Rattus norvegicus

67 known processes

Hprt1

hypoxanthine phosphoribosyltransferase 1

(Aliases: MGC112554,Hgprtase,Hprt)

Hprt1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of rna metabolic process GO:0051252 391 0.449
cellular response to peptide GO:1901653 133 0.415
regulation of nucleic acid templated transcription GO:1903506 380 0.311
inorganic ion transmembrane transport GO:0098660 229 0.308
regulation of transcription dna templated GO:0006355 374 0.302
apoptotic process GO:0006915 381 0.246
transcription dna templated GO:0006351 377 0.228
single organism organelle organization GO:1902589 180 0.220
macromolecular complex assembly GO:0065003 273 0.209
Human
nucleic acid templated transcription GO:0097659 379 0.202
macromolecular complex subunit organization GO:0043933 339 0.202
Human
regulation of rna biosynthetic process GO:2001141 381 0.197
regulation of programmed cell death GO:0043067 341 0.193
rna metabolic process GO:0016070 406 0.177
reproduction GO:0000003 245 0.158
organic acid metabolic process GO:0006082 292 0.157
protein complex subunit organization GO:0071822 302 0.152
Human
actin filament based process GO:0030029 86 0.151
response to insulin GO:0032868 133 0.147
programmed cell death GO:0012501 392 0.140
regulation of proteasomal protein catabolic process GO:0061136 4 0.140
response to nutrient levels GO:0031667 370 0.136
transcription from rna polymerase ii promoter GO:0006366 252 0.136
response to peptide hormone GO:0043434 278 0.131
reproductive process GO:0022414 372 0.124
protein complex biogenesis GO:0070271 263 0.121
Human
cellular response to endogenous stimulus GO:0071495 377 0.114
response to peptide GO:1901652 292 0.110
single organism biosynthetic process GO:0044711 342 0.108
Human
protein sumoylation GO:0016925 4 0.108
ion transmembrane transport GO:0034220 365 0.105
response to hypoxia GO:0001666 231 0.104
negative regulation of metabolic process GO:0009892 331 0.104
response to extracellular stimulus GO:0009991 380 0.101
cellular component assembly GO:0022607 360 0.101
Human
single organism reproductive process GO:0044702 297 0.098
negative regulation of nucleic acid templated transcription GO:1903507 117 0.095
cellular component morphogenesis GO:0032989 155 0.093
nucleoside monophosphate metabolic process GO:0009123 93 0.091
Human
organelle organization GO:0006996 266 0.089
proteasomal protein catabolic process GO:0010498 8 0.086
regulation of protein metabolic process GO:0051246 289 0.084
regulation of protein catabolic process GO:0042176 16 0.083
cellular protein catabolic process GO:0044257 19 0.082
response to decreased oxygen levels GO:0036293 237 0.082
macromolecule catabolic process GO:0009057 58 0.081
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.080
response to oxygen levels GO:0070482 265 0.079
regulation of apoptotic process GO:0042981 335 0.073
cation transmembrane transport GO:0098655 263 0.071
regulation of phosphorus metabolic process GO:0051174 349 0.071
actin cytoskeleton organization GO:0030036 73 0.069
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.069
cellular response to xenobiotic stimulus GO:0071466 19 0.067
negative regulation of cellular biosynthetic process GO:0031327 161 0.066
cellular response to stress GO:0033554 269 0.065
cellular component biogenesis GO:0044085 368 0.064
Human
cell projection morphogenesis GO:0048858 123 0.062
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.062
protein complex assembly GO:0006461 263 0.062
Human
regulation of transmembrane transport GO:0034762 122 0.061
negative regulation of apoptotic process GO:0043066 181 0.059
sexual reproduction GO:0019953 148 0.057
regulation of cellular component organization GO:0051128 368 0.057
heart contraction GO:0060047 57 0.057
inorganic cation transmembrane transport GO:0098662 202 0.057
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.056
biological adhesion GO:0022610 110 0.056
organic substance catabolic process GO:1901575 316 0.055
Human
rna biosynthetic process GO:0032774 380 0.055
carboxylic acid metabolic process GO:0019752 289 0.055
regulation of cell proliferation GO:0042127 359 0.055
blood circulation GO:0008015 183 0.054
metal ion transport GO:0030001 289 0.053
er associated ubiquitin dependent protein catabolic process GO:0030433 1 0.052
regulation of phosphorylation GO:0042325 248 0.052
oxoacid metabolic process GO:0043436 290 0.049
regulation of response to stress GO:0080134 126 0.048
negative regulation of programmed cell death GO:0043069 183 0.048
cellular response to insulin stimulus GO:0032869 81 0.047
