Rattus norvegicus

0 known processes

Igfbp6

insulin-like growth factor binding protein 6

(Aliases: IGF-BP6,RBP6A)

Igfbp6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
reproductive process GO:0022414 372 0.378
Rat
response to inorganic substance GO:0010035 377 0.192
Rat
immune system process GO:0002376 204 0.172
response to mechanical stimulus GO:0009612 134 0.153
Rat
programmed cell death GO:0012501 392 0.148
positive regulation of response to stimulus GO:0048584 285 0.137
regulation of multicellular organismal development GO:2000026 376 0.127
multi organism reproductive process GO:0044703 262 0.120
Rat
anatomical structure morphogenesis GO:0009653 298 0.119
cellular component assembly GO:0022607 360 0.115
female pregnancy GO:0007565 122 0.110
Rat
multi multicellular organism process GO:0044706 138 0.099
Rat
rna metabolic process GO:0016070 406 0.099
response to extracellular stimulus GO:0009991 380 0.095
Rat
rna biosynthetic process GO:0032774 380 0.093
regulation of apoptotic process GO:0042981 335 0.089
cellular response to endogenous stimulus GO:0071495 377 0.088
Rat
developmental process involved in reproduction GO:0003006 159 0.085
cellular response to hormone stimulus GO:0032870 247 0.082
Rat
reproductive system development GO:0061458 128 0.081
transcription dna templated GO:0006351 377 0.078
regulation of cell proliferation GO:0042127 359 0.078
positive regulation of apoptotic process GO:0043065 154 0.074
apoptotic process GO:0006915 381 0.074
cellular response to oxygen containing compound GO:1901701 386 0.074
Rat
response to hypoxia GO:0001666 231 0.072
response to wounding GO:0009611 254 0.071
Rat
nucleic acid templated transcription GO:0097659 379 0.071
response to metal ion GO:0010038 253 0.070
Rat
cellular response to organic cyclic compound GO:0071407 202 0.067
metal ion transport GO:0030001 289 0.066
positive regulation of multicellular organismal process GO:0051240 387 0.066
transcription from rna polymerase ii promoter GO:0006366 252 0.065
regulation of programmed cell death GO:0043067 341 0.063
cellular component biogenesis GO:0044085 368 0.061
response to monosaccharide GO:0034284 159 0.061
regulation of immune system process GO:0002682 123 0.060
homeostatic process GO:0042592 331 0.059
cell motility GO:0048870 202 0.058
oxoacid metabolic process GO:0043436 290 0.057
cellular amino acid metabolic process GO:0006520 107 0.057
regulation of rna metabolic process GO:0051252 391 0.056
localization of cell GO:0051674 202 0.056
response to ketone GO:1901654 182 0.056
cellular response to stress GO:0033554 269 0.056
gland development GO:0048732 155 0.055
wound healing GO:0042060 122 0.055
Rat
enzyme linked receptor protein signaling pathway GO:0007167 116 0.054
Rat
cell projection organization GO:0030030 302 0.054
response to estrogen GO:0043627 232 0.053
Rat
bmp signaling pathway GO:0030509 4 0.053
response to oxygen levels GO:0070482 265 0.053
protein complex biogenesis GO:0070271 263 0.053
positive regulation of developmental process GO:0051094 283 0.053
reproduction GO:0000003 245 0.053
regulation of protein metabolic process GO:0051246 289 0.052
negative regulation of multicellular organismal process GO:0051241 203 0.050
positive regulation of phosphate metabolic process GO:0045937 262 0.050
macromolecular complex assembly GO:0065003 273 0.049
response to corticosteroid GO:0031960 235 0.049
Rat
rhythmic process GO:0048511 156 0.048
single organism reproductive process GO:0044702 297 0.048
regulation of locomotion GO:0040012 148 0.048
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.047
cellular response to external stimulus GO:0071496 118 0.047
regulation of bmp signaling pathway GO:0030510 2 0.046
regulation of cellular component movement GO:0051270 150 0.046
regulation of nucleic acid templated transcription GO:1903506 380 0.046
positive regulation of cell death GO:0010942 184 0.046
single organism biosynthetic process GO:0044711 342 0.045
