Rattus norvegicus

18 known processes

Hrh4

histamine receptor H4

Hrh4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of ion transport GO:0043269 245 0.617
Rat
cation transport GO:0006812 382 0.588
Rat
organic acid transport GO:0015849 116 0.497
Rat
secretion GO:0046903 307 0.382
Rat
metal ion transport GO:0030001 289 0.353
ion transmembrane transport GO:0034220 365 0.341
brain development GO:0007420 247 0.332
Rat
response to inorganic substance GO:0010035 377 0.327
inorganic ion transmembrane transport GO:0098660 229 0.280
transmembrane transport GO:0055085 412 0.277
response to external biotic stimulus GO:0043207 221 0.270
cation transmembrane transport GO:0098655 263 0.264
response to metal ion GO:0010038 253 0.242
reproductive process GO:0022414 372 0.229
response to cocaine GO:0042220 39 0.228
response to ammonium ion GO:0060359 71 0.196
positive regulation of multicellular organismal process GO:0051240 387 0.191
regulation of tube size GO:0035150 89 0.181
synaptic transmission GO:0007268 235 0.176
response to alkaloid GO:0043279 132 0.154
response to biotic stimulus GO:0009607 226 0.144
positive regulation of secretion GO:0051047 140 0.142
cytosolic calcium ion homeostasis GO:0051480 140 0.130
Rat
regulation of secretion by cell GO:1903530 208 0.130
Rat
cellular response to stress GO:0033554 269 0.127
inorganic cation transmembrane transport GO:0098662 202 0.125
macromolecular complex subunit organization GO:0043933 339 0.124
reproduction GO:0000003 245 0.122
learning or memory GO:0007611 90 0.118
Rat
regulation of secretion GO:0051046 224 0.118
Rat
response to extracellular stimulus GO:0009991 380 0.110
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.105
defense response GO:0006952 194 0.102
cell cell signaling GO:0007267 335 0.101
response to nutrient levels GO:0031667 370 0.093
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.090
positive regulation of ion transport GO:0043270 94 0.090
negative regulation of multicellular organismal process GO:0051241 203 0.089
response to oxygen levels GO:0070482 265 0.089
nucleic acid templated transcription GO:0097659 379 0.088
multicellular organismal reproductive process GO:0048609 233 0.088
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.087
Rat
nitrogen compound transport GO:0071705 229 0.087
Rat
acid secretion GO:0046717 48 0.087
Rat
cellular homeostasis GO:0019725 252 0.086
Rat
regulation of cell proliferation GO:0042127 359 0.086
Rat
response to transition metal nanoparticle GO:1990267 122 0.083
multi multicellular organism process GO:0044706 138 0.081
cellular ion homeostasis GO:0006873 184 0.080
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.077
carbohydrate derivative metabolic process GO:1901135 346 0.076
Rat
amine transport GO:0015837 57 0.075
Rat
protein complex assembly GO:0006461 263 0.074
cellular response to endogenous stimulus GO:0071495 377 0.071
positive regulation of gene expression GO:0010628 244 0.070
positive regulation of cell proliferation GO:0008284 249 0.069
Rat
regulation of synaptic transmission GO:0050804 141 0.069
cellular response to abiotic stimulus GO:0071214 85 0.069
positive regulation of cellular biosynthetic process GO:0031328 295 0.069
response to hypoxia GO:0001666 231 0.069
cellular metal ion homeostasis GO:0006875 172 0.068
Rat
calcium ion homeostasis GO:0055074 162 0.067
Rat
positive regulation of biosynthetic process GO:0009891 319 0.067
regulation of transcription dna templated GO:0006355 374 0.067
regulation of multicellular organismal development GO:2000026 376 0.067
regulation of rna biosynthetic process GO:2001141 381 0.066
protein complex biogenesis GO:0070271 263 0.066
homeostatic process GO:0042592 331 0.066
Rat
cellular component movement GO:0006928 248 0.066
rna metabolic process GO:0016070 406 0.065
cellular component biogenesis GO:0044085 368 0.065
cellular response to lipopolysaccharide GO:0071222 55 0.065
positive regulation of response to stimulus GO:0048584 285 0.063
multi organism reproductive process GO:0044703 262 0.063
regulation of hormone levels GO:0010817 187 0.062
anion transport GO:0006820 178 0.062
Rat
positive regulation of secretion by cell GO:1903532 128 0.062
transcription dna templated GO:0006351 377 0.061
response to lead ion GO:0010288 33 0.060
regulation of amine transport GO:0051952 54 0.060
Rat
secretion by cell GO:0032940 248 0.060
Rat
circulatory system development GO:0072359 134 0.059
oxoacid metabolic process GO:0043436 290 0.058
response to estrogen GO:0043627 232 0.058
multicellular organism reproduction GO:0032504 233 0.057
regulation of cell motility GO:2000145 131 0.057
response to estradiol GO:0032355 164 0.056
amino acid transport GO:0006865 70 0.055
Rat
immune system process GO:0002376 204 0.055
positive regulation of amine transport GO:0051954 26 0.054
regulation of blood vessel size GO:0050880 89 0.053
response to decreased oxygen levels GO:0036293 237 0.052
anion transmembrane transport GO:0098656 77 0.051
cell migration GO:0016477 197 0.050
positive regulation of transport GO:0051050 245 0.050
response to hyperoxia GO:0055093 45 0.049
response to oxidative stress GO:0006979 186 0.048
cell motility GO:0048870 202 0.048
head development GO:0060322 247 0.047
Rat
transcription from rna polymerase ii promoter GO:0006366 252 0.047
single organism behavior GO:0044708 130 0.047
Rat
cellular response to oxygen containing compound GO:1901701 386 0.047
carboxylic acid metabolic process GO:0019752 289 0.046
cation homeostasis GO:0055080 195 0.046
Rat
carboxylic acid transport GO:0046942 115 0.046
Rat
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.046
divalent inorganic cation transport GO:0072511 134 0.045
negative regulation of ion transport GO:0043271 51 0.045
Rat
single organism reproductive process GO:0044702 297 0.045
metal ion homeostasis GO:0055065 186 0.044
Rat
neurological system process GO:0050877 219 0.044
Rat
catabolic process GO:0009056 351 0.043
cellular response to hormone stimulus GO:0032870 247 0.043
positive regulation of nucleic acid templated transcription GO:1903508 197 0.043
cellular divalent inorganic cation homeostasis GO:0072503 162 0.043
Rat
response to ethanol GO:0045471 162 0.042
organic hydroxy compound transport GO:0015850 77 0.042
Rat
macromolecular complex assembly GO:0065003 273 0.041
blood circulation GO:0008015 183 0.041
Rat
divalent metal ion transport GO:0070838 132 0.041
nucleoside phosphate metabolic process GO:0006753 283 0.040
Rat
response to ketone GO:1901654 182 0.040
negative regulation of cell death GO:0060548 229 0.040
regulation of system process GO:0044057 208 0.040
response to bacterium GO:0009617 200 0.040
learning GO:0007612 33 0.039
Rat
sodium ion transport GO:0006814 82 0.038
protein oligomerization GO:0051259 191 0.038
regulation of amino acid transport GO:0051955 25 0.038
Rat
organic anion transport GO:0015711 132 0.038
Rat
tissue development GO:0009888 252 0.038
response to nicotine GO:0035094 51 0.037
cyclic nucleotide biosynthetic process GO:0009190 63 0.037
Rat
rna biosynthetic process GO:0032774 380 0.037
circulatory system process GO:0003013 183 0.037
Rat
response to mechanical stimulus GO:0009612 134 0.037
behavior GO:0007610 205 0.037
Rat
ribonucleotide metabolic process GO:0009259 231 0.036
Rat
positive regulation of rna biosynthetic process GO:1902680 197 0.035
response to acid chemical GO:0001101 222 0.035
central nervous system development GO:0007417 311 0.035
Rat
cellular chemical homeostasis GO:0055082 247 0.035
Rat
organophosphate metabolic process GO:0019637 370 0.035
Rat
regulation of protein metabolic process GO:0051246 289 0.035
