Rattus norvegicus

74 known processes

Hmgcs1

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)

Hmgcs1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
lipid biosynthetic process GO:0008610 128 1.000
alcohol biosynthetic process GO:0046165 38 0.993
isoprenoid metabolic process GO:0006720 45 0.980
cholesterol metabolic process GO:0008203 17 0.921
lipid metabolic process GO:0006629 283 0.915
single organism biosynthetic process GO:0044711 342 0.858
Rat
steroid biosynthetic process GO:0006694 48 0.855
sterol metabolic process GO:0016125 18 0.844
response to fatty acid GO:0070542 65 0.787
Rat
steroid metabolic process GO:0008202 73 0.780
sterol biosynthetic process GO:0016126 10 0.779
alcohol metabolic process GO:0006066 77 0.712
isoprenoid biosynthetic process GO:0008299 12 0.653
cellular lipid metabolic process GO:0044255 208 0.645
gonad development GO:0008406 104 0.584
cellular response to oxygen containing compound GO:1901701 386 0.562
cellular ketone body metabolic process GO:0046950 4 0.537
Rat
response to acid chemical GO:0001101 222 0.495
Rat
positive regulation of cardiac muscle cell apoptotic process GO:0010666 3 0.493
regulation of cholesterol metabolic process GO:0090181 5 0.476
response to peptide hormone GO:0043434 278 0.442
Rat
cellular response to nitrogen compound GO:1901699 210 0.427
Rat
head development GO:0060322 247 0.403
metanephric tubule development GO:0072170 4 0.383
organic hydroxy compound metabolic process GO:1901615 115 0.366
cellular response to organonitrogen compound GO:0071417 197 0.365
Rat
metanephric epithelium development GO:0072207 4 0.346
cholesterol biosynthetic process GO:0006695 10 0.337
small molecule biosynthetic process GO:0044283 124 0.328
Rat
tissue development GO:0009888 252 0.283
Rat
cofactor metabolic process GO:0051186 95 0.218
organophosphate metabolic process GO:0019637 370 0.194
demethylation GO:0070988 7 0.181
muscle cell apoptotic process GO:0010657 30 0.173
secretion GO:0046903 307 0.156
organic hydroxy compound biosynthetic process GO:1901617 51 0.148
regulation of response to wounding GO:1903034 69 0.146
positive regulation of cell growth GO:0030307 44 0.137
organophosphate biosynthetic process GO:0090407 143 0.131
coenzyme metabolic process GO:0006732 86 0.125
intracellular signal transduction GO:0035556 314 0.095
regulation of developmental growth GO:0048638 45 0.092
regulation of multicellular organismal development GO:2000026 376 0.089
positive regulation of skeletal muscle tissue development GO:0048643 4 0.083
fatty acid metabolic process GO:0006631 99 0.078
brain development GO:0007420 247 0.075
cation transport GO:0006812 382 0.071
positive regulation of muscle organ development GO:0048636 13 0.070
monocarboxylic acid metabolic process GO:0032787 152 0.070
regulation of muscle organ development GO:0048634 26 0.069
thioester metabolic process GO:0035383 28 0.066
striated muscle tissue development GO:0014706 58 0.059
carboxylic acid metabolic process GO:0019752 289 0.058
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.057
phospholipid biosynthetic process GO:0008654 29 0.057
response to interleukin 15 GO:0070672 4 0.056
cellular response to lipid GO:0071396 201 0.053
acetate metabolic process GO:0006083 2 0.052
neuron differentiation GO:0030182 368 0.052
negative regulation of vasodilation GO:0045908 3 0.051
cellular chemical homeostasis GO:0055082 247 0.051
response to ketone GO:1901654 182 0.050
Rat
reproductive process GO:0022414 372 0.050
positive regulation of response to stimulus GO:0048584 285 0.049
oxidoreduction coenzyme metabolic process GO:0006733 31 0.048
growth GO:0040007 165 0.047
response to metal ion GO:0010038 253 0.046
Rat
positive regulation of multicellular organismal process GO:0051240 387 0.046
protein complex biogenesis GO:0070271 263 0.045
regulation of cell development GO:0060284 263 0.042
regulation of cell differentiation GO:0045595 320 0.041
response to hexose GO:0009746 144 0.040
tube development GO:0035295 89 0.040
Rat
regulation of phosphate metabolic process GO:0019220 349 0.039
positive regulation of signaling GO:0023056 270 0.039
neuron projection development GO:0031175 273 0.039
metanephric nephron tubule development GO:0072234 3 0.038
positive regulation of phosphorus metabolic process GO:0010562 262 0.038
response to external biotic stimulus GO:0043207 221 0.038
Rat
macromolecular complex assembly GO:0065003 273 0.038
regulation of cell growth GO:0001558 85 0.038
positive regulation of developmental process GO:0051094 283 0.038
acyl coa metabolic process GO:0006637 28 0.038
nitrogen compound transport GO:0071705 229 0.037
organonitrogen compound biosynthetic process GO:1901566 167 0.037
regulation of cell proliferation GO:0042127 359 0.036
cellular response to peptide hormone stimulus GO:0071375 120 0.036
Rat
regulation of intracellular signal transduction GO:1902531 218 0.036
regulation of secretion by cell GO:1903530 208 0.036
regulation of phosphorus metabolic process GO:0051174 349 0.035
regulation of hormone levels GO:0010817 187 0.035
cellular component assembly GO:0022607 360 0.035
response to nutrient GO:0007584 248 0.035
regulation of cell growth involved in cardiac muscle cell development GO:0061050 6 0.035
regulation of alcohol biosynthetic process GO:1902930 12 0.034
regulation of signal transduction GO:0009966 318 0.034
protein oligomerization GO:0051259 191 0.034
response to extracellular stimulus GO:0009991 380 0.034
central nervous system development GO:0007417 311 0.034
cellular response to peptide GO:1901653 133 0.034
Rat
single organism catabolic process GO:0044712 283 0.033
cell cell signaling GO:0007267 335 0.033
spinal cord dorsal ventral patterning GO:0021513 2 0.033
regulation of cellular localization GO:0060341 263 0.032
organic acid metabolic process GO:0006082 292 0.032
cellular homeostasis GO:0019725 252 0.031
amide transport GO:0042886 105 0.031
regulation of stress activated protein kinase signaling cascade GO:0070302 23 0.031
regulation of stress activated mapk cascade GO:0032872 23 0.031
regulation of cholesterol biosynthetic process GO:0045540 4 0.030
response to glucose GO:0009749 136 0.030
response to estrogen GO:0043627 232 0.030
positive regulation of phosphorylation GO:0042327 177 0.030
cellular amino acid metabolic process GO:0006520 107 0.029
positive regulation of intracellular signal transduction GO:1902533 138 0.029
regulation of apoptotic process GO:0042981 335 0.029
muscle system process GO:0003012 115 0.028
regulation of rna biosynthetic process GO:2001141 381 0.028
regulation of programmed cell death GO:0043067 341 0.028
regulation of cellular amine metabolic process GO:0033238 8 0.028
cellular catabolic process GO:0044248 295 0.028
mapk cascade GO:0000165 140 0.028
organic acid biosynthetic process GO:0016053 83 0.028
positive regulation of striated muscle cell apoptotic process GO:0010663 3 0.027
reproduction GO:0000003 245 0.027
cellular response to stress GO:0033554 269 0.027
insulin secretion GO:0030073 69 0.027
long chain fatty acid transport GO:0015909 14 0.026
response to peptide GO:1901652 292 0.026
Rat
regulation of cellular component organization GO:0051128 368 0.026
programmed cell death GO:0012501 392 0.026
neuron development GO:0048666 286 0.026
regulation of secretion GO:0051046 224 0.026
positive regulation of cell development GO:0010720 176 0.026
metal ion transport GO:0030001 289 0.026
gamete generation GO:0007276 124 0.025
response to estradiol GO:0032355 164 0.025
regulation of system process GO:0044057 208 0.025
response to nutrient levels GO:0031667 370 0.025
secretion by cell GO:0032940 248 0.024
negative regulation of cell communication GO:0010648 158 0.024
cellular component biogenesis GO:0044085 368 0.024
