Rattus norvegicus

0 known processes

Hist1h2aa

histone cluster 1, H2aa

(Aliases: Th2a)

Hist1h2aa biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of ion transport GO:0043269 245 0.173
negative regulation of macromolecule metabolic process GO:0010605 260 0.159
negative regulation of biosynthetic process GO:0009890 168 0.147
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.138
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.130
positive regulation of ion transport GO:0043270 94 0.126
negative regulation of multicellular organismal process GO:0051241 203 0.123
regulation of cell proliferation GO:0042127 359 0.111
cellular ion homeostasis GO:0006873 184 0.110
negative regulation of gene expression GO:0010629 199 0.109
cellular response to endogenous stimulus GO:0071495 377 0.108
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.107
rna metabolic process GO:0016070 406 0.105
amine metabolic process GO:0009308 38 0.104
regulation of behavior GO:0050795 61 0.102
peptide secretion GO:0002790 86 0.102
cellular homeostasis GO:0019725 252 0.100
g protein coupled receptor signaling pathway GO:0007186 242 0.099
regulation of wound healing GO:0061041 14 0.098
response to cytokine GO:0034097 215 0.098
regulation of cellular ketone metabolic process GO:0010565 27 0.095
regulation of response to external stimulus GO:0032101 106 0.094
response to biotic stimulus GO:0009607 226 0.094
negative regulation of response to stimulus GO:0048585 155 0.092
protein complex subunit organization GO:0071822 302 0.088
cellular chemical homeostasis GO:0055082 247 0.087
cation transport GO:0006812 382 0.085
macromolecular complex subunit organization GO:0043933 339 0.085
regulation of cellular amine metabolic process GO:0033238 8 0.084
regulation of nucleic acid templated transcription GO:1903506 380 0.083
regulation of rna biosynthetic process GO:2001141 381 0.080
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.078
regulation of cellular amino acid metabolic process GO:0006521 2 0.076
protein complex assembly GO:0006461 263 0.076
response to nutrient GO:0007584 248 0.075
transcription from rna polymerase ii promoter GO:0006366 252 0.074
response to monosaccharide GO:0034284 159 0.074
positive regulation of long term synaptic potentiation GO:1900273 4 0.072
nitrogen compound transport GO:0071705 229 0.071
response to estradiol GO:0032355 164 0.067
negative regulation of transcription dna templated GO:0045892 116 0.067
multicellular organism reproduction GO:0032504 233 0.067
negative regulation of cellular metabolic process GO:0031324 281 0.067
cellular amine metabolic process GO:0044106 38 0.066
cellular component biogenesis GO:0044085 368 0.065
regulation of apoptotic process GO:0042981 335 0.064
negative regulation of developmental process GO:0051093 125 0.063
response to toxic substance GO:0009636 133 0.063
nucleic acid templated transcription GO:0097659 379 0.063
negative regulation of cell proliferation GO:0008285 119 0.062
positive regulation of cell proliferation GO:0008284 249 0.062
protein heterooligomerization GO:0051291 89 0.061
response to extracellular stimulus GO:0009991 380 0.061
response to carbohydrate GO:0009743 183 0.060
regulation of multicellular organismal development GO:2000026 376 0.059
response to estrogen GO:0043627 232 0.059
positive regulation of biosynthetic process GO:0009891 319 0.058
negative regulation of rna metabolic process GO:0051253 123 0.057
regulation of programmed cell death GO:0043067 341 0.057
regulation of phosphorus metabolic process GO:0051174 349 0.055
protein complex biogenesis GO:0070271 263 0.055
regulation of secretion by cell GO:1903530 208 0.055
regulation of response to wounding GO:1903034 69 0.055
divalent inorganic cation transport GO:0072511 134 0.054
positive regulation of cellular amine metabolic process GO:0033240 3 0.054
intracellular transport GO:0046907 185 0.054
