Rattus norvegicus

36 known processes

Hcn2

hyperpolarization activated cyclic nucleotide-gated potassium channel 2

Hcn2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neurological system process GO:0050877 219 0.251
cellular component biogenesis GO:0044085 368 0.129
Rat
positive regulation of phosphorus metabolic process GO:0010562 262 0.095
macromolecular complex assembly GO:0065003 273 0.080
Rat
transmission of nerve impulse GO:0019226 42 0.075
regulation of phosphate metabolic process GO:0019220 349 0.075
cellular component assembly GO:0022607 360 0.074
Rat
protein complex subunit organization GO:0071822 302 0.071
Rat
action potential GO:0001508 54 0.061
multicellular organismal signaling GO:0035637 44 0.060
positive regulation of cell proliferation GO:0008284 249 0.060
rna metabolic process GO:0016070 406 0.058
regulation of membrane repolarization GO:0060306 1 0.054
regulation of membrane potential GO:0042391 110 0.054
Human Mouse
organic acid metabolic process GO:0006082 292 0.052
oxoacid metabolic process GO:0043436 290 0.051
regulation of cellular component organization GO:0051128 368 0.048
membrane repolarization GO:0086009 1 0.048
carbohydrate derivative metabolic process GO:1901135 346 0.048
regulation of muscle system process GO:0090257 79 0.047
synaptic transmission GO:0007268 235 0.047
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.046
metal ion homeostasis GO:0055065 186 0.046
Rat
sensory perception GO:0007600 101 0.045
regulation of system process GO:0044057 208 0.044
cardiovascular system development GO:0072358 134 0.043
regulation of molecular function GO:0065009 398 0.040
blood circulation GO:0008015 183 0.039
neuronal action potential GO:0019228 35 0.038
regulation of phosphorus metabolic process GO:0051174 349 0.038
nucleic acid templated transcription GO:0097659 379 0.037
heart process GO:0003015 57 0.037
cellular cation homeostasis GO:0030003 180 0.036
Rat
cellular response to oxygen containing compound GO:1901701 386 0.035
Human
heart contraction GO:0060047 57 0.035
regulation of cell proliferation GO:0042127 359 0.035
cellular chemical homeostasis GO:0055082 247 0.035
Rat
transcription dna templated GO:0006351 377 0.034
nucleobase containing small molecule metabolic process GO:0055086 316 0.034
regulation of rna biosynthetic process GO:2001141 381 0.033
response to growth factor GO:0070848 189 0.033
regulation of ion transport GO:0043269 245 0.033
Human
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.033
cellular divalent inorganic cation homeostasis GO:0072503 162 0.033
Rat
ribose phosphate metabolic process GO:0019693 235 0.032
purine containing compound metabolic process GO:0072521 253 0.032
transmembrane transport GO:0055085 412 0.032
Human Rat
potassium ion transport GO:0006813 97 0.032
Human
cation transmembrane transport GO:0098655 263 0.032
Human Rat
cellular ion homeostasis GO:0006873 184 0.030
Rat
carbohydrate derivative biosynthetic process GO:1901137 124 0.029
response to oxygen levels GO:0070482 265 0.028
circulatory system process GO:0003013 183 0.028
nucleoside phosphate biosynthetic process GO:1901293 102 0.028
purine ribonucleotide biosynthetic process GO:0009152 81 0.028
positive regulation of phosphate metabolic process GO:0045937 262 0.028
cation transport GO:0006812 382 0.027
Human Rat
homeostatic process GO:0042592 331 0.027
Rat
nucleoside phosphate metabolic process GO:0006753 283 0.026
cellular response to endogenous stimulus GO:0071495 377 0.026
Human
protein complex biogenesis GO:0070271 263 0.025
Rat
defense response GO:0006952 194 0.024
inorganic ion transmembrane transport GO:0098660 229 0.024
Human
purine nucleotide biosynthetic process GO:0006164 83 0.024
single organism biosynthetic process GO:0044711 342 0.024
negative regulation of cellular metabolic process GO:0031324 281 0.024
positive regulation of gene expression GO:0010628 244 0.024
striated muscle contraction GO:0006941 44 0.023
nucleotide metabolic process GO:0009117 279 0.023
nucleotide biosynthetic process GO:0009165 98 0.023
ion homeostasis GO:0050801 212 0.023
Rat
cell projection organization GO:0030030 302 0.022