regulation of blood pressure GO:0008217 83 0.045
cellular component movement GO:0006928 248 0.044
aging GO:0007568 241 0.044
Rat
negative regulation of metabolic process GO:0009892 331 0.043
circulatory system development GO:0072359 134 0.043
protein oligomerization GO:0051259 191 0.042
cellular catabolic process GO:0044248 295 0.042
protein complex assembly GO:0006461 263 0.042
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.041
regulation of cell motility GO:2000145 131 0.041
cellular response to growth factor stimulus GO:0071363 162 0.041
positive regulation of cellular biosynthetic process GO:0031328 295 0.041
regulation of transcription dna templated GO:0006355 374 0.040
circulatory system process GO:0003013 183 0.040
response to nutrient levels GO:0031667 370 0.038
Rat
response to growth factor GO:0070848 189 0.038
multicellular organism reproduction GO:0032504 233 0.038
positive regulation of cellular protein metabolic process GO:0032270 167 0.038
cell cell signaling GO:0007267 335 0.038
response to ethanol GO:0045471 162 0.038
regulation of signal transduction GO:0009966 318 0.037
response to hexose GO:0009746 144 0.037
positive regulation of signaling GO:0023056 270 0.037
cellular response to extracellular stimulus GO:0031668 73 0.036
multicellular organismal reproductive process GO:0048609 233 0.036
protein phosphorylation GO:0006468 345 0.036
negative regulation of cellular biosynthetic process GO:0031327 161 0.036
regeneration GO:0031099 163 0.036
Rat
positive regulation of locomotion GO:0040017 102 0.035
central nervous system development GO:0007417 311 0.035
response to glucose GO:0009749 136 0.035
tissue development GO:0009888 252 0.035
Rat
catabolic process GO:0009056 351 0.034
regulation of neuron differentiation GO:0045664 208 0.034
response to radiation GO:0009314 137 0.033
negative regulation of cellular metabolic process GO:0031324 281 0.033
organic acid metabolic process GO:0006082 292 0.033
carboxylic acid metabolic process GO:0019752 289 0.033
sexual reproduction GO:0019953 148 0.033
negative regulation of biosynthetic process GO:0009890 168 0.032
positive regulation of gene expression GO:0010628 244 0.032
intracellular signal transduction GO:0035556 314 0.032
Rat
regulation of cellular protein metabolic process GO:0032268 267 0.032
renal system development GO:0072001 67 0.032
response to external biotic stimulus GO:0043207 221 0.032
multicellular organismal macromolecule metabolic process GO:0044259 21 0.031
positive regulation of programmed cell death GO:0043068 157 0.031
cellular amine metabolic process GO:0044106 38 0.030
neuron differentiation GO:0030182 368 0.030
organophosphate metabolic process GO:0019637 370 0.030
response to other organism GO:0051707 220 0.030
response to purine containing compound GO:0014074 126 0.029
response to peptide GO:1901652 292 0.029
Rat
lipid metabolic process GO:0006629 283 0.029
regulation of rna biosynthetic process GO:2001141 381 0.029
secretion GO:0046903 307 0.029
positive regulation of cell proliferation GO:0008284 249 0.028
positive regulation of phosphorylation GO:0042327 177 0.028
respiratory system development GO:0060541 45 0.027
protein complex subunit organization GO:0071822 302 0.027
response to decreased oxygen levels GO:0036293 237 0.027
response to peptide hormone GO:0043434 278 0.027
Rat
response to oxidative stress GO:0006979 186 0.027
positive regulation of biosynthetic process GO:0009891 319 0.027
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.027
reproductive structure development GO:0048608 128 0.026
chemical homeostasis GO:0048878 292 0.026
negative regulation of immune system process GO:0002683 39 0.026
macromolecular complex subunit organization GO:0043933 339 0.026
kidney development GO:0001822 67 0.026
cell type specific apoptotic process GO:0097285 134 0.026
positive regulation of protein metabolic process GO:0051247 178 0.025
neuron projection development GO:0031175 273 0.025
