Rattus norvegicus

58 known processes

Htra1

HtrA serine peptidase 1

(Aliases: Prss11,MGC93339)

Htra1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carbohydrate derivative metabolic process GO:1901135 346 0.111
organic substance catabolic process GO:1901575 316 0.108
carboxylic acid metabolic process GO:0019752 289 0.088
cellular response to endogenous stimulus GO:0071495 377 0.086
Zebrafish Mouse
aging GO:0007568 241 0.082
oxoacid metabolic process GO:0043436 290 0.076
catabolic process GO:0009056 351 0.072
positive regulation of multicellular organismal process GO:0051240 387 0.070
apoptotic process GO:0006915 381 0.070
Rat
cellular catabolic process GO:0044248 295 0.067
positive regulation of response to stimulus GO:0048584 285 0.065
cellular response to hormone stimulus GO:0032870 247 0.060
multicellular organismal reproductive process GO:0048609 233 0.059
intracellular signal transduction GO:0035556 314 0.057
organonitrogen compound catabolic process GO:1901565 179 0.052
regulation of multicellular organismal development GO:2000026 376 0.049
positive regulation of cell proliferation GO:0008284 249 0.049
negative regulation of cell death GO:0060548 229 0.048
Rat
positive regulation of intracellular signal transduction GO:1902533 138 0.048
cellular amino acid metabolic process GO:0006520 107 0.045
single organism reproductive process GO:0044702 297 0.044
single organism biosynthetic process GO:0044711 342 0.043
positive regulation of signal transduction GO:0009967 175 0.043
lipid metabolic process GO:0006629 283 0.043
Rat
regulation of body fluid levels GO:0050878 90 0.043
response to acid chemical GO:0001101 222 0.042
positive regulation of cell communication GO:0010647 271 0.042
response to glucocorticoid GO:0051384 223 0.041
regulation of molecular function GO:0065009 398 0.041
negative regulation of programmed cell death GO:0043069 183 0.039
regulation of programmed cell death GO:0043067 341 0.039
Rat
multi organism reproductive process GO:0044703 262 0.038
homeostatic process GO:0042592 331 0.038
cellular ketone metabolic process GO:0042180 51 0.037
reproductive process GO:0022414 372 0.037
wound healing GO:0042060 122 0.036
hormone metabolic process GO:0042445 69 0.036
signal transduction by phosphorylation GO:0023014 144 0.036
response to metal ion GO:0010038 253 0.034
regulation of protein metabolic process GO:0051246 289 0.032
response to nutrient levels GO:0031667 370 0.032
carbohydrate derivative catabolic process GO:1901136 147 0.032
sexual reproduction GO:0019953 148 0.031
response to inorganic substance GO:0010035 377 0.031
cellular amine metabolic process GO:0044106 38 0.031
regulation of signal transduction GO:0009966 318 0.031
Zebrafish Mouse
monocarboxylic acid metabolic process GO:0032787 152 0.031
response to peptide hormone GO:0043434 278 0.030
regulation of catalytic activity GO:0050790 304 0.030
chemical homeostasis GO:0048878 292 0.029
regulation of neuron apoptotic process GO:0043523 83 0.028
amine metabolic process GO:0009308 38 0.028
regulation of protein localization GO:0032880 81 0.028
negative regulation of apoptotic process GO:0043066 181 0.027
response to extracellular stimulus GO:0009991 380 0.027
response to hexose GO:0009746 144 0.027
response to nutrient GO:0007584 248 0.027
lipid biosynthetic process GO:0008610 128 0.027
multicellular organism reproduction GO:0032504 233 0.027
regulation of neuron death GO:1901214 115 0.027
cell type specific apoptotic process GO:0097285 134 0.027
response to carbohydrate GO:0009743 183 0.026
positive regulation of nervous system development GO:0051962 178 0.026
peptidyl amino acid modification GO:0018193 126 0.026
regulation of hydrolase activity GO:0051336 143 0.026
respiratory system development GO:0060541 45 0.026
gamete generation GO:0007276 124 0.026
positive regulation of protein metabolic process GO:0051247 178 0.025
cellular response to oxygen containing compound GO:1901701 386 0.025
regulation of cell differentiation GO:0045595 320 0.025
positive regulation of phosphate metabolic process GO:0045937 262 0.025
neuron projection development GO:0031175 273 0.024
regulation of cell development GO:0060284 263 0.024
response to peptide GO:1901652 292 0.024
organic acid metabolic process GO:0006082 292 0.024
response to estrogen GO:0043627 232 0.023
central nervous system development GO:0007417 311 0.023
developmental growth GO:0048589 100 0.023
reproduction GO:0000003 245 0.023
brain development GO:0007420 247 0.023
regulation of nervous system development GO:0051960 264 0.023
programmed cell death GO:0012501 392 0.022
Rat
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
protein phosphorylation GO:0006468 345 0.022
positive regulation of signaling GO:0023056 270 0.022
cellular response to organic cyclic compound GO:0071407 202 0.022
single organism catabolic process GO:0044712 283 0.022
regulation of cellular amine metabolic process GO:0033238 8 0.021
positive regulation of phosphorylation GO:0042327 177 0.021
regulation of apoptotic process GO:0042981 335 0.021
Rat
growth GO:0040007 165 0.021
cellular modified amino acid metabolic process GO:0006575 61 0.020
organic cyclic compound catabolic process GO:1901361 175 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
cellular lipid metabolic process GO:0044255 208 0.019
Rat
positive regulation of catalytic activity GO:0043085 184 0.019
response to insulin GO:0032868 133 0.019
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
organophosphate metabolic process GO:0019637 370 0.019
response to monosaccharide GO:0034284 159 0.018
regulation of phosphorylation GO:0042325 248 0.018
regulation of anatomical structure size GO:0090066 135 0.018