response to cholesterol GO:0070723 13 0.024
positive regulation of cellular component organization GO:0051130 200 0.024
positive regulation of cell communication GO:0010647 271 0.024
positive regulation of transport GO:0051050 245 0.024
regulation of nucleic acid templated transcription GO:1903506 380 0.023
single organism reproductive process GO:0044702 297 0.023
peptide secretion GO:0002790 86 0.023
cellular response to insulin stimulus GO:0032869 81 0.023
Rat
positive regulation of phosphate metabolic process GO:0045937 262 0.022
negative regulation of multicellular organismal process GO:0051241 203 0.022
response to carbohydrate GO:0009743 183 0.022
Rat
neuron death GO:0070997 127 0.022
regulation of peptide transport GO:0090087 87 0.022
protein complex assembly GO:0006461 263 0.022
cellular amine metabolic process GO:0044106 38 0.022
circulatory system development GO:0072359 134 0.022
terpenoid biosynthetic process GO:0016114 8 0.022
hormone transport GO:0009914 121 0.022
multicellular organism reproduction GO:0032504 233 0.022
multicellular organismal signaling GO:0035637 44 0.021
developmental growth GO:0048589 100 0.021
organic acid transport GO:0015849 116 0.021
hormone secretion GO:0046879 115 0.021
response to fungus GO:0009620 8 0.021
chemical homeostasis GO:0048878 292 0.021
response to stilbenoid GO:0035634 1 0.021
rna metabolic process GO:0016070 406 0.021
ras protein signal transduction GO:0007265 29 0.021
regulation of neuron differentiation GO:0045664 208 0.021
cell projection organization GO:0030030 302 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
positive regulation of cell proliferation GO:0008284 249 0.021
response to ethanol GO:0045471 162 0.021
Rat
phospholipid metabolic process GO:0006644 61 0.021
catabolic process GO:0009056 351 0.020
positive regulation of stress activated protein kinase signaling cascade GO:0070304 17 0.020
oxoacid metabolic process GO:0043436 290 0.020
positive regulation of programmed cell death GO:0043068 157 0.020
regulation of cell projection organization GO:0031344 175 0.020
regulation of lipid biosynthetic process GO:0046890 38 0.020
cellular response to fatty acid GO:0071398 29 0.020
Rat
cellular response to endogenous stimulus GO:0071495 377 0.020
cell type specific apoptotic process GO:0097285 134 0.020
amine metabolic process GO:0009308 38 0.020
single organism behavior GO:0044708 130 0.020
positive regulation of cell differentiation GO:0045597 217 0.020
response to corticosteroid GO:0031960 235 0.020
Rat
blood circulation GO:0008015 183 0.019
regulation of molecular function GO:0065009 398 0.019
acid secretion GO:0046717 48 0.019
aging GO:0007568 241 0.019
carbohydrate derivative biosynthetic process GO:1901137 124 0.019
negative regulation of developmental process GO:0051093 125 0.019
response to monosaccharide GO:0034284 159 0.019
Rat
negative regulation of signaling GO:0023057 157 0.019
response to biotic stimulus GO:0009607 226 0.018
Rat
nucleobase containing small molecule metabolic process GO:0055086 316 0.018
multicellular organismal reproductive process GO:0048609 233 0.018
salivary gland development GO:0007431 3 0.018
cellular ketone metabolic process GO:0042180 51 0.018
signal transduction by phosphorylation GO:0023014 144 0.018
dendrite development GO:0016358 72 0.018
macromolecular complex subunit organization GO:0043933 339 0.018
cation transmembrane transport GO:0098655 263 0.018
carboxylic acid transport GO:0046942 115 0.018
regulation of ion transport GO:0043269 245 0.018
developmental process involved in reproduction GO:0003006 159 0.018
organic substance catabolic process GO:1901575 316 0.018
positive regulation of secretion GO:0051047 140 0.017
neurological system process GO:0050877 219 0.017
cellular response to carbohydrate stimulus GO:0071322 72 0.017
response to oxygen levels GO:0070482 265 0.017
muscle structure development GO:0061061 87 0.017
