Rattus norvegicus

36 known processes

Hpd

4-hydroxyphenylpyruvate dioxygenase

Hpd biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxoacid metabolic process GO:0043436 290 0.602
cellular response to insulin stimulus GO:0032869 81 0.411
organic acid metabolic process GO:0006082 292 0.403
cofactor metabolic process GO:0051186 95 0.390
response to extracellular stimulus GO:0009991 380 0.372
alpha amino acid metabolic process GO:1901605 71 0.365
coenzyme metabolic process GO:0006732 86 0.315
single organism biosynthetic process GO:0044711 342 0.300
carboxylic acid metabolic process GO:0019752 289 0.297
cellular amino acid metabolic process GO:0006520 107 0.253
response to insulin GO:0032868 133 0.203
response to inorganic substance GO:0010035 377 0.197
response to peptide hormone GO:0043434 278 0.186
response to metal ion GO:0010038 253 0.175
cellular response to peptide hormone stimulus GO:0071375 120 0.165
gland development GO:0048732 155 0.161
cellular ketone metabolic process GO:0042180 51 0.140
response to nutrient GO:0007584 248 0.138
amine metabolic process GO:0009308 38 0.125
response to transition metal nanoparticle GO:1990267 122 0.124
carboxylic acid biosynthetic process GO:0046394 83 0.113
fructose metabolic process GO:0006000 1 0.112
organonitrogen compound biosynthetic process GO:1901566 167 0.111
catabolic process GO:0009056 351 0.105
negative regulation of serine type peptidase activity GO:1902572 1 0.102
response to nutrient levels GO:0031667 370 0.098
cellular lipid metabolic process GO:0044255 208 0.096
cellular response to xenobiotic stimulus GO:0071466 19 0.096
cellular response to hormone stimulus GO:0032870 247 0.092
cellular response to organonitrogen compound GO:0071417 197 0.091
cellular response to peptide GO:1901653 133 0.088
response to acid chemical GO:0001101 222 0.086
aromatic amino acid family catabolic process GO:0009074 7 0.084
response to peptide GO:1901652 292 0.076
response to herbicide GO:0009635 16 0.076
protein homotetramerization GO:0051289 25 0.075
regulation of cellular ketone metabolic process GO:0010565 27 0.075
nucleobase containing small molecule metabolic process GO:0055086 316 0.072
pyridine containing compound metabolic process GO:0072524 32 0.071
single organism reproductive process GO:0044702 297 0.070
alkaloid metabolic process GO:0009820 3 0.067
cellular amine metabolic process GO:0044106 38 0.067
extracellular matrix constituent secretion GO:0070278 4 0.064
aromatic compound catabolic process GO:0019439 168 0.063
carbohydrate derivative metabolic process GO:1901135 346 0.062
reproductive process GO:0022414 372 0.060
hepaticobiliary system development GO:0061008 90 0.059
liver development GO:0001889 90 0.057
regulation of cell projection organization GO:0031344 175 0.055
macromolecular complex assembly GO:0065003 273 0.054
response to mineralocorticoid GO:0051385 49 0.053
regulation of serine type peptidase activity GO:1902571 1 0.053
response to zinc ion GO:0010043 39 0.052
response to radiation GO:0009314 137 0.052
regulation of cellular amino acid metabolic process GO:0006521 2 0.050
trichloroethylene metabolic process GO:0018979 1 0.048
response to ionizing radiation GO:0010212 59 0.046
monocarboxylic acid metabolic process GO:0032787 152 0.045
dicarboxylic acid metabolic process GO:0043648 42 0.045
carbohydrate metabolic process GO:0005975 130 0.044
response to vitamin b6 GO:0034516 1 0.044
halogenated hydrocarbon metabolic process GO:0042197 4 0.044
pteridine containing compound metabolic process GO:0042558 14 0.044
androgen biosynthetic process GO:0006702 10 0.043
nicotinamide nucleotide metabolic process GO:0046496 28 0.043
regulation of cellular amine metabolic process GO:0033238 8 0.043
xenobiotic metabolic process GO:0006805 19 0.043
glycerolipid metabolic process GO:0046486 67 0.042
response to oxygen levels GO:0070482 265 0.042
response to hexose GO:0009746 144 0.042
phthalate metabolic process GO:0018963 8 0.041
response to food GO:0032094 27 0.041
cellular catabolic process GO:0044248 295 0.040
regulation of programmed cell death GO:0043067 341 0.040
leydig cell differentiation GO:0033327 8 0.039
alpha amino acid biosynthetic process GO:1901607 23 0.038
cellular response to external stimulus GO:0071496 118 0.037
multi multicellular organism process GO:0044706 138 0.037
response to ethanol GO:0045471 162 0.036
regulation of serine type endopeptidase activity GO:1900003 1 0.036