growth GO:0040007 165 0.034
female pregnancy GO:0007565 122 0.034
regulation of metal ion transport GO:0010959 118 0.033
g protein coupled receptor signaling pathway GO:0007186 242 0.033
response to temperature stimulus GO:0009266 94 0.033
positive regulation of cell migration GO:0030335 96 0.033
response to morphine GO:0043278 27 0.032
single organism biosynthetic process GO:0044711 342 0.032
Rat
negative regulation of cellular metabolic process GO:0031324 281 0.032
Rat
negative regulation of macromolecule metabolic process GO:0010605 260 0.032
response to antibiotic GO:0046677 39 0.032
cellular lipid metabolic process GO:0044255 208 0.032
cellular response to organic cyclic compound GO:0071407 202 0.032
mononuclear cell proliferation GO:0032943 29 0.032
nucleobase containing small molecule metabolic process GO:0055086 316 0.031
Rat
programmed cell death GO:0012501 392 0.031
macromolecule localization GO:0033036 252 0.031
micturition GO:0060073 4 0.031
response to starvation GO:0042594 59 0.031
regulation of blood pressure GO:0008217 83 0.029
Rat
response to growth factor GO:0070848 189 0.029
monocarboxylic acid transport GO:0015718 52 0.029
Rat
regulation of phosphorylation GO:0042325 248 0.029
regulation of rna metabolic process GO:0051252 391 0.029
multicellular organismal response to stress GO:0033555 25 0.029
regulation of membrane potential GO:0042391 110 0.029
organic substance catabolic process GO:1901575 316 0.029
epithelium development GO:0060429 96 0.029
response to other organism GO:0051707 220 0.028
cellular cation homeostasis GO:0030003 180 0.028
Rat
cellular calcium ion homeostasis GO:0006874 160 0.028
Rat
regulation of immune system process GO:0002682 123 0.028
regulation of nervous system development GO:0051960 264 0.028
cellular response to lipid GO:0071396 201 0.028
positive regulation of phosphorus metabolic process GO:0010562 262 0.027
lipid metabolic process GO:0006629 283 0.027
cellular response to growth factor stimulus GO:0071363 162 0.027
positive regulation of cellular component movement GO:0051272 102 0.027
nucleotide metabolic process GO:0009117 279 0.027
Rat
cellular catabolic process GO:0044248 295 0.027
lipid localization GO:0010876 62 0.027
response to increased oxygen levels GO:0036296 45 0.027
organonitrogen compound biosynthetic process GO:1901566 167 0.027
Rat
positive regulation of cell communication GO:0010647 271 0.027
monovalent inorganic cation transport GO:0015672 172 0.027
forebrain development GO:0030900 98 0.027
regulation of cell differentiation GO:0045595 320 0.027
response to calcium ion GO:0051592 59 0.027
localization of cell GO:0051674 202 0.027
regulation of cellular localization GO:0060341 263 0.026
Rat
positive regulation of catalytic activity GO:0043085 184 0.025
cognition GO:0050890 92 0.025
Rat
regulation of saliva secretion GO:0046877 3 0.025
sodium ion transmembrane transport GO:0035725 67 0.025
rhythmic process GO:0048511 156 0.025
response to lipopolysaccharide GO:0032496 191 0.025
response to carbohydrate GO:0009743 183 0.024
calcium ion transport GO:0006816 131 0.024
positive regulation of phosphate metabolic process GO:0045937 262 0.024
protein complex subunit organization GO:0071822 302 0.024
mapk cascade GO:0000165 140 0.024
cytokine production GO:0001816 61 0.024
aging GO:0007568 241 0.024
regulation of hormone secretion GO:0046883 106 0.024
response to corticosteroid GO:0031960 235 0.023
regulation of catalytic activity GO:0050790 304 0.023
Rat
reactive oxygen species metabolic process GO:0072593 37 0.023
positive regulation of immune system process GO:0002684 90 0.023
regulation of transferase activity GO:0051338 123 0.023
positive regulation of rna metabolic process GO:0051254 203 0.023
response to cadmium ion GO:0046686 35 0.023