regulation of cellular localization GO:0060341 263 0.022
regulation of rna metabolic process GO:0051252 391 0.022
muscle system process GO:0003012 115 0.022
response to metal ion GO:0010038 253 0.021
positive regulation of biosynthetic process GO:0009891 319 0.021
inorganic cation transmembrane transport GO:0098662 202 0.021
Human
response to cytokine GO:0034097 215 0.021
regulation of nucleotide metabolic process GO:0006140 117 0.021
cation homeostasis GO:0055080 195 0.021
Rat
response to inorganic substance GO:0010035 377 0.020
purine nucleotide metabolic process GO:0006163 229 0.020
response to decreased oxygen levels GO:0036293 237 0.020
carboxylic acid metabolic process GO:0019752 289 0.020
cell cell signaling GO:0007267 335 0.020
negative regulation of metabolic process GO:0009892 331 0.019
regulation of signal transduction GO:0009966 318 0.019
intracellular signal transduction GO:0035556 314 0.019
organophosphate metabolic process GO:0019637 370 0.019
regulation of blood circulation GO:1903522 110 0.019
metal ion transport GO:0030001 289 0.019
Human
mechanoreceptor differentiation GO:0042490 2 0.019
negative regulation of cell communication GO:0010648 158 0.019
negative regulation of transport GO:0051051 136 0.019
cellular response to nitrogen compound GO:1901699 210 0.018
Human
positive regulation of cellular component organization GO:0051130 200 0.018
ion transmembrane transport GO:0034220 365 0.018
Human Rat
ribonucleotide metabolic process GO:0009259 231 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.018
positive regulation of cellular biosynthetic process GO:0031328 295 0.018
monovalent inorganic cation transport GO:0015672 172 0.018
Human
protein complex assembly GO:0006461 263 0.017
Rat
negative regulation of cellular component organization GO:0051129 83 0.017
regulation of catalytic activity GO:0050790 304 0.017
monosaccharide metabolic process GO:0005996 61 0.017
positive regulation of nucleotide metabolic process GO:0045981 91 0.017
rna biosynthetic process GO:0032774 380 0.017
sodium ion transmembrane transport GO:0035725 67 0.017
Human
positive regulation of protein metabolic process GO:0051247 178 0.017
negative regulation of multicellular organismal process GO:0051241 203 0.016
positive regulation of response to stimulus GO:0048584 285 0.016
response to hypoxia GO:0001666 231 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
nitrogen compound transport GO:0071705 229 0.016
single organism carbohydrate metabolic process GO:0044723 118 0.016
negative regulation of gene expression GO:0010629 199 0.016
cellular amino acid metabolic process GO:0006520 107 0.015
response to acid chemical GO:0001101 222 0.015
regulation of transmembrane transport GO:0034762 122 0.015
Human
g protein coupled receptor signaling pathway GO:0007186 242 0.015
circulatory system development GO:0072359 134 0.015
ribonucleotide biosynthetic process GO:0009260 85 0.015
cellular metal ion homeostasis GO:0006875 172 0.015
Rat
positive regulation of synaptic vesicle transport GO:1902805 3 0.015
heart development GO:0007507 72 0.015
response to peptide GO:1901652 292 0.015
organophosphate biosynthetic process GO:0090407 143 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
inner ear receptor cell differentiation GO:0060113 2 0.014
regulation of nucleic acid templated transcription GO:1903506 380 0.014
regulation of anatomical structure size GO:0090066 135 0.014
single organism organelle organization GO:1902589 180 0.014
central nervous system development GO:0007417 311 0.014
cellular response to insulin stimulus GO:0032869 81 0.014
cellular amine metabolic process GO:0044106 38 0.014
regulation of potassium ion transport GO:0043266 29 0.014
gonad development GO:0008406 104 0.014
protein oligomerization GO:0051259 191 0.014
Rat
regulation of cellular amino acid metabolic process GO:0006521 2 0.014
cellular potassium ion transport GO:0071804 72 0.013
Human
cellular protein complex assembly GO:0043623 44 0.013
purine ribonucleotide metabolic process GO:0009150 227 0.013
purine nucleoside metabolic process GO:0042278 169 0.013
