Rattus norvegicus

67 known processes

Impdh2

IMP (inosine monophosphate) dehydrogenase 2

(Aliases: MGC72938)

Impdh2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of programmed cell death GO:0043067 341 0.428
regulation of apoptotic process GO:0042981 335 0.419
programmed cell death GO:0012501 392 0.412
reproductive process GO:0022414 372 0.292
translation GO:0006412 35 0.276
macromolecular complex subunit organization GO:0043933 339 0.261
spindle organization GO:0007051 2 0.243
sperm egg recognition GO:0035036 1 0.229
cell cycle GO:0007049 101 0.228
carboxylic acid metabolic process GO:0019752 289 0.206
apoptotic process GO:0006915 381 0.202
regulation of intracellular signal transduction GO:1902531 218 0.197
response to peptide hormone GO:0043434 278 0.192
cell cycle process GO:0022402 57 0.188
positive regulation of molecular function GO:0044093 230 0.179
monosaccharide metabolic process GO:0005996 61 0.179
regulation of catalytic activity GO:0050790 304 0.175
single organism reproductive process GO:0044702 297 0.170
mitotic spindle organization GO:0007052 2 0.155
response to inorganic substance GO:0010035 377 0.154
protein complex subunit organization GO:0071822 302 0.154
cardiovascular system development GO:0072358 134 0.140
regulation of molecular function GO:0065009 398 0.138
positive regulation of response to stimulus GO:0048584 285 0.132
regulation of cell proliferation GO:0042127 359 0.126
tissue development GO:0009888 252 0.125
aromatic compound catabolic process GO:0019439 168 0.124
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.121
negative regulation of cellular metabolic process GO:0031324 281 0.119
intracellular signal transduction GO:0035556 314 0.117
multi organism reproductive process GO:0044703 262 0.117
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.116
activation of cysteine type endopeptidase activity GO:0097202 4 0.116
positive regulation of catalytic activity GO:0043085 184 0.105
cellular response to endogenous stimulus GO:0071495 377 0.103
carbohydrate metabolic process GO:0005975 130 0.099
negative regulation of cell death GO:0060548 229 0.099
regulation of hydrolase activity GO:0051336 143 0.099
positive regulation of cell proliferation GO:0008284 249 0.098
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.096
organelle organization GO:0006996 266 0.094
positive regulation of signal transduction GO:0009967 175 0.091
positive regulation of cell death GO:0010942 184 0.090
single organism biosynthetic process GO:0044711 342 0.089
negative regulation of cell differentiation GO:0045596 99 0.087
positive regulation of programmed cell death GO:0043068 157 0.086
reproduction GO:0000003 245 0.085
negative regulation of macromolecule metabolic process GO:0010605 260 0.081
cellular nitrogen compound catabolic process GO:0044270 163 0.080
toxin transport GO:1901998 3 0.080
polysaccharide metabolic process GO:0005976 25 0.078
negative regulation of gene expression GO:0010629 199 0.077
protein processing GO:0016485 68 0.077
single fertilization GO:0007338 3 0.077
regulation of neuron death GO:1901214 115 0.076
binding of sperm to zona pellucida GO:0007339 1 0.075
regulation of phosphorylation GO:0042325 248 0.073
rna metabolic process GO:0016070 406 0.073
positive regulation of hydrolase activity GO:0051345 86 0.071
negative regulation of programmed cell death GO:0043069 183 0.070
cellular response to oxygen containing compound GO:1901701 386 0.069
sexual reproduction GO:0019953 148 0.069
positive regulation of apoptotic process GO:0043065 154 0.069
regulation of response to stress GO:0080134 126 0.069
amine metabolic process GO:0009308 38 0.068
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.068
positive regulation of cellular biosynthetic process GO:0031328 295 0.067
protein complex biogenesis GO:0070271 263 0.065
positive regulation of signaling GO:0023056 270 0.064
regulation of cell differentiation GO:0045595 320 0.064
negative regulation of metabolic process GO:0009892 331 0.063
regulation of cell motility GO:2000145 131 0.063
organic acid metabolic process GO:0006082 292 0.062
neuron death GO:0070997 127 0.062
macromolecular complex assembly GO:0065003 273 0.062
nucleobase containing small molecule metabolic process GO:0055086 316 0.061
regulation of membrane potential GO:0042391 110 0.061
positive regulation of protein metabolic process GO:0051247 178 0.060
regulation of phosphate metabolic process GO:0019220 349 0.060
nitrogen compound transport GO:0071705 229 0.059
response to carbohydrate GO:0009743 183 0.058
negative regulation of apoptotic process GO:0043066 181 0.057
regulation of signal transduction GO:0009966 318 0.057
regulation of multicellular organismal development GO:2000026 376 0.054
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.054
circulatory system development GO:0072359 134 0.054
oxoacid metabolic process GO:0043436 290 0.054
response to hypoxia GO:0001666 231 0.052
cellular amine metabolic process GO:0044106 38 0.052
negative regulation of rna metabolic process GO:0051253 123 0.052
cellular response to hormone stimulus GO:0032870 247 0.052
protein complex assembly GO:0006461 263 0.051
response to oxygen levels GO:0070482 265 0.051
glycosyl compound metabolic process GO:1901657 182 0.051
response to nutrient levels GO:0031667 370 0.051
positive regulation of cell migration GO:0030335 96 0.051
organic substance catabolic process GO:1901575 316 0.050
fertilization GO:0009566 3 0.049
single organism carbohydrate metabolic process GO:0044723 118 0.049