regulation of cellular ketone metabolic process GO:0010565 27 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
cellular response to acid chemical GO:0071229 75 0.017
Rat
vesicle mediated transport GO:0016192 181 0.017
sexual reproduction GO:0019953 148 0.017
regulation of organ growth GO:0046620 13 0.017
positive regulation of neurogenesis GO:0050769 165 0.016
multi organism reproductive process GO:0044703 262 0.016
response to wounding GO:0009611 254 0.016
positive regulation of cell death GO:0010942 184 0.016
small molecule catabolic process GO:0044282 59 0.016
forebrain development GO:0030900 98 0.016
regulation of catalytic activity GO:0050790 304 0.016
regulation of neurogenesis GO:0050767 247 0.016
development of primary sexual characteristics GO:0045137 107 0.016
positive regulation of biosynthetic process GO:0009891 319 0.016
organic anion transport GO:0015711 132 0.016
metanephros development GO:0001656 14 0.016
heart morphogenesis GO:0003007 3 0.015
smooth muscle cell proliferation GO:0048659 77 0.015
insecticide metabolic process GO:0017143 4 0.015
protein homooligomerization GO:0051260 91 0.015
vascular process in circulatory system GO:0003018 96 0.015
regulation of neuron projection development GO:0010975 161 0.015
signal release GO:0023061 145 0.015
inorganic ion transmembrane transport GO:0098660 229 0.015
regulation of nervous system development GO:0051960 264 0.015
protein complex subunit organization GO:0071822 302 0.015
positive regulation of apoptotic process GO:0043065 154 0.015
nucleotide metabolic process GO:0009117 279 0.015
carbohydrate homeostasis GO:0033500 75 0.015
positive regulation of neuron differentiation GO:0045666 126 0.015
transmission of nerve impulse GO:0019226 42 0.015
positive regulation of nervous system development GO:0051962 178 0.015
purine ribonucleotide biosynthetic process GO:0009152 81 0.014
negative regulation of peptide hormone secretion GO:0090278 30 0.014
apoptotic process GO:0006915 381 0.014
regulation of peptide secretion GO:0002791 82 0.014
positive regulation of cellular biosynthetic process GO:0031328 295 0.014
positive regulation of molecular function GO:0044093 230 0.014
neuronal action potential GO:0019228 35 0.014
multicellular organism growth GO:0035264 1 0.014
positive regulation of mapk cascade GO:0043410 92 0.014
cellular response to extracellular stimulus GO:0031668 73 0.014
reproductive system development GO:0061458 128 0.014
regulation of cellular amino acid metabolic process GO:0006521 2 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.013
regulation of muscle tissue development GO:1901861 25 0.013
regulation of phosphorylation GO:0042325 248 0.013
gland development GO:0048732 155 0.013
sex differentiation GO:0007548 113 0.013
muscle cell differentiation GO:0042692 52 0.013
negative regulation of cell death GO:0060548 229 0.013
organic acid catabolic process GO:0016054 49 0.013
ion transmembrane transport GO:0034220 365 0.013
salivary gland morphogenesis GO:0007435 1 0.013
neuron neuron synaptic transmission GO:0007270 60 0.013
response to alkaloid GO:0043279 132 0.013
cellular nitrogen compound catabolic process GO:0044270 163 0.013
oxidation reduction process GO:0055114 304 0.013
membrane depolarization during action potential GO:0086010 1 0.013
glucose homeostasis GO:0042593 75 0.013
purine nucleotide biosynthetic process GO:0006164 83 0.013
regulation of response to external stimulus GO:0032101 106 0.013
negative regulation of response to stimulus GO:0048585 155 0.013
taxis GO:0042330 67 0.013
cell morphogenesis involved in differentiation GO:0000904 119 0.013
response to decreased oxygen levels GO:0036293 237 0.013
cofactor biosynthetic process GO:0051188 28 0.013
regulation of growth GO:0040008 105 0.013
synaptic growth at neuromuscular junction GO:0051124 1 0.012
regulation of homeostatic process GO:0032844 101 0.012
