Rattus norvegicus

62 known processes

Igfbp7

insulin-like growth factor binding protein 7

Igfbp7 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to estrogen GO:0043627 232 0.197
response to glucocorticoid GO:0051384 223 0.181
cellular response to lipid GO:0071396 201 0.181
response to peptide hormone GO:0043434 278 0.159
regulation of cellular protein metabolic process GO:0032268 267 0.143
response to growth factor GO:0070848 189 0.127
response to peptide GO:1901652 292 0.123
response to radiation GO:0009314 137 0.121
response to cytokine GO:0034097 215 0.119
tissue development GO:0009888 252 0.116
regulation of protein metabolic process GO:0051246 289 0.115
response to mechanical stimulus GO:0009612 134 0.109
reproductive process GO:0022414 372 0.107
carboxylic acid metabolic process GO:0019752 289 0.105
protein phosphorylation GO:0006468 345 0.103
response to inorganic substance GO:0010035 377 0.101
response to extracellular stimulus GO:0009991 380 0.100
growth GO:0040007 165 0.090
extracellular matrix organization GO:0030198 13 0.089
multi organism reproductive process GO:0044703 262 0.089
regulation of multicellular organismal development GO:2000026 376 0.088
response to nutrient levels GO:0031667 370 0.087
positive regulation of signal transduction GO:0009967 175 0.084
response to carbohydrate GO:0009743 183 0.083
oxoacid metabolic process GO:0043436 290 0.083
wound healing GO:0042060 122 0.082
response to corticosteroid GO:0031960 235 0.081
response to nutrient GO:0007584 248 0.081
protein complex assembly GO:0006461 263 0.079
regulation of protein kinase activity GO:0045859 105 0.075
positive regulation of cellular protein metabolic process GO:0032270 167 0.074
positive regulation of apoptotic process GO:0043065 154 0.073
regulation of phosphate metabolic process GO:0019220 349 0.071
organic acid metabolic process GO:0006082 292 0.070
regulation of protein phosphorylation GO:0001932 183 0.070
cellular ketone metabolic process GO:0042180 51 0.069
regulation of cell proliferation GO:0042127 359 0.069
regulation of phosphorus metabolic process GO:0051174 349 0.069
positive regulation of catalytic activity GO:0043085 184 0.063
sensory organ development GO:0007423 74 0.062
negative regulation of response to stimulus GO:0048585 155 0.061
response to estradiol GO:0032355 164 0.060
muscle tissue development GO:0060537 58 0.060
positive regulation of response to stimulus GO:0048584 285 0.059
regulation of programmed cell death GO:0043067 341 0.059
protein complex biogenesis GO:0070271 263 0.058
cellular response to fibroblast growth factor stimulus GO:0044344 24 0.058
cellular component biogenesis GO:0044085 368 0.057
respiratory system development GO:0060541 45 0.056
response to fluoride GO:1902617 3 0.056
response to oxidative stress GO:0006979 186 0.055
positive regulation of multicellular organismal process GO:0051240 387 0.055
aging GO:0007568 241 0.054
cellular component assembly GO:0022607 360 0.054
cellular response to organic cyclic compound GO:0071407 202 0.053
response to wounding GO:0009611 254 0.052
regulation of neurogenesis GO:0050767 247 0.052
regulation of molecular function GO:0065009 398 0.051
cellular amino acid metabolic process GO:0006520 107 0.049
amine metabolic process GO:0009308 38 0.048
cellular response to growth factor stimulus GO:0071363 162 0.048
protein oligomerization GO:0051259 191 0.048
single organism reproductive process GO:0044702 297 0.048
cardiovascular system development GO:0072358 134 0.046
regulation of cellular amine metabolic process GO:0033238 8 0.046
circulatory system development GO:0072359 134 0.046
positive regulation of signaling GO:0023056 270 0.045
response to external biotic stimulus GO:0043207 221 0.045
regulation of cellular ketone metabolic process GO:0010565 27 0.045
cellular response to endogenous stimulus GO:0071495 377 0.042
positive regulation of developmental process GO:0051094 283 0.042
reproductive system development GO:0061458 128 0.042