response to hexose GO:0009746 144 0.023
negative regulation of metabolic process GO:0009892 331 0.022
Rat
angiotensin mediated drinking behavior GO:0003051 2 0.022
positive regulation of hormone secretion GO:0046887 65 0.022
establishment of organ orientation GO:0048561 1 0.022
cell activation GO:0001775 97 0.022
protein localization GO:0008104 191 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.022
regulation of locomotion GO:0040012 148 0.022
regulation of cellular component movement GO:0051270 150 0.022
muscle contraction GO:0006936 88 0.022
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.021
cellular response to acid chemical GO:0071229 75 0.021
choline transport GO:0015871 4 0.021
regulation of cellular protein metabolic process GO:0032268 267 0.021
regulation of anatomical structure size GO:0090066 135 0.021
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.021
hyperosmotic response GO:0006972 18 0.021
sexual reproduction GO:0019953 148 0.021
negative regulation of cell communication GO:0010648 158 0.021
circadian rhythm GO:0007623 88 0.021
cellular response to molecule of bacterial origin GO:0071219 56 0.020
cellular amino acid metabolic process GO:0006520 107 0.020
regulation of blood circulation GO:1903522 110 0.020
positive regulation of signaling GO:0023056 270 0.020
response to light stimulus GO:0009416 52 0.020
cellular response to steroid hormone stimulus GO:0071383 93 0.020
peristalsis GO:0030432 2 0.020
organic acid metabolic process GO:0006082 292 0.020
dopamine secretion GO:0014046 15 0.020
positive regulation of molecular function GO:0044093 230 0.020
positive regulation of dopamine secretion GO:0033603 8 0.019
regulation of nucleic acid templated transcription GO:1903506 380 0.019
regulation of programmed cell death GO:0043067 341 0.019
regulation of ion transmembrane transport GO:0034765 121 0.019
cellular response to peptide GO:1901653 133 0.019
cellular ketone metabolic process GO:0042180 51 0.018
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.018
Rat
regulation of cellular amine metabolic process GO:0033238 8 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
single organism catabolic process GO:0044712 283 0.018
chemical homeostasis GO:0048878 292 0.018
Rat
response to interleukin 1 GO:0070555 55 0.018
regulation of anion transport GO:0044070 43 0.018
Rat
response to wounding GO:0009611 254 0.018
regulation of response to external stimulus GO:0032101 106 0.018
cellular response to external stimulus GO:0071496 118 0.018
positive regulation of saliva secretion GO:0046878 3 0.018
response to isoquinoline alkaloid GO:0014072 28 0.018
cellular response to alcohol GO:0097306 87 0.017
positive regulation of response to external stimulus GO:0032103 51 0.017
positive regulation of cell differentiation GO:0045597 217 0.017
positive regulation of blood circulation GO:1903524 65 0.017
regulation of protein kinase activity GO:0045859 105 0.017
response to reactive oxygen species GO:0000302 120 0.017
positive regulation of transcription dna templated GO:0045893 197 0.017
locomotion GO:0040011 237 0.017
negative regulation of developmental process GO:0051093 125 0.017
vasoconstriction GO:0042310 54 0.017
regulation of cytokine production GO:0001817 56 0.017
protein phosphorylation GO:0006468 345 0.017
peptide transport GO:0015833 97 0.017
sensory perception GO:0007600 101 0.017
positive regulation of somatostatin secretion GO:0090274 4 0.016
negative regulation of transport GO:0051051 136 0.016
Rat
regulation of cellular amino acid metabolic process GO:0006521 2 0.016
endocrine process GO:0050886 32 0.016
hormone secretion GO:0046879 115 0.016
telencephalon development GO:0021537 62 0.016
response to molecule of bacterial origin GO:0002237 194 0.016
negative regulation of secretion GO:0051048 82 0.016
Rat