organophosphate metabolic process GO:0019637 370 0.035
response to toxic substance GO:0009636 133 0.034
sulfur compound metabolic process GO:0006790 70 0.034
response to molecule of bacterial origin GO:0002237 194 0.034
cellular response to nitrogen compound GO:1901699 210 0.034
female pregnancy GO:0007565 122 0.033
cellular amino acid catabolic process GO:0009063 21 0.033
response to triglyceride GO:0034014 3 0.032
organic acid biosynthetic process GO:0016053 83 0.031
small molecule biosynthetic process GO:0044283 124 0.031
cellular response to oxygen containing compound GO:1901701 386 0.031
response to chromate GO:0046687 3 0.031
cellular nitrogen compound catabolic process GO:0044270 163 0.030
locomotion GO:0040011 237 0.030
organic cyclic compound catabolic process GO:1901361 175 0.029
proteolysis GO:0006508 175 0.029
negative regulation of serine type endopeptidase activity GO:1900004 1 0.029
immune response GO:0006955 104 0.028
regulation of molecular function GO:0065009 398 0.028
multi organism reproductive process GO:0044703 262 0.028
epoxygenase p450 pathway GO:0019373 1 0.028
response to platinum ion GO:0070541 4 0.028
response to estrogen GO:0043627 232 0.027
response to vitamin GO:0033273 131 0.027
response to glucose GO:0009749 136 0.027
cellular amino acid biosynthetic process GO:0008652 32 0.027
plasminogen activation GO:0031639 2 0.027
negative regulation of cellular metabolic process GO:0031324 281 0.026
purine nucleoside metabolic process GO:0042278 169 0.026
response to decreased oxygen levels GO:0036293 237 0.026
negative regulation of response to stimulus GO:0048585 155 0.026
homeostatic process GO:0042592 331 0.025
protein complex biogenesis GO:0070271 263 0.025
oxidation reduction process GO:0055114 304 0.025
organic hydroxy compound metabolic process GO:1901615 115 0.025
aromatic amino acid family metabolic process GO:0009072 9 0.025
response to alkaloid GO:0043279 132 0.025
response to corticosteroid GO:0031960 235 0.025
dibenzo p dioxin metabolic process GO:0018894 10 0.025
estrogen biosynthetic process GO:0006703 6 0.025
response to sulfur dioxide GO:0010477 3 0.024
response to ketone GO:1901654 182 0.024
response to glucocorticoid GO:0051384 223 0.024
positive regulation of extracellular matrix constituent secretion GO:0003331 2 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
response to carbohydrate GO:0009743 183 0.024
negative regulation of molecular function GO:0044092 133 0.024
regulation of hydrolase activity GO:0051336 143 0.023
organ regeneration GO:0031100 101 0.023
cellular hormone metabolic process GO:0034754 49 0.023
developmental process involved in reproduction GO:0003006 159 0.022
response to organophosphorus GO:0046683 102 0.022
lipid metabolic process GO:0006629 283 0.022
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.022
response to monosaccharide GO:0034284 159 0.022
heterocycle catabolic process GO:0046700 167 0.022
aspartate family amino acid metabolic process GO:0009066 10 0.021
response to activity GO:0014823 73 0.021
brain development GO:0007420 247 0.021
phosphatidylethanolamine metabolic process GO:0046337 1 0.021
cell motility GO:0048870 202 0.021
cellular response to stress GO:0033554 269 0.021
testosterone biosynthetic process GO:0061370 5 0.021
central nervous system development GO:0007417 311 0.020
chemical homeostasis GO:0048878 292 0.020
regulation of blood volume by renal aldosterone GO:0002017 1 0.020
anatomical structure morphogenesis GO:0009653 298 0.020
sulfur compound biosynthetic process GO:0044272 19 0.020
response to fungicide GO:0060992 20 0.020
response to starvation GO:0042594 59 0.020
response to amino acid GO:0043200 75 0.020
organonitrogen compound catabolic process GO:1901565 179 0.019
epithelial cell proliferation involved in liver morphogenesis GO:0072575 3 0.019
protein complex assembly GO:0006461 263 0.019
response to corticosterone GO:0051412 40 0.019
aging GO:0007568 241 0.019
xenobiotic catabolic process GO:0042178 7 0.019
regulation of neuron projection development GO:0010975 161 0.019
regulation of phosphate metabolic process GO:0019220 349 0.019
response to vitamin e GO:0033197 24 0.019
regulation of cell development GO:0060284 263 0.019
nucleoside metabolic process GO:0009116 179 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
cellular chemical homeostasis GO:0055082 247 0.018
positive regulation of blood coagulation GO:0030194 4 0.018
