Rattus norvegicus

59 known processes

Ilkap

integrin-linked kinase-associated serine/threonine phosphatase 2C

Ilkap biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
rna metabolic process GO:0016070 406 0.343
regulation of rna metabolic process GO:0051252 391 0.117
negative regulation of metabolic process GO:0009892 331 0.103
negative regulation of cellular biosynthetic process GO:0031327 161 0.094
negative regulation of macromolecule metabolic process GO:0010605 260 0.092
regulation of molecular function GO:0065009 398 0.091
nucleic acid templated transcription GO:0097659 379 0.078
positive regulation of response to stimulus GO:0048584 285 0.072
negative regulation of biosynthetic process GO:0009890 168 0.069
rna biosynthetic process GO:0032774 380 0.066
programmed cell death GO:0012501 392 0.065
regulation of catalytic activity GO:0050790 304 0.065
regulation of cellular component organization GO:0051128 368 0.065
regulation of phosphorus metabolic process GO:0051174 349 0.065
regulation of nucleic acid templated transcription GO:1903506 380 0.064
negative regulation of transcription dna templated GO:0045892 116 0.063
regulation of phosphate metabolic process GO:0019220 349 0.062
regulation of signal transduction GO:0009966 318 0.062
transcription dna templated GO:0006351 377 0.062
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.057
organophosphate metabolic process GO:0019637 370 0.055
positive regulation of cell communication GO:0010647 271 0.054
growth GO:0040007 165 0.054
intracellular signal transduction GO:0035556 314 0.053
homeostatic process GO:0042592 331 0.051
regulation of apoptotic process GO:0042981 335 0.051
negative regulation of gene expression GO:0010629 199 0.050
apoptotic process GO:0006915 381 0.050
negative regulation of cellular metabolic process GO:0031324 281 0.048
regulation of rna biosynthetic process GO:2001141 381 0.048
cellular catabolic process GO:0044248 295 0.046
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.045
macromolecule localization GO:0033036 252 0.045
single organism biosynthetic process GO:0044711 342 0.044
regulation of cellular protein metabolic process GO:0032268 267 0.044
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.042
cellular homeostasis GO:0019725 252 0.042
cell migration GO:0016477 197 0.041
negative regulation of rna metabolic process GO:0051253 123 0.040
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.040
regulation of phosphorylation GO:0042325 248 0.040
nucleobase containing small molecule metabolic process GO:0055086 316 0.039
reproduction GO:0000003 245 0.039
regulation of protein metabolic process GO:0051246 289 0.038
regulation of programmed cell death GO:0043067 341 0.038
cellular component movement GO:0006928 248 0.038
response to oxidative stress GO:0006979 186 0.038
macromolecular complex subunit organization GO:0043933 339 0.037
organelle organization GO:0006996 266 0.036
positive regulation of phosphate metabolic process GO:0045937 262 0.036
positive regulation of molecular function GO:0044093 230 0.036
transcription from rna polymerase ii promoter GO:0006366 252 0.036
peptidyl amino acid modification GO:0018193 126 0.035
cellular component assembly GO:0022607 360 0.035
protein phosphorylation GO:0006468 345 0.035
cellular response to stress GO:0033554 269 0.035
positive regulation of signaling GO:0023056 270 0.034
positive regulation of intracellular signal transduction GO:1902533 138 0.034
protein localization GO:0008104 191 0.034
cell growth GO:0016049 104 0.034
regulation of kinase activity GO:0043549 117 0.033
negative regulation of nucleic acid templated transcription GO:1903507 117 0.033
nucleotide metabolic process GO:0009117 279 0.033
regulation of transcription dna templated GO:0006355 374 0.032
positive regulation of signal transduction GO:0009967 175 0.032
negative regulation of rna biosynthetic process GO:1902679 118 0.032
regulation of cell cycle GO:0051726 73 0.031
positive regulation of phosphorus metabolic process GO:0010562 262 0.031
oxidation reduction process GO:0055114 304 0.031
multicellular organismal reproductive process GO:0048609 233 0.030
cellular amino acid metabolic process GO:0006520 107 0.030
cell motility GO:0048870 202 0.030
cellular ketone metabolic process GO:0042180 51 0.030
positive regulation of developmental process GO:0051094 283 0.030
carbohydrate derivative metabolic process GO:1901135 346 0.029
negative regulation of signaling GO:0023057 157 0.029
cell projection organization GO:0030030 302 0.029
oxoacid metabolic process GO:0043436 290 0.029