response to metal ion GO:0010038 253 0.042
regulation of cell differentiation GO:0045595 320 0.042
positive regulation of cell proliferation GO:0008284 249 0.041
cellular response to oxygen containing compound GO:1901701 386 0.041
positive regulation of protein metabolic process GO:0051247 178 0.041
regulation of cell development GO:0060284 263 0.041
central nervous system development GO:0007417 311 0.041
positive regulation of phosphorus metabolic process GO:0010562 262 0.041
glial cell differentiation GO:0010001 65 0.040
positive regulation of molecular function GO:0044093 230 0.040
apoptotic process GO:0006915 381 0.040
proteolysis GO:0006508 175 0.039
organophosphate metabolic process GO:0019637 370 0.039
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.038
positive regulation of phosphate metabolic process GO:0045937 262 0.038
regulation of catalytic activity GO:0050790 304 0.037
positive regulation of neurogenesis GO:0050769 165 0.036
cellular amine metabolic process GO:0044106 38 0.036
positive regulation of cell differentiation GO:0045597 217 0.035
anatomical structure morphogenesis GO:0009653 298 0.035
positive regulation of cell death GO:0010942 184 0.035
cell adhesion GO:0007155 110 0.034
negative regulation of cell death GO:0060548 229 0.034
negative regulation of multicellular organismal process GO:0051241 203 0.034
cell motility GO:0048870 202 0.033
developmental growth GO:0048589 100 0.033
response to vitamin GO:0033273 131 0.033
response to oxygen levels GO:0070482 265 0.033
odontogenesis GO:0042476 32 0.033
regulation of cellular amino acid metabolic process GO:0006521 2 0.032
positive regulation of intracellular signal transduction GO:1902533 138 0.032
positive regulation of protein modification process GO:0031401 142 0.032
macromolecular complex assembly GO:0065003 273 0.031
cellular lipid metabolic process GO:0044255 208 0.031
ossification GO:0001503 70 0.031
positive regulation of protein kinase activity GO:0045860 73 0.030
peptidyl tyrosine phosphorylation GO:0018108 72 0.030
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.030
multicellular organism reproduction GO:0032504 233 0.030
developmental process involved in reproduction GO:0003006 159 0.030
response to hydrogen peroxide GO:0042542 89 0.030
response to other organism GO:0051707 220 0.029
response to biotic stimulus GO:0009607 226 0.029
head development GO:0060322 247 0.029
peptidyl amino acid modification GO:0018193 126 0.028
dna metabolic process GO:0006259 96 0.027
programmed cell death GO:0012501 392 0.027
response to ethanol GO:0045471 162 0.027
regulation of protein modification process GO:0031399 194 0.027
response to reactive oxygen species GO:0000302 120 0.027
response to organophosphorus GO:0046683 102 0.027
regulation of signal transduction GO:0009966 318 0.027
positive regulation of cell development GO:0010720 176 0.026
response to monosaccharide GO:0034284 159 0.026
female pregnancy GO:0007565 122 0.026
inner ear morphogenesis GO:0042472 1 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.026
regulation of locomotion GO:0040012 148 0.026
cellular response to hormone stimulus GO:0032870 247 0.025
regeneration GO:0031099 163 0.024
negative regulation of molecular function GO:0044092 133 0.024
tube development GO:0035295 89 0.024
negative regulation of cellular metabolic process GO:0031324 281 0.024
response to amino acid GO:0043200 75 0.023
multi multicellular organism process GO:0044706 138 0.023
regulation of transferase activity GO:0051338 123 0.023
regulation of phosphorylation GO:0042325 248 0.023
positive regulation of biosynthetic process GO:0009891 319 0.023
response to fibroblast growth factor GO:0071774 29 0.023
response to ketone GO:1901654 182 0.023
positive regulation of protein phosphorylation GO:0001934 135 0.022
protein complex subunit organization GO:0071822 302 0.022
secretion GO:0046903 307 0.022
maternal process involved in female pregnancy GO:0060135 38 0.021
