Rattus norvegicus

47 known processes

Hmgcl

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase

Hmgcl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
lipid modification GO:0030258 52 0.346
lipid oxidation GO:0034440 30 0.311
oxoacid metabolic process GO:0043436 290 0.232
fatty acid beta oxidation GO:0006635 22 0.160
monocarboxylic acid metabolic process GO:0032787 152 0.154
single organism biosynthetic process GO:0044711 342 0.133
carboxylic acid metabolic process GO:0019752 289 0.133
organic acid metabolic process GO:0006082 292 0.122
cofactor metabolic process GO:0051186 95 0.116
small molecule catabolic process GO:0044282 59 0.116
catabolic process GO:0009056 351 0.112
single organism catabolic process GO:0044712 283 0.100
monocarboxylic acid catabolic process GO:0072329 28 0.096
cellular lipid catabolic process GO:0044242 37 0.092
lipid metabolic process GO:0006629 283 0.082
cellular lipid metabolic process GO:0044255 208 0.080
lipid catabolic process GO:0016042 46 0.079
oxidation reduction process GO:0055114 304 0.077
cellular catabolic process GO:0044248 295 0.073
coenzyme metabolic process GO:0006732 86 0.071
regulation of molecular function GO:0065009 398 0.067
organophosphate metabolic process GO:0019637 370 0.065
fatty acid oxidation GO:0019395 29 0.064
fatty acid metabolic process GO:0006631 99 0.052
organic substance catabolic process GO:1901575 316 0.049
organic acid catabolic process GO:0016054 49 0.047
response to oxygen levels GO:0070482 265 0.042
cellular ketone metabolic process GO:0042180 51 0.041
regulation of cellular ketone metabolic process GO:0010565 27 0.040
programmed cell death GO:0012501 392 0.038
cellular amino acid metabolic process GO:0006520 107 0.038
regulation of cell projection organization GO:0031344 175 0.037
organelle organization GO:0006996 266 0.036
carboxylic acid catabolic process GO:0046395 49 0.036
nucleoside phosphate metabolic process GO:0006753 283 0.036
fatty acid catabolic process GO:0009062 26 0.035
response to nutrient GO:0007584 248 0.035
positive regulation of multicellular organismal process GO:0051240 387 0.035
neuron differentiation GO:0030182 368 0.034
response to nutrient levels GO:0031667 370 0.033
regulation of multicellular organismal development GO:2000026 376 0.032
cellular response to oxygen containing compound GO:1901701 386 0.032
gland development GO:0048732 155 0.032
regulation of catalytic activity GO:0050790 304 0.031
reproductive process GO:0022414 372 0.031
neuron projection development GO:0031175 273 0.030
response to peptide GO:1901652 292 0.029
cell projection organization GO:0030030 302 0.029
regulation of programmed cell death GO:0043067 341 0.029
regulation of nervous system development GO:0051960 264 0.028
cellular response to nitrogen compound GO:1901699 210 0.028
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
cellular response to hormone stimulus GO:0032870 247 0.027
positive regulation of developmental process GO:0051094 283 0.027
response to glucocorticoid GO:0051384 223 0.026
steroid metabolic process GO:0008202 73 0.026
transcription dna templated GO:0006351 377 0.026
cellular response to organonitrogen compound GO:0071417 197 0.025
regulation of cell differentiation GO:0045595 320 0.025
regulation of phosphorus metabolic process GO:0051174 349 0.025
cellular component assembly GO:0022607 360 0.025
Human
lipid biosynthetic process GO:0008610 128 0.025
organic acid biosynthetic process GO:0016053 83 0.025
brain development GO:0007420 247 0.024
regulation of cellular amino acid metabolic process GO:0006521 2 0.023
positive regulation of molecular function GO:0044093 230 0.023
cellular response to endogenous stimulus GO:0071495 377 0.023
cation homeostasis GO:0055080 195 0.023
regulation of neurogenesis GO:0050767 247 0.023
carboxylic acid biosynthetic process GO:0046394 83 0.023
neuron development GO:0048666 286 0.023
cellular amine metabolic process GO:0044106 38 0.023
regulation of cell development GO:0060284 263 0.023
carbohydrate derivative metabolic process GO:1901135 346 0.023
ion homeostasis GO:0050801 212 0.023
cellular response to stress GO:0033554 269 0.022
multi organism reproductive process GO:0044703 262 0.022
regulation of apoptotic process GO:0042981 335 0.022
response to extracellular stimulus GO:0009991 380 0.022
negative regulation of protein metabolic process GO:0051248 114 0.022
response to peptide hormone GO:0043434 278 0.022
metal ion homeostasis GO:0055065 186 0.022
chemical homeostasis GO:0048878 292 0.021
regulation of neuron differentiation GO:0045664 208 0.021
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
response to decreased oxygen levels GO:0036293 237 0.021
response to cytokine GO:0034097 215 0.021
regulation of protein metabolic process GO:0051246 289 0.021
regulation of phosphorylation GO:0042325 248 0.021
developmental process involved in reproduction GO:0003006 159 0.021
immune system process GO:0002376 204 0.020
