Rattus norvegicus

249 known processes

Hmgb1

high mobility group box 1

(Aliases: MGC93599,Hmg1,Ac2-008,MGC93598)

Hmgb1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of rna metabolic process GO:0051252 391 0.408
nucleic acid templated transcription GO:0097659 379 0.334
cellular response to endogenous stimulus GO:0071495 377 0.330
rna biosynthetic process GO:0032774 380 0.279
rna metabolic process GO:0016070 406 0.271
translation GO:0006412 35 0.268
negative regulation of rna biosynthetic process GO:1902679 118 0.254
positive regulation of gene expression GO:0010628 244 0.243
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.233
regulation of translation GO:0006417 27 0.212
aging GO:0007568 241 0.210
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.198
negative regulation of rna metabolic process GO:0051253 123 0.196
transcription from rna polymerase ii promoter GO:0006366 252 0.185
regulation of nucleic acid templated transcription GO:1903506 380 0.185
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.182
negative regulation of cellular biosynthetic process GO:0031327 161 0.181
regulation of rna biosynthetic process GO:2001141 381 0.174
hemidesmosome assembly GO:0031581 1 0.167
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.157
apoptotic process GO:0006915 381 0.141
negative regulation of cellular metabolic process GO:0031324 281 0.135
transcription dna templated GO:0006351 377 0.133
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.130
positive regulation of cellular biosynthetic process GO:0031328 295 0.123
regulation of apoptotic process GO:0042981 335 0.123
positive regulation of rna biosynthetic process GO:1902680 197 0.121
positive regulation of biosynthetic process GO:0009891 319 0.120
negative regulation of macromolecule metabolic process GO:0010605 260 0.119
cellular response to oxygen containing compound GO:1901701 386 0.116
cellular response to nitrogen compound GO:1901699 210 0.116
negative regulation of gene expression GO:0010629 199 0.107
reproductive process GO:0022414 372 0.107
regeneration GO:0031099 163 0.101
nucleosome organization GO:0034728 1 0.100
regulation of protein metabolic process GO:0051246 289 0.100
regulation of transcription dna templated GO:0006355 374 0.098
programmed cell death GO:0012501 392 0.096
central nervous system development GO:0007417 311 0.094
negative regulation of biosynthetic process GO:0009890 168 0.089
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.088
reproductive system development GO:0061458 128 0.087
organic acid metabolic process GO:0006082 292 0.087
cell cycle GO:0007049 101 0.086
regulation of cellular protein metabolic process GO:0032268 267 0.082
negative regulation of nucleic acid templated transcription GO:1903507 117 0.080
positive regulation of transcription dna templated GO:0045893 197 0.080
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.080
negative regulation of rna splicing GO:0033119 3 0.076
positive regulation of protein metabolic process GO:0051247 178 0.073
response to peptide GO:1901652 292 0.071
cellular response to organonitrogen compound GO:0071417 197 0.069
single organism organelle organization GO:1902589 180 0.068
response to temperature stimulus GO:0009266 94 0.062
positive regulation of nucleic acid templated transcription GO:1903508 197 0.062
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.059
multi organism reproductive process GO:0044703 262 0.059
head development GO:0060322 247 0.056
multicellular organismal reproductive process GO:0048609 233 0.056
gonad development GO:0008406 104 0.056
reproduction GO:0000003 245 0.055
regulation of rna splicing GO:0043484 6 0.054
organelle organization GO:0006996 266 0.052
response to extracellular stimulus GO:0009991 380 0.052
cellular response to hormone stimulus GO:0032870 247 0.052
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.051
cellular amino acid metabolic process GO:0006520 107 0.051
single organism reproductive process GO:0044702 297 0.048
reproductive structure development GO:0048608 128 0.048
response to inorganic substance GO:0010035 377 0.047
response to nutrient levels GO:0031667 370 0.046
negative regulation of transcription dna templated GO:0045892 116 0.044
negative regulation of metabolic process GO:0009892 331 0.044
regulation of signal transduction GO:0009966 318 0.044
carboxylic acid metabolic process GO:0019752 289 0.042
sex differentiation GO:0007548 113 0.041
regulation of cellular amine metabolic process GO:0033238 8 0.041
positive regulation of rna metabolic process GO:0051254 203 0.040