response to cytokine GO:0034097 215 0.012
negative regulation of transport GO:0051051 136 0.012
regulation of mapk cascade GO:0043408 116 0.012
negative regulation of cellular metabolic process GO:0031324 281 0.012
regulation of ion transmembrane transport GO:0034765 121 0.012
positive regulation of developmental growth GO:0048639 29 0.012
negative regulation of homeostatic process GO:0032845 47 0.012
negative regulation of cellular component organization GO:0051129 83 0.012
muscle tissue development GO:0060537 58 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
epithelium development GO:0060429 96 0.012
cellular response to glucose stimulus GO:0071333 65 0.012
adipose tissue development GO:0060612 6 0.012
Rat
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
regulation of organelle organization GO:0033043 80 0.012
heart growth GO:0060419 20 0.012
microtubule organizing center organization GO:0031023 1 0.012
cellular response to hormone stimulus GO:0032870 247 0.012
fatty acid biosynthetic process GO:0006633 33 0.012
regulation of anatomical structure size GO:0090066 135 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
synaptic transmission GO:0007268 235 0.012
glycerophospholipid metabolic process GO:0006650 47 0.012
transcription dna templated GO:0006351 377 0.011
regulation of lipid metabolic process GO:0019216 68 0.011
negative regulation of neurogenesis GO:0050768 78 0.011
cellular response to hexose stimulus GO:0071331 65 0.011
response to sterol GO:0036314 13 0.011
regulation of body fluid levels GO:0050878 90 0.011
regulation of fatty acid oxidation GO:0046320 10 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 5 0.011
triglyceride metabolic process GO:0006641 21 0.011
cell growth GO:0016049 104 0.011
peptide hormone secretion GO:0030072 84 0.011
response to inorganic substance GO:0010035 377 0.011
centrosome organization GO:0051297 1 0.011
carbohydrate derivative metabolic process GO:1901135 346 0.011
terpenoid metabolic process GO:0006721 37 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
regulation of response to stress GO:0080134 126 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
regulation of organic acid transport GO:0032890 35 0.011
cell motility GO:0048870 202 0.011
regulation of heart growth GO:0060420 12 0.011
negative regulation of secretion GO:0051048 82 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
ribonucleotide biosynthetic process GO:0009260 85 0.011
regeneration GO:0031099 163 0.011
positive regulation of cardiac muscle tissue growth GO:0055023 9 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
nucleoside phosphate metabolic process GO:0006753 283 0.011
regulation of catecholamine secretion GO:0050433 32 0.011
regulation of transmembrane transport GO:0034762 122 0.010
cellular divalent inorganic cation homeostasis GO:0072503 162 0.010
ribose phosphate metabolic process GO:0019693 235 0.010
inorganic cation transmembrane transport GO:0098662 202 0.010
cellular response to external stimulus GO:0071496 118 0.010
divalent metal ion transport GO:0070838 132 0.010
adult locomotory behavior GO:0008344 4 0.010
positive regulation of neuron projection development GO:0010976 99 0.010
bmp signaling pathway GO:0030509 4 0.010
sequestering of metal ion GO:0051238 9 0.010
positive regulation of growth GO:0045927 55 0.010
negative regulation of neuron differentiation GO:0045665 62 0.010
regulation of striated muscle tissue development GO:0016202 25 0.010
negative regulation of programmed cell death GO:0043069 183 0.010
embryonic axis specification GO:0000578 1 0.010
regulation of muscle system process GO:0090257 79 0.010
negative regulation of response to wounding GO:1903035 23 0.010
cellular calcium ion homeostasis GO:0006874 160 0.010

Hmgcs1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.016
disease of anatomical entity DOID:7 0 0.016