Rattus norvegicus

13 known processes

Hspa5

heat shock protein 5

(Aliases: BIP)

Hspa5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chaperone mediated protein folding GO:0061077 6 0.996
er associated ubiquitin dependent protein catabolic process GO:0030433 1 0.894
Yeast
protein refolding GO:0042026 3 0.784
protein folding GO:0006457 12 0.556
regulation of programmed cell death GO:0043067 341 0.522
Human
cellular response to topologically incorrect protein GO:0035967 3 0.469
Mouse
apoptotic process GO:0006915 381 0.387
Human
organic acid metabolic process GO:0006082 292 0.259
positive regulation of multicellular organismal process GO:0051240 387 0.247
cell chemotaxis GO:0060326 31 0.218
chaperone mediated protein folding requiring cofactor GO:0051085 2 0.198
programmed cell death GO:0012501 392 0.196
Human
regulation of apoptotic process GO:0042981 335 0.181
Human
regulation of cell development GO:0060284 263 0.181
regulation of interleukin 6 production GO:0032675 12 0.167
negative regulation of gene expression GO:0010629 199 0.152
Fly
negative regulation of programmed cell death GO:0043069 183 0.149
Human
cellular protein complex assembly GO:0043623 44 0.144
response to atp GO:0033198 13 0.136
de novo posttranslational protein folding GO:0051084 2 0.135
negative regulation of cell death GO:0060548 229 0.128
Human
neurological system process GO:0050877 219 0.128
response to nutrient levels GO:0031667 370 0.125
Human
cellular catabolic process GO:0044248 295 0.121
Yeast Mouse
cellular response to atp GO:0071318 5 0.121
positive regulation of cardiac muscle contraction GO:0060452 4 0.120
cardiovascular system development GO:0072358 134 0.107
negative regulation of apoptotic process GO:0043066 181 0.105
Human
cellular macromolecule catabolic process GO:0044265 29 0.098
Yeast Mouse
response to purine containing compound GO:0014074 126 0.097
regulation of catalytic activity GO:0050790 304 0.092
Yeast Mouse
circulatory system development GO:0072359 134 0.088
regulation of vasculature development GO:1901342 44 0.081
cellular response to organonitrogen compound GO:0071417 197 0.079
blood vessel development GO:0001568 69 0.077
regulation of multicellular organismal development GO:2000026 376 0.076
actin filament based process GO:0030029 86 0.069
cellular response to organic cyclic compound GO:0071407 202 0.068
positive regulation of transport GO:0051050 245 0.067
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.067
Yeast Mouse
macromolecular complex assembly GO:0065003 273 0.066
synaptic vesicle endocytosis GO:0048488 4 0.066
b cell activation involved in immune response GO:0002312 1 0.065
cell motility GO:0048870 202 0.065
Human
striated muscle tissue development GO:0014706 58 0.063
polyamine biosynthetic process GO:0006596 4 0.063
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.062
positive regulation of cell differentiation GO:0045597 217 0.061
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.060
Mouse
proteolysis GO:0006508 175 0.059
Yeast Mouse
regulation of molecular function GO:0065009 398 0.059
Yeast Mouse
macromolecular complex subunit organization GO:0043933 339 0.057
regulation of striated muscle contraction GO:0006942 21 0.055
cellular component biogenesis GO:0044085 368 0.055
muscle structure development GO:0061061 87 0.055
regulation of phosphorylation GO:0042325 248 0.055
Mouse
organelle organization GO:0006996 266 0.054
Yeast Fly
modification dependent protein catabolic process GO:0019941 14 0.053
Yeast
response to tumor cell GO:0002347 4 0.053
homeostatic process GO:0042592 331 0.051
organic substance catabolic process GO:1901575 316 0.050
Yeast Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.049
aging GO:0007568 241 0.049
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 1 0.048
cell cell signaling GO:0007267 335 0.048
response to biotic stimulus GO:0009607 226 0.046
Zebrafish Mouse
regulation of ion homeostasis GO:2000021 63 0.046
cytokine production GO:0001816 61 0.046
positive regulation of biosynthetic process GO:0009891 319 0.044
single organism organelle organization GO:1902589 180 0.044
Fly
regulation of anatomical structure morphogenesis GO:0022603 141 0.043
cellular component assembly GO:0022607 360 0.043
myosin filament organization GO:0031033 2 0.042
synaptic transmission GO:0007268 235 0.042
chemosensory behavior GO:0007635 2 0.042
response to unfolded protein GO:0006986 6 0.042
