Rattus norvegicus

254 known processes

Hmgcr

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

(Aliases: 3H3M)

Hmgcr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cholesterol metabolic process GO:0008203 17 0.781
lipid biosynthetic process GO:0008610 128 0.776
alcohol biosynthetic process GO:0046165 38 0.773
steroid metabolic process GO:0008202 73 0.571
lipid metabolic process GO:0006629 283 0.538
single organism biosynthetic process GO:0044711 342 0.490
cellular response to oxygen containing compound GO:1901701 386 0.454
steroid biosynthetic process GO:0006694 48 0.406
sterol metabolic process GO:0016125 18 0.394
cellular response to fatty acid GO:0071398 29 0.319
cellular lipid metabolic process GO:0044255 208 0.313
cellular response to nitrogen compound GO:1901699 210 0.301
hepaticobiliary system development GO:0061008 90 0.299
cellular response to peptide GO:1901653 133 0.297
cellular response to alcohol GO:0097306 87 0.294
response to triglyceride GO:0034014 3 0.235
response to molecule of bacterial origin GO:0002237 194 0.229
cellular response to gonadotropin stimulus GO:0071371 17 0.228
response to temperature stimulus GO:0009266 94 0.226
gonad development GO:0008406 104 0.200
response to fatty acid GO:0070542 65 0.192
regulation of cholesterol metabolic process GO:0090181 5 0.180
response to metal ion GO:0010038 253 0.179
cellular response to lipid GO:0071396 201 0.165
cellular response to organic cyclic compound GO:0071407 202 0.159
tube development GO:0035295 89 0.154
growth GO:0040007 165 0.135
response to extracellular stimulus GO:0009991 380 0.134
cellular ketone body metabolic process GO:0046950 4 0.133
cellular response to insulin stimulus GO:0032869 81 0.128
response to organophosphorus GO:0046683 102 0.126
cellular response to organonitrogen compound GO:0071417 197 0.121
response to ketone GO:1901654 182 0.114
cellular response to molecule of bacterial origin GO:0071219 56 0.110
liver development GO:0001889 90 0.102
response to acid chemical GO:0001101 222 0.101
response to peptide GO:1901652 292 0.095
organic hydroxy compound metabolic process GO:1901615 115 0.092
response to nutrient GO:0007584 248 0.092
cellular response to cholesterol GO:0071397 9 0.090
cellular response to peptide hormone stimulus GO:0071375 120 0.089
intracellular signal transduction GO:0035556 314 0.084
head development GO:0060322 247 0.084
cellular response to follicle stimulating hormone stimulus GO:0071372 13 0.083
brain development GO:0007420 247 0.078
urogenital system development GO:0001655 78 0.077
protein complex subunit organization GO:0071822 302 0.069
coenzyme metabolic process GO:0006732 86 0.065
response to linoleic acid GO:0070543 3 0.065
cellular response to hormone stimulus GO:0032870 247 0.061
demethylation GO:0070988 7 0.060
cholesterol biosynthetic process GO:0006695 10 0.059
response to starvation GO:0042594 59 0.059
cellular response to stress GO:0033554 269 0.059
small molecule biosynthetic process GO:0044283 124 0.059
secretion GO:0046903 307 0.058
response to monosaccharide GO:0034284 159 0.058
regulation of fatty acid transport GO:2000191 10 0.055
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.054
regulation of apoptotic process GO:0042981 335 0.054
central nervous system development GO:0007417 311 0.054
anatomical structure morphogenesis GO:0009653 298 0.053
response to cholesterol GO:0070723 13 0.053
response to nutrient levels GO:0031667 370 0.051
response to oxygen levels GO:0070482 265 0.051
cellular response to lipopolysaccharide GO:0071222 55 0.051
protein complex biogenesis GO:0070271 263 0.051
positive regulation of cell growth GO:0030307 44 0.051
response to inorganic substance GO:0010035 377 0.050
monocarboxylic acid metabolic process GO:0032787 152 0.050
tissue development GO:0009888 252 0.049
response to cytokine GO:0034097 215 0.048
regulation of multicellular organismal development GO:2000026 376 0.048
response to insulin GO:0032868 133 0.047
positive regulation of programmed cell death GO:0043068 157 0.046
metanephric epithelium development GO:0072207 4 0.045
positive regulation of multicellular organismal process GO:0051240 387 0.044
single organism reproductive process GO:0044702 297 0.041
regulation of developmental growth GO:0048638 45 0.040
macromolecular complex assembly GO:0065003 273 0.040
sterol homeostasis GO:0055092 3 0.039
organic acid metabolic process GO:0006082 292 0.039
cellular response to endogenous stimulus GO:0071495 377 0.039
nucleic acid templated transcription GO:0097659 379 0.039
regulation of phosphate metabolic process GO:0019220 349 0.039
neuron differentiation GO:0030182 368 0.039
alcohol metabolic process GO:0006066 77 0.038
midgut development GO:0007494 13 0.036
amine metabolic process GO:0009308 38 0.036