positive regulation of phosphorylation GO:0042327 177 0.021
striated muscle tissue development GO:0014706 58 0.021
nucleotide metabolic process GO:0009117 279 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
cellular homeostasis GO:0019725 252 0.021
cellular ion homeostasis GO:0006873 184 0.021
organ morphogenesis GO:0009887 75 0.021
cellular response to nitrogen compound GO:1901699 210 0.021
regulation of apoptotic process GO:0042981 335 0.020
response to camp GO:0051591 91 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
regulation of growth GO:0040008 105 0.020
positive regulation of endothelial cell migration GO:0010595 4 0.020
sexual reproduction GO:0019953 148 0.020
immune response GO:0006955 104 0.020
regulation of response to stress GO:0080134 126 0.020
regulation of cell cycle GO:0051726 73 0.019
response to purine containing compound GO:0014074 126 0.019
chemical homeostasis GO:0048878 292 0.019
gliogenesis GO:0042063 93 0.019
regulation of protein maturation GO:1903317 50 0.019
growth plate cartilage development GO:0003417 2 0.018
cellular response to cytokine stimulus GO:0071345 127 0.018
negative regulation of protein processing GO:0010955 47 0.018
positive regulation of nervous system development GO:0051962 178 0.018
cellular cation homeostasis GO:0030003 180 0.018
regulation of body fluid levels GO:0050878 90 0.018
cellular response to reactive oxygen species GO:0034614 55 0.018
renal system development GO:0072001 67 0.017
regulation of schwann cell migration GO:1900147 2 0.017
regulation of nervous system development GO:0051960 264 0.017
negative regulation of metabolic process GO:0009892 331 0.017
negative regulation of developmental process GO:0051093 125 0.017
positive regulation of transferase activity GO:0051347 81 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.017
multicellular organism growth GO:0035264 1 0.016
negative regulation of catalytic activity GO:0043086 103 0.016
muscle structure development GO:0061061 87 0.016
positive regulation of cell communication GO:0010647 271 0.016
cellular carbohydrate metabolic process GO:0044262 72 0.016
multicellular organismal reproductive process GO:0048609 233 0.016
regulation of kinase activity GO:0043549 117 0.016
cellular divalent inorganic cation homeostasis GO:0072503 162 0.016
skeletal system development GO:0001501 41 0.016
brain development GO:0007420 247 0.016
astrocyte development GO:0014002 4 0.016
positive regulation of mapk cascade GO:0043410 92 0.016
response to vitamin k GO:0032571 4 0.016
blood vessel development GO:0001568 69 0.015
heart development GO:0007507 72 0.015
behavior GO:0007610 205 0.015
response to transition metal nanoparticle GO:1990267 122 0.015
localization of cell GO:0051674 202 0.015
urogenital system development GO:0001655 78 0.015
cellular response to organonitrogen compound GO:0071417 197 0.015
intracellular signal transduction GO:0035556 314 0.015
reproductive structure development GO:0048608 128 0.015
secretion by cell GO:0032940 248 0.014
cation homeostasis GO:0055080 195 0.014
angiogenesis GO:0001525 53 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
macromolecular complex subunit organization GO:0043933 339 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
negative regulation of protein maturation GO:1903318 47 0.014
single organism biosynthetic process GO:0044711 342 0.014
regulation of anatomical structure morphogenesis GO:0022603 141 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
cellular chemical homeostasis GO:0055082 247 0.014
response to acid chemical GO:0001101 222 0.014
regulation of secretion by cell GO:1903530 208 0.014
negative regulation of cell differentiation GO:0045596 99 0.014
tissue regeneration GO:0042246 36 0.014
organic substance catabolic process GO:1901575 316 0.014
response to toxic substance GO:0009636 133 0.014
regulation of lipid metabolic process GO:0019216 68 0.014
positive regulation of neuron projection development GO:0010976 99 0.014
organ regeneration GO:0031100 101 0.013
negative regulation of gene expression GO:0010629 199 0.013
kidney vasculature development GO:0061440 6 0.013
negative regulation of multicellular organismal metabolic process GO:0044252 4 0.013
negative regulation of programmed cell death GO:0043069 183 0.013
cyclic nucleotide metabolic process GO:0009187 80 0.013
regulation of cell motility GO:2000145 131 0.013
intermediate filament bundle assembly GO:0045110 1 0.013
regulation of protein processing GO:0070613 50 0.013
purine containing compound metabolic process GO:0072521 253 0.013
ion homeostasis GO:0050801 212 0.013
epithelium development GO:0060429 96 0.013
negative regulation of proteolysis GO:0045861 41 0.012
lung development GO:0030324 43 0.012
carbohydrate derivative metabolic process GO:1901135 346 0.012
response to zinc ion GO:0010043 39 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
cellular catabolic process GO:0044248 295 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
cellular component morphogenesis GO:0032989 155 0.012
protein homooligomerization GO:0051260 91 0.012
neurological system process GO:0050877 219 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
extracellular fibril organization GO:0043206 1 0.012
cell activation GO:0001775 97 0.012
heterocycle catabolic process GO:0046700 167 0.012
response to hexose GO:0009746 144 0.012
extracellular structure organization GO:0043062 13 0.011
positive regulation of programmed cell death GO:0043068 157 0.011
response to cadmium ion GO:0046686 35 0.011
camp metabolic process GO:0046058 63 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
negative regulation of endopeptidase activity GO:0010951 36 0.011
rho protein signal transduction GO:0007266 11 0.011
regulation of transcription dna templated GO:0006355 374 0.011
positive regulation of kinase activity GO:0033674 77 0.011
reproduction GO:0000003 245 0.011
respiratory tube development GO:0030323 43 0.011
cellular component movement GO:0006928 248 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
blood vessel morphogenesis GO:0048514 58 0.011
nucleoside phosphate metabolic process GO:0006753 283 0.011
negative regulation of macromolecule metabolic process GO:0010605 260 0.011
response to insulin GO:0032868 133 0.011
gonad development GO:0008406 104 0.011
negative regulation of peptidase activity GO:0010466 38 0.011
regulation of proteolysis GO:0030162 66 0.011
blood coagulation GO:0007596 26 0.011
enzyme linked receptor protein signaling pathway GO:0007167 116 0.011
circadian rhythm GO:0007623 88 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
regulation of rna metabolic process GO:0051252 391 0.011
ribose phosphate metabolic process GO:0019693 235 0.011
epithelial cell differentiation GO:0030855 71 0.011
regulation of catabolic process GO:0009894 113 0.011
negative regulation of transport GO:0051051 136 0.011
tissue morphogenesis GO:0048729 22 0.010
development of primary sexual characteristics GO:0045137 107 0.010
innate immune response GO:0045087 35 0.010
cellular metal ion homeostasis GO:0006875 172 0.010
regulation of membrane potential GO:0042391 110 0.010
response to activity GO:0014823 73 0.010
positive regulation of cellular biosynthetic process GO:0031328 295 0.010
nucleobase containing small molecule metabolic process GO:0055086 316 0.010
calcium ion homeostasis GO:0055074 162 0.010
response to decreased oxygen levels GO:0036293 237 0.010
glial cell development GO:0021782 19 0.010

Igfbp7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
nervous system disease DOID:863 0 0.047
sensory system disease DOID:0050155 0 0.030
retinal disease DOID:5679 0 0.025
eye and adnexa disease DOID:1492 0 0.025
eye disease DOID:5614 0 0.025
musculoskeletal system disease DOID:17 0 0.024
connective tissue disease DOID:65 0 0.024
central nervous system disease DOID:331 0 0.013
disease of metabolism DOID:0014667 0 0.012