65 0.015
positive regulation of cellular component organization GO:0051130 200 0.015
potassium ion transmembrane transport GO:0071805 71 0.015
Human Mouse
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
cellular modified amino acid metabolic process GO:0006575 61 0.015
positive regulation of neuron differentiation GO:0045666 126 0.015
synaptic vesicle exocytosis GO:0016079 15 0.015
positive regulation of peptide secretion GO:0002793 52 0.015
response to radiation GO:0009314 137 0.015
regulation of metal ion transport GO:0010959 118 0.015
spermatogenesis GO:0007283 99 0.015
nucleoside phosphate catabolic process GO:1901292 140 0.015
motor neuron axon guidance GO:0008045 1 0.015
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.015
response to osmotic stress GO:0006970 42 0.015
response to toxic substance GO:0009636 133 0.014
male gonad development GO:0008584 59 0.014
regulation of apoptotic process GO:0042981 335 0.014
regulation of lipid biosynthetic process GO:0046890 38 0.014
anion transmembrane transport GO:0098656 77 0.014
alternative mrna splicing via spliceosome GO:0000380 4 0.014
calcium ion dependent exocytosis of neurotransmitter GO:0048791 2 0.014
male mating behavior GO:0060179 3 0.014
response to oxygen levels GO:0070482 265 0.014
cytoskeleton organization GO:0007010 111 0.014
regulation of signal transduction GO:0009966 318 0.014
response to nutrient GO:0007584 248 0.014
cell migration GO:0016477 197 0.014
regulation of cell proliferation GO:0042127 359 0.014
response to amphetamine GO:0001975 25 0.014
regulation of purine nucleotide metabolic process GO:1900542 115 0.014
positive regulation of cell proliferation GO:0008284 249 0.014
regulation of rna biosynthetic process GO:2001141 381 0.014
somatostatin secretion GO:0070253 7 0.013
negative regulation of nervous system development GO:0051961 79 0.013
guanosine containing compound metabolic process GO:1901068 74 0.013
phenol containing compound metabolic process GO:0018958 30 0.013
hormone metabolic process GO:0042445 69 0.013
cell cycle GO:0007049 101 0.013
c21 steroid hormone biosynthetic process GO:0006700 10 0.013
regulation of cellular component movement GO:0051270 150 0.013
camp biosynthetic process GO:0006171 47 0.013
tachykinin receptor signaling pathway GO:0007217 3 0.013
cellular response to stress GO:0033554 269 0.013
glial cell differentiation GO:0010001 65 0.013
operant conditioning GO:0035106 4 0.013
regeneration GO:0031099 163 0.013
development of primary sexual characteristics GO:0045137 107 0.013
synaptic vesicle transport GO:0048489 23 0.013
gamete generation GO:0007276 124 0.012
acid secretion GO:0046717 48 0.012
progesterone biosynthetic process GO:0006701 3 0.012
positive regulation of cell development GO:0010720 176 0.012
ossification GO:0001503 70 0.012
regulation of neuronal synaptic plasticity GO:0048168 31 0.012
small molecule biosynthetic process GO:0044283 124 0.012
regulation of neuron differentiation GO:0045664 208 0.012
protein transport GO:0015031 132 0.012
retina morphogenesis in camera type eye GO:0060042 1 0.012
Mouse
response to hydrogen peroxide GO:0042542 89 0.012
response to fatty acid GO:0070542 65 0.012
response to oxidative stress GO:0006979 186 0.012
dicarboxylic acid metabolic process GO:0043648 42 0.012
localization of cell GO:0051674 202 0.012
tissue development GO:0009888 252 0.012
Mouse
positive regulation of phosphate metabolic process GO:0045937 262 0.012
chemosensory behavior GO:0007635 2 0.012
dicarboxylic acid transport GO:0006835 34 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.012
muscle contraction GO:0006936 88 0.012
regulation of phosphatidylinositol dephosphorylation GO:0060304 1 0.012
fractalkine metabolic process GO:0050756 3 0.012
regulation of cell cycle GO:0051726 73 0.012
single organism catabolic process GO:0044712 283 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.012
cellular response to organic cyclic compound GO:0071407 202 0.012
Human Mouse
response to glucocorticoid GO:0051384 223 0.012
ribonucleoside triphosphate metabolic process GO:0009199 141 0.012
olfactory behavior GO:0042048 2 0.012
sodium ion transport GO:0006814 82 0.012
Human
sexual reproduction GO:0019953 148 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
male sex differentiation GO:0046661 64 0.012
gliogenesis GO:0042063 93 0.012
actin filament based process GO:0030029 86 0.011
response to corticosteroid GO:0031960 235 0.011
intracellular protein transport GO:0006886 79 0.011
monocarboxylic acid transport GO:0015718 52 0.011
response to mechanical stimulus GO:0009612 134 0.011
protein localization to organelle GO:0033365 57 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
response to peptide GO:1901652 292 0.011
negative regulation of signal transduction GO:0009968 83 0.011
response to lipopolysaccharide GO:0032496 191 0.011
response to glucose GO:0009749 136 0.011
rna biosynthetic process GO:0032774 380 0.011
response to wounding GO:0009611 254 0.011
regulation of protein modification process GO:0031399 194 0.011
endocrine system development GO:0035270 30 0.011
purine containing compound catabolic process GO:0072523 138 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
glycerophospholipid metabolic process GO:0006650 47 0.011
fatty acid transport GO:0015908 25 0.011
male gamete generation GO:0048232 99 0.011
cellular response to alcohol GO:0097306 87 0.011
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
Rat
sulfur compound metabolic process GO:0006790 70 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
response to monosaccharide GO:0034284 159 0.011
visual perception GO:0007601 3 0.011
response to ketone GO:1901654 182 0.011
acute inflammatory response GO:0002526 58 0.011
protein tetramerization GO:0051262 38 0.010
Rat
response to morphine GO:0043278 27 0.010
vasoconstriction GO:0042310 54 0.010
positive regulation of hormone secretion GO:0046887 65 0.010
cellular modified amino acid biosynthetic process GO:0042398 18 0.010
metal ion homeostasis GO:0055065 186 0.010
Rat
calcium ion transport GO:0006816 131 0.010
regulation of cellular component biogenesis GO:0044087 86 0.010
lipid modification GO:0030258 52 0.010
sex differentiation GO:0007548 113 0.010
heart morphogenesis GO:0003007 3 0.010
endoplasmic reticulum organization GO:0007029 1 0.010
steroid metabolic process GO:0008202 73 0.010
spinal cord development GO:0021510 27 0.010
somatostatin signaling pathway GO:0038170 4 0.010
positive regulation of apoptotic process GO:0043065 154 0.010
generation of ovulation cycle rhythm GO:0060112 2 0.010

Hcn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 0 0.232
sensory system disease DOID:0050155 0 0.232
disease of anatomical entity DOID:7 0 0.232
eye and adnexa disease DOID:1492 0 0.232
nervous system disease DOID:863 0 0.232
eye disease DOID:5614 0 0.232
retinal degeneration DOID:8466 0 0.107
congenital adrenal hyperplasia DOID:0050811 0 0.040
disease of metabolism DOID:0014667 0 0.040
lipid metabolism disorder DOID:3146 0 0.040
inherited metabolic disorder DOID:655 0 0.040
steroid inherited metabolic disorder DOID:1701 0 0.040
retinitis pigmentosa DOID:10584 0 0.020
substance dependence DOID:9973 0 0.016
substance related disorder DOID:303 0 0.016
disease of mental health DOID:150 0 0.016
cone rod dystrophy DOID:0050572 0 0.012