response to biotic stimulus GO:0009607 226 0.036
cellular component assembly GO:0022607 360 0.036
response to corticosteroid GO:0031960 235 0.034
cellular amine metabolic process GO:0044106 38 0.034
regulation of secretion GO:0051046 224 0.033
neuron development GO:0048666 286 0.033
organic anion transport GO:0015711 132 0.033
positive regulation of biosynthetic process GO:0009891 319 0.033
regulation of cell differentiation GO:0045595 320 0.033
regulation of cell development GO:0060284 263 0.033
response to testosterone GO:0033574 55 0.032
regulation of molecular function GO:0065009 398 0.032
response to carbohydrate GO:0009743 183 0.031
isoprenoid metabolic process GO:0006720 45 0.030
reproductive structure development GO:0048608 128 0.030
rna biosynthetic process GO:0032774 380 0.030
lipid localization GO:0010876 62 0.030
positive regulation of signaling GO:0023056 270 0.029
protein autophosphorylation GO:0046777 66 0.028
cellular response to steroid hormone stimulus GO:0071383 93 0.028
regulation of cellular amine metabolic process GO:0033238 8 0.028
regulation of rna biosynthetic process GO:2001141 381 0.028
signal transduction by phosphorylation GO:0023014 144 0.028
cellular response to biotic stimulus GO:0071216 59 0.028
negative regulation of molecular function GO:0044092 133 0.028
respiratory system development GO:0060541 45 0.028
response to purine containing compound GO:0014074 126 0.027
response to peptide hormone GO:0043434 278 0.027
regulation of cellular component organization GO:0051128 368 0.027
reproduction GO:0000003 245 0.026
cellular component biogenesis GO:0044085 368 0.026
cation transmembrane transport GO:0098655 263 0.026
response to interleukin 15 GO:0070672 4 0.026
regulation of signal transduction GO:0009966 318 0.026
macromolecular complex subunit organization GO:0043933 339 0.025
metal ion transport GO:0030001 289 0.025
cellular response to acid chemical GO:0071229 75 0.025
reproductive process GO:0022414 372 0.025
positive regulation of cell development GO:0010720 176 0.024
erythrocyte differentiation GO:0030218 1 0.024
cell morphogenesis GO:0000902 142 0.024
ras protein signal transduction GO:0007265 29 0.024
single organism organelle organization GO:1902589 180 0.024
response to other organism GO:0051707 220 0.024
protein phosphorylation GO:0006468 345 0.023
regulation of response to stress GO:0080134 126 0.023
nucleobase containing small molecule metabolic process GO:0055086 316 0.023
regulation of hormone secretion GO:0046883 106 0.023
response to hypoxia GO:0001666 231 0.023
positive regulation of transport GO:0051050 245 0.023
response to estrogen GO:0043627 232 0.023
organophosphate catabolic process GO:0046434 148 0.023
positive regulation of cell death GO:0010942 184 0.022
cation transport GO:0006812 382 0.022
fatty acid metabolic process GO:0006631 99 0.022
isoprenoid biosynthetic process GO:0008299 12 0.022
regulation of synaptic transmission GO:0050804 141 0.022
icosanoid metabolic process GO:0006690 38 0.022
regulation of neuron projection development GO:0010975 161 0.022
catabolic process GO:0009056 351 0.022
response to amino acid GO:0043200 75 0.022
positive regulation of secretion GO:0051047 140 0.022
rna metabolic process GO:0016070 406 0.021
organic acid biosynthetic process GO:0016053 83 0.021
cell projection organization GO:0030030 302 0.021
programmed cell death GO:0012501 392 0.021
inorganic ion transmembrane transport GO:0098660 229 0.021
neuron projection development GO:0031175 273 0.021
apoptotic process GO:0006915 381 0.021
transcription dna templated GO:0006351 377 0.021
organelle organization GO:0006996 266 0.020
organic substance catabolic process GO:1901575 316 0.020
response to wounding GO:0009611 254 0.020
single organism catabolic process GO:0044712 283 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
circulatory system development GO:0072359 134 0.020
carbohydrate homeostasis GO:0033500 75 0.020
response to interleukin 1 GO:0070555 55 0.020
reproductive system development GO:0061458 128 0.020
cellular catabolic process GO:0044248 295 0.020
positive regulation of cellular component organization GO:0051130 200 0.019
regulation of cellular ketone metabolic process GO:0010565 27 0.019
positive regulation of apoptotic process GO:0043065 154 0.019
regulation of system process GO:0044057 208 0.019
anion transport GO:0006820 178 0.019
regulation of bmp signaling pathway GO:0030510 2 0.019
regulation of programmed cell death GO:0043067 341 0.019
positive regulation of cell differentiation GO:0045597 217 0.019
regulation of intracellular signal transduction GO:1902531 218 0.019
lipid transport GO:0006869 61 0.019
positive regulation of developmental process GO:0051094 283 0.019
response to camp GO:0051591 91 0.019