regulation of phosphorylation GO:0042325 248 0.025
regulation of protein phosphorylation GO:0001932 183 0.025
response to starvation GO:0042594 59 0.025
regulation of cell differentiation GO:0045595 320 0.025
protein heterooligomerization GO:0051291 89 0.025
positive regulation of protein modification process GO:0031401 142 0.025
cellular response to nutrient levels GO:0031669 60 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.025
regulation of phosphate metabolic process GO:0019220 349 0.025
response to acid chemical GO:0001101 222 0.024
Rat
growth GO:0040007 165 0.024
Rat
negative regulation of cell death GO:0060548 229 0.024
blood circulation GO:0008015 183 0.024
single organism carbohydrate metabolic process GO:0044723 118 0.024
organonitrogen compound biosynthetic process GO:1901566 167 0.024
regulation of neuron apoptotic process GO:0043523 83 0.023
oxidation reduction process GO:0055114 304 0.023
tissue remodeling GO:0048771 40 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
amine metabolic process GO:0009308 38 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.022
carbohydrate derivative metabolic process GO:1901135 346 0.022
positive regulation of signal transduction GO:0009967 175 0.022
regulation of cellular amino acid metabolic process GO:0006521 2 0.022
neuron development GO:0048666 286 0.022
regulation of nervous system development GO:0051960 264 0.022
positive regulation of cell communication GO:0010647 271 0.021
response to insulin GO:0032868 133 0.021
Rat
regulation of protein modification process GO:0031399 194 0.021
mapk cascade GO:0000165 140 0.021
head development GO:0060322 247 0.021
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.021
regulation of anatomical structure morphogenesis GO:0022603 141 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.021
regulation of cellular ketone metabolic process GO:0010565 27 0.021
action potential GO:0001508 54 0.020
positive regulation of molecular function GO:0044093 230 0.020
neuronal action potential GO:0019228 35 0.020
locomotion GO:0040011 237 0.020
positive regulation of nucleic acid templated transcription GO:1903508 197 0.020
response to biotic stimulus GO:0009607 226 0.020
negative regulation of cell proliferation GO:0008285 119 0.020
cellular response to organonitrogen compound GO:0071417 197 0.019
Rat
collagen catabolic process GO:0030574 2 0.019
single organism catabolic process GO:0044712 283 0.019
regulation of molecular function GO:0065009 398 0.019
cellular response to alcohol GO:0097306 87 0.019
cation transmembrane transport GO:0098655 263 0.019
positive regulation of nervous system development GO:0051962 178 0.019
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.019
response to toxic substance GO:0009636 133 0.019
negative regulation of innate immune response GO:0045824 4 0.019
isoprenoid metabolic process GO:0006720 45 0.019
regulation of catalytic activity GO:0050790 304 0.019
negative regulation of cellular protein metabolic process GO:0032269 106 0.019
negative regulation of developmental process GO:0051093 125 0.019
behavior GO:0007610 205 0.019
regulation of response to stress GO:0080134 126 0.019
response to carbohydrate GO:0009743 183 0.018
regulation of neurogenesis GO:0050767 247 0.018
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 10 0.018
regulation of phosphorus metabolic process GO:0051174 349 0.018
gonad development GO:0008406 104 0.018
muscle organ development GO:0007517 50 0.018
Rat
negative regulation of signaling GO:0023057 157 0.018
organic hydroxy compound metabolic process GO:1901615 115 0.018
negative regulation of cell communication GO:0010648 158 0.018
negative regulation of macromolecule metabolic process GO:0010605 260 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
cellular ketone metabolic process GO:0042180 51 0.018
positive regulation of rna metabolic process GO:0051254 203 0.018
immune system development GO:0002520 41 0.018