regulation of organelle organization GO:0033043 80 0.054
central nervous system development GO:0007417 311 0.053
negative regulation of nucleic acid templated transcription GO:1903507 117 0.053
negative regulation of rna biosynthetic process GO:1902679 118 0.053
circadian sleep wake cycle process GO:0022410 21 0.053
rna biosynthetic process GO:0032774 380 0.052
regulation of secretion GO:0051046 224 0.052
monoamine transport GO:0015844 43 0.052
locomotion GO:0040011 237 0.051
signal release GO:0023061 145 0.051
regulation of protein modification process GO:0031399 194 0.049
cellular ketone metabolic process GO:0042180 51 0.049
ion homeostasis GO:0050801 212 0.049
maintenance of location GO:0051235 17 0.048
calcium ion transport GO:0006816 131 0.048
organic acid metabolic process GO:0006082 292 0.048
embryonic skeletal system development GO:0048706 3 0.048
regulation of cellular localization GO:0060341 263 0.047
positive regulation of transport GO:0051050 245 0.047
cellular calcium ion homeostasis GO:0006874 160 0.046
peptidyl amino acid modification GO:0018193 126 0.046
cellular response to growth factor stimulus GO:0071363 162 0.045
negative regulation of metabolic process GO:0009892 331 0.045
regulation of signal transduction GO:0009966 318 0.045
secretion by cell GO:0032940 248 0.045
epithelial cell proliferation GO:0050673 54 0.044
neurological system process GO:0050877 219 0.044
response to glucose GO:0009749 136 0.044
response to histamine GO:0034776 3 0.044
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.043
negative regulation of programmed cell death GO:0043069 183 0.043
protein oligomerization GO:0051259 191 0.043
negative regulation of nervous system development GO:0051961 79 0.043
striated muscle contraction GO:0006941 44 0.043
cellular amino acid metabolic process GO:0006520 107 0.043
regulation of cell motility GO:2000145 131 0.043
positive regulation of phosphorylation GO:0042327 177 0.043
tissue development GO:0009888 252 0.042
cellular divalent inorganic cation homeostasis GO:0072503 162 0.042
anterior posterior pattern specification GO:0009952 1 0.041
regulation of cell development GO:0060284 263 0.041
inflammatory response GO:0006954 150 0.041
regulation of catalytic activity GO:0050790 304 0.040
regulation of cell differentiation GO:0045595 320 0.039
regulation of neurogenesis GO:0050767 247 0.039
metal ion transport GO:0030001 289 0.039
cellular component assembly GO:0022607 360 0.039
response to inorganic substance GO:0010035 377 0.039
regulation of kinase activity GO:0043549 117 0.039
carbohydrate derivative metabolic process GO:1901135 346 0.039
response to nutrient levels GO:0031667 370 0.039
negative regulation of cell differentiation GO:0045596 99 0.038
urinary bladder smooth muscle contraction GO:0014832 4 0.038
desensitization of g protein coupled receptor protein signaling pathway by arrestin GO:0002032 1 0.038
nucleoside metabolic process GO:0009116 179 0.038
cell cell signaling GO:0007267 335 0.038
cytosolic calcium ion homeostasis GO:0051480 140 0.038
immune system process GO:0002376 204 0.037
sequestering of metal ion GO:0051238 9 0.037
response to hydrogen peroxide GO:0042542 89 0.037
negative regulation of cell death GO:0060548 229 0.036
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.036
release of sequestered calcium ion into cytosol GO:0051209 25 0.035
response to temperature stimulus GO:0009266 94 0.035
hormone secretion GO:0046879 115 0.035
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.035
defense response GO:0006952 194 0.035
homeostatic process GO:0042592 331 0.034
brain development GO:0007420 247 0.034
divalent metal ion transport GO:0070838 132 0.034
apoptotic process GO:0006915 381 0.034
response to oxidative stress GO:0006979 186 0.034
regulation of protein phosphorylation GO:0001932 183 0.034
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.033
