Rattus norvegicus

120 known processes

Hmgcs2

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)

(Aliases: Hmgcs1,Mt3h3mg)

Hmgcs2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
monocarboxylic acid metabolic process GO:0032787 152 0.683
cellular lipid metabolic process GO:0044255 208 0.648
organic acid metabolic process GO:0006082 292 0.597
oxoacid metabolic process GO:0043436 290 0.529
response to nutrient levels GO:0031667 370 0.449
acylglycerol metabolic process GO:0006639 21 0.440
long chain fatty acid metabolic process GO:0001676 32 0.404
cellular lipid catabolic process GO:0044242 37 0.343
cellular catabolic process GO:0044248 295 0.336
lipid metabolic process GO:0006629 283 0.330
monocarboxylic acid catabolic process GO:0072329 28 0.297
fatty acid beta oxidation GO:0006635 22 0.294
carboxylic acid metabolic process GO:0019752 289 0.275
organic acid catabolic process GO:0016054 49 0.228
cellular response to lipid GO:0071396 201 0.227
oxidation reduction process GO:0055114 304 0.222
single organism biosynthetic process GO:0044711 342 0.221
fatty acid oxidation GO:0019395 29 0.209
response to corticosteroid GO:0031960 235 0.204
catabolic process GO:0009056 351 0.181
response to acid chemical GO:0001101 222 0.171
fatty acid metabolic process GO:0006631 99 0.169
response to metal ion GO:0010038 253 0.160
cellular response to oxygen containing compound GO:1901701 386 0.154
response to hypoxia GO:0001666 231 0.154
response to extracellular stimulus GO:0009991 380 0.154
aging GO:0007568 241 0.144
response to inorganic substance GO:0010035 377 0.143
response to glucocorticoid GO:0051384 223 0.140
organic hydroxy compound metabolic process GO:1901615 115 0.139
response to decreased oxygen levels GO:0036293 237 0.138
cellular response to organic cyclic compound GO:0071407 202 0.137
response to other organism GO:0051707 220 0.129
response to oxygen levels GO:0070482 265 0.129
neutral lipid metabolic process GO:0006638 21 0.127
glycerolipid metabolic process GO:0046486 67 0.126
lipid modification GO:0030258 52 0.126
organic substance catabolic process GO:1901575 316 0.119
small molecule catabolic process GO:0044282 59 0.112
reproductive process GO:0022414 372 0.112
Rat
triglyceride metabolic process GO:0006641 21 0.111
response to camp GO:0051591 91 0.107
liver development GO:0001889 90 0.101
positive regulation of fatty acid beta oxidation GO:0032000 4 0.101
sulfur compound metabolic process GO:0006790 70 0.100
protein oligomerization GO:0051259 191 0.098
protein complex assembly GO:0006461 263 0.094
response to peptide GO:1901652 292 0.093
response to biotic stimulus GO:0009607 226 0.093
response to toxic substance GO:0009636 133 0.092
regulation of hormone levels GO:0010817 187 0.091
neurological system process GO:0050877 219 0.089
multicellular organism reproduction GO:0032504 233 0.087
antral ovarian follicle growth GO:0001547 3 0.081
single organism catabolic process GO:0044712 283 0.081
regulation of apoptotic process GO:0042981 335 0.078
multi organism reproductive process GO:0044703 262 0.076
nitrogen compound transport GO:0071705 229 0.074
gland development GO:0048732 155 0.073
response to insecticide GO:0017085 21 0.073
macromolecular complex assembly GO:0065003 273 0.073
programmed cell death GO:0012501 392 0.070
macromolecular complex subunit organization GO:0043933 339 0.070
secretion GO:0046903 307 0.070
positive regulation of lipid catabolic process GO:0050996 4 0.070
steroid metabolic process GO:0008202 73 0.069
response to ethanol GO:0045471 162 0.068
cellular ketone metabolic process GO:0042180 51 0.066
response to peptide hormone GO:0043434 278 0.065
lipid localization GO:0010876 62 0.064
regulation of cell proliferation GO:0042127 359 0.064
carboxylic acid biosynthetic process GO:0046394 83 0.063
protein complex biogenesis GO:0070271 263 0.062
response to wounding GO:0009611 254 0.061
response to fatty acid GO:0070542 65 0.060
reproductive system development GO:0061458 128 0.058
Rat
lipid catabolic process GO:0016042 46 0.058
organic acid transport GO:0015849 116 0.056
regulation of catalytic activity GO:0050790 304 0.056
phenol containing compound metabolic process GO:0018958 30 0.056
apoptotic process GO:0006915 381 0.055
reproduction GO:0000003 245 0.055
cellular component biogenesis GO:0044085 368 0.055
cell cell signaling GO:0007267 335 0.053