positive regulation of cell differentiation GO:0045597 217 0.018
cellular response to interleukin 2 GO:0071352 1 0.018
negative regulation of molecular function GO:0044092 133 0.017
sex differentiation GO:0007548 113 0.017
spermatogenesis GO:0007283 99 0.017
regulation of cell migration GO:0030334 128 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
organ morphogenesis GO:0009887 75 0.017
cellular response to corticosteroid stimulus GO:0071384 69 0.017
regulation of cellular localization GO:0060341 263 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
cellular ion homeostasis GO:0006873 184 0.017
positive regulation of cellular amine metabolic process GO:0033240 3 0.017
cell migration GO:0016477 197 0.017
negative regulation of response to stimulus GO:0048585 155 0.017
response to molecule of bacterial origin GO:0002237 194 0.017
regulation of cellular component organization GO:0051128 368 0.016
Rat
cellular response to peptide hormone stimulus GO:0071375 120 0.016
Rat
cellular lipid metabolic process GO:0044255 208 0.016
response to transforming growth factor beta GO:0071559 46 0.016
retinal metabolic process GO:0042574 3 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.016
regulation of synaptic transmission GO:0050804 141 0.016
gamete generation GO:0007276 124 0.016
negative regulation of gene expression GO:0010629 199 0.016
type b pancreatic cell proliferation GO:0044342 3 0.016
organelle organization GO:0006996 266 0.016
positive regulation of transport GO:0051050 245 0.016
transmission of nerve impulse GO:0019226 42 0.016
cellular response to peptide GO:1901653 133 0.016
Rat
negative regulation of signal transduction GO:0009968 83 0.016
response to retinoic acid GO:0032526 63 0.016
Rat
protein homooligomerization GO:0051260 91 0.016
multicellular organismal catabolic process GO:0044243 2 0.016
male sex differentiation GO:0046661 64 0.016
response to fluoride GO:1902617 3 0.015
urogenital system development GO:0001655 78 0.015
glucose homeostasis GO:0042593 75 0.015
regulation of growth GO:0040008 105 0.015
Rat
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.015
multicellular organismal signaling GO:0035637 44 0.015
vasculature development GO:0001944 70 0.015
cellular response to nitrogen compound GO:1901699 210 0.015
Rat
regulation of vasculature development GO:1901342 44 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
inorganic cation transmembrane transport GO:0098662 202 0.015
positive regulation of cell projection organization GO:0031346 111 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
neuron apoptotic process GO:0051402 88 0.015
transmembrane transport GO:0055085 412 0.015
negative regulation of neuron death GO:1901215 69 0.014
response to nutrient GO:0007584 248 0.014
Rat
defense response GO:0006952 194 0.014
Rat
cation transport GO:0006812 382 0.014
male gamete generation GO:0048232 99 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
regulation of system process GO:0044057 208 0.014
negative regulation of cardiac muscle tissue development GO:0055026 3 0.014
regulation of cell development GO:0060284 263 0.014
response to transition metal nanoparticle GO:1990267 122 0.014
cellular component morphogenesis GO:0032989 155 0.014
development of primary sexual characteristics GO:0045137 107 0.014
response to glucocorticoid GO:0051384 223 0.014
Rat
ovulation cycle GO:0042698 67 0.014
metanephric mesenchymal cell migration GO:0035789 2 0.014
circadian rhythm GO:0007623 88 0.014
regulation of neuron projection development GO:0010975 161 0.014
cellular response to acid chemical GO:0071229 75 0.014
ion homeostasis GO:0050801 212 0.014
regulation of dna metabolic process GO:0051052 60 0.014
s shaped body morphogenesis GO:0072050 2 0.014
cellular amino acid biosynthetic process GO:0008652 32 0.014
regulation of membrane potential GO:0042391 110 0.013
positive regulation of cell motility GO:2000147 97 0.013