ribose phosphate metabolic process GO:0019693 235 0.018
cofactor biosynthetic process GO:0051188 28 0.018
response to testosterone GO:0033574 55 0.018
ribonucleoside metabolic process GO:0009119 174 0.018
isoquinoline alkaloid metabolic process GO:0033076 2 0.018
serine family amino acid biosynthetic process GO:0009070 4 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
negative regulation of gene expression GO:0010629 199 0.018
regeneration GO:0031099 163 0.018
chlorinated hydrocarbon metabolic process GO:0042196 4 0.018
isoprenoid metabolic process GO:0006720 45 0.018
blood circulation GO:0008015 183 0.017
protein complex subunit organization GO:0071822 302 0.017
protein homooligomerization GO:0051260 91 0.017
alpha amino acid catabolic process GO:1901606 20 0.017
regulation of neurogenesis GO:0050767 247 0.017
negative regulation of protein metabolic process GO:0051248 114 0.017
reproduction GO:0000003 245 0.017
benzene containing compound metabolic process GO:0042537 22 0.017
gamete generation GO:0007276 124 0.017
purine containing compound metabolic process GO:0072521 253 0.017
nadh oxidation GO:0006116 2 0.017
renin angiotensin regulation of aldosterone production GO:0002018 3 0.017
negative regulation of programmed cell death GO:0043069 183 0.016
response to camp GO:0051591 91 0.016
negative regulation of biomineral tissue development GO:0070168 2 0.016
regulation of catalytic activity GO:0050790 304 0.016
single organism catabolic process GO:0044712 283 0.016
reproductive structure development GO:0048608 128 0.016
cellular response to lipid GO:0071396 201 0.016
negative regulation of rna biosynthetic process GO:1902679 118 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
c21 steroid hormone biosynthetic process GO:0006700 10 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
serine family amino acid metabolic process GO:0009069 12 0.016
organic substance catabolic process GO:1901575 316 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.016
naphthalene metabolic process GO:0018931 2 0.016
regulation of extracellular matrix constituent secretion GO:0003330 2 0.016
cellular modified amino acid metabolic process GO:0006575 61 0.015
programmed cell death GO:0012501 392 0.015
catechol containing compound biosynthetic process GO:0009713 9 0.015
response to lipopolysaccharide GO:0032496 191 0.015
positive regulation of hormone secretion GO:0046887 65 0.015
cellular response to inorganic substance GO:0071241 65 0.015
phospholipid metabolic process GO:0006644 61 0.015
protein transport GO:0015031 132 0.015
cellular response to gonadotropin stimulus GO:0071371 17 0.015
negative regulation of signaling GO:0023057 157 0.015
protein tetramerization GO:0051262 38 0.015
behavior GO:0007610 205 0.015
regulation of body fluid levels GO:0050878 90 0.015
fatty acid metabolic process GO:0006631 99 0.015
acetyl coa metabolic process GO:0006084 17 0.015
icosanoid metabolic process GO:0006690 38 0.015
response to purine containing compound GO:0014074 126 0.015
response to muscle activity involved in regulation of muscle adaptation GO:0014873 2 0.015
cellular response to interleukin 6 GO:0071354 9 0.015
sulfur amino acid metabolic process GO:0000096 9 0.014
monocarboxylic acid biosynthetic process GO:0072330 48 0.014
cellular protein localization GO:0034613 122 0.014
response to retinoic acid GO:0032526 63 0.014
small molecule catabolic process GO:0044282 59 0.014
organophosphate catabolic process GO:0046434 148 0.014
response to mechanical stimulus GO:0009612 134 0.014
response to mercury ion GO:0046689 15 0.014
nicotine metabolic process GO:0018933 1 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.014
regulation of neuron differentiation GO:0045664 208 0.014
cellular response to molecule of bacterial origin GO:0071219 56 0.014
unsaturated fatty acid metabolic process GO:0033559 39 0.014
glycine metabolic process GO:0006544 7 0.014
cellular biogenic amine metabolic process GO:0006576 30 0.014
regulation of fibrinolysis GO:0051917 2 0.014
negative regulation of metabolic process GO:0009892 331 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
establishment of tissue polarity GO:0007164 2 0.014
peptidyl amino acid modification GO:0018193 126 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
negative regulation of macromolecule metabolic process GO:0010605 260 0.014
negative regulation of cell death GO:0060548 229 0.014
protein phosphorylation GO:0006468 345 0.013
