Rattus norvegicus

0 known processes

Hlf

hepatic leukemia factor

Hlf biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of multicellular organismal process GO:0051240 387 0.437
regulation of rna biosynthetic process GO:2001141 381 0.331
response to glucocorticoid GO:0051384 223 0.217
developmental process involved in reproduction GO:0003006 159 0.202
positive regulation of biosynthetic process GO:0009891 319 0.193
reproductive process GO:0022414 372 0.181
cell projection organization GO:0030030 302 0.172
cellular ketone metabolic process GO:0042180 51 0.152
carboxylic acid metabolic process GO:0019752 289 0.152
regulation of cell differentiation GO:0045595 320 0.151
transcription dna templated GO:0006351 377 0.149
single organism reproductive process GO:0044702 297 0.143
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.126
reproductive system development GO:0061458 128 0.119
positive regulation of rna metabolic process GO:0051254 203 0.110
organic acid metabolic process GO:0006082 292 0.109
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.108
regulation of programmed cell death GO:0043067 341 0.108
positive regulation of rna biosynthetic process GO:1902680 197 0.106
response to peptide GO:1901652 292 0.106
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.103
regulation of system process GO:0044057 208 0.102
positive regulation of phosphate metabolic process GO:0045937 262 0.098
response to estradiol GO:0032355 164 0.092
central nervous system development GO:0007417 311 0.092
transmembrane transport GO:0055085 412 0.091
response to alkaloid GO:0043279 132 0.091
regulation of cell projection organization GO:0031344 175 0.089
brain development GO:0007420 247 0.089
macromolecule localization GO:0033036 252 0.089
reproductive structure development GO:0048608 128 0.086
positive regulation of transcription dna templated GO:0045893 197 0.085
regulation of molecular function GO:0065009 398 0.084
multicellular organism reproduction GO:0032504 233 0.082
regulation of catalytic activity GO:0050790 304 0.082
response to inorganic substance GO:0010035 377 0.081
regulation of transcription dna templated GO:0006355 374 0.080
transcription from rna polymerase ii promoter GO:0006366 252 0.077
cellular amino acid metabolic process GO:0006520 107 0.076
positive regulation of nucleic acid templated transcription GO:1903508 197 0.075
positive regulation of gene expression GO:0010628 244 0.075
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.075
regulation of multicellular organismal development GO:2000026 376 0.073
multi organism reproductive process GO:0044703 262 0.070
cellular protein localization GO:0034613 122 0.070
positive regulation of cellular biosynthetic process GO:0031328 295 0.068
oxoacid metabolic process GO:0043436 290 0.068
regulation of nervous system development GO:0051960 264 0.067
response to extracellular stimulus GO:0009991 380 0.066
regulation of neuron projection development GO:0010975 161 0.066
development of primary sexual characteristics GO:0045137 107 0.066
store operated calcium entry GO:0002115 2 0.065
reproduction GO:0000003 245 0.064
rna metabolic process GO:0016070 406 0.063
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.063
regulation of phosphorylation GO:0042325 248 0.062
neuron differentiation GO:0030182 368 0.058
positive regulation of synaptic transmission GO:0050806 62 0.056
cellular response to organonitrogen compound GO:0071417 197 0.056
cardiac chamber development GO:0003205 1 0.056
neurological system process GO:0050877 219 0.055
negative regulation of apoptotic process GO:0043066 181 0.055
regulation of rna metabolic process GO:0051252 391 0.054
cellular response to stress GO:0033554 269 0.054
sexual reproduction GO:0019953 148 0.053
cellular response to endogenous stimulus GO:0071495 377 0.053
male sex differentiation GO:0046661 64 0.052
head development GO:0060322 247 0.052
nucleic acid templated transcription GO:0097659 379 0.050
response to peptide hormone GO:0043434 278 0.050
nitrogen compound transport GO:0071705 229 0.050
carboxylic acid biosynthetic process GO:0046394 83 0.049
cell cell signaling GO:0007267 335 0.049
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.049
positive regulation of nervous system development GO:0051962 178 0.049
regulation of signal transduction GO:0009966 318 0.048
gonad development GO:0008406 104 0.048
rna biosynthetic process GO:0032774 380 0.048
cellular component assembly GO:0022607 360 0.048
regulation of cell development GO:0060284 263 0.047
response to tumor necrosis factor GO:0034612 56 0.047