regulation of nucleic acid templated transcription GO:1903506 380 0.020
positive regulation of transport GO:0051050 245 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.020
central nervous system development GO:0007417 311 0.020
negative regulation of metabolic process GO:0009892 331 0.020
nucleotide metabolic process GO:0009117 279 0.019
reactive nitrogen species metabolic process GO:2001057 1 0.019
rna biosynthetic process GO:0032774 380 0.019
negative regulation of programmed cell death GO:0043069 183 0.019
rna metabolic process GO:0016070 406 0.019
regulation of phosphate metabolic process GO:0019220 349 0.019
head development GO:0060322 247 0.019
homeostatic process GO:0042592 331 0.019
anion transport GO:0006820 178 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
Human
positive regulation of cell differentiation GO:0045597 217 0.019
cellular component biogenesis GO:0044085 368 0.019
Human
cellular chemical homeostasis GO:0055082 247 0.019
negative regulation of signaling GO:0023057 157 0.018
apoptotic process GO:0006915 381 0.018
ion transmembrane transport GO:0034220 365 0.018
reproduction GO:0000003 245 0.018
intracellular signal transduction GO:0035556 314 0.018
regulation of neuron projection development GO:0010975 161 0.018
single organism organelle organization GO:1902589 180 0.018
organonitrogen compound biosynthetic process GO:1901566 167 0.018
response to ketone GO:1901654 182 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
regulation of cellular protein metabolic process GO:0032268 267 0.017
thioester metabolic process GO:0035383 28 0.017
negative regulation of cellular protein metabolic process GO:0032269 106 0.017
cellular response to organic cyclic compound GO:0071407 202 0.017
protein phosphorylation GO:0006468 345 0.017
positive regulation of biosynthetic process GO:0009891 319 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
negative regulation of biosynthetic process GO:0009890 168 0.017
amine metabolic process GO:0009308 38 0.017
regulation of rna biosynthetic process GO:2001141 381 0.017
response to external biotic stimulus GO:0043207 221 0.017
regulation of hormone levels GO:0010817 187 0.017
positive regulation of catalytic activity GO:0043085 184 0.016
response to glucose GO:0009749 136 0.016
positive regulation of response to stimulus GO:0048584 285 0.016
hematopoietic progenitor cell differentiation GO:0002244 2 0.016
intracellular transport GO:0046907 185 0.016
multicellular organism reproduction GO:0032504 233 0.016
response to inorganic substance GO:0010035 377 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
response to vitamin GO:0033273 131 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
purine containing compound metabolic process GO:0072521 253 0.016
transmembrane transport GO:0055085 412 0.016
cation transport GO:0006812 382 0.016
metal ion transport GO:0030001 289 0.016
negative regulation of cellular metabolic process GO:0031324 281 0.016
cellular metal ion homeostasis GO:0006875 172 0.015
steroid biosynthetic process GO:0006694 48 0.015
response to hypoxia GO:0001666 231 0.015
regulation of catabolic process GO:0009894 113 0.015
multicellular organismal reproductive process GO:0048609 233 0.015
positive regulation of cell motility GO:2000147 97 0.015
cellular cation homeostasis GO:0030003 180 0.015
regulation of cellular localization GO:0060341 263 0.015
cellular response to peptide hormone stimulus GO:0071375 120 0.015
organophosphate biosynthetic process GO:0090407 143 0.015
gamete generation GO:0007276 124 0.015
negative regulation of cell communication GO:0010648 158 0.015
positive regulation of phosphorus metabolic process GO:0010562 262 0.015
regulation of intracellular signal transduction GO:1902531 218 0.015
response to hexose GO:0009746 144 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
sexual reproduction GO:0019953 148 0.014
positive regulation of phosphate metabolic process GO:0045937 262 0.014
regeneration GO:0031099 163 0.014
negative regulation of gene expression GO:0010629 199 0.014
response to radiation GO:0009314 137 0.014
cellular homeostasis GO:0019725 252 0.014
organic acid transport GO:0015849 116 0.014
carbohydrate metabolic process GO:0005975 130 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.014
regulation of transcription dna templated GO:0006355 374 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
negative regulation of macromolecule metabolic process GO:0010605 260 0.014
protein localization GO:0008104 191 0.014
regulation of hydrolase activity GO:0051336 143 0.014
protein complex assembly GO:0006461 263 0.014
Human
protein oligomerization GO:0051259 191 0.014
Human
nucleic acid templated transcription GO:0097659 379 0.014
negative regulation of neurogenesis GO:0050768 78 0.014
small molecule biosynthetic process GO:0044283 124 0.014
regulation of cellular component organization GO:0051128 368 0.014