neuron projection development GO:0031175 273 0.047
dna damage response detection of dna damage GO:0042769 2 0.047
cellular response to hormone stimulus GO:0032870 247 0.047
regulation of ion transport GO:0043269 245 0.047
protein catabolic process GO:0030163 30 0.047
proteolysis GO:0006508 175 0.047
regulation of cardiac muscle contraction GO:0055117 17 0.046
cellular amino acid metabolic process GO:0006520 107 0.046
neuron development GO:0048666 286 0.046
organonitrogen compound biosynthetic process GO:1901566 167 0.046
Human
regeneration GO:0031099 163 0.046
amine metabolic process GO:0009308 38 0.045
Human
neuron apoptotic process GO:0051402 88 0.045
negative regulation of cell death GO:0060548 229 0.045
heart process GO:0003015 57 0.044
multicellular organism reproduction GO:0032504 233 0.044
regulation of neuron death GO:1901214 115 0.044
cation transport GO:0006812 382 0.044
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 2 0.043
regulation of calcium ion transmembrane transporter activity GO:1901019 17 0.043
cellular catabolic process GO:0044248 295 0.043
Human
protein modification by small protein conjugation GO:0032446 31 0.043
negative regulation of molecular function GO:0044092 133 0.042
regulation of protein phosphorylation GO:0001932 183 0.042
negative regulation of rna metabolic process GO:0051253 123 0.042
divalent metal ion transport GO:0070838 132 0.042
regulation of cell differentiation GO:0045595 320 0.042
internal peptidyl lysine acetylation GO:0018393 9 0.041
mitochondrion organization GO:0007005 35 0.041
negative regulation of response to stimulus GO:0048585 155 0.041
negative regulation of gene expression GO:0010629 199 0.041
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.041
modification dependent macromolecule catabolic process GO:0043632 14 0.040
histone methylation GO:0016571 3 0.040
anatomical structure morphogenesis GO:0009653 298 0.040
negative regulation of transcription dna templated GO:0045892 116 0.040
peptidyl amino acid modification GO:0018193 126 0.039
centrosome organization GO:0051297 1 0.039
nitrogen compound transport GO:0071705 229 0.038
cellular response to oxygen containing compound GO:1901701 386 0.038
transmembrane transport GO:0055085 412 0.038
positive regulation of proteasomal protein catabolic process GO:1901800 3 0.038
synaptic transmission GO:0007268 235 0.038
regulation of ion transmembrane transport GO:0034765 121 0.037
cell morphogenesis GO:0000902 142 0.036
single organism catabolic process GO:0044712 283 0.036
Human
dephosphorylation GO:0016311 98 0.036
negative regulation of rna biosynthetic process GO:1902679 118 0.036
regulation of protein modification process GO:0031399 194 0.036
positive regulation of biosynthetic process GO:0009891 319 0.036
neuron projection morphogenesis GO:0048812 122 0.036
regulation of blood circulation GO:1903522 110 0.035
cell projection organization GO:0030030 302 0.035
circulatory system process GO:0003013 183 0.035
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.034
developmental process involved in reproduction GO:0003006 159 0.034
negative regulation of macromolecule metabolic process GO:0010605 260 0.034
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.034
response to oxidative stress GO:0006979 186 0.034
endomembrane system organization GO:0010256 48 0.033
spermatogenesis GO:0007283 99 0.033
somatic stem cell division GO:0048103 2 0.033
positive regulation of pseudopodium assembly GO:0031274 1 0.033
calcium ion transmembrane transport GO:0070588 70 0.033
regulation of actin filament based process GO:0032970 42 0.033
small molecule biosynthetic process GO:0044283 124 0.032
multicellular organismal reproductive process GO:0048609 233 0.032
oligopeptide transport GO:0006857 4 0.032
calcium ion transport GO:0006816 131 0.032
dendrite development GO:0016358 72 0.031
response to ethanol GO:0045471 162 0.031
nucleobase containing small molecule metabolic process GO:0055086 316 0.031
positive regulation of protein metabolic process GO:0051247 178 0.030
protein phosphorylation GO:0006468 345 0.030
carbohydrate derivative metabolic process GO:1901135 346 0.030
Human
growth GO:0040007 165 0.030
response to xenobiotic stimulus GO:0009410 23 0.030
positive regulation of cellular biosynthetic process GO:0031328 295 0.029
cellular amine metabolic process GO:0044106 38 0.029
Human
hair follicle development GO:0001942 2 0.029
dna metabolic process GO:0006259 96 0.028
ribonucleoside metabolic process GO:0009119 174 0.028
Human
embryonic axis specification GO:0000578 1 0.028