programmed cell death GO:0012501 392 0.047
negative regulation of cellular biosynthetic process GO:0031327 161 0.046
negative regulation of signaling GO:0023057 157 0.046
negative regulation of gene expression GO:0010629 199 0.046
negative regulation of cell death GO:0060548 229 0.046
organic acid biosynthetic process GO:0016053 83 0.045
cellular response to hormone stimulus GO:0032870 247 0.044
single organism behavior GO:0044708 130 0.043
apoptotic process GO:0006915 381 0.043
regulation of apoptotic process GO:0042981 335 0.042
intracellular transport GO:0046907 185 0.042
sex differentiation GO:0007548 113 0.041
response to corticosteroid GO:0031960 235 0.041
protein phosphorylation GO:0006468 345 0.041
positive regulation of secretion GO:0051047 140 0.041
positive regulation of cell differentiation GO:0045597 217 0.041
positive regulation of cellular component organization GO:0051130 200 0.041
macromolecular complex assembly GO:0065003 273 0.041
regulation of cellular ketone metabolic process GO:0010565 27 0.040
regulation of intracellular signal transduction GO:1902531 218 0.040
cellular response to oxygen containing compound GO:1901701 386 0.040
regulation of protein localization GO:0032880 81 0.040
cellular response to peptide hormone stimulus GO:0071375 120 0.040
regulation of neuron differentiation GO:0045664 208 0.040
regulation of lipid metabolic process GO:0019216 68 0.039
multicellular organismal reproductive process GO:0048609 233 0.039
regulation of cell cycle GO:0051726 73 0.039
positive regulation of molecular function GO:0044093 230 0.039
regulation of cytokine production GO:0001817 56 0.039
cellular catabolic process GO:0044248 295 0.038
positive regulation of peptide secretion GO:0002793 52 0.038
carboxylic acid transport GO:0046942 115 0.038
hormone transport GO:0009914 121 0.037
cellular response to peptide GO:1901653 133 0.037
response to toxic substance GO:0009636 133 0.037
response to radiation GO:0009314 137 0.037
regulation of phosphate metabolic process GO:0019220 349 0.036
neuron development GO:0048666 286 0.036
cellular response to insulin stimulus GO:0032869 81 0.036
intracellular receptor signaling pathway GO:0030522 35 0.035
heart morphogenesis GO:0003007 3 0.035
negative regulation of cell communication GO:0010648 158 0.035
negative regulation of metabolic process GO:0009892 331 0.035
organic acid transport GO:0015849 116 0.035
regulation of systemic arterial blood pressure GO:0003073 30 0.035
regulation of secretion by cell GO:1903530 208 0.035
regulation of cellular amino acid metabolic process GO:0006521 2 0.034
regulation of cellular localization GO:0060341 263 0.034
organelle organization GO:0006996 266 0.034
secretion GO:0046903 307 0.034
regulation of cellular component organization GO:0051128 368 0.034
multi multicellular organism process GO:0044706 138 0.033
response to reactive oxygen species GO:0000302 120 0.033
cellular response to organic cyclic compound GO:0071407 202 0.033
protein complex subunit organization GO:0071822 302 0.033
response to insulin GO:0032868 133 0.033
metal ion transport GO:0030001 289 0.033
positive regulation of protein transport GO:0051222 41 0.033
regulation of protein modification process GO:0031399 194 0.032
protein complex biogenesis GO:0070271 263 0.032
tube development GO:0035295 89 0.032
negative regulation of cellular metabolic process GO:0031324 281 0.032
regulation of neurogenesis GO:0050767 247 0.032
protein transport GO:0015031 132 0.032
negative regulation of macromolecule metabolic process GO:0010605 260 0.031
cellular response to cytokine stimulus GO:0071345 127 0.031
lipid metabolic process GO:0006629 283 0.031
positive regulation of cell communication GO:0010647 271 0.031
response to hexose GO:0009746 144 0.030
cellular response to nitrogen compound GO:1901699 210 0.030
positive regulation of developmental process GO:0051094 283 0.030
negative regulation of nucleic acid templated transcription GO:1903507 117 0.030
negative regulation of programmed cell death GO:0043069 183 0.030
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.030
response to ethanol GO:0045471 162 0.030
male gonad development GO:0008584 59 0.029
response to decreased oxygen levels GO:0036293 237 0.029
single organism organelle organization GO:1902589 180 0.029
positive regulation of neurogenesis GO:0050769 165 0.028
negative regulation of transcription dna templated GO:0045892 116 0.028
anatomical structure morphogenesis GO:0009653 298 0.028
positive regulation of intracellular signal transduction GO:1902533 138 0.028
regulation of secretion GO:0051046 224 0.027