negative regulation of cell communication GO:0010648 158 0.028
regulation of mrna splicing via spliceosome GO:0048024 3 0.028
ion homeostasis GO:0050801 212 0.027
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.027
regulation of cellular ketone metabolic process GO:0010565 27 0.027
establishment of protein localization GO:0045184 141 0.027
neuron differentiation GO:0030182 368 0.026
cellular ion homeostasis GO:0006873 184 0.026
negative regulation of cell death GO:0060548 229 0.026
immune response GO:0006955 104 0.026
reproductive process GO:0022414 372 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
catabolic process GO:0009056 351 0.026
positive regulation of programmed cell death GO:0043068 157 0.025
negative regulation of response to stimulus GO:0048585 155 0.025
localization of cell GO:0051674 202 0.025
positive regulation of protein modification process GO:0031401 142 0.025
purine containing compound metabolic process GO:0072521 253 0.025
cellular lipid metabolic process GO:0044255 208 0.025
macromolecular complex assembly GO:0065003 273 0.025
regulation of transferase activity GO:0051338 123 0.024
regulation of growth GO:0040008 105 0.024
positive regulation of phosphorylation GO:0042327 177 0.024
regulation of intracellular signal transduction GO:1902531 218 0.024
embryonic pattern specification GO:0009880 1 0.024
positive regulation of cell migration GO:0030335 96 0.024
cellular component biogenesis GO:0044085 368 0.024
response to wounding GO:0009611 254 0.024
purine ribonucleotide metabolic process GO:0009150 227 0.023
regulation of protein kinase activity GO:0045859 105 0.023
regulation of cell migration GO:0030334 128 0.023
cellular response to endogenous stimulus GO:0071495 377 0.023
locomotion GO:0040011 237 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
regulation of cell motility GO:2000145 131 0.022
negative regulation of signal transduction GO:0009968 83 0.022
positive regulation of apoptotic process GO:0043065 154 0.022
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.022
cellular amine metabolic process GO:0044106 38 0.022
secretion GO:0046903 307 0.022
regulation of protein modification process GO:0031399 194 0.021
response to carbohydrate GO:0009743 183 0.021
regulation of immune system process GO:0002682 123 0.021
positive regulation of multicellular organismal process GO:0051240 387 0.021
organic substance catabolic process GO:1901575 316 0.021
response to metal ion GO:0010038 253 0.021
negative regulation of molecular function GO:0044092 133 0.021
axis specification GO:0009798 4 0.021
positive regulation of rna biosynthetic process GO:1902680 197 0.021
embryonic axis specification GO:0000578 1 0.021
positive regulation of biosynthetic process GO:0009891 319 0.020
positive regulation of secretion GO:0051047 140 0.020
positive regulation of cell death GO:0010942 184 0.020
regulation of cell differentiation GO:0045595 320 0.020
intracellular transport GO:0046907 185 0.020
cation transport GO:0006812 382 0.020
cell cycle GO:0007049 101 0.020
regulation of cellular localization GO:0060341 263 0.019
positive regulation of cellular component movement GO:0051272 102 0.019
regulation of hydrolase activity GO:0051336 143 0.019
nucleoside phosphate metabolic process GO:0006753 283 0.019
single organism catabolic process GO:0044712 283 0.019
carboxylic acid metabolic process GO:0019752 289 0.019
chemical homeostasis GO:0048878 292 0.019
heterocycle catabolic process GO:0046700 167 0.019
anterior posterior pattern specification GO:0009952 1 0.019
regulation of cellular component movement GO:0051270 150 0.019
protein complex biogenesis GO:0070271 263 0.019
cellular cation homeostasis GO:0030003 180 0.019
regulation of secretion by cell GO:1903530 208 0.019
regulation of multicellular organismal development GO:2000026 376 0.019
anion transport GO:0006820 178 0.018
single organism intracellular transport GO:1902582 166 0.018
g protein coupled receptor signaling pathway GO:0007186 242 0.018
lipid metabolic process GO:0006629 283 0.018
regulation of cell development GO:0060284 263 0.018
cellular nitrogen compound catabolic process GO:0044270 163 0.018
multicellular organism reproduction GO:0032504 233 0.018
response to peptide GO:1901652 292 0.018
positive regulation of cellular biosynthetic process GO:0031328 295 0.018
regulation of cell proliferation GO:0042127 359 0.018
nuclear transport GO:0051169 49 0.018
regulation of locomotion GO:0040012 148 0.018
single organism organelle organization GO:1902589 180 0.018
positive regulation of transcription dna templated GO:0045893 197 0.018
neuron projection development GO:0031175 273 0.018
regulation of system process GO:0044057 208 0.018
amine metabolic process GO:0009308 38 0.018
protein autophosphorylation GO:0046777 66 0.017
cation transmembrane transport GO:0098655 263 0.017
protein complex subunit organization GO:0071822 302 0.017
positive regulation of cell motility GO:2000147 97 0.017
response to monosaccharide GO:0034284 159 0.017
regulation of secretion GO:0051046 224 0.017
positive regulation of cellular protein metabolic process GO:0032270 167 0.017
multicellular organism growth GO:0035264 1 0.017
dna integrity checkpoint GO:0031570 2 0.017
regulation of response to stress GO:0080134 126 0.017
metal ion homeostasis GO:0055065 186 0.017
cell cycle checkpoint GO:0000075 2 0.017
response to inorganic substance GO:0010035 377 0.017
gastrulation GO:0007369 2 0.017
regulation of protein phosphorylation GO:0001932 183 0.017
mitotic spindle organization GO:0007052 2 0.017
organic acid metabolic process GO:0006082 292 0.017
regulation of cell growth GO:0001558 85 0.016
hematopoietic progenitor cell differentiation GO:0002244 2 0.016
negative regulation of programmed cell death GO:0043069 183 0.016
single organism reproductive process GO:0044702 297 0.016
response to temperature stimulus GO:0009266 94 0.016
negative regulation of protein metabolic process GO:0051248 114 0.016
negative regulation of cell differentiation GO:0045596 99 0.016
positive regulation of locomotion GO:0040017 102 0.016
negative regulation of phosphate metabolic process GO:0045936 80 0.016
regulation of nervous system development GO:0051960 264 0.016
ribose phosphate metabolic process GO:0019693 235 0.016
nucleoside catabolic process GO:0009164 126 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.015
cellular response to oxidative stress GO:0034599 76 0.015
divalent inorganic cation homeostasis GO:0072507 165 0.015
regulation of mapk cascade GO:0043408 116 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
inorganic ion transmembrane transport GO:0098660 229 0.015
reactive oxygen species biosynthetic process GO:1903409 8 0.015
regulation of anatomical structure size GO:0090066 135 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.015
response to cytokine GO:0034097 215 0.015
positive regulation of transport GO:0051050 245 0.015
gamete generation GO:0007276 124 0.015
regulation of cellular catabolic process GO:0031329 101 0.015
transmembrane transport GO:0055085 412 0.015
signal transduction by phosphorylation GO:0023014 144 0.015
tissue development GO:0009888 252 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
negative regulation of catalytic activity GO:0043086 103 0.014
nucleoside triphosphate catabolic process GO:0009143 123 0.014
defense response GO:0006952 194 0.014
positive regulation of catalytic activity GO:0043085 184 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
ras protein signal transduction GO:0007265 29 0.014
cellular calcium ion homeostasis GO:0006874 160 0.014
multi organism reproductive process GO:0044703 262 0.014
dna metabolic process GO:0006259 96 0.014
single organism carbohydrate metabolic process GO:0044723 118 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.014
purine containing compound catabolic process GO:0072523 138 0.014
purine nucleoside triphosphate catabolic process GO:0009146 122 0.014
response to bacterium GO:0009617 200 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
mapk cascade GO:0000165 140 0.014
central nervous system development GO:0007417 311 0.014
regulation of neurogenesis GO:0050767 247 0.014
response to oxygen levels GO:0070482 265 0.014
calcium ion homeostasis GO:0055074 162 0.014
developmental growth GO:0048589 100 0.014
purine nucleotide metabolic process GO:0006163 229 0.014
behavior GO:0007610 205 0.014
protein complex assembly GO:0006461 263 0.014
regulation of neuron projection development GO:0010975 161 0.014
small molecule biosynthetic process GO:0044283 124 0.014
circulatory system development GO:0072359 134 0.014
regulation of proteasomal protein catabolic process GO:0061136 4 0.013
nucleoside metabolic process GO:0009116 179 0.013
cytosolic calcium ion homeostasis GO:0051480 140 0.013
cellular response to abiotic stimulus GO:0071214 85 0.013
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
cation homeostasis GO:0055080 195 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
negative regulation of phosphorus metabolic process GO:0010563 80 0.013
response to glucose GO:0009749 136 0.013
carbohydrate metabolic process GO:0005975 130 0.013
protein transport GO:0015031 132 0.013
mrna metabolic process GO:0016071 20 0.013
positive regulation of cellular amine metabolic process GO:0033240 3 0.013
sequestering of calcium ion GO:0051208 8 0.013
organic anion transport GO:0015711 132 0.013
cell cell signaling GO:0007267 335 0.013
inorganic cation transmembrane transport GO:0098662 202 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
response to external biotic stimulus GO:0043207 221 0.013
nucleobase containing compound catabolic process GO:0034655 152 0.013
cardiovascular system development GO:0072358 134 0.013
carbohydrate derivative catabolic process GO:1901136 147 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
response to starvation GO:0042594 59 0.013
neurological system process GO:0050877 219 0.012
cellular response to nitrogen compound GO:1901699 210 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
cytokine production GO:0001816 61 0.012
sexual reproduction GO:0019953 148 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
antigen receptor mediated signaling pathway GO:0050851 1 0.012
response to heat GO:0009408 60 0.012
regulation of catabolic process GO:0009894 113 0.012
regulation of immune response GO:0050776 55 0.012
positive regulation of cell differentiation GO:0045597 217 0.012
divalent inorganic cation transport GO:0072511 134 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
glycosyl compound metabolic process GO:1901657 182 0.012
ribonucleotide metabolic process GO:0009259 231 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.012
regeneration GO:0031099 163 0.012
negative regulation of developmental process GO:0051093 125 0.012
response to acid chemical GO:0001101 222 0.012
cellular chemical homeostasis GO:0055082 247 0.012
positive regulation of cell proliferation GO:0008284 249 0.012
sex differentiation GO:0007548 113 0.012
heart morphogenesis GO:0003007 3 0.012
regulation of neuron differentiation GO:0045664 208 0.012
response to growth factor GO:0070848 189 0.012
calcium ion transport GO:0006816 131 0.012
positive regulation of ion transport GO:0043270 94 0.012
immune system process GO:0002376 204 0.011
secretion by cell GO:0032940 248 0.011
purine nucleoside catabolic process GO:0006152 124 0.011
positive regulation of cellular component organization GO:0051130 200 0.011
response to estrogen GO:0043627 232 0.011
cytoplasmic transport GO:0016482 115 0.011
negative regulation of immune system process GO:0002683 39 0.011
response to biotic stimulus GO:0009607 226 0.011
response to ammonium ion GO:0060359 71 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
multi multicellular organism process GO:0044706 138 0.011
blood vessel development GO:0001568 69 0.011
activation of cysteine type endopeptidase activity GO:0097202 4 0.011
cellular response to oxygen containing compound GO:1901701 386 0.011
ribonucleotide catabolic process GO:0009261 136 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
positive regulation of gene expression GO:0010628 244 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
response to extracellular stimulus GO:0009991 380 0.011
response to reactive oxygen species GO:0000302 120 0.011
regulation of canonical wnt signaling pathway GO:0060828 4 0.011
erythrocyte homeostasis GO:0034101 2 0.011
positive regulation of nervous system development GO:0051962 178 0.011
response to decreased oxygen levels GO:0036293 237 0.011
positive regulation of immune system process GO:0002684 90 0.011
peptidyl tyrosine phosphorylation GO:0018108 72 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
rna splicing via transesterification reactions GO:0000375 7 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.010
purine nucleoside triphosphate metabolic process GO:0009144 141 0.010
sequestering of metal ion GO:0051238 9 0.010
positive regulation of cell development GO:0010720 176 0.010
positive regulation of protein metabolic process GO:0051247 178 0.010
organophosphate catabolic process GO:0046434 148 0.010
metal ion transport GO:0030001 289 0.010
aging GO:0007568 241 0.010
response to other organism GO:0051707 220 0.010
spindle organization GO:0007051 2 0.010
negative regulation of transferase activity GO:0051348 29 0.010
lymphocyte homeostasis GO:0002260 2 0.010
neuron development GO:0048666 286 0.010
regulation of fat cell differentiation GO:0045598 3 0.010

Ilkap disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013
disease of metabolism DOID:0014667 0 0.011