Rattus norvegicus

0 known processes

Hibadh

3-hydroxyisobutyrate dehydrogenase

Hibadh biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
organic acid metabolic process GO:0006082 292 0.856
Human
carboxylic acid metabolic process GO:0019752 289 0.575
Human
oxoacid metabolic process GO:0043436 290 0.562
Human
oxidation reduction process GO:0055114 304 0.210
Human
coenzyme metabolic process GO:0006732 86 0.172
thioester metabolic process GO:0035383 28 0.155
progesterone biosynthetic process GO:0006701 3 0.145
cellular polysaccharide metabolic process GO:0044264 23 0.137
single organism catabolic process GO:0044712 283 0.117
Human
response to extracellular stimulus GO:0009991 380 0.097
response to nitrosative stress GO:0051409 2 0.094
response to inorganic substance GO:0010035 377 0.091
response to nutrient levels GO:0031667 370 0.087
regulation of apoptotic process GO:0042981 335 0.083
sulfur compound metabolic process GO:0006790 70 0.082
acyl coa metabolic process GO:0006637 28 0.081
monocarboxylic acid metabolic process GO:0032787 152 0.072
branched chain amino acid metabolic process GO:0009081 4 0.067
Human
programmed cell death GO:0012501 392 0.066
single organism biosynthetic process GO:0044711 342 0.066
organic substance catabolic process GO:1901575 316 0.062
Human
organophosphate metabolic process GO:0019637 370 0.061
response to nutrient GO:0007584 248 0.060
cofactor metabolic process GO:0051186 95 0.059
response to reactive oxygen species GO:0000302 120 0.059
cellular amino acid metabolic process GO:0006520 107 0.058
Human
mitochondrial rna metabolic process GO:0000959 1 0.057
cellular response to oxidative stress GO:0034599 76 0.057
organic acid biosynthetic process GO:0016053 83 0.056
thioester biosynthetic process GO:0035384 7 0.052
response to oxygen levels GO:0070482 265 0.051
energy derivation by oxidation of organic compounds GO:0015980 46 0.048
catabolic process GO:0009056 351 0.047
Human
cellular response to reactive oxygen species GO:0034614 55 0.046
reactive oxygen species metabolic process GO:0072593 37 0.045
sulfur compound biosynthetic process GO:0044272 19 0.043
negative regulation of cell death GO:0060548 229 0.042
regulation of hormone levels GO:0010817 187 0.041
branched chain amino acid catabolic process GO:0009083 4 0.040
Human
aging GO:0007568 241 0.038
response to ethanol GO:0045471 162 0.037
cellular catabolic process GO:0044248 295 0.037
Human
cellular amine metabolic process GO:0044106 38 0.036
negative regulation of programmed cell death GO:0043069 183 0.036
acetyl coa metabolic process GO:0006084 17 0.035
coenzyme biosynthetic process GO:0009108 22 0.035
apoptotic process GO:0006915 381 0.035
cold acclimation GO:0009631 1 0.033
glycogen metabolic process GO:0005977 23 0.033
response to oxidative stress GO:0006979 186 0.033
cellular component assembly GO:0022607 360 0.033
cellular response to endogenous stimulus GO:0071495 377 0.033
amine metabolic process GO:0009308 38 0.033
lipid metabolic process GO:0006629 283 0.032
organelle organization GO:0006996 266 0.031
positive regulation of biosynthetic process GO:0009891 319 0.031
ion homeostasis GO:0050801 212 0.030
cellular ketone metabolic process GO:0042180 51 0.030
regulation of programmed cell death GO:0043067 341 0.030
macromolecule localization GO:0033036 252 0.029
negative regulation of apoptotic process GO:0043066 181 0.029
intracellular signal transduction GO:0035556 314 0.029
cellular amino acid biosynthetic process GO:0008652 32 0.029
cell type specific apoptotic process GO:0097285 134 0.029
negative regulation of macromolecule metabolic process GO:0010605 260 0.028
response to estrogen GO:0043627 232 0.028
pyruvate metabolic process GO:0006090 27 0.028
regulation of phosphorus metabolic process GO:0051174 349 0.028
polysaccharide metabolic process GO:0005976 25 0.027
regulation of cell proliferation GO:0042127 359 0.026
carbohydrate biosynthetic process GO:0016051 42 0.026
regulation of cellular localization GO:0060341 263 0.026
cation homeostasis GO:0055080 195 0.025
positive regulation of cell proliferation GO:0008284 249 0.025
negative regulation of metabolic process GO:0009892 331 0.025
cellular response to oxygen containing compound GO:1901701 386 0.025
transcription dna templated GO:0006351 377 0.025
central nervous system development GO:0007417 311 0.024
single organism reproductive process GO:0044702 297 0.024
cellular glucan metabolic process GO:0006073 23 0.024
cellular response to stress GO:0033554 269 0.023
chemical homeostasis GO:0048878 292 0.023
negative regulation of cellular metabolic process GO:0031324 281 0.023
cellular protein localization GO:0034613 122 0.023
acyl coa biosynthetic process GO:0071616 7 0.023
response to estradiol GO:0032355 164 0.023