cellular amine metabolic process GO:0044106 38 0.027
synaptic growth at neuromuscular junction GO:0051124 1 0.027
forebrain development GO:0030900 98 0.027
response to nutrient levels GO:0031667 370 0.027
positive regulation of transport GO:0051050 245 0.027
regulation of hormone levels GO:0010817 187 0.027
female mating behavior GO:0060180 6 0.027
g protein coupled acetylcholine receptor signaling pathway GO:0007213 5 0.026
positive regulation of secretion by cell GO:1903532 128 0.026
gamete generation GO:0007276 124 0.026
secretion by cell GO:0032940 248 0.026
glycosyl compound metabolic process GO:1901657 182 0.026
cellular response to lipid GO:0071396 201 0.026
cellular component morphogenesis GO:0032989 155 0.026
negative regulation of rna biosynthetic process GO:1902679 118 0.025
response to cytokine GO:0034097 215 0.025
response to oxidative stress GO:0006979 186 0.025
positive regulation of phosphorus metabolic process GO:0010562 262 0.025
negative regulation of neurogenesis GO:0050768 78 0.025
proteolysis GO:0006508 175 0.025
positive regulation of catalytic activity GO:0043085 184 0.024
purine containing compound metabolic process GO:0072521 253 0.024
cardiac ventricle development GO:0003231 1 0.024
diencephalon development GO:0021536 21 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
nephric duct development GO:0072176 1 0.023
response to growth factor GO:0070848 189 0.023
protein localization GO:0008104 191 0.023
intracellular signal transduction GO:0035556 314 0.023
response to transition metal nanoparticle GO:1990267 122 0.023
sympathetic nervous system development GO:0048485 1 0.023
regulation of hydrolase activity GO:0051336 143 0.022
muscle contraction GO:0006936 88 0.022
small gtpase mediated signal transduction GO:0007264 36 0.022
negative regulation of molecular function GO:0044092 133 0.022
cellular response to tumor necrosis factor GO:0071356 46 0.022
l glutamate import GO:0051938 2 0.022
nucleoside triphosphate metabolic process GO:0009141 144 0.022
cellular lipid metabolic process GO:0044255 208 0.022
development of primary male sexual characteristics GO:0046546 59 0.021
cell type specific apoptotic process GO:0097285 134 0.021
cellular component movement GO:0006928 248 0.021
response to acid chemical GO:0001101 222 0.021
nucleoside metabolic process GO:0009116 179 0.021
positive regulation of protein metabolic process GO:0051247 178 0.021
metanephric comma shaped body morphogenesis GO:0072278 2 0.021
establishment of protein localization GO:0045184 141 0.021
response to glucose GO:0009749 136 0.021
regulation of nucleic acid templated transcription GO:1903506 380 0.021
axonogenesis GO:0007409 71 0.021
multicellular organism growth GO:0035264 1 0.021
comma shaped body morphogenesis GO:0072049 2 0.021
positive regulation of long term synaptic potentiation GO:1900273 4 0.020
regulation of protein phosphorylation GO:0001932 183 0.020
n methyl d aspartate receptor clustering GO:0097114 2 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
regulation of kinase activity GO:0043549 117 0.020
peptide biosynthetic process GO:0043043 3 0.020
protein homooligomerization GO:0051260 91 0.020
purine nucleoside metabolic process GO:0042278 169 0.019
organonitrogen compound biosynthetic process GO:1901566 167 0.019
purine nucleoside catabolic process GO:0006152 124 0.019
nucleoside monophosphate metabolic process GO:0009123 93 0.019
axon development GO:0061564 96 0.019
synapse organization GO:0050808 46 0.019
hormone metabolic process GO:0042445 69 0.019
response to metal ion GO:0010038 253 0.019
positive regulation of cell development GO:0010720 176 0.019
regulation of acrosome reaction GO:0060046 1 0.019
sensory perception of pain GO:0019233 73 0.019
protein complex assembly GO:0006461 263 0.019
cellular component biogenesis GO:0044085 368 0.019
motor neuron axon guidance GO:0008045 1 0.019
neurotransmitter gated ion channel clustering GO:0072578 3 0.018
neuron projection development GO:0031175 273 0.018
leydig cell differentiation GO:0033327 8 0.018
negative regulation of response to stimulus GO:0048585 155 0.018
fatty acid metabolic process GO:0006631 99 0.018
amine metabolic process GO:0009308 38 0.018
telencephalon development GO:0021537 62 0.018
spermatogenesis GO:0007283 99 0.018
negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 2 0.018
muscle structure development GO:0061061 87 0.018
inorganic cation transmembrane transport GO:0098662 202 0.018
gliogenesis GO:0042063 93 0.017
protein maturation GO:0051604 68 0.017
cardiac muscle cell contraction GO:0086003 10 0.017