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 3 0.028
pigment biosynthetic process GO:0046148 4 0.028
Human
neuron differentiation GO:0030182 368 0.028
protein oligomerization GO:0051259 191 0.028
Human
regulation of protein transport GO:0051223 68 0.028
embryo development GO:0009790 49 0.028
negative regulation of signaling GO:0023057 157 0.028
negative regulation of biosynthetic process GO:0009890 168 0.027
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.027
Human
response to cytokine GO:0034097 215 0.027
synaptic growth at neuromuscular junction GO:0051124 1 0.027
positive regulation of cell projection organization GO:0031346 111 0.027
neurotransmitter uptake GO:0001504 3 0.027
cytoskeleton organization GO:0007010 111 0.027
neuron death GO:0070997 127 0.027
organelle localization GO:0051640 55 0.026
microtubule organizing center organization GO:0031023 1 0.026
anion transport GO:0006820 178 0.026
protein refolding GO:0042026 3 0.026
cell part morphogenesis GO:0032990 123 0.026
cellular ketone metabolic process GO:0042180 51 0.025
regulation of cellular amine metabolic process GO:0033238 8 0.025
Human
divalent inorganic cation transport GO:0072511 134 0.025
nucleosome organization GO:0034728 1 0.025
positive regulation of transport GO:0051050 245 0.025
regulation of molecular function GO:0065009 398 0.025
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.025
cellular response to peptide hormone stimulus GO:0071375 120 0.025
glial cell apoptotic process GO:0034349 8 0.025
response to metal ion GO:0010038 253 0.025
central nervous system development GO:0007417 311 0.025
positive regulation of cell differentiation GO:0045597 217 0.025
catabolic process GO:0009056 351 0.025
Human
positive regulation of cell development GO:0010720 176 0.025
positive regulation of response to stimulus GO:0048584 285 0.025
ribonucleotide metabolic process GO:0009259 231 0.024
Human
positive regulation of dna metabolic process GO:0051054 39 0.024
cell morphogenesis involved in differentiation GO:0000904 119 0.024
halogenated hydrocarbon metabolic process GO:0042197 4 0.024
gland development GO:0048732 155 0.024
negative regulation of cell cycle phase transition GO:1901988 4 0.024
cellular divalent inorganic cation homeostasis GO:0072503 162 0.023
protein homooligomerization GO:0051260 91 0.023
Human
response to inorganic substance GO:0010035 377 0.023
positive regulation of developmental process GO:0051094 283 0.023
hair cycle process GO:0022405 2 0.023
response to external biotic stimulus GO:0043207 221 0.023
positive regulation of transcription dna templated GO:0045893 197 0.023
cellular homeostasis GO:0019725 252 0.022
homeostatic process GO:0042592 331 0.022
nucleoside triphosphate metabolic process GO:0009141 144 0.022
gamete generation GO:0007276 124 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
Human
cell fate determination GO:0001709 2 0.022
cell type specific apoptotic process GO:0097285 134 0.022
phospholipid metabolic process GO:0006644 61 0.022
regulation of metalloenzyme activity GO:0048552 1 0.022
positive regulation of cellular protein metabolic process GO:0032270 167 0.022
cytosolic calcium ion homeostasis GO:0051480 140 0.022
response to other organism GO:0051707 220 0.022
digestive system development GO:0055123 41 0.021
positive regulation of cell proliferation GO:0008284 249 0.021
purine nucleoside catabolic process GO:0006152 124 0.021
Human
pseudopodium organization GO:0031268 3 0.021
regulation of cellular protein metabolic process GO:0032268 267 0.021
male gamete generation GO:0048232 99 0.021
modification dependent protein catabolic process GO:0019941 14 0.021
regulation of proteolysis GO:0030162 66 0.021
multi organism reproductive process GO:0044703 262 0.021
cardiac muscle cell contraction GO:0086003 10 0.020
purine nucleotide metabolic process GO:0006163 229 0.020
Human
regulation of neuron projection development GO:0010975 161 0.020
protein modification by small protein conjugation or removal GO:0070647 35 0.020
brain development GO:0007420 247 0.020
ribose phosphate metabolic process GO:0019693 235 0.020
Human
regulation of cell growth GO:0001558 85 0.020
positive regulation of cellular component organization GO:0051130 200 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
Human
nucleoside phosphate metabolic process GO:0006753 283 0.020
Human
response to starvation GO:0042594 59 0.020
regulation of neuron apoptotic process GO:0043523 83 0.019
positive regulation of multicellular organismal process GO:0051240 387 0.019
carboxylic acid transport GO:0046942 115 0.019