cofactor metabolic process GO:0051186 95 0.053
single organism behavior GO:0044708 130 0.053
regulation of secretion by cell GO:1903530 208 0.051
circulatory system process GO:0003013 183 0.050
carbohydrate metabolic process GO:0005975 130 0.049
protein homooligomerization GO:0051260 91 0.049
female pregnancy GO:0007565 122 0.048
carboxylic acid transport GO:0046942 115 0.047
cellular hormone metabolic process GO:0034754 49 0.047
lipid transport GO:0006869 61 0.046
sex differentiation GO:0007548 113 0.046
Rat
chemical homeostasis GO:0048878 292 0.046
response to molecule of bacterial origin GO:0002237 194 0.045
coenzyme metabolic process GO:0006732 86 0.045
xenobiotic metabolic process GO:0006805 19 0.045
organic anion transport GO:0015711 132 0.044
amine metabolic process GO:0009308 38 0.044
multicellular organismal reproductive process GO:0048609 233 0.042
single organism reproductive process GO:0044702 297 0.042
Rat
linoleic acid metabolic process GO:0043651 4 0.041
sulfur compound biosynthetic process GO:0044272 19 0.041
cellular amine metabolic process GO:0044106 38 0.040
carboxylic acid catabolic process GO:0046395 49 0.040
single organism carbohydrate metabolic process GO:0044723 118 0.040
lipid oxidation GO:0034440 30 0.040
neurotransmitter biosynthetic process GO:0042136 2 0.039
cognition GO:0050890 92 0.039
gonad development GO:0008406 104 0.039
Rat
regulation of cellular ketone metabolic process GO:0010565 27 0.039
head development GO:0060322 247 0.039
cellular amino acid metabolic process GO:0006520 107 0.039
developmental process involved in reproduction GO:0003006 159 0.039
Rat
peptide hormone secretion GO:0030072 84 0.038
regeneration GO:0031099 163 0.038
epithelial cell differentiation GO:0030855 71 0.038
protein complex subunit organization GO:0071822 302 0.038
hexose metabolic process GO:0019318 58 0.037
anion transport GO:0006820 178 0.037
monocarboxylic acid transport GO:0015718 52 0.037
response to external biotic stimulus GO:0043207 221 0.037
cellular response to peptide hormone stimulus GO:0071375 120 0.036
response to vitamin GO:0033273 131 0.036
Rat
regulation of cellular catabolic process GO:0031329 101 0.036
epithelium development GO:0060429 96 0.035
cellular component assembly GO:0022607 360 0.035
feeding behavior GO:0007631 53 0.035
regulation of programmed cell death GO:0043067 341 0.035
amide transport GO:0042886 105 0.035
blood circulation GO:0008015 183 0.034
regulation of hormone secretion GO:0046883 106 0.034
regulation of peptide hormone secretion GO:0090276 80 0.034
organophosphate metabolic process GO:0019637 370 0.033
sulfur amino acid metabolic process GO:0000096 9 0.033
hepaticobiliary system development GO:0061008 90 0.033
drug metabolic process GO:0017144 11 0.032
isoprenoid metabolic process GO:0006720 45 0.032
development of primary sexual characteristics GO:0045137 107 0.032
Rat
regulation of fatty acid metabolic process GO:0019217 18 0.032
regulation of anatomical structure size GO:0090066 135 0.032
regulation of cellular amine metabolic process GO:0033238 8 0.031
secretion by cell GO:0032940 248 0.031
cellular response to endogenous stimulus GO:0071495 377 0.031
macromolecule localization GO:0033036 252 0.031
developmental growth GO:0048589 100 0.031
terpenoid metabolic process GO:0006721 37 0.031
regulation of molecular function GO:0065009 398 0.031
regulation of multicellular organismal development GO:2000026 376 0.031
cellular modified amino acid metabolic process GO:0006575 61 0.030
female gonad development GO:0008585 53 0.030
central nervous system development GO:0007417 311 0.030
multicellular organismal signaling GO:0035637 44 0.029
positive regulation of cell death GO:0010942 184 0.029
regulation of lipid metabolic process GO:0019216 68 0.029
amino acid betaine metabolic process GO:0006577 3 0.029
regulation of secretion GO:0051046 224 0.029
response to transition metal nanoparticle GO:1990267 122 0.029
regulation of blood pressure GO:0008217 83 0.029
response to cytokine GO:0034097 215 0.028
alcohol metabolic process GO:0006066 77 0.028
intracellular signal transduction GO:0035556 314 0.028
positive regulation of lipid metabolic process GO:0045834 33 0.028
peptide secretion GO:0002790 86 0.028
regulation of peptide secretion GO:0002791 82 0.028
fatty acid catabolic process GO:0009062 26 0.028
regulation of cellular amino acid metabolic process GO:0006521 2 0.027