cellular response to organonitrogen compound GO:0071417 197 0.022
cellular response to nitrogen compound GO:1901699 210 0.022
cellular response to insulin stimulus GO:0032869 81 0.022
regulation of intracellular signal transduction GO:1902531 218 0.022
response to lipopolysaccharide GO:0032496 191 0.022
regulation of proteasomal protein catabolic process GO:0061136 4 0.022
ribonucleoside metabolic process GO:0009119 174 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.021
cellular hormone metabolic process GO:0034754 49 0.021
regulation of cellular amino acid metabolic process GO:0006521 2 0.021
c21 steroid hormone biosynthetic process GO:0006700 10 0.021
regulation of protein metabolic process GO:0051246 289 0.021
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.020
cellular cation homeostasis GO:0030003 180 0.020
regulation of rna biosynthetic process GO:2001141 381 0.020
nucleic acid templated transcription GO:0097659 379 0.020
response to external biotic stimulus GO:0043207 221 0.020
cellular response to peptide hormone stimulus GO:0071375 120 0.020
neuron apoptotic process GO:0051402 88 0.019
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
positive regulation of molecular function GO:0044093 230 0.019
rna metabolic process GO:0016070 406 0.019
negative regulation of gene expression GO:0010629 199 0.019
glycosyl compound metabolic process GO:1901657 182 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
regulation of ion transport GO:0043269 245 0.019
cellular lipid metabolic process GO:0044255 208 0.019
cellular amino acid catabolic process GO:0009063 21 0.018
Human
cellular chemical homeostasis GO:0055082 247 0.018
single organism organelle organization GO:1902589 180 0.018
response to peptide hormone GO:0043434 278 0.018
macromolecular complex assembly GO:0065003 273 0.017
cellular biogenic amine metabolic process GO:0006576 30 0.017
small molecule biosynthetic process GO:0044283 124 0.017
response to metal ion GO:0010038 253 0.017
regulation of protein modification process GO:0031399 194 0.017
neurological system process GO:0050877 219 0.017
lipid biosynthetic process GO:0008610 128 0.017
chromosome segregation GO:0007059 2 0.017
generation of precursor metabolites and energy GO:0006091 62 0.017
brain development GO:0007420 247 0.017
glucan biosynthetic process GO:0009250 15 0.017
response to hyperoxia GO:0055093 45 0.017
purine nucleotide metabolic process GO:0006163 229 0.017
regulation of phosphorylation GO:0042325 248 0.017
regulation of kinase activity GO:0043549 117 0.017
regulation of transcription dna templated GO:0006355 374 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.016
response to hydrogen peroxide GO:0042542 89 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
nucleotide metabolic process GO:0009117 279 0.016
response to alkaloid GO:0043279 132 0.016
kidney development GO:0001822 67 0.016
positive regulation of multicellular organismal process GO:0051240 387 0.016
regulation of cellular amine metabolic process GO:0033238 8 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
cell projection organization GO:0030030 302 0.016
response to glucocorticoid GO:0051384 223 0.016
neuron development GO:0048666 286 0.016
cellular response to peptide GO:1901653 133 0.016
regulation of phosphate metabolic process GO:0019220 349 0.015
nitrogen compound transport GO:0071705 229 0.015
response to toxic substance GO:0009636 133 0.015
cellular response to hormone stimulus GO:0032870 247 0.015
head development GO:0060322 247 0.015
metal ion homeostasis GO:0055065 186 0.015
succinate metabolic process GO:0006105 7 0.015
neuron differentiation GO:0030182 368 0.015
organic hydroxy compound metabolic process GO:1901615 115 0.015
peptidyl amino acid modification GO:0018193 126 0.015
regulation of catalytic activity GO:0050790 304 0.015
response to other organism GO:0051707 220 0.015
protein complex subunit organization GO:0071822 302 0.015
cellular response to cytokine stimulus GO:0071345 127 0.015
cellular homeostasis GO:0019725 252 0.015
positive regulation of neurogenesis GO:0050769 165 0.014
immune system process GO:0002376 204 0.014
regulation of nucleic acid templated transcription GO:1903506 380 0.014
regulation of molecular function GO:0065009 398 0.014
mitotic sister chromatid separation GO:0051306 1 0.014
regulation of rna metabolic process GO:0051252 391 0.014
cellular metal ion homeostasis GO:0006875 172 0.014
glucan metabolic process GO:0044042 23 0.014
regulation of peptide transport GO:0090087 87 0.014
tricarboxylic acid metabolic process GO:0072350 10 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.014
anterior posterior pattern specification GO:0009952 1 0.014
regulation of homeostatic process GO:0032844 101 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