glycosyl compound metabolic process GO:1901657 182 0.033
positive regulation of response to stimulus GO:0048584 285 0.033
regulation of nervous system development GO:0051960 264 0.033
negative regulation of signaling GO:0023057 157 0.033
muscle system process GO:0003012 115 0.033
cation homeostasis GO:0055080 195 0.033
cell activation GO:0001775 97 0.033
regulation of body fluid levels GO:0050878 90 0.032
response to peptide GO:1901652 292 0.032
cellular response to abiotic stimulus GO:0071214 85 0.032
protein phosphorylation GO:0006468 345 0.031
cellular response to histamine GO:0071420 3 0.031
regulation of circadian sleep wake cycle GO:0042749 18 0.031
chemical homeostasis GO:0048878 292 0.030
negative regulation of cellular biosynthetic process GO:0031327 161 0.030
vascular process in circulatory system GO:0003018 96 0.030
positive regulation of cell death GO:0010942 184 0.030
cellular metal ion homeostasis GO:0006875 172 0.030
amine transport GO:0015837 57 0.029
positive regulation of protein modification process GO:0031401 142 0.029
response to mechanical stimulus GO:0009612 134 0.029
regulation of tube size GO:0035150 89 0.029
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.028
reproductive process GO:0022414 372 0.028
response to peptide hormone GO:0043434 278 0.028
regulation of calcium ion transport GO:0051924 77 0.028
response to alkaloid GO:0043279 132 0.028
response to ketone GO:1901654 182 0.028
peptide hormone secretion GO:0030072 84 0.027
positive regulation of nucleic acid templated transcription GO:1903508 197 0.027
regulation of cytokine production GO:0001817 56 0.027
embryonic pattern specification GO:0009880 1 0.027
regulation of blood pressure GO:0008217 83 0.027
carboxylic acid metabolic process GO:0019752 289 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.027
metal ion homeostasis GO:0055065 186 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
regulation of protein metabolic process GO:0051246 289 0.026
response to growth factor GO:0070848 189 0.026
oxoacid metabolic process GO:0043436 290 0.026
positive regulation of nervous system development GO:0051962 178 0.026
response to hypoxia GO:0001666 231 0.026
positive regulation of behavior GO:0048520 38 0.026
leukocyte activation GO:0045321 76 0.025
single organism intracellular transport GO:1902582 166 0.025
cellular cation homeostasis GO:0030003 180 0.025
positive regulation of blood circulation GO:1903524 65 0.025
neuron differentiation GO:0030182 368 0.025
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.025
response to metal ion GO:0010038 253 0.024
regulation of cell activation GO:0050865 50 0.024
macromolecular complex assembly GO:0065003 273 0.024
regulation of phosphate metabolic process GO:0019220 349 0.024
embryonic skeletal system morphogenesis GO:0048704 3 0.024
response to acid chemical GO:0001101 222 0.024
wound healing GO:0042060 122 0.024
renal system process GO:0003014 40 0.024
response to corticosteroid GO:0031960 235 0.023
response to hexose GO:0009746 144 0.023
synaptic transmission glycinergic GO:0060012 2 0.023
regulation of feeding behavior GO:0060259 14 0.023
response to ammonium ion GO:0060359 71 0.022
positive regulation of signaling GO:0023056 270 0.022
negative regulation of response to wounding GO:1903035 23 0.022
positive regulation of cell communication GO:0010647 271 0.022
regulation of transcription dna templated GO:0006355 374 0.022
negative regulation of secretion GO:0051048 82 0.022
positive regulation of intracellular signal transduction GO:1902533 138 0.022
sequestering of calcium ion GO:0051208 8 0.021
regulation of locomotion GO:0040012 148 0.021
negative regulation of osteoblast differentiation GO:0045668 2 0.021
regulation of defense response GO:0031347 68 0.021
multi organism reproductive process GO:0044703 262 0.021
regulation of inflammatory response GO:0050727 48 0.021