response to peptide hormone GO:0043434 278 0.013
calcium ion dependent exocytosis of neurotransmitter GO:0048791 2 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
positive regulation of cell development GO:0010720 176 0.013
cyclic purine nucleotide metabolic process GO:0052652 62 0.013
purine containing compound biosynthetic process GO:0072522 85 0.013
phototransduction visible light GO:0007603 2 0.013
response to nutrient levels GO:0031667 370 0.013
lipid metabolic process GO:0006629 283 0.013
hair cell differentiation GO:0035315 2 0.013
apoptotic process GO:0006915 381 0.013
auditory receptor cell differentiation GO:0042491 2 0.013
cellular ketone metabolic process GO:0042180 51 0.013
response to glucocorticoid GO:0051384 223 0.013
positive regulation of rna biosynthetic process GO:1902680 197 0.013
cyclic nucleotide biosynthetic process GO:0009190 63 0.013
single organism reproductive process GO:0044702 297 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
regulation of cellular amine metabolic process GO:0033238 8 0.012
muscle structure development GO:0061061 87 0.012
regulation of cellular ketone metabolic process GO:0010565 27 0.012
intracellular protein transport GO:0006886 79 0.012
ear development GO:0043583 21 0.012
organelle organization GO:0006996 266 0.012
actin filament based process GO:0030029 86 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.012
negative regulation of secretion by cell GO:1903531 72 0.012
macromolecule localization GO:0033036 252 0.012
axonogenesis GO:0007409 71 0.012
regulation of apoptotic process GO:0042981 335 0.012
brain development GO:0007420 247 0.012
positive regulation of signaling GO:0023056 270 0.012
positive regulation of nucleic acid templated transcription GO:1903508 197 0.012
sex differentiation GO:0007548 113 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
Rat
regulation of secretion by cell GO:1903530 208 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
Rat
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
response to mechanical stimulus GO:0009612 134 0.012
peptide secretion GO:0002790 86 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.011
Rat
cellular response to cytokine stimulus GO:0071345 127 0.011
amine metabolic process GO:0009308 38 0.011
neuron projection development GO:0031175 273 0.011
bmp signaling pathway GO:0030509 4 0.011
circadian rhythm GO:0007623 88 0.011
regulation of neurogenesis GO:0050767 247 0.011
cellular macromolecular complex assembly GO:0034622 58 0.011
sensory perception of light stimulus GO:0050953 3 0.011
protein maturation GO:0051604 68 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
neuron differentiation GO:0030182 368 0.011
regulation of cell projection organization GO:0031344 175 0.011
detection of calcium ion GO:0005513 1 0.011
cytoplasmic transport GO:0016482 115 0.011
positive regulation of cell communication GO:0010647 271 0.011
negative regulation of macromolecule metabolic process GO:0010605 260 0.010
rhythmic process GO:0048511 156 0.010
potassium ion transmembrane transport GO:0071805 71 0.010
Human
response to amino acid GO:0043200 75 0.010
negative regulation of response to stimulus GO:0048585 155 0.010
regulation of heart contraction GO:0008016 48 0.010
negative regulation of rna biosynthetic process GO:1902679 118 0.010
positive regulation of transport GO:0051050 245 0.010
anatomical structure morphogenesis GO:0009653 298 0.010
heart morphogenesis GO:0003007 3 0.010
cardiac muscle cell action potential involved in contraction GO:0086002 2 0.010
regulation of ion transmembrane transport GO:0034765 121 0.010
Human

Hcn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.038
eye disease DOID:5614 0 0.038
sensory system disease DOID:0050155 0 0.038
disease of anatomical entity DOID:7 0 0.038
eye and adnexa disease DOID:1492 0 0.038
retinal disease DOID:5679 0 0.038
musculoskeletal system disease DOID:17 0 0.035
long qt syndrome DOID:2843 0 0.023
muscle tissue disease DOID:66 0 0.013
muscular disease DOID:0080000 0 0.013
myopathy DOID:423 0 0.013
cardiovascular system disease DOID:1287 0 0.012
retinal degeneration DOID:8466 0 0.010