anatomical structure formation involved in morphogenesis GO:0048646 83 0.013
positive regulation of transcription dna templated GO:0045893 197 0.013
cell growth GO:0016049 104 0.013
Rat
ras protein signal transduction GO:0007265 29 0.013
myeloid leukocyte differentiation GO:0002573 20 0.013
cellular response to cytokine stimulus GO:0071345 127 0.013
secretion by cell GO:0032940 248 0.013
dna metabolic process GO:0006259 96 0.013
cytoskeleton organization GO:0007010 111 0.013
negative regulation of rna biosynthetic process GO:1902679 118 0.013
liver development GO:0001889 90 0.013
nucleobase containing small molecule metabolic process GO:0055086 316 0.013
female sex differentiation GO:0046660 59 0.013
cellular carbohydrate metabolic process GO:0044262 72 0.013
positive regulation of cellular component movement GO:0051272 102 0.013
positive regulation of cell development GO:0010720 176 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
cellular chemical homeostasis GO:0055082 247 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
acute inflammatory response GO:0002526 58 0.013
response to amino acid GO:0043200 75 0.012
proteolysis GO:0006508 175 0.012
response to herbicide GO:0009635 16 0.012
positive regulation of cell migration GO:0030335 96 0.012
neurological system process GO:0050877 219 0.012
cellular response to glucocorticoid stimulus GO:0071385 68 0.012
organic substance catabolic process GO:1901575 316 0.012
metal ion homeostasis GO:0055065 186 0.012
regulation of response to external stimulus GO:0032101 106 0.012
negative regulation of rna metabolic process GO:0051253 123 0.012
hepaticobiliary system development GO:0061008 90 0.012
myelination GO:0042552 39 0.012
monosaccharide metabolic process GO:0005996 61 0.012
response to vitamin GO:0033273 131 0.012
organic acid biosynthetic process GO:0016053 83 0.012
cyclic purine nucleotide metabolic process GO:0052652 62 0.012
cyclic nucleotide metabolic process GO:0009187 80 0.012
axis specification GO:0009798 4 0.012
organ regeneration GO:0031100 101 0.012
regulation of body fluid levels GO:0050878 90 0.012
macromolecule localization GO:0033036 252 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.012
immune response GO:0006955 104 0.012
male gonad development GO:0008584 59 0.012
negative regulation of nucleic acid templated transcription GO:1903507 117 0.012
collagen metabolic process GO:0032963 21 0.011
response to zinc ion GO:0010043 39 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
prostate gland morphogenesis GO:0060512 2 0.011
cellular response to lipid GO:0071396 201 0.011
neuron death GO:0070997 127 0.011
small molecule biosynthetic process GO:0044283 124 0.011
cellular homeostasis GO:0019725 252 0.011
response to hydrogen peroxide GO:0042542 89 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
cellular response to steroid hormone stimulus GO:0071383 93 0.011
hexose metabolic process GO:0019318 58 0.011
vesicle mediated transport GO:0016192 181 0.011
negative regulation of transcription dna templated GO:0045892 116 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
regulation of ion transport GO:0043269 245 0.011
response to camp GO:0051591 91 0.011
glucose metabolic process GO:0006006 52 0.011
response to cytokine GO:0034097 215 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
comma shaped body morphogenesis GO:0072049 2 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
regulation of cell growth GO:0001558 85 0.011
Rat
small gtpase mediated signal transduction GO:0007264 36 0.010
positive regulation of neurogenesis GO:0050769 165 0.010
cell adhesion GO:0007155 110 0.010
carbohydrate homeostasis GO:0033500 75 0.010
extracellular fibril organization GO:0043206 1 0.010
regulation of protein kinase activity GO:0045859 105 0.010
metanephric s shaped body morphogenesis GO:0072284 2 0.010

Igfbp6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 0 0.017
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.011