cellular macromolecule catabolic process GO:0044265 29 0.019
mapk cascade GO:0000165 140 0.019
cellular response to nitrogen compound GO:1901699 210 0.019
regulation of heart contraction GO:0008016 48 0.019
cellular macromolecular complex assembly GO:0034622 58 0.019
chromosome segregation GO:0007059 2 0.018
regulation of transporter activity GO:0032409 50 0.018
centrosome cycle GO:0007098 1 0.018
protein transport GO:0015031 132 0.018
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
regulation of striated muscle contraction GO:0006942 21 0.018
regulation of neuron differentiation GO:0045664 208 0.018
negative regulation of transport GO:0051051 136 0.018
cardiac muscle contraction GO:0060048 27 0.018
multi multicellular organism process GO:0044706 138 0.018
locomotion GO:0040011 237 0.018
cellular lipid metabolic process GO:0044255 208 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
regulation of cellular response to stress GO:0080135 49 0.018
cardiovascular system development GO:0072358 134 0.018
immune response to tumor cell GO:0002418 3 0.017
response to corticosteroid GO:0031960 235 0.017
purine containing compound metabolic process GO:0072521 253 0.017
pigment metabolic process GO:0042440 7 0.017
Human
organ regeneration GO:0031100 101 0.017
negative regulation of cellular metabolic process GO:0031324 281 0.017
embryonic pattern specification GO:0009880 1 0.017
cellular response to external stimulus GO:0071496 118 0.017
regulation of intracellular signal transduction GO:1902531 218 0.017
positive regulation of molecular function GO:0044093 230 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.017
response to wounding GO:0009611 254 0.017
dendrite morphogenesis GO:0048813 43 0.017
regulation of ion transmembrane transporter activity GO:0032412 48 0.017
mitotic spindle organization GO:0007052 2 0.017
response to bacterium GO:0009617 200 0.017
negative regulation of cell communication GO:0010648 158 0.017
multicellular organism growth GO:0035264 1 0.016
reactive oxygen species biosynthetic process GO:1903409 8 0.016
organophosphate metabolic process GO:0019637 370 0.016
Human
cell adhesion GO:0007155 110 0.016
regulation of phosphate metabolic process GO:0019220 349 0.016
autophagic cell death GO:0048102 4 0.016
regulation of protein localization GO:0032880 81 0.016
gastrulation GO:0007369 2 0.016
canonical wnt signaling pathway GO:0060070 9 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
Human
cell growth GO:0016049 104 0.016
protein ubiquitination GO:0016567 28 0.016
response to lipopolysaccharide GO:0032496 191 0.016
protein localization to membrane GO:0072657 36 0.016
female pregnancy GO:0007565 122 0.016
muscle contraction GO:0006936 88 0.015
posttranscriptional regulation of gene expression GO:0010608 37 0.015
protein prenylation GO:0018342 4 0.015
positive regulation of signaling GO:0023056 270 0.015
cellular response to nutrient levels GO:0031669 60 0.015
regulation of neurogenesis GO:0050767 247 0.015
nucleotide biosynthetic process GO:0009165 98 0.015
Human
peptide transport GO:0015833 97 0.015
striated muscle contraction GO:0006941 44 0.015
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 3 0.015
regulation of cellular component movement GO:0051270 150 0.015
regulation of kinase activity GO:0043549 117 0.015
toxin transport GO:1901998 3 0.015
positive regulation of protein kinase activity GO:0045860 73 0.015
negative regulation of cellular component organization GO:0051129 83 0.015
reproductive structure development GO:0048608 128 0.015
intracellular signal transduction GO:0035556 314 0.015
positive regulation of lipid kinase activity GO:0090218 2 0.014
tissue development GO:0009888 252 0.014
establishment of organelle localization GO:0051656 37 0.014
cell cell signaling GO:0007267 335 0.014
cellular response to organonitrogen compound GO:0071417 197 0.014
regulation of peptide transport GO:0090087 87 0.014
asymmetric stem cell division GO:0098722 2 0.014
chromosome organization GO:0051276 36 0.014
regulation of nervous system development GO:0051960 264 0.014
positive regulation of lamellipodium assembly GO:0010592 4 0.014
circulatory system development GO:0072359 134 0.014
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.014
xenobiotic metabolic process GO:0006805 19 0.014
regulation of mapk cascade GO:0043408 116 0.014
cellular component movement GO:0006928 248 0.014
skin morphogenesis GO:0043589 2 0.014
response to alkaloid GO:0043279 132 0.014
positive regulation of transporter activity GO:0032411 14 0.014
positive regulation of calcium ion transmembrane transporter activity GO:1901021 7 0.014
inflammatory response GO:0006954 150 0.014
reactive nitrogen species metabolic process GO:2001057 1 0.014
regulation of anatomical structure size GO:0090066 135 0.013
response to biotic stimulus GO:0009607 226 0.013
regulation of muscle system process GO:0090257 79 0.013
defense response GO:0006952 194 0.013
positive regulation of apoptotic process GO:0043065 154 0.013
cellular chemical homeostasis GO:0055082 247 0.013
cellular carbohydrate metabolic process GO:0044262 72 0.013
melanosome localization GO:0032400 1 0.013
regulation of protein kinase activity GO:0045859 105 0.013
molting cycle process GO:0022404 2 0.013
positive regulation of ion transport GO:0043270 94 0.013
organic acid biosynthetic process GO:0016053 83 0.013
purine nucleoside metabolic process GO:0042278 169 0.013
Human
histone h3 acetylation GO:0043966 2 0.013
positive regulation of transmembrane transport GO:0034764 25 0.013
carboxylic acid biosynthetic process GO:0046394 83 0.013
anterior posterior pattern specification GO:0009952 1 0.013
molting cycle GO:0042303 3 0.013
cellular calcium ion homeostasis GO:0006874 160 0.013
organ morphogenesis GO:0009887 75 0.013
organelle assembly GO:0070925 22 0.013
chromatin organization GO:0006325 34 0.013
chromatin remodeling GO:0006338 3 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
cellular protein complex assembly GO:0043623 44 0.012
regulation of system process GO:0044057 208 0.012
positive regulation of phosphorus metabolic process GO:0010562 262 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
lipid metabolic process GO:0006629 283 0.012
regulation of protein heterodimerization activity GO:0043497 1 0.012
regulation of inflammatory response GO:0050727 48 0.012
response to growth factor GO:0070848 189 0.012
regulation of dna metabolic process GO:0051052 60 0.012
wnt signaling pathway GO:0016055 17 0.012
chromatin assembly or disassembly GO:0006333 1 0.012
single organism membrane organization GO:0044802 74 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
negative regulation of hydrogen peroxide biosynthetic process GO:0010730 2 0.012
regulation of cell projection organization GO:0031344 175 0.012
cellular response to growth factor stimulus GO:0071363 162 0.012
heart development GO:0007507 72 0.012
cellular response to starvation GO:0009267 27 0.012
actin filament organization GO:0007015 42 0.012
response to nutrient GO:0007584 248 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
regulation of embryonic development GO:0045995 2 0.012
aging GO:0007568 241 0.012
positive regulation of calcium transporting atpase activity GO:1901896 1 0.011
regulation of protein serine threonine kinase activity GO:0071900 64 0.011
mast cell migration GO:0097531 4 0.011
pseudopodium assembly GO:0031269 3 0.011
palate development GO:0060021 2 0.011
vesicle localization GO:0051648 33 0.011
cell cycle checkpoint GO:0000075 2 0.011
positive regulation of smoothened signaling pathway GO:0045880 1 0.011
negative regulation of reactive oxygen species metabolic process GO:2000378 7 0.011
negative regulation of signal transduction GO:0009968 83 0.011
single organism cellular localization GO:1902580 102 0.011
covalent chromatin modification GO:0016569 30 0.011
chlorinated hydrocarbon metabolic process GO:0042196 4 0.010
regulation of synaptic transmission GO:0050804 141 0.010
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 3 0.010
mitotic cell cycle process GO:1903047 35 0.010
purine ribonucleoside metabolic process GO:0046128 168 0.010
Human
muscle structure development GO:0061061 87 0.010
nucleoside phosphate biosynthetic process GO:1901293 102 0.010
Human
response to activity GO:0014823 73 0.010
chromatin modification GO:0016568 33 0.010
head development GO:0060322 247 0.010
cellular macromolecule localization GO:0070727 122 0.010
histone modification GO:0016570 30 0.010
negative regulation of ion transport GO:0043271 51 0.010
cellular nitrogen compound catabolic process GO:0044270 163 0.010
Human
metal ion homeostasis GO:0055065 186 0.010
positive regulation of protein modification process GO:0031401 142 0.010

Hprt1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.071
disease of anatomical entity DOID:7 0 0.071
myopathy DOID:423 0 0.030
muscular disease DOID:0080000 0 0.030
musculoskeletal system disease DOID:17 0 0.030
muscular dystrophy DOID:9884 0 0.030
muscle tissue disease DOID:66 0 0.030
sensory system disease DOID:0050155 0 0.022
eye and adnexa disease DOID:1492 0 0.016
eye disease DOID:5614 0 0.015