negative regulation of signal transduction GO:0009968 83 0.017
grooming behavior GO:0007625 4 0.017
cellular carbohydrate metabolic process GO:0044262 72 0.017
regulation of protein transport GO:0051223 68 0.017
negative regulation of rna metabolic process GO:0051253 123 0.017
purine ribonucleoside metabolic process GO:0046128 168 0.017
nucleobase containing small molecule metabolic process GO:0055086 316 0.017
carbohydrate derivative metabolic process GO:1901135 346 0.017
hormone secretion GO:0046879 115 0.017
cellular response to abiotic stimulus GO:0071214 85 0.017
tissue development GO:0009888 252 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
response to oxygen levels GO:0070482 265 0.016
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.016
regulation of protein metabolic process GO:0051246 289 0.016
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 2 0.016
regulation of ion transmembrane transport GO:0034765 121 0.016
regulation of cellular amine metabolic process GO:0033238 8 0.016
regulation of cellular catabolic process GO:0031329 101 0.016
regulation of cellular protein metabolic process GO:0032268 267 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
regulation of cell growth GO:0001558 85 0.015
regulation of embryonic development GO:0045995 2 0.015
defense response GO:0006952 194 0.015
actin filament based process GO:0030029 86 0.015
hematopoietic progenitor cell differentiation GO:0002244 2 0.015
circadian rhythm GO:0007623 88 0.015
response to vitamin e GO:0033197 24 0.015
circulatory system process GO:0003013 183 0.015
response to temperature stimulus GO:0009266 94 0.015
positive regulation of cellular catabolic process GO:0031331 71 0.015
dendrite development GO:0016358 72 0.015
developmental growth GO:0048589 100 0.015
heart process GO:0003015 57 0.015
heart development GO:0007507 72 0.015
metanephric s shaped body morphogenesis GO:0072284 2 0.015
chemosensory behavior GO:0007635 2 0.015
response to carbohydrate GO:0009743 183 0.015
interleukin 6 production GO:0032635 12 0.015
response to interleukin 1 GO:0070555 55 0.015
regulation of sensory perception GO:0051931 29 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
regulation of systemic arterial blood pressure by norepinephrine epinephrine GO:0001993 2 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.014
response to transforming growth factor beta GO:0071559 46 0.014
protein oligomerization GO:0051259 191 0.014
gastrulation GO:0007369 2 0.014
locomotory exploration behavior GO:0035641 1 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
monocarboxylic acid metabolic process GO:0032787 152 0.014
insulin secretion GO:0030073 69 0.014
cytoplasmic transport GO:0016482 115 0.014
small molecule biosynthetic process GO:0044283 124 0.014
negative regulation of developmental process GO:0051093 125 0.014
single organism biosynthetic process GO:0044711 342 0.014
leukocyte differentiation GO:0002521 30 0.014
cell morphogenesis GO:0000902 142 0.014
olfactory behavior GO:0042048 2 0.014
axon midline choice point recognition GO:0016199 2 0.014
regulation of muscle contraction GO:0006937 53 0.014
positive regulation of lipid kinase activity GO:0090218 2 0.014
nucleoside triphosphate catabolic process GO:0009143 123 0.014
sensory perception GO:0007600 101 0.014
cellular response to hexose stimulus GO:0071331 65 0.014
icosanoid metabolic process GO:0006690 38 0.014
c21 steroid hormone biosynthetic process GO:0006700 10 0.013
muscle tissue morphogenesis GO:0060415 1 0.013
cellular macromolecule localization GO:0070727 122 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
antral ovarian follicle growth GO:0001547 3 0.013
cell growth GO:0016049 104 0.013
ion transmembrane transport GO:0034220 365 0.013
cellular response to oxidative stress GO:0034599 76 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
male gamete generation GO:0048232 99 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
negative regulation of cell differentiation GO:0045596 99 0.013
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.013
nucleotide metabolic process GO:0009117 279 0.013
locomotion GO:0040011 237 0.013
developmental growth involved in morphogenesis GO:0060560 33 0.013
peptide secretion GO:0002790 86 0.013
fertilization GO:0009566 3 0.013
response to estrogen GO:0043627 232 0.013
cell projection morphogenesis GO:0048858 123 0.013
regulation of axonogenesis GO:0050770 37 0.013
nucleoside phosphate metabolic process GO:0006753 283 0.013
female pregnancy GO:0007565 122 0.013
carbohydrate derivative catabolic process GO:1901136 147 0.012