learning or memory GO:0007611 90 0.027
behavior GO:0007610 205 0.027
response to carbohydrate GO:0009743 183 0.027
negative regulation of programmed cell death GO:0043069 183 0.026
cellular response to external stimulus GO:0071496 118 0.026
reproductive structure development GO:0048608 128 0.026
Rat
inflammatory response GO:0006954 150 0.025
cellular response to hormone stimulus GO:0032870 247 0.025
anatomical structure morphogenesis GO:0009653 298 0.025
regulation of catabolic process GO:0009894 113 0.025
regulation of cellular localization GO:0060341 263 0.025
negative regulation of metabolic process GO:0009892 331 0.025
hormone transport GO:0009914 121 0.024
hormone metabolic process GO:0042445 69 0.024
cellular response to alcohol GO:0097306 87 0.024
Rat
response to organophosphorus GO:0046683 102 0.024
transmission of nerve impulse GO:0019226 42 0.024
positive regulation of molecular function GO:0044093 230 0.024
neuron projection development GO:0031175 273 0.024
negative regulation of apoptotic process GO:0043066 181 0.024
regulation of membrane potential GO:0042391 110 0.024
growth GO:0040007 165 0.023
g protein coupled receptor signaling pathway GO:0007186 242 0.023
peptide transport GO:0015833 97 0.023
nucleobase containing small molecule metabolic process GO:0055086 316 0.023
brain development GO:0007420 247 0.023
organ regeneration GO:0031100 101 0.023
negative regulation of multicellular organismal process GO:0051241 203 0.023
response to herbicide GO:0009635 16 0.023
cellular response to acid chemical GO:0071229 75 0.023
regulation of hydrolase activity GO:0051336 143 0.023
rhythmic process GO:0048511 156 0.023
regulation of neuron projection development GO:0010975 161 0.023
regulation of body fluid levels GO:0050878 90 0.022
response to activity GO:0014823 73 0.022
response to ketone GO:1901654 182 0.022
regulation of phosphorus metabolic process GO:0051174 349 0.022
response to purine containing compound GO:0014074 126 0.022
organonitrogen compound biosynthetic process GO:1901566 167 0.022
regulation of fatty acid beta oxidation GO:0031998 8 0.022
response to retinoic acid GO:0032526 63 0.022
negative regulation of cellular metabolic process GO:0031324 281 0.022
response to bacterium GO:0009617 200 0.022
transmembrane transport GO:0055085 412 0.022
synaptic transmission GO:0007268 235 0.021
positive regulation of fatty acid oxidation GO:0046321 6 0.021
toxin metabolic process GO:0009404 9 0.021
regulation of neurogenesis GO:0050767 247 0.021
small molecule biosynthetic process GO:0044283 124 0.021
glucose metabolic process GO:0006006 52 0.021
regulation of cell projection organization GO:0031344 175 0.021
signal release GO:0023061 145 0.021
unsaturated fatty acid metabolic process GO:0033559 39 0.020
cellular response to organonitrogen compound GO:0071417 197 0.020
regulation of protein metabolic process GO:0051246 289 0.020
regulation of cellular protein metabolic process GO:0032268 267 0.020
gamete generation GO:0007276 124 0.020
naphthalene containing compound metabolic process GO:0090420 2 0.020
development of primary female sexual characteristics GO:0046545 56 0.020
female sex differentiation GO:0046660 59 0.020
acetate ester metabolic process GO:1900619 4 0.020
regulation of nervous system development GO:0051960 264 0.020
regulation of signal transduction GO:0009966 318 0.020
multi multicellular organism process GO:0044706 138 0.020
tissue development GO:0009888 252 0.019
cellular response to nutrient levels GO:0031669 60 0.019
memory GO:0007613 54 0.019
regulation of cell development GO:0060284 263 0.019
response to alkaloid GO:0043279 132 0.019
carnitine metabolic process GO:0009437 3 0.019
acetylcholine biosynthetic process GO:0008292 2 0.019
positive regulation of biosynthetic process GO:0009891 319 0.019
cellular amino acid biosynthetic process GO:0008652 32 0.019
lipid biosynthetic process GO:0008610 128 0.019
regulation of cell differentiation GO:0045595 320 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
positive regulation of developmental process GO:0051094 283 0.019
sexual reproduction GO:0019953 148 0.019
positive regulation of catabolic process GO:0009896 78 0.018
diterpenoid metabolic process GO:0016101 33 0.018
nucleotide metabolic process GO:0009117 279 0.018
neuron differentiation GO:0030182 368 0.018
regulation of phosphorylation GO:0042325 248 0.018