single organism cellular localization GO:1902580 102 0.014
reproduction GO:0000003 245 0.014
carbohydrate derivative metabolic process GO:1901135 346 0.014
purine containing compound metabolic process GO:0072521 253 0.014
regulation of blood pressure GO:0008217 83 0.014
energy reserve metabolic process GO:0006112 25 0.014
regulation of neuron death GO:1901214 115 0.013
macromolecular complex subunit organization GO:0043933 339 0.013
glycogen biosynthetic process GO:0005978 15 0.013
dephosphorylation GO:0016311 98 0.013
transcription from rna polymerase ii promoter GO:0006366 252 0.013
regulation of transferase activity GO:0051338 123 0.013
hormone metabolic process GO:0042445 69 0.013
amine catabolic process GO:0009310 9 0.013
rhythmic process GO:0048511 156 0.013
regulation of gluconeogenesis GO:0006111 4 0.013
valine metabolic process GO:0006573 1 0.013
Human
regulation of cellular component organization GO:0051128 368 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
dicarboxylic acid metabolic process GO:0043648 42 0.013
cellular ion homeostasis GO:0006873 184 0.012
protein phosphorylation GO:0006468 345 0.012
glucose metabolic process GO:0006006 52 0.012
positive regulation of protein phosphorylation GO:0001934 135 0.012
neuron projection development GO:0031175 273 0.012
protein complex biogenesis GO:0070271 263 0.012
regulation of cellular catabolic process GO:0031329 101 0.012
embryonic pattern specification GO:0009880 1 0.012
positive regulation of protein metabolic process GO:0051247 178 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.012
protein maturation GO:0051604 68 0.012
protein localization GO:0008104 191 0.012
positive regulation of transport GO:0051050 245 0.012
ribonucleotide metabolic process GO:0009259 231 0.012
positive regulation of developmental process GO:0051094 283 0.011
intracellular transport GO:0046907 185 0.011
spindle organization GO:0007051 2 0.011
positive regulation of apoptotic process GO:0043065 154 0.011
multi organism reproductive process GO:0044703 262 0.011
negative regulation of phosphorus metabolic process GO:0010563 80 0.011
cellular polysaccharide biosynthetic process GO:0033692 15 0.011
regulation of intracellular transport GO:0032386 65 0.011
eye morphogenesis GO:0048592 4 0.011
multicellular organism reproduction GO:0032504 233 0.011
negative regulation of neuron death GO:1901215 69 0.011
multicellular organismal reproductive process GO:0048609 233 0.011
carboxylic acid catabolic process GO:0046395 49 0.011
Human
response to cytokine GO:0034097 215 0.011
muscle structure development GO:0061061 87 0.011
neuron death GO:0070997 127 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
cytoskeleton organization GO:0007010 111 0.011
fatty acid beta oxidation GO:0006635 22 0.011
sequestering of calcium ion GO:0051208 8 0.011
response to hypoxia GO:0001666 231 0.011
ras protein signal transduction GO:0007265 29 0.011
response to insulin GO:0032868 133 0.011
ncrna processing GO:0034470 3 0.011
cognition GO:0050890 92 0.011
negative regulation of signaling GO:0023057 157 0.011
urogenital system development GO:0001655 78 0.011
lipid catabolic process GO:0016042 46 0.011
blood circulation GO:0008015 183 0.011
rna localization GO:0006403 4 0.011
cellular response to external stimulus GO:0071496 118 0.011
axis specification GO:0009798 4 0.011
response to peptide GO:1901652 292 0.011
regulation of neuron apoptotic process GO:0043523 83 0.011
circulatory system development GO:0072359 134 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.011
response to biotic stimulus GO:0009607 226 0.011
acetyl coa biosynthetic process from pyruvate GO:0006086 5 0.010
peptide biosynthetic process GO:0043043 3 0.010
regulation of catabolic process GO:0009894 113 0.010
tissue development GO:0009888 252 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.010
glutamate metabolic process GO:0006536 3 0.010
ion transmembrane transport GO:0034220 365 0.010
negative regulation of ion transport GO:0043271 51 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.010
ribose phosphate metabolic process GO:0019693 235 0.010
positive regulation of cellular component organization GO:0051130 200 0.010
homeostatic process GO:0042592 331 0.010
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 3 0.010
sequestering of metal ion GO:0051238 9 0.010
hexose metabolic process GO:0019318 58 0.010

Hibadh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
amino acid metabolic disorder DOID:9252 0 0.037
inherited metabolic disorder DOID:655 0 0.037
disease of metabolism DOID:0014667 0 0.037
disease of cellular proliferation DOID:14566 0 0.021
organic acidemia DOID:0060159 0 0.020
nervous system disease DOID:863 0 0.012
disease of anatomical entity DOID:7 0 0.012