metanephric part of ureteric bud development GO:0035502 1 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
growth GO:0040007 165 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.012
atp metabolic process GO:0046034 72 0.012
regulation of nephron tubule epithelial cell differentiation GO:0072182 1 0.012
negative regulation of cell development GO:0010721 82 0.012
response to monosaccharide GO:0034284 159 0.012
regulation of blood pressure GO:0008217 83 0.012
response to ketone GO:1901654 182 0.012
cellular response to reactive oxygen species GO:0034614 55 0.012
embryo development GO:0009790 49 0.012
negative regulation of calcium ion import GO:0090281 2 0.012
locomotor rhythm GO:0045475 1 0.012
regulation of peptide secretion GO:0002791 82 0.012
odontogenesis GO:0042476 32 0.012
cellular response to carbohydrate stimulus GO:0071322 72 0.012
vasoconstriction GO:0042310 54 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
negative regulation of neuron differentiation GO:0045665 62 0.012
potassium ion transport GO:0006813 97 0.012
response to ionizing radiation GO:0010212 59 0.012
glial cell differentiation GO:0010001 65 0.012
cytokine production GO:0001816 61 0.012
response to herbicide GO:0009635 16 0.012
regulation of sensory perception of pain GO:0051930 29 0.012
blood circulation GO:0008015 183 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
mapk cascade GO:0000165 140 0.011
positive regulation of transferase activity GO:0051347 81 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
macromolecular complex subunit organization GO:0043933 339 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.011
peptide hormone secretion GO:0030072 84 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
lipid biosynthetic process GO:0008610 128 0.011
positive regulation of protein modification process GO:0031401 142 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
adult locomotory behavior GO:0008344 4 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
cellular response to external stimulus GO:0071496 118 0.011
negative regulation of uterine smooth muscle contraction GO:0070473 2 0.011
actin cytoskeleton organization GO:0030036 73 0.011
positive regulation of ruffle assembly GO:1900029 1 0.011
olfactory bulb interneuron differentiation GO:0021889 1 0.011
cation transport GO:0006812 382 0.011
regulation of establishment of protein localization GO:0070201 69 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
cell activation GO:0001775 97 0.011
synaptic transmission GO:0007268 235 0.011
response to nicotine GO:0035094 51 0.011
carbohydrate homeostasis GO:0033500 75 0.011
reproductive behavior GO:0019098 10 0.011
response to nutrient GO:0007584 248 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
cellular response to extracellular stimulus GO:0031668 73 0.011
regulation of insulin secretion GO:0050796 65 0.011
oxidation reduction process GO:0055114 304 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
excretion GO:0007588 24 0.011
autonomic nervous system development GO:0048483 3 0.011
muscle organ morphogenesis GO:0048644 1 0.010
organic substance catabolic process GO:1901575 316 0.010
negative regulation of biosynthetic process GO:0009890 168 0.010
ras protein signal transduction GO:0007265 29 0.010
regulation of cell proliferation GO:0042127 359 0.010
positive regulation of neuron migration GO:2001224 2 0.010
glucose homeostasis GO:0042593 75 0.010
respiratory gaseous exchange GO:0007585 4 0.010
behavioral response to ethanol GO:0048149 1 0.010
neuron neuron synaptic transmission GO:0007270 60 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.010
axon choice point recognition GO:0016198 2 0.010
morphogenesis of embryonic epithelium GO:0016331 3 0.010
axis specification GO:0009798 4 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
nucleoside catabolic process GO:0009164 126 0.010
regulation of interferon gamma production GO:0032649 3 0.010
positive regulation of lipid metabolic process GO:0045834 33 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
response to starvation GO:0042594 59 0.010
positive regulation of kinase activity GO:0033674 77 0.010
energy derivation by oxidation of organic compounds GO:0015980 46 0.010

Hlf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
musculoskeletal system disease DOID:17 0 0.029
nervous system disease DOID:863 0 0.028
urinary system disease DOID:18 0 0.026
epilepsy syndrome DOID:1826 0 0.013
central nervous system disease DOID:331 0 0.013
brain disease DOID:936 0 0.013
kidney disease DOID:557 0 0.012
connective tissue disease DOID:65 0 0.012