negative regulation of cell death GO:0060548 229 0.018
cellular amino acid metabolic process GO:0006520 107 0.018
cellular response to cytokine stimulus GO:0071345 127 0.018
regulation of rna metabolic process GO:0051252 391 0.018
cellular response to external stimulus GO:0071496 118 0.018
protein complex assembly GO:0006461 263 0.018
response to vitamin GO:0033273 131 0.018
monovalent inorganic cation transport GO:0015672 172 0.018
hormone secretion GO:0046879 115 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.017
transmembrane transport GO:0055085 412 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
endocytosis GO:0006897 84 0.017
carboxylic acid metabolic process GO:0019752 289 0.017
negative regulation of developmental process GO:0051093 125 0.017
multicellular organism reproduction GO:0032504 233 0.017
cellular amino acid biosynthetic process GO:0008652 32 0.017
reactive oxygen species biosynthetic process GO:1903409 8 0.017
response to external biotic stimulus GO:0043207 221 0.017
response to lipopolysaccharide GO:0032496 191 0.016
response to estradiol GO:0032355 164 0.016
response to sterol GO:0036314 13 0.016
macromolecule localization GO:0033036 252 0.016
negative regulation of multicellular organismal process GO:0051241 203 0.016
nucleoside triphosphate metabolic process GO:0009141 144 0.016
immune system process GO:0002376 204 0.016
circulatory system process GO:0003013 183 0.016
cellular chemical homeostasis GO:0055082 247 0.016
cytoskeleton organization GO:0007010 111 0.016
cellular homeostasis GO:0019725 252 0.016
regulation of transferase activity GO:0051338 123 0.016
regulation of cellular localization GO:0060341 263 0.016
bmp signaling pathway GO:0030509 4 0.016
organophosphate metabolic process GO:0019637 370 0.015
regulation of nucleic acid templated transcription GO:1903506 380 0.015
transcription from rna polymerase ii promoter GO:0006366 252 0.015
response to follicle stimulating hormone GO:0032354 18 0.015
regulation of ion transport GO:0043269 245 0.015
cellular response to extracellular stimulus GO:0031668 73 0.015
embryonic pattern specification GO:0009880 1 0.015
multicellular organism growth GO:0035264 1 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
inorganic cation transmembrane transport GO:0098662 202 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.015
negative regulation of metabolic process GO:0009892 331 0.015
regulation of transcription dna templated GO:0006355 374 0.015
short chain fatty acid biosynthetic process GO:0051790 2 0.014
signal release GO:0023061 145 0.014
acetate metabolic process GO:0006083 2 0.014
gland development GO:0048732 155 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
monocarboxylic acid transport GO:0015718 52 0.014
digestive tract development GO:0048565 39 0.014
regulation of anatomical structure morphogenesis GO:0022603 141 0.014
regulation of cell projection organization GO:0031344 175 0.014
negative regulation of apoptotic process GO:0043066 181 0.014
regulation of lipid biosynthetic process GO:0046890 38 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
response to radiation GO:0009314 137 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
synaptic transmission GO:0007268 235 0.014
homeostatic process GO:0042592 331 0.014
nucleotide metabolic process GO:0009117 279 0.014
acid secretion GO:0046717 48 0.014
regulation of hormone levels GO:0010817 187 0.014
positive regulation of hydrolase activity GO:0051345 86 0.013
locomotion GO:0040011 237 0.013
response to decreased oxygen levels GO:0036293 237 0.013
enzyme linked receptor protein signaling pathway GO:0007167 116 0.013
actin filament based process GO:0030029 86 0.013
peptide hormone secretion GO:0030072 84 0.013
response to bacterium GO:0009617 200 0.013
dendrite development GO:0016358 72 0.013
carbohydrate derivative metabolic process GO:1901135 346 0.013
organic acid transport GO:0015849 116 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.013
regulation of lipid metabolic process GO:0019216 68 0.013
oxidation reduction process GO:0055114 304 0.013
developmental process involved in reproduction GO:0003006 159 0.013
muscle system process GO:0003012 115 0.013
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.013
striated muscle tissue development GO:0014706 58 0.013
regulation of homeostatic process GO:0032844 101 0.013
positive regulation of molecular function GO:0044093 230 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
cellular response to ketone GO:1901655 51 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
cellular ketone metabolic process GO:0042180 51 0.013
mammary gland epithelium development GO:0061180 1 0.013
peptide secretion GO:0002790 86 0.013
membrane organization GO:0061024 94 0.012
lung development GO:0030324 43 0.012