positive regulation of apoptotic process GO:0043065 154 0.018
thioester metabolic process GO:0035383 28 0.018
response to lipopolysaccharide GO:0032496 191 0.018
positive regulation of cellular component organization GO:0051130 200 0.018
insulin secretion GO:0030073 69 0.018
action potential GO:0001508 54 0.018
defense response GO:0006952 194 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
organic acid biosynthetic process GO:0016053 83 0.017
positive regulation of cellular catabolic process GO:0031331 71 0.017
metal ion transport GO:0030001 289 0.017
regulation of insulin secretion GO:0050796 65 0.017
epithelial cell proliferation GO:0050673 54 0.017
chlorinated hydrocarbon metabolic process GO:0042196 4 0.017
positive regulation of multicellular organismal process GO:0051240 387 0.017
negative regulation of cell communication GO:0010648 158 0.017
neuron development GO:0048666 286 0.017
regulation of protein modification process GO:0031399 194 0.016
proteolysis GO:0006508 175 0.016
negative regulation of cell death GO:0060548 229 0.016
heterocycle catabolic process GO:0046700 167 0.016
response to estradiol GO:0032355 164 0.016
response to estrogen GO:0043627 232 0.016
long chain fatty acid transport GO:0015909 14 0.016
response to nicotine GO:0035094 51 0.016
naphthalene metabolic process GO:0018931 2 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
cellular response to extracellular stimulus GO:0031668 73 0.016
heart morphogenesis GO:0003007 3 0.016
positive regulation of phosphorus metabolic process GO:0010562 262 0.016
positive regulation of protein metabolic process GO:0051247 178 0.016
cellular response to stress GO:0033554 269 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.016
response to xenobiotic stimulus GO:0009410 23 0.016
protein phosphorylation GO:0006468 345 0.016
localization of cell GO:0051674 202 0.016
regulation of synaptic transmission GO:0050804 141 0.016
response to oxidative stress GO:0006979 186 0.016
positive regulation of cell development GO:0010720 176 0.015
regulation of cellular component organization GO:0051128 368 0.015
negative regulation of signaling GO:0023057 157 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
regulation of tube size GO:0035150 89 0.015
hormone secretion GO:0046879 115 0.015
regulation of neuron differentiation GO:0045664 208 0.015
positive regulation of hydrolase activity GO:0051345 86 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
response to osmotic stress GO:0006970 42 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
response to nutrient GO:0007584 248 0.015
positive regulation of secretion GO:0051047 140 0.015
regulation of peptide transport GO:0090087 87 0.015
cellular response to corticosteroid stimulus GO:0071384 69 0.015
regulation of growth GO:0040008 105 0.015
carbohydrate derivative metabolic process GO:1901135 346 0.014
regulation of system process GO:0044057 208 0.014
positive regulation of cell communication GO:0010647 271 0.014
response to hexose GO:0009746 144 0.014
ion transmembrane transport GO:0034220 365 0.014
regulation of phosphate metabolic process GO:0019220 349 0.014
mapk cascade GO:0000165 140 0.014
reactive nitrogen species metabolic process GO:2001057 1 0.014
regulation of neurotransmitter levels GO:0001505 42 0.014
response to growth factor GO:0070848 189 0.014
insecticide metabolic process GO:0017143 4 0.014
ras protein signal transduction GO:0007265 29 0.014
response to insulin GO:0032868 133 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
neuronal action potential GO:0019228 35 0.013
c21 steroid hormone biosynthetic process GO:0006700 10 0.013
organonitrogen compound catabolic process GO:1901565 179 0.013
regulation of intracellular signal transduction GO:1902531 218 0.013
response to testosterone GO:0033574 55 0.013
positive regulation of response to stimulus GO:0048584 285 0.013
organophosphate catabolic process GO:0046434 148 0.013
regulation of rna biosynthetic process GO:2001141 381 0.013
acetyl coa metabolic process GO:0006084 17 0.013
endothelial cell apoptotic process GO:0072577 3 0.013
vesicle mediated transport GO:0016192 181 0.013
negative regulation of macromolecule metabolic process GO:0010605 260 0.013
cation transport GO:0006812 382 0.013
regulation of transcription dna templated GO:0006355 374 0.013
cellular response to glucocorticoid stimulus GO:0071385 68 0.013