positive regulation of cell communication GO:0010647 271 0.014
positive regulation of cellular component organization GO:0051130 200 0.014
response to reactive oxygen species GO:0000302 120 0.013
regulation of homeostatic process GO:0032844 101 0.013
positive regulation of cell development GO:0010720 176 0.013
tissue development GO:0009888 252 0.013
secretion GO:0046903 307 0.013
regulation of signal transduction GO:0009966 318 0.013
nucleoside phosphate biosynthetic process GO:1901293 102 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
coenzyme biosynthetic process GO:0009108 22 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
hepaticobiliary system development GO:0061008 90 0.013
response to mechanical stimulus GO:0009612 134 0.013
cellular response to peptide GO:1901653 133 0.013
cellular protein localization GO:0034613 122 0.013
single organism reproductive process GO:0044702 297 0.013
regulation of kinase activity GO:0043549 117 0.013
response to biotic stimulus GO:0009607 226 0.013
regulation of rna metabolic process GO:0051252 391 0.013
regulation of cell proliferation GO:0042127 359 0.013
negative regulation of nervous system development GO:0051961 79 0.013
positive regulation of cell proliferation GO:0008284 249 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
peptidyl amino acid modification GO:0018193 126 0.012
response to bacterium GO:0009617 200 0.012
cellular ion homeostasis GO:0006873 184 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
blood circulation GO:0008015 183 0.012
cellular component movement GO:0006928 248 0.012
alpha amino acid metabolic process GO:1901605 71 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
response to corticosteroid GO:0031960 235 0.012
growth GO:0040007 165 0.012
response to estrogen GO:0043627 232 0.012
regulation of cellular catabolic process GO:0031329 101 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
organic anion transport GO:0015711 132 0.012
nitrogen compound transport GO:0071705 229 0.012
defense response GO:0006952 194 0.012
regulation of protein kinase activity GO:0045859 105 0.012
response to metal ion GO:0010038 253 0.012
carboxylic acid transport GO:0046942 115 0.012
development of primary sexual characteristics GO:0045137 107 0.012
purine ribonucleotide metabolic process GO:0009150 227 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
female pregnancy GO:0007565 122 0.012
response to molecule of bacterial origin GO:0002237 194 0.012
regulation of protein modification process GO:0031399 194 0.012
macromolecule localization GO:0033036 252 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
protein complex biogenesis GO:0070271 263 0.012
Human
lymphoid progenitor cell differentiation GO:0002320 2 0.012
neurological system process GO:0050877 219 0.012
negative regulation of molecular function GO:0044092 133 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
aging GO:0007568 241 0.011
nucleotide biosynthetic process GO:0009165 98 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.011
negative regulation of cell development GO:0010721 82 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
regulation of blood pressure GO:0008217 83 0.011
axon development GO:0061564 96 0.011
divalent inorganic cation transport GO:0072511 134 0.011
positive regulation of nervous system development GO:0051962 178 0.011
negative regulation of phosphorus metabolic process GO:0010563 80 0.011
acetyl coa metabolic process GO:0006084 17 0.011
negative regulation of secretion GO:0051048 82 0.011
pteridine containing compound metabolic process GO:0042558 14 0.011
mitochondrion organization GO:0007005 35 0.011
pyridine containing compound metabolic process GO:0072524 32 0.011
response to monosaccharide GO:0034284 159 0.011
positive regulation of cellular protein metabolic process GO:0032270 167 0.011
purine nucleotide biosynthetic process GO:0006164 83 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
protein complex subunit organization GO:0071822 302 0.011
Human
response to insulin GO:0032868 133 0.011
calcium ion homeostasis GO:0055074 162 0.011
carbohydrate catabolic process GO:0016052 40 0.011
cellular response to alcohol GO:0097306 87 0.010
nicotinamide nucleotide metabolic process GO:0046496 28 0.010
heterocycle catabolic process GO:0046700 167 0.010
chromosome segregation GO:0007059 2 0.010
negative regulation of signal transduction GO:0009968 83 0.010
localization of cell GO:0051674 202 0.010
kidney development GO:0001822 67 0.010
g protein coupled receptor signaling pathway GO:0007186 242 0.010
spermatogenesis GO:0007283 99 0.010
cofactor biosynthetic process GO:0051188 28 0.010

Hmgcl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.026
inherited metabolic disorder DOID:655 0 0.026
nervous system disease DOID:863 0 0.018
disease of anatomical entity DOID:7 0 0.018
disease of cellular proliferation DOID:14566 0 0.012
sensory system disease DOID:0050155 0 0.010