cellular component morphogenesis GO:0032989 155 0.012
hemopoiesis GO:0030097 34 0.012
regulation of phosphorylation GO:0042325 248 0.012
positive regulation of protein metabolic process GO:0051247 178 0.012
nitrogen compound transport GO:0071705 229 0.012
negative regulation of cell communication GO:0010648 158 0.012
positive regulation of phosphate metabolic process GO:0045937 262 0.012
nucleoside phosphate metabolic process GO:0006753 283 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
metanephric nephron tubule development GO:0072234 3 0.012
muscle contraction GO:0006936 88 0.012
oxoacid metabolic process GO:0043436 290 0.012
adipose tissue development GO:0060612 6 0.012
hormone transport GO:0009914 121 0.012
neuron death GO:0070997 127 0.012
chemical homeostasis GO:0048878 292 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
heart morphogenesis GO:0003007 3 0.012
regulation of cell morphogenesis GO:0022604 77 0.012
negative regulation of ion transport GO:0043271 51 0.012
cell cycle GO:0007049 101 0.012
regulation of cholesterol biosynthetic process GO:0045540 4 0.012
regulation of cytokine production GO:0001817 56 0.012
response to ethanol GO:0045471 162 0.012
regulation of protein metabolic process GO:0051246 289 0.012
response to hexose GO:0009746 144 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
purine containing compound metabolic process GO:0072521 253 0.011
positive regulation of protein phosphorylation GO:0001934 135 0.011
respiratory tube development GO:0030323 43 0.011
b cell differentiation GO:0030183 2 0.011
regulation of phosphorus metabolic process GO:0051174 349 0.011
regulation of cellular protein metabolic process GO:0032268 267 0.011
regulation of synaptic plasticity GO:0048167 70 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.011
ion transmembrane transport GO:0034220 365 0.011
regulation of nervous system development GO:0051960 264 0.011
microtubule based process GO:0007017 36 0.011
organic hydroxy compound biosynthetic process GO:1901617 51 0.011
response to alkaloid GO:0043279 132 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
negative regulation of rna metabolic process GO:0051253 123 0.011
regulation of cell growth GO:0001558 85 0.011
wound healing GO:0042060 122 0.011
response to lipoprotein particle GO:0055094 8 0.011
axis specification GO:0009798 4 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
cell cell signaling GO:0007267 335 0.011
response to glucocorticoid GO:0051384 223 0.011
glucose homeostasis GO:0042593 75 0.011
regulation of organic acid transport GO:0032890 35 0.011
regulation of cell proliferation GO:0042127 359 0.011
regulation of vesicle mediated transport GO:0060627 81 0.011
chromosome segregation GO:0007059 2 0.011
regulation of insulin secretion GO:0050796 65 0.011
potassium ion transmembrane transport GO:0071805 71 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
protein oligomerization GO:0051259 191 0.011
gliogenesis GO:0042063 93 0.011
female pregnancy GO:0007565 122 0.011
regulation of protein serine threonine kinase activity GO:0071900 64 0.010
prostaglandin transport GO:0015732 8 0.010
regulation of neuron differentiation GO:0045664 208 0.010
glycerolipid metabolic process GO:0046486 67 0.010
protein homooligomerization GO:0051260 91 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.010
centrosome cycle GO:0007098 1 0.010
response to stilbenoid GO:0035634 1 0.010
response to hydrogen peroxide GO:0042542 89 0.010
single organism behavior GO:0044708 130 0.010
mechanoreceptor differentiation GO:0042490 2 0.010
regulation of reactive oxygen species metabolic process GO:2000377 26 0.010
reactive nitrogen species metabolic process GO:2001057 1 0.010
thioester metabolic process GO:0035383 28 0.010
positive regulation of catalytic activity GO:0043085 184 0.010
positive regulation of ion transport GO:0043270 94 0.010
multi organism reproductive process GO:0044703 262 0.010
regulation of hydrolase activity GO:0051336 143 0.010
mitotic spindle organization GO:0007052 2 0.010
regulation of cell motility GO:2000145 131 0.010
protein heterooligomerization GO:0051291 89 0.010
negative regulation of catalytic activity GO:0043086 103 0.010

Hmgcr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
intellectual disability DOID:1059 0 0.046
specific developmental disorder DOID:0060038 0 0.046
non specific x linked mental retardation DOID:0050776 0 0.046
developmental disorder of mental health DOID:0060037 0 0.046
disease of mental health DOID:150 0 0.046
non syndromic intellectual disability DOID:0050889 0 0.046
nervous system disease DOID:863 0 0.012
disease of anatomical entity DOID:7 0 0.012
disease of metabolism DOID:0014667 0 0.011
disease of cellular proliferation DOID:14566 0 0.010