cellular response to organic cyclic compound GO:0071407 202 0.040
spermatogenesis GO:0007283 99 0.040
chromatin assembly or disassembly GO:0006333 1 0.040
multicellular organism reproduction GO:0032504 233 0.040
response to peptide hormone GO:0043434 278 0.039
development of primary sexual characteristics GO:0045137 107 0.039
growth GO:0040007 165 0.039
regulation of cellular ketone metabolic process GO:0010565 27 0.039
posttranscriptional regulation of gene expression GO:0010608 37 0.038
cellular component biogenesis GO:0044085 368 0.036
positive regulation of developmental process GO:0051094 283 0.036
regulation of catalytic activity GO:0050790 304 0.035
brain development GO:0007420 247 0.035
sexual reproduction GO:0019953 148 0.035
positive regulation of cellular protein metabolic process GO:0032270 167 0.034
development of primary female sexual characteristics GO:0046545 56 0.034
neuron projection development GO:0031175 273 0.034
negative regulation of cell death GO:0060548 229 0.033
gamete generation GO:0007276 124 0.032
regulation of programmed cell death GO:0043067 341 0.032
cellular amine metabolic process GO:0044106 38 0.032
response to molecule of bacterial origin GO:0002237 194 0.031
positive regulation of cellular amine metabolic process GO:0033240 3 0.031
response to other organism GO:0051707 220 0.031
cellular response to insulin stimulus GO:0032869 81 0.030
oxoacid metabolic process GO:0043436 290 0.030
developmental growth GO:0048589 100 0.029
negative regulation of programmed cell death GO:0043069 183 0.029
positive regulation of cell differentiation GO:0045597 217 0.029
response to wounding GO:0009611 254 0.029
single organism behavior GO:0044708 130 0.028
single organism biosynthetic process GO:0044711 342 0.028
female gonad development GO:0008585 53 0.028
cellular component movement GO:0006928 248 0.027
regulation of hydrolase activity GO:0051336 143 0.026
neuron differentiation GO:0030182 368 0.026
gliogenesis GO:0042063 93 0.026
dna metabolic process GO:0006259 96 0.025
macromolecular complex assembly GO:0065003 273 0.025
amine metabolic process GO:0009308 38 0.025
rna splicing GO:0008380 11 0.024
negative regulation of apoptotic process GO:0043066 181 0.024
response to reactive oxygen species GO:0000302 120 0.024
protein complex assembly GO:0006461 263 0.024
positive regulation of dna metabolic process GO:0051054 39 0.023
cellular component assembly GO:0022607 360 0.023
behavior GO:0007610 205 0.023
response to oxygen levels GO:0070482 265 0.023
developmental process involved in reproduction GO:0003006 159 0.023
negative regulation of cell differentiation GO:0045596 99 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.022
response to oxidative stress GO:0006979 186 0.022
response to metal ion GO:0010038 253 0.022
protein oligomerization GO:0051259 191 0.022
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.022
dna packaging GO:0006323 4 0.021
intracellular signal transduction GO:0035556 314 0.021
organ regeneration GO:0031100 101 0.021
response to lipopolysaccharide GO:0032496 191 0.021
organic cyclic compound catabolic process GO:1901361 175 0.021
response to purine containing compound GO:0014074 126 0.021
male gamete generation GO:0048232 99 0.021
regulation of cell proliferation GO:0042127 359 0.021
cellular response to stress GO:0033554 269 0.020
meiotic cell cycle process GO:1903046 3 0.020
negative regulation of protein metabolic process GO:0051248 114 0.019
cell cycle checkpoint GO:0000075 2 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.018
regulation of growth GO:0040008 105 0.018
cellular response to lipid GO:0071396 201 0.018
positive regulation of cell proliferation GO:0008284 249 0.018
regulation of cell cycle GO:0051726 73 0.017
response to increased oxygen levels GO:0036296 45 0.017
negative regulation of signaling GO:0023057 157 0.017
response to decreased oxygen levels GO:0036293 237 0.017
response to insulin GO:0032868 133 0.017
response to ethanol GO:0045471 162 0.017
regulation of cell development GO:0060284 263 0.017
chromosome segregation GO:0007059 2 0.017
lipid metabolic process GO:0006629 283 0.017
cell projection organization GO:0030030 302 0.017
negative regulation of developmental process GO:0051093 125 0.017
protein homooligomerization GO:0051260 91 0.016
locomotion GO:0040011 237 0.016
regulation of dna metabolic process GO:0051052 60 0.016
negative regulation of molecular function GO:0044092 133 0.016
regulation of neuron apoptotic process GO:0043523 83 0.016
chemical homeostasis GO:0048878 292 0.016