Yeast Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.040
Mouse
transmembrane transport GO:0055085 412 0.040
Yeast
calcium ion homeostasis GO:0055074 162 0.040
regulation of cell differentiation GO:0045595 320 0.039
regulation of phosphorus metabolic process GO:0051174 349 0.039
Mouse
response to organophosphorus GO:0046683 102 0.039
positive regulation of programmed cell death GO:0043068 157 0.038
retinoic acid receptor signaling pathway GO:0048384 7 0.038
regulation of cellular component organization GO:0051128 368 0.037
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 1 0.036
catabolic process GO:0009056 351 0.036
Yeast Mouse
positive regulation of response to stimulus GO:0048584 285 0.035
cellular amine metabolic process GO:0044106 38 0.035
carbohydrate derivative metabolic process GO:1901135 346 0.035
Yeast
positive regulation of cellular biosynthetic process GO:0031328 295 0.035
myosin filament assembly GO:0031034 1 0.034
protein phosphorylation GO:0006468 345 0.034
Mouse
rna biosynthetic process GO:0032774 380 0.034
vasculature development GO:0001944 70 0.033
somatic diversification of immune receptors GO:0002200 2 0.033
protein complex subunit organization GO:0071822 302 0.033
angiogenesis GO:0001525 53 0.032
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 7 0.032
Yeast
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
Mouse
positive regulation of protein import into nucleus translocation GO:0033160 7 0.032
positive regulation of gene expression GO:0010628 244 0.031
regulation of protein modification process GO:0031399 194 0.031
Mouse
isotype switching to igg isotypes GO:0048291 1 0.031
response to amine GO:0014075 46 0.031
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.031
reactive oxygen species metabolic process GO:0072593 37 0.031
neuron differentiation GO:0030182 368 0.031
negative regulation of multicellular organismal process GO:0051241 203 0.031
macromolecule catabolic process GO:0009057 58 0.031
Yeast Mouse
positive regulation of developmental process GO:0051094 283 0.030
negative regulation of metabolic process GO:0009892 331 0.030
Fly
cellular divalent inorganic cation homeostasis GO:0072503 162 0.030
response to inorganic substance GO:0010035 377 0.029
positive regulation of cell motility GO:2000147 97 0.029
Human
negative regulation of developmental process GO:0051093 125 0.029
regulation of protein phosphorylation GO:0001932 183 0.029
Mouse
actin filament organization GO:0007015 42 0.028
response to endoplasmic reticulum stress GO:0034976 10 0.028
negative regulation of macromolecule metabolic process GO:0010605 260 0.027
Fly
anatomical structure morphogenesis GO:0009653 298 0.027
Mouse
protein complex biogenesis GO:0070271 263 0.027
blood vessel morphogenesis GO:0048514 58 0.027
positive regulation of cell development GO:0010720 176 0.027
response to hypoxia GO:0001666 231 0.027
intracellular steroid hormone receptor signaling pathway GO:0030518 20 0.027
neuromuscular process GO:0050905 2 0.027
response to oxygen levels GO:0070482 265 0.027
cation homeostasis GO:0055080 195 0.027
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.026
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.026
cellular response to nitrogen compound GO:1901699 210 0.026
response to topologically incorrect protein GO:0035966 8 0.025
Yeast Mouse
positive regulation of cell death GO:0010942 184 0.025
positive regulation of intracellular protein transport GO:0090316 20 0.025
regulation of neuron differentiation GO:0045664 208 0.025
protein catabolic process GO:0030163 30 0.024
Yeast Mouse
chemical homeostasis GO:0048878 292 0.024
synaptic vesicle localization GO:0097479 24 0.024
ion homeostasis GO:0050801 212 0.024
regulation of protein transport GO:0051223 68 0.024
positive regulation of cellular component organization GO:0051130 200 0.023
cellular cation homeostasis GO:0030003 180 0.022
regulation of hydrolase activity GO:0051336 143 0.022
Mouse
muscle system process GO:0003012 115 0.022
metal ion homeostasis GO:0055065 186 0.022
apoptotic signaling pathway GO:0097190 27 0.022
regulation of cellular localization GO:0060341 263 0.022
divalent inorganic cation homeostasis GO:0072507 165 0.022
regulation of response to tumor cell GO:0002834 3 0.022
regulation of secretion GO:0051046 224 0.022
cellular macromolecular complex assembly GO:0034622 58 0.021
actin cytoskeleton organization GO:0030036 73 0.021