monoamine transport GO:0015844 43 0.016
Rat
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.016
response to glucocorticoid GO:0051384 223 0.016
response to hydrogen peroxide GO:0042542 89 0.016
gamete generation GO:0007276 124 0.016
regulation of cell migration GO:0030334 128 0.016
receptor metabolic process GO:0043112 18 0.016
divalent inorganic cation homeostasis GO:0072507 165 0.016
Rat
smooth muscle contraction involved in micturition GO:0060083 1 0.016
granulocyte migration GO:0097530 16 0.015
regulation of catecholamine secretion GO:0050433 32 0.015
Rat
positive regulation of cell motility GO:2000147 97 0.015
negative regulation of transcription dna templated GO:0045892 116 0.015
negative regulation of biosynthetic process GO:0009890 168 0.015
Rat
axis specification GO:0009798 4 0.015
negative regulation of rna biosynthetic process GO:1902679 118 0.015
cellular response to biotic stimulus GO:0071216 59 0.015
sulfur compound transport GO:0072348 8 0.015
lipid transport GO:0006869 61 0.015
regulation of nucleotide metabolic process GO:0006140 117 0.015
Rat
regulation of dopamine secretion GO:0014059 15 0.015
positive regulation of developmental process GO:0051094 283 0.014
cellular response to inorganic substance GO:0071241 65 0.014
potassium ion transport GO:0006813 97 0.014
leukocyte activation GO:0045321 76 0.014
neuron neuron synaptic transmission GO:0007270 60 0.014
positive regulation of cellular component biogenesis GO:0044089 55 0.014
cellular amine metabolic process GO:0044106 38 0.014
cellular response to metal ion GO:0071248 55 0.014
response to toxic substance GO:0009636 133 0.014
amine metabolic process GO:0009308 38 0.014
regulation of body fluid levels GO:0050878 90 0.014
cellular response to peptide hormone stimulus GO:0071375 120 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
regulation of defense response GO:0031347 68 0.014
apoptotic process GO:0006915 381 0.014
gland development GO:0048732 155 0.013
tube development GO:0035295 89 0.013
steroid biosynthetic process GO:0006694 48 0.013
dopamine transport GO:0015872 18 0.013
steroid metabolic process GO:0008202 73 0.013
intracellular signal transduction GO:0035556 314 0.013
estrous cycle phase GO:0060206 15 0.013
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.013
regulation of endocytosis GO:0030100 42 0.013
nucleoside phosphate biosynthetic process GO:1901293 102 0.013
Rat
innate immune response GO:0045087 35 0.013
negative regulation of gene expression GO:0010629 199 0.013
amino acid transmembrane transport GO:0003333 33 0.013
regulation of homeostatic process GO:0032844 101 0.013
activation of protein kinase activity GO:0032147 47 0.013
monocarboxylic acid metabolic process GO:0032787 152 0.013
glutamate secretion GO:0014047 19 0.013
Rat
sleep GO:0030431 30 0.013
cell growth GO:0016049 104 0.013
ion homeostasis GO:0050801 212 0.013
Rat
regulation of cell projection size GO:0032536 1 0.013
action potential GO:0001508 54 0.013
regulation of kinase activity GO:0043549 117 0.013
inflammatory response to antigenic stimulus GO:0002437 18 0.013
regulation of behavior GO:0050795 61 0.012
muscle system process GO:0003012 115 0.012
developmental process involved in reproduction GO:0003006 159 0.012
cellular response to organonitrogen compound GO:0071417 197 0.012
cellular component assembly GO:0022607 360 0.012
regulation of organic acid transport GO:0032890 35 0.012
Rat
operant conditioning GO:0035106 4 0.012
wound healing GO:0042060 122 0.012
response to fungicide GO:0060992 20 0.012
oligopeptide transport GO:0006857 4 0.012
inorganic anion transport GO:0015698 41 0.012
gonad development GO:0008406 104 0.012
ovulation cycle process GO:0022602 50 0.012
regulation of smooth muscle cell proliferation GO:0048660 75 0.012
sensory perception of bitter taste GO:0050913 4 0.012