potassium ion transport GO:0006813 97 0.021
leukocyte cell cell adhesion GO:0007159 4 0.021
regulation of amine transport GO:0051952 54 0.021
negative regulation of cell communication GO:0010648 158 0.020
regulation of intracellular signal transduction GO:1902531 218 0.020
response to amino acid GO:0043200 75 0.020
circulatory system development GO:0072359 134 0.020
sleep GO:0030431 30 0.020
response to lipopolysaccharide GO:0032496 191 0.020
response to wounding GO:0009611 254 0.020
multi multicellular organism process GO:0044706 138 0.020
rhythmic process GO:0048511 156 0.020
positive regulation of protein phosphorylation GO:0001934 135 0.020
cellular response to external stimulus GO:0071496 118 0.020
feeding behavior GO:0007631 53 0.020
reproduction GO:0000003 245 0.020
hematopoietic progenitor cell differentiation GO:0002244 2 0.019
negative regulation of secretion by cell GO:1903531 72 0.019
organelle organization GO:0006996 266 0.019
regulation of blood vessel size GO:0050880 89 0.019
positive regulation of response to wounding GO:1903036 34 0.019
single organism organelle organization GO:1902589 180 0.019
positive regulation of gene expression GO:0010628 244 0.019
muscle contraction GO:0006936 88 0.019
neuron neuron synaptic transmission GO:0007270 60 0.019
axonogenesis GO:0007409 71 0.019
regulation of peptide hormone secretion GO:0090276 80 0.019
female pregnancy GO:0007565 122 0.019
circadian rhythm GO:0007623 88 0.018
positive regulation of rna biosynthetic process GO:1902680 197 0.018
lipid metabolic process GO:0006629 283 0.018
complement receptor mediated signaling pathway GO:0002430 2 0.018
protein homooligomerization GO:0051260 91 0.018
negative regulation of response to external stimulus GO:0032102 37 0.018
circadian sleep wake cycle GO:0042745 23 0.018
response to reactive oxygen species GO:0000302 120 0.018
spinal cord development GO:0021510 27 0.018
cellular response to ammonium ion GO:0071242 17 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
positive regulation of map kinase activity GO:0043406 46 0.018
negative regulation of apoptotic process GO:0043066 181 0.018
regulation of neuron differentiation GO:0045664 208 0.018
response to other organism GO:0051707 220 0.018
positive regulation of multicellular organismal process GO:0051240 387 0.018
secretion GO:0046903 307 0.018
regulation of rna metabolic process GO:0051252 391 0.017
positive regulation of protein kinase activity GO:0045860 73 0.017
peptidyl tyrosine phosphorylation GO:0018108 72 0.017
positive regulation of wound healing GO:0090303 6 0.017
purine nucleoside metabolic process GO:0042278 169 0.017
intracellular signal transduction GO:0035556 314 0.017
positive regulation of phosphate metabolic process GO:0045937 262 0.017
secretion by tissue GO:0032941 37 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
regulation of systemic arterial blood pressure GO:0003073 30 0.017
negative regulation of cell development GO:0010721 82 0.016
biological adhesion GO:0022610 110 0.016
regulation of peptide transport GO:0090087 87 0.016
regulation of epithelial cell proliferation GO:0050678 49 0.016
programmed cell death GO:0012501 392 0.016
insulin secretion GO:0030073 69 0.016
single organism reproductive process GO:0044702 297 0.016
positive regulation of apoptotic process GO:0043065 154 0.016
peptide transport GO:0015833 97 0.016
cytosolic calcium ion transport GO:0060401 39 0.016
head development GO:0060322 247 0.016
regulation of hormone levels GO:0010817 187 0.016
establishment of protein localization GO:0045184 141 0.016
cardiovascular system development GO:0072358 134 0.016
negative regulation of neuron differentiation GO:0045665 62 0.016
signal transduction by phosphorylation GO:0023014 144 0.016
response to electrical stimulus GO:0051602 56 0.016
positive regulation of cell development GO:0010720 176 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