positive regulation of nervous system development GO:0051962 178 0.013
estrogen metabolic process GO:0008210 11 0.012
response to mechanical stimulus GO:0009612 134 0.012
fatty acid derivative metabolic process GO:1901568 38 0.012
nucleic acid templated transcription GO:0097659 379 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
regulation of rna metabolic process GO:0051252 391 0.012
phthalate metabolic process GO:0018963 8 0.012
positive regulation of cell differentiation GO:0045597 217 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
steroid biosynthetic process GO:0006694 48 0.012
response to calcium ion GO:0051592 59 0.012
negative regulation of gene expression GO:0010629 199 0.012
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.012
cellular sodium ion homeostasis GO:0006883 4 0.012
positive regulation of phosphate metabolic process GO:0045937 262 0.012
regulation of fatty acid oxidation GO:0046320 10 0.012
regulation of nucleic acid templated transcription GO:1903506 380 0.012
circadian rhythm GO:0007623 88 0.012
response to acetate GO:0010034 3 0.012
response to amino acid GO:0043200 75 0.012
regulation of blood vessel size GO:0050880 89 0.012
regulation of inflammatory response GO:0050727 48 0.012
alpha amino acid metabolic process GO:1901605 71 0.012
forebrain development GO:0030900 98 0.011
metal ion homeostasis GO:0055065 186 0.011
response to food GO:0032094 27 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
monocarboxylic acid biosynthetic process GO:0072330 48 0.011
brain renin angiotensin system GO:0002035 3 0.011
axis specification GO:0009798 4 0.011
positive regulation of programmed cell death GO:0043068 157 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
glial cell differentiation GO:0010001 65 0.011
icosanoid metabolic process GO:0006690 38 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
sulfation GO:0051923 2 0.011
cellular response to fatty acid GO:0071398 29 0.011
regulation of defense response GO:0031347 68 0.011
cation transmembrane transport GO:0098655 263 0.011
artery smooth muscle contraction GO:0014824 4 0.011
rna biosynthetic process GO:0032774 380 0.011
response to glucose GO:0009749 136 0.011
chemosensory behavior GO:0007635 2 0.011
intestinal absorption GO:0050892 3 0.011
very long chain fatty acid metabolic process GO:0000038 3 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
ribonucleotide metabolic process GO:0009259 231 0.011
cellular response to steroid hormone stimulus GO:0071383 93 0.011
positive regulation of transport GO:0051050 245 0.011
rna metabolic process GO:0016070 406 0.011
positive regulation of protein modification process GO:0031401 142 0.011
cellular response to xenobiotic stimulus GO:0071466 19 0.011
sensory perception of pain GO:0019233 73 0.011
retinal metabolic process GO:0042574 3 0.011
catechol containing compound metabolic process GO:0009712 19 0.011
response to sulfur dioxide GO:0010477 3 0.011
lipid storage GO:0019915 1 0.011
axonogenesis GO:0007409 71 0.011
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.011
response to monosaccharide GO:0034284 159 0.010
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
pyridine containing compound metabolic process GO:0072524 32 0.010
regulation of kinase activity GO:0043549 117 0.010
positive regulation of cellular biosynthetic process GO:0031328 295 0.010
cellular homeostasis GO:0019725 252 0.010
negative regulation of innate immune response GO:0045824 4 0.010
choline transport GO:0015871 4 0.010
muscle cell proliferation GO:0033002 84 0.010
tetrapyrrole metabolic process GO:0033013 11 0.010
cardiovascular system development GO:0072358 134 0.010
regulation of endothelial cell apoptotic process GO:2000351 3 0.010
negative regulation of protein metabolic process GO:0051248 114 0.010
cell projection organization GO:0030030 302 0.010
transcription dna templated GO:0006351 377 0.010
eating behavior GO:0042755 21 0.010
alpha amino acid biosynthetic process GO:1901607 23 0.010

Hmgcs2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
inherited metabolic disorder DOID:655 0 0.038
disease of metabolism DOID:0014667 0 0.038
artery disease DOID:0050828 0 0.011
vascular disease DOID:178 0 0.011
disease of anatomical entity DOID:7 0 0.011
cardiovascular system disease DOID:1287 0 0.011
disease of cellular proliferation DOID:14566 0 0.010