proteolysis GO:0006508 175 0.018
Mouse Rat
posttranscriptional regulation of gene expression GO:0010608 37 0.018
neuron development GO:0048666 286 0.018
mapk cascade GO:0000165 140 0.017
response to oxidative stress GO:0006979 186 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.017
single organism behavior GO:0044708 130 0.017
multicellular organismal homeostasis GO:0048871 49 0.017
spermatogenesis GO:0007283 99 0.017
protein maturation GO:0051604 68 0.017
neuron death GO:0070997 127 0.017
regulation of cellular protein metabolic process GO:0032268 267 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
defense response GO:0006952 194 0.016
positive regulation of blood coagulation GO:0030194 4 0.016
positive regulation of hemostasis GO:1900048 4 0.016
response to decreased oxygen levels GO:0036293 237 0.016
neuron differentiation GO:0030182 368 0.016
positive regulation of cell development GO:0010720 176 0.016
regulation of hormone levels GO:0010817 187 0.015
behavior GO:0007610 205 0.015
male gamete generation GO:0048232 99 0.015
positive regulation of cell differentiation GO:0045597 217 0.015
response to biotic stimulus GO:0009607 226 0.015
negative regulation of response to stimulus GO:0048585 155 0.015
cellular response to lipid GO:0071396 201 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
locomotion GO:0040011 237 0.015
response to wounding GO:0009611 254 0.015
transmembrane transport GO:0055085 412 0.015
cellular homeostasis GO:0019725 252 0.015
cellular response to external stimulus GO:0071496 118 0.015
head development GO:0060322 247 0.014
organic hydroxy compound metabolic process GO:1901615 115 0.014
regulation of cellular component organization GO:0051128 368 0.014
negative regulation of neuron death GO:1901215 69 0.014
regulation of response to stress GO:0080134 126 0.014
steroid biosynthetic process GO:0006694 48 0.014
cellular response to metal ion GO:0071248 55 0.014
regulation of cellular amino acid metabolic process GO:0006521 2 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
sulfur compound metabolic process GO:0006790 70 0.014
respiratory tube development GO:0030323 43 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.013
positive regulation of cell death GO:0010942 184 0.013
Rat
regulation of membrane potential GO:0042391 110 0.013
glycosyl compound catabolic process GO:1901658 126 0.013
secretion GO:0046903 307 0.013
renal system development GO:0072001 67 0.013
carboxylic acid catabolic process GO:0046395 49 0.013
anion transport GO:0006820 178 0.013
protein processing GO:0016485 68 0.013
regulation of cellular ketone metabolic process GO:0010565 27 0.013
vesicle mediated transport GO:0016192 181 0.013
isoprenoid metabolic process GO:0006720 45 0.013
Rat
sulfur compound biosynthetic process GO:0044272 19 0.013
response to estradiol GO:0032355 164 0.013
cellular component movement GO:0006928 248 0.013
regulation of cell projection organization GO:0031344 175 0.012
multi multicellular organism process GO:0044706 138 0.012
cognition GO:0050890 92 0.012
response to retinoic acid GO:0032526 63 0.012
coagulation GO:0050817 28 0.012
activation of cysteine type endopeptidase activity GO:0097202 4 0.012
organonitrogen compound biosynthetic process GO:1901566 167 0.012
tissue homeostasis GO:0001894 28 0.012
positive regulation of cell projection organization GO:0031346 111 0.012
neuronal action potential GO:0019228 35 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.012
regulation of phosphorus metabolic process GO:0051174 349 0.012
positive regulation of molecular function GO:0044093 230 0.012
positive regulation of neuron projection development GO:0010976 99 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
positive regulation of developmental process GO:0051094 283 0.012
heterocycle catabolic process GO:0046700 167 0.012
regulation of cell proliferation GO:0042127 359 0.011
cellular response to stress GO:0033554 269 0.011
response to glucose GO:0009749 136 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
adult locomotory behavior GO:0008344 4 0.011
salivary gland development GO:0007431 3 0.011
regulation of lipid biosynthetic process GO:0046890 38 0.011
cellular component assembly GO:0022607 360 0.011
regulation of growth GO:0040008 105 0.011
regulation of defense response GO:0031347 68 0.011
cell adhesion GO:0007155 110 0.011
cellular response to steroid hormone stimulus GO:0071383 93 0.011
regulation of cell motility GO:2000145 131 0.011
response to radiation GO:0009314 137 0.011
metal ion transport GO:0030001 289 0.011
regulation of peptidase activity GO:0052547 55 0.011
cell part morphogenesis GO:0032990 123 0.011
response to ethanol GO:0045471 162 0.011
positive regulation of epithelial cell migration GO:0010634 13 0.011
rho protein signal transduction GO:0007266 11 0.010
monosaccharide metabolic process GO:0005996 61 0.010
cellular chemical homeostasis GO:0055082 247 0.010
female pregnancy GO:0007565 122 0.010
carbohydrate metabolic process GO:0005975 130 0.010
neurological system process GO:0050877 219 0.010
negative regulation of metabolic process GO:0009892 331 0.010
regulation of proteolysis GO:0030162 66 0.010
glucose homeostasis GO:0042593 75 0.010
regulation of phosphate metabolic process GO:0019220 349 0.010

Htra1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
Human
musculoskeletal system disease DOID:17 0 0.034
connective tissue disease DOID:65 0 0.034
bone development disease DOID:0080006 0 0.018
bone disease DOID:0080001 0 0.018
disease of metabolism DOID:0014667 0 0.012
nervous system disease DOID:863 0 0.011
Human
inherited metabolic disorder DOID:655 0 0.011
cardiovascular system disease DOID:1287 0 0.011