carboxylic acid catabolic process GO:0046395 49 0.013
liver morphogenesis GO:0072576 3 0.013
regulation of cellular component movement GO:0051270 150 0.013
nucleotide metabolic process GO:0009117 279 0.013
response to estradiol GO:0032355 164 0.013
single organism carbohydrate metabolic process GO:0044723 118 0.013
multicellular organism reproduction GO:0032504 233 0.013
lipid storage GO:0019915 1 0.013
cellular component biogenesis GO:0044085 368 0.013
pallium development GO:0021543 42 0.013
lipid biosynthetic process GO:0008610 128 0.013
negative regulation of phosphate metabolic process GO:0045936 80 0.013
neuron projection development GO:0031175 273 0.013
progesterone biosynthetic process GO:0006701 3 0.013
immune system process GO:0002376 204 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.012
response to acetate GO:0010034 3 0.012
positive regulation of extracellular matrix organization GO:1903055 4 0.012
circadian rhythm GO:0007623 88 0.012
cellular response to fluid shear stress GO:0071498 4 0.012
hepatocyte proliferation GO:0072574 3 0.012
tissue remodeling GO:0048771 40 0.012
cellular component assembly GO:0022607 360 0.012
regulation of cell differentiation GO:0045595 320 0.012
intracellular protein transport GO:0006886 79 0.012
regulation of reactive oxygen species metabolic process GO:2000377 26 0.012
nuclear transport GO:0051169 49 0.012
response to cadmium ion GO:0046686 35 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
ethanolamine containing compound metabolic process GO:0042439 14 0.012
regulation of rna biosynthetic process GO:2001141 381 0.012
sulfur amino acid biosynthetic process GO:0000097 5 0.012
innate immune response GO:0045087 35 0.012
regulation of immune response GO:0050776 55 0.012
naphthalene containing compound metabolic process GO:0090420 2 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
cellular component movement GO:0006928 248 0.011
negative regulation of cell communication GO:0010648 158 0.011
rhythmic behavior GO:0007622 24 0.011
circadian sleep wake cycle process GO:0022410 21 0.011
neuron differentiation GO:0030182 368 0.011
positive regulation of hemostasis GO:1900048 4 0.011
development of primary male sexual characteristics GO:0046546 59 0.011
phenol containing compound metabolic process GO:0018958 30 0.011
acylglycerol metabolic process GO:0006639 21 0.011
cellular response to lipopolysaccharide GO:0071222 55 0.011
response to biotic stimulus GO:0009607 226 0.011
cellular homeostasis GO:0019725 252 0.011
purine ribonucleoside catabolic process GO:0046130 124 0.011
negative regulation of developmental process GO:0051093 125 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
folic acid containing compound metabolic process GO:0006760 10 0.011
regulation of response to stress GO:0080134 126 0.011
androgen metabolic process GO:0008209 14 0.011
negative regulation of signal transduction GO:0009968 83 0.011
catenin import into nucleus GO:0035411 1 0.011
regulation of nervous system development GO:0051960 264 0.011
regulation of blood circulation GO:1903522 110 0.011
positive regulation of cell development GO:0010720 176 0.011
nad metabolic process GO:0019674 15 0.011
coenzyme biosynthetic process GO:0009108 22 0.011
triglyceride metabolic process GO:0006641 21 0.011
regulation of apoptotic process GO:0042981 335 0.011
retinoid metabolic process GO:0001523 24 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
macromolecule localization GO:0033036 252 0.011
circulatory system process GO:0003013 183 0.011
male gamete generation GO:0048232 99 0.010
cellular response to endogenous stimulus GO:0071495 377 0.010
regulation of signal transduction GO:0009966 318 0.010
male gonad development GO:0008584 59 0.010
circadian sleep wake cycle GO:0042745 23 0.010
nitrogen compound transport GO:0071705 229 0.010
positive regulation of multicellular organismal process GO:0051240 387 0.010
response to xenobiotic stimulus GO:0009410 23 0.010
ras protein signal transduction GO:0007265 29 0.010
cation homeostasis GO:0055080 195 0.010
regulation of lipid metabolic process GO:0019216 68 0.010

Hpd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
inherited metabolic disorder DOID:655 0 0.069
disease of metabolism DOID:0014667 0 0.069
acquired metabolic disease DOID:0060158 0 0.017
lipid metabolism disorder DOID:3146 0 0.010
steroid inherited metabolic disorder DOID:1701 0 0.010
congenital adrenal hyperplasia DOID:0050811 0 0.010