regulation of canonical wnt signaling pathway GO:0060828 4 0.015
membrane organization GO:0061024 94 0.015
positive regulation of cytokine production GO:0001819 42 0.015
n methyl d aspartate receptor clustering GO:0097114 2 0.015
negative regulation of chronic inflammatory response GO:0002677 2 0.015
cellular response to cytokine stimulus GO:0071345 127 0.015
bmp signaling pathway GO:0030509 4 0.015
regulation of molecular function GO:0065009 398 0.015
sex determination GO:0007530 2 0.015
negative adaptation of signaling pathway GO:0022401 10 0.015
positive regulation of secretion GO:0051047 140 0.015
regulation of ion homeostasis GO:2000021 63 0.015
glucose homeostasis GO:0042593 75 0.014
positive regulation of growth GO:0045927 55 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
blood circulation GO:0008015 183 0.014
response to radiation GO:0009314 137 0.014
regulation of homeostatic process GO:0032844 101 0.014
cellular response to nitrogen compound GO:1901699 210 0.014
response to transition metal nanoparticle GO:1990267 122 0.014
negative regulation of homeostatic process GO:0032845 47 0.014
negative regulation of transport GO:0051051 136 0.014
sensory perception GO:0007600 101 0.014
cellular response to peptide hormone stimulus GO:0071375 120 0.014
negative regulation of uterine smooth muscle contraction GO:0070473 2 0.014
mapk cascade GO:0000165 140 0.014
respiratory system process GO:0003016 3 0.014
regulation of peptide secretion GO:0002791 82 0.014
regulation of excretion GO:0044062 21 0.014
response to lithium ion GO:0010226 28 0.013
regulation of proteolysis GO:0030162 66 0.013
synaptic transmission gabaergic GO:0051932 22 0.013
epithelial cell differentiation GO:0030855 71 0.013
response to vitamin GO:0033273 131 0.013
body fluid secretion GO:0007589 41 0.013
phototransduction visible light GO:0007603 2 0.013
s shaped body morphogenesis GO:0072050 2 0.013
detection of visible light GO:0009584 3 0.013
positive regulation of cell migration GO:0030335 96 0.013
regulation of circadian sleep wake cycle sleep GO:0045187 18 0.013
circulatory system process GO:0003013 183 0.013
regulation of the force of heart contraction by chemical signal GO:0003057 2 0.013
positive regulation of the force of heart contraction by norepinephrine GO:0003061 1 0.013
embryonic cranial skeleton morphogenesis GO:0048701 2 0.013
cellular response to oxygen containing compound GO:1901701 386 0.013
positive regulation of calcium ion transport GO:0051928 36 0.013
multicellular organismal reproductive process GO:0048609 233 0.013
positive regulation of transcription dna templated GO:0045893 197 0.013
nucleobase containing small molecule metabolic process GO:0055086 316 0.013
cell cycle checkpoint GO:0000075 2 0.013
camera type eye development GO:0043010 48 0.013
blood vessel morphogenesis GO:0048514 58 0.013
cell migration GO:0016477 197 0.013
cellular response to carbohydrate stimulus GO:0071322 72 0.013
neuron death GO:0070997 127 0.013
negative regulation of hormone secretion GO:0046888 46 0.012
regulation of peptidase activity GO:0052547 55 0.012
purine containing compound metabolic process GO:0072521 253 0.012
regulation of hormone secretion GO:0046883 106 0.012
amide transport GO:0042886 105 0.012
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.012
cellular response to tumor necrosis factor GO:0071356 46 0.012
cellular response to mechanical stimulus GO:0071260 48 0.012
cell cycle GO:0007049 101 0.012
negative regulation of molecular function GO:0044092 133 0.012
positive regulation of secretion by cell GO:1903532 128 0.012
ribonucleotide metabolic process GO:0009259 231 0.012
regulation of phosphorylation GO:0042325 248 0.012
ribonucleotide biosynthetic process GO:0009260 85 0.012
cytokine production GO:0001816 61 0.012
renal system development GO:0072001 67 0.012
regulation of mapk cascade GO:0043408 116 0.012