hematopoietic progenitor cell differentiation GO:0002244 2 0.016
cell cycle process GO:0022402 57 0.016
female sex differentiation GO:0046660 59 0.016
circadian rhythm GO:0007623 88 0.016
regulation of cell projection organization GO:0031344 175 0.015
response to acid chemical GO:0001101 222 0.015
regulation of protein maturation GO:1903317 50 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
regulation of multicellular organismal development GO:2000026 376 0.015
behavioral response to ethanol GO:0048149 1 0.015
wound healing GO:0042060 122 0.015
response to bacterium GO:0009617 200 0.015
multi multicellular organism process GO:0044706 138 0.015
negative regulation of protein maturation GO:1903318 47 0.015
cellular catabolic process GO:0044248 295 0.014
negative regulation of catalytic activity GO:0043086 103 0.014
glial cell differentiation GO:0010001 65 0.014
positive regulation of nervous system development GO:0051962 178 0.014
multicellular organism growth GO:0035264 1 0.014
regulation of mrna splicing via spliceosome GO:0048024 3 0.014
response to external biotic stimulus GO:0043207 221 0.014
stem cell development GO:0048864 11 0.014
regulation of molecular function GO:0065009 398 0.014
response to corticosteroid GO:0031960 235 0.014
gland development GO:0048732 155 0.013
male mating behavior GO:0060179 3 0.013
cellular component morphogenesis GO:0032989 155 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
stem cell maintenance GO:0019827 6 0.013
neuron development GO:0048666 286 0.013
regulation of cell differentiation GO:0045595 320 0.013
cellular response to peptide hormone stimulus GO:0071375 120 0.013
positive regulation of stem cell differentiation GO:2000738 2 0.013
response to camp GO:0051591 91 0.013
cellular ketone metabolic process GO:0042180 51 0.013
cell junction assembly GO:0034329 18 0.013
rhythmic process GO:0048511 156 0.013
negative regulation of cell cycle phase transition GO:1901988 4 0.012
heterocycle catabolic process GO:0046700 167 0.012
cell motility GO:0048870 202 0.012
regulation of myeloid cell differentiation GO:0045637 12 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
response to hydrogen peroxide GO:0042542 89 0.012
response to amine GO:0014075 46 0.012
cell cell signaling GO:0007267 335 0.012
catabolic process GO:0009056 351 0.012
cell type specific apoptotic process GO:0097285 134 0.012
cell junction organization GO:0034330 21 0.012
oxidation reduction process GO:0055114 304 0.012
mrna stabilization GO:0048255 2 0.012
localization of cell GO:0051674 202 0.012
positive regulation of myeloid cell differentiation GO:0045639 7 0.012
erythrocyte differentiation GO:0030218 1 0.012
embryonic pattern specification GO:0009880 1 0.012
protein processing GO:0016485 68 0.012
cellular lipid metabolic process GO:0044255 208 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
chromatin modification GO:0016568 33 0.011
cellular response to peptide GO:1901653 133 0.011
circadian regulation of gene expression GO:0032922 3 0.011
ncrna processing GO:0034470 3 0.011
response to glucose GO:0009749 136 0.011
neuron apoptotic process GO:0051402 88 0.011
neurological system process GO:0050877 219 0.011
liver development GO:0001889 90 0.011
embryo development GO:0009790 49 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
secretion GO:0046903 307 0.011
response to alkaloid GO:0043279 132 0.011
negative regulation of protein processing GO:0010955 47 0.011
stem cell differentiation GO:0048863 16 0.011
protein complex biogenesis GO:0070271 263 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
axis specification GO:0009798 4 0.011
dna integrity checkpoint GO:0031570 2 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
negative regulation of peptidase activity GO:0010466 38 0.011
regulation of neuron differentiation GO:0045664 208 0.011
cell growth GO:0016049 104 0.011
negative regulation of proteolysis GO:0045861 41 0.011
negative regulation of cell communication GO:0010648 158 0.010
sex determination GO:0007530 2 0.010
cellular macromolecule localization GO:0070727 122 0.010
regulation of protein processing GO:0070613 50 0.010
cellular response to reactive oxygen species GO:0034614 55 0.010
regulation of anatomical structure size GO:0090066 135 0.010
hepaticobiliary system development GO:0061008 90 0.010
male sex differentiation GO:0046661 64 0.010
heart morphogenesis GO:0003007 3 0.010
regulation of neuron death GO:1901214 115 0.010

Hmgb1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
nervous system disease DOID:863 0 0.029