cytoplasmic transport GO:0016482 115 0.021
Yeast
positive regulation of cytokine production GO:0001819 42 0.021
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.021
regulation of cell projection organization GO:0031344 175 0.021
single organism behavior GO:0044708 130 0.021
dna replication GO:0006260 37 0.021
positive regulation of angiogenesis GO:0045766 28 0.021
startle response GO:0001964 2 0.021
response to testosterone GO:0033574 55 0.021
reactive nitrogen species metabolic process GO:2001057 1 0.020
interleukin 10 production GO:0032613 3 0.020
interleukin 12 production GO:0032615 3 0.020
protein transmembrane transport GO:0071806 2 0.020
Yeast
muscle tissue development GO:0060537 58 0.020
dephosphorylation GO:0016311 98 0.020
cellular component morphogenesis GO:0032989 155 0.019
maintenance of location GO:0051235 17 0.019
Human
response to lipopolysaccharide GO:0032496 191 0.019
regulation of cellular protein metabolic process GO:0032268 267 0.019
Mouse
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.019
locomotion GO:0040011 237 0.019
Human
negative regulation of rna metabolic process GO:0051253 123 0.019
cellular response to unfolded protein GO:0034620 2 0.019
Mouse
cellular response to nutrient levels GO:0031669 60 0.019
Human
tissue development GO:0009888 252 0.019
carbohydrate derivative biosynthetic process GO:1901137 124 0.019
b cell mediated immunity GO:0019724 4 0.019
cellular response to stress GO:0033554 269 0.019
response to estrogen GO:0043627 232 0.019
single organism carbohydrate metabolic process GO:0044723 118 0.018
regulation of homeostatic process GO:0032844 101 0.018
positive regulation of apoptotic process GO:0043065 154 0.018
regulation of nervous system development GO:0051960 264 0.018
protein complex assembly GO:0006461 263 0.018
negative regulation of protein phosphorylation GO:0001933 44 0.018
response to heat GO:0009408 60 0.018
endocytosis GO:0006897 84 0.018
transcription dna templated GO:0006351 377 0.018
muscle contraction GO:0006936 88 0.018
negative regulation of molecular function GO:0044092 133 0.018
cytosolic calcium ion homeostasis GO:0051480 140 0.018
intracellular transport GO:0046907 185 0.018
Yeast
carboxylic acid metabolic process GO:0019752 289 0.017
de novo protein folding GO:0006458 2 0.017
dna metabolic process GO:0006259 96 0.017
arp2 3 complex mediated actin nucleation GO:0034314 2 0.017
regulation of cellular component size GO:0032535 51 0.017
sequestering of metal ion GO:0051238 9 0.017
toxin transport GO:1901998 3 0.017
Mouse
oxoacid metabolic process GO:0043436 290 0.017
regulation of reactive oxygen species metabolic process GO:2000377 26 0.016
circulatory system process GO:0003013 183 0.016
positive regulation of cellular component biogenesis GO:0044089 55 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
regulation of adaptive immune response GO:0002819 8 0.016
somatic recombination of immunoglobulin gene segments GO:0016447 1 0.016
amine metabolic process GO:0009308 38 0.016
modification dependent macromolecule catabolic process GO:0043632 14 0.016
Yeast
negative regulation of response to stimulus GO:0048585 155 0.016
Mouse
positive regulation of neuron differentiation GO:0045666 126 0.016
head development GO:0060322 247 0.015
Human Mouse
regulation of cellular component biogenesis GO:0044087 86 0.015
regulation of cytokine production GO:0001817 56 0.015
regulation of immune system process GO:0002682 123 0.015
regulation of protein metabolic process GO:0051246 289 0.015
Mouse
positive regulation of muscle contraction GO:0045933 22 0.015
regulation of interferon gamma production GO:0032649 3 0.015
response to decreased oxygen levels GO:0036293 237 0.015
response to cytokine GO:0034097 215 0.015
Mouse
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 1 0.015
response to extracellular stimulus GO:0009991 380 0.015
Human
regulation of angiogenesis GO:0045765 39 0.015
nucleobase containing small molecule metabolic process GO:0055086 316 0.015
Yeast
regulation of cell morphogenesis GO:0022604 77 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
immune response GO:0006955 104 0.014
regulation of systemic arterial blood pressure GO:0003073 30 0.014
negative regulation of rna biosynthetic process GO:1902679 118 0.014
regulation of membrane potential GO:0042391 110 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
Mouse