axis specification GO:0009798 4 0.012
cytoplasmic transport GO:0016482 115 0.012
negative regulation of neurogenesis GO:0050768 78 0.012
cellular response to monosaccharide stimulus GO:0071326 67 0.012
organ regeneration GO:0031100 101 0.012
response to ethanol GO:0045471 162 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.012
circadian sleep wake cycle sleep GO:0050802 21 0.012
cellular response to acid chemical GO:0071229 75 0.012
vasoconstriction GO:0042310 54 0.012
blood vessel development GO:0001568 69 0.012
reactive nitrogen species metabolic process GO:2001057 1 0.012
regulation of smooth muscle cell proliferation GO:0048660 75 0.012
regulation of cell migration GO:0030334 128 0.012
cell fate determination GO:0001709 2 0.012
positive regulation of the force of heart contraction by epinephrine GO:0003059 1 0.012
cell morphogenesis involved in differentiation GO:0000904 119 0.012
peptidyl tyrosine modification GO:0018212 72 0.012
regulation of metal ion transport GO:0010959 118 0.011
transcription dna templated GO:0006351 377 0.011
comma shaped body morphogenesis GO:0072049 2 0.011
alpha beta t cell activation GO:0046631 3 0.011
positive regulation of smooth muscle cell apoptotic process GO:0034393 2 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
regulation of sensory perception GO:0051931 29 0.011
regulation of transferase activity GO:0051338 123 0.011
immune effector process GO:0002252 53 0.011
positive regulation of amine transport GO:0051954 26 0.011
nucleoside phosphate metabolic process GO:0006753 283 0.011
organophosphate metabolic process GO:0019637 370 0.011
digestion GO:0007586 26 0.011
cellular macromolecule localization GO:0070727 122 0.011
regulation of systemic arterial blood pressure by norepinephrine epinephrine GO:0001993 2 0.011
catecholamine transport GO:0051937 37 0.011
regulation of system process GO:0044057 208 0.011
positive regulation of molecular function GO:0044093 230 0.011
cellular response to metal ion GO:0071248 55 0.011
cellular response to glucose stimulus GO:0071333 65 0.011
regulation of blood circulation GO:1903522 110 0.011
jak stat cascade GO:0007259 26 0.011
regulation of saliva secretion GO:0046877 3 0.011
tube development GO:0035295 89 0.011
cellular response to lipid GO:0071396 201 0.011
macrophage chemotaxis GO:0048246 2 0.011
response to glucocorticoid GO:0051384 223 0.011
positive regulation of the force of heart contraction by chemical signal GO:0003099 2 0.011
renal sodium excretion GO:0035812 20 0.010
regulation of vasodilation GO:0042312 36 0.010
cellular response to lipopolysaccharide GO:0071222 55 0.010
regulation of amino acid transport GO:0051955 25 0.010
response to purine containing compound GO:0014074 126 0.010
protein maturation GO:0051604 68 0.010
negative regulation of phosphate metabolic process GO:0045936 80 0.010
regulation of long term synaptic potentiation GO:1900271 5 0.010
negative regulation of protein phosphorylation GO:0001933 44 0.010
positive regulation of neurogenesis GO:0050769 165 0.010
neurotransmitter uptake GO:0001504 3 0.010
transmembrane transport GO:0055085 412 0.010
localization of cell GO:0051674 202 0.010
cellular response to hexose stimulus GO:0071331 65 0.010
purine ribonucleotide catabolic process GO:0009154 136 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
regulation of ossification GO:0030278 32 0.010
digestive tract development GO:0048565 39 0.010
negative regulation of catalytic activity GO:0043086 103 0.010
negative regulation of vasculature development GO:1901343 11 0.010
organic hydroxy compound metabolic process GO:1901615 115 0.010
carbohydrate homeostasis GO:0033500 75 0.010

Hist1h2aa disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.014
nutrition disease DOID:374 0 0.014
acquired metabolic disease DOID:0060158 0 0.014
obesity DOID:9970 0 0.011
overnutrition DOID:654 0 0.011