chlorinated hydrocarbon metabolic process GO:0042196 4 0.012
regulation of transmembrane transport GO:0034762 122 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
Rat
hormone transport GO:0009914 121 0.012
regulation of catabolic process GO:0009894 113 0.012
saliva secretion GO:0046541 3 0.012
regulation of heart rate GO:0002027 16 0.012
response to transforming growth factor beta GO:0071559 46 0.012
protein heterooligomerization GO:0051291 89 0.012
regulation of vasoconstriction GO:0019229 44 0.012
defense response to gram negative bacterium GO:0050829 3 0.012
limbic system development GO:0021761 38 0.012
positive regulation of protein kinase activity GO:0045860 73 0.012
calcitriol biosynthetic process from calciol GO:0036378 2 0.012
establishment of protein localization GO:0045184 141 0.011
regulation of cell activation GO:0050865 50 0.011
response to retinoic acid GO:0032526 63 0.011
regulation of cellular response to stress GO:0080135 49 0.011
regulation of growth GO:0040008 105 0.011
renal sodium excretion GO:0035812 20 0.011
calcium ion transmembrane transport GO:0070588 70 0.011
response to peptide hormone GO:0043434 278 0.011
positive regulation of organic acid transport GO:0032892 22 0.011
purine containing compound metabolic process GO:0072521 253 0.011
Rat
amide transport GO:0042886 105 0.011
response to pain GO:0048265 11 0.011
positive regulation of cellular protein metabolic process GO:0032270 167 0.011
serotonin receptor signaling pathway GO:0007210 10 0.011
phasic smooth muscle contraction GO:0014821 3 0.011
regulation of molecular function GO:0065009 398 0.011
Rat
regulation of cellular component organization GO:0051128 368 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
protein homooligomerization GO:0051260 91 0.011
sex differentiation GO:0007548 113 0.011
insecticide metabolic process GO:0017143 4 0.011
regulation of calcium ion transport GO:0051924 77 0.011
ossification GO:0001503 70 0.011
regulation of immune response GO:0050776 55 0.011
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.011
spermatogenesis GO:0007283 99 0.011
trichloroethylene metabolic process GO:0018979 1 0.011
small molecule catabolic process GO:0044282 59 0.011
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.011
Rat
positive regulation of nervous system development GO:0051962 178 0.011
response to radiation GO:0009314 137 0.010
immune response GO:0006955 104 0.010
peptide secretion GO:0002790 86 0.010
striated muscle contraction GO:0006941 44 0.010
purine ribonucleotide metabolic process GO:0009150 227 0.010
Rat
negative regulation of catalytic activity GO:0043086 103 0.010
Rat
ribose phosphate biosynthetic process GO:0046390 87 0.010
Rat
stress activated mapk cascade GO:0051403 35 0.010
circadian sleep wake cycle process GO:0022410 21 0.010
positive regulation of cellular amine metabolic process GO:0033240 3 0.010
response to amine GO:0014075 46 0.010
negative regulation of immune system process GO:0002683 39 0.010
lymphocyte proliferation GO:0046651 29 0.010
regulation of phosphorus metabolic process GO:0051174 349 0.010
Rat
feeding behavior GO:0007631 53 0.010
Rat
positive regulation of cellular component organization GO:0051130 200 0.010
protein transport GO:0015031 132 0.010
ribose phosphate metabolic process GO:0019693 235 0.010
Rat
male gamete generation GO:0048232 99 0.010

Hrh4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.032
disease of anatomical entity DOID:7 0 0.032
nervous system disease DOID:863 0 0.032
urinary system disease DOID:18 0 0.028
congenital adrenal hyperplasia DOID:0050811 0 0.014
disease of metabolism DOID:0014667 0 0.014
lipid metabolism disorder DOID:3146 0 0.014
inherited metabolic disorder DOID:655 0 0.014
steroid inherited metabolic disorder DOID:1701 0 0.014