regulation of phosphate metabolic process GO:0019220 349 0.014
Mouse
somatic cell dna recombination GO:0016444 2 0.014
organelle localization GO:0051640 55 0.014
positive regulation of neuron projection development GO:0010976 99 0.014
cellular response to metal ion GO:0071248 55 0.014
positive regulation of nervous system development GO:0051962 178 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
localization of cell GO:0051674 202 0.013
Human
regulation of blood circulation GO:1903522 110 0.013
nucleotide metabolic process GO:0009117 279 0.013
Yeast
receptor mediated endocytosis GO:0006898 42 0.013
cation transport GO:0006812 382 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
anterograde axon cargo transport GO:0008089 1 0.013
positive regulation of cell projection organization GO:0031346 111 0.013
anatomical structure homeostasis GO:0060249 29 0.013
immunoglobulin mediated immune response GO:0016064 4 0.013
nucleoside phosphate metabolic process GO:0006753 283 0.013
Yeast
spermatogenesis GO:0007283 99 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
olfactory behavior GO:0042048 2 0.012
positive regulation of locomotion GO:0040017 102 0.012
Human
skeletal muscle contraction GO:0003009 17 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.012
response to estradiol GO:0032355 164 0.012
nucleic acid templated transcription GO:0097659 379 0.012
regulation of metal ion transport GO:0010959 118 0.012
regulation of signal transduction GO:0009966 318 0.012
Mouse
cell morphogenesis involved in differentiation GO:0000904 119 0.012
vasoconstriction GO:0042310 54 0.012
transmission of nerve impulse GO:0019226 42 0.012
negative regulation of cellular metabolic process GO:0031324 281 0.012
negative regulation of cell communication GO:0010648 158 0.012
Mouse
small gtpase mediated signal transduction GO:0007264 36 0.011
regulation of cellular amine metabolic process GO:0033238 8 0.011
proteasomal protein catabolic process GO:0010498 8 0.011
Yeast
central nervous system development GO:0007417 311 0.011
Human Mouse
reproduction GO:0000003 245 0.011
Yeast
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
regulation of interleukin 12 production GO:0032655 3 0.011
endoplasmic reticulum unfolded protein response GO:0030968 2 0.011
Mouse
regulation of cell activation GO:0050865 50 0.011
single organism cell adhesion GO:0098602 46 0.011
positive regulation of cell communication GO:0010647 271 0.011
positive regulation of organelle organization GO:0010638 48 0.011
regulation of kinase activity GO:0043549 117 0.011
Mouse
macromolecule glycosylation GO:0043413 14 0.011
positive regulation of lamellipodium organization GO:1902745 4 0.011
muscle cell apoptotic process GO:0010657 30 0.011
regulation of immune response to tumor cell GO:0002837 3 0.011
neuronal action potential GO:0019228 35 0.011
immune response to tumor cell GO:0002418 3 0.011
regulation of catabolic process GO:0009894 113 0.011
positive regulation of phosphate metabolic process GO:0045937 262 0.011
Mouse
regulation of cardiac muscle contraction GO:0055117 17 0.011
gastrulation GO:0007369 2 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
negative regulation of transcription dna templated GO:0045892 116 0.011
neuron development GO:0048666 286 0.010
male gamete generation GO:0048232 99 0.010
regulation of immune effector process GO:0002697 32 0.010
heterocycle catabolic process GO:0046700 167 0.010
Yeast
cellular response to oxygen containing compound GO:1901701 386 0.010
cell projection organization GO:0030030 302 0.010
regulation of intracellular transport GO:0032386 65 0.010
response to starvation GO:0042594 59 0.010
Human
cardiocyte differentiation GO:0035051 22 0.010
regulation of cell migration GO:0030334 128 0.010
Human
divalent inorganic cation transport GO:0072511 134 0.010
regulation of synaptic transmission GO:0050804 141 0.010
single organism intracellular transport GO:1902582 166 0.010
Yeast
blood circulation GO:0008015 183 0.010
cellular response to inorganic substance GO:0071241 65 0.010
rna metabolic process GO:0016070 406 0.010
somatic diversification of immunoglobulins involved in immune response GO:0002208 1 0.010
macroautophagy GO:0016236 4 0.010

Hspa5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
central nervous system disease DOID:331 0 0.017
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.017
organ system cancer DOID:0050686 0 0.011