positive regulation of intracellular signal transduction GO:1902533 138 0.049
cellular carbohydrate metabolic process GO:0044262 72 0.049
cellular component biogenesis GO:0044085 368 0.049
nucleoside phosphate metabolic process GO:0006753 283 0.048
positive regulation of gene expression GO:0010628 244 0.048
protein maturation GO:0051604 68 0.048
positive regulation of nucleic acid templated transcription GO:1903508 197 0.047
glucose metabolic process GO:0006006 52 0.047
regulation of nucleoside metabolic process GO:0009118 66 0.047
positive regulation of cell communication GO:0010647 271 0.046
multicellular organism reproduction GO:0032504 233 0.044
nucleic acid templated transcription GO:0097659 379 0.044
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.044
regulation of protein metabolic process GO:0051246 289 0.043
cellular amino acid metabolic process GO:0006520 107 0.041
regulation of apoptotic signaling pathway GO:2001233 13 0.041
cell type specific apoptotic process GO:0097285 134 0.041
response to decreased oxygen levels GO:0036293 237 0.041
nucleotide metabolic process GO:0009117 279 0.040
hexose metabolic process GO:0019318 58 0.040
chromosome segregation GO:0007059 2 0.040
generation of precursor metabolites and energy GO:0006091 62 0.040
neuron projection development GO:0031175 273 0.040
regulation of transcription dna templated GO:0006355 374 0.040
cell projection organization GO:0030030 302 0.039
regulation of cellular ketone metabolic process GO:0010565 27 0.039
cellular ketone metabolic process GO:0042180 51 0.038
single organism organelle organization GO:1902589 180 0.038
mitotic cell cycle GO:0000278 49 0.037
protein oligomerization GO:0051259 191 0.036
gastrulation GO:0007369 2 0.036
positive regulation of biosynthetic process GO:0009891 319 0.036
developmental process involved in reproduction GO:0003006 159 0.036
positive regulation of transcription dna templated GO:0045893 197 0.035
organophosphate metabolic process GO:0019637 370 0.035
regulation of cell cycle GO:0051726 73 0.035
regulation of cellular amine metabolic process GO:0033238 8 0.035
negative regulation of neuron death GO:1901215 69 0.034
response to cytokine GO:0034097 215 0.034
protein localization GO:0008104 191 0.034
transcription dna templated GO:0006351 377 0.034
mrna processing GO:0006397 14 0.033
positive regulation of rna biosynthetic process GO:1902680 197 0.033
regulation of anatomical structure morphogenesis GO:0022603 141 0.033
heterocycle catabolic process GO:0046700 167 0.033
cellular response to cytokine stimulus GO:0071345 127 0.032
regulation of phosphorus metabolic process GO:0051174 349 0.032
anatomical structure morphogenesis GO:0009653 298 0.032
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 31 0.032
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.031
cell recognition GO:0008037 11 0.031
axonogenesis GO:0007409 71 0.031
regulation of nucleic acid templated transcription GO:1903506 380 0.031
response to extracellular stimulus GO:0009991 380 0.030
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.030
regulation of cellular carbohydrate metabolic process GO:0010675 39 0.030
organonitrogen compound biosynthetic process GO:1901566 167 0.030
developmental growth involved in morphogenesis GO:0060560 33 0.029
positive regulation of nucleotide metabolic process GO:0045981 91 0.029
localization of cell GO:0051674 202 0.029
energy derivation by oxidation of organic compounds GO:0015980 46 0.029
cell cell recognition GO:0009988 1 0.029
regulation of camp metabolic process GO:0030814 43 0.028
neurological system process GO:0050877 219 0.028
gamete generation GO:0007276 124 0.028
regulation of phagocytosis GO:0050764 13 0.028
regulation of rna biosynthetic process GO:2001141 381 0.028
response to glucose GO:0009749 136 0.028
motor neuron axon guidance GO:0008045 1 0.028
ribonucleotide metabolic process GO:0009259 231 0.028
positive regulation of phosphate metabolic process GO:0045937 262 0.027
sensory organ development GO:0007423 74 0.027
single organism membrane organization GO:0044802 74 0.027
carbohydrate derivative metabolic process GO:1901135 346 0.027
cellular response to insulin stimulus GO:0032869 81 0.027
positive regulation of protein phosphorylation GO:0001934 135 0.027
membrane organization GO:0061024 94 0.027
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.027
ribose phosphate metabolic process GO:0019693 235 0.026
organic cyclic compound catabolic process GO:1901361 175 0.026
negative regulation of signal transduction GO:0009968 83 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
regulation of cellular catabolic process GO:0031329 101 0.026
neuron differentiation GO:0030182 368 0.026
negative regulation of transport GO:0051051 136 0.026
cellular homeostasis GO:0019725 252 0.025
regulation of cell development GO:0060284 263 0.025
homeostatic process GO:0042592 331 0.025
regulation of cellular localization GO:0060341 263 0.025
positive regulation of developmental process GO:0051094 283 0.025
positive regulation of cellular protein metabolic process GO:0032270 167 0.024
positive regulation of catabolic process GO:0009896 78 0.024
regulation of homeostatic process GO:0032844 101 0.024
g protein coupled receptor signaling pathway GO:0007186 242 0.024
regulation of nucleotide metabolic process GO:0006140 117 0.024
peptidyl amino acid modification GO:0018193 126 0.024
epithelium development GO:0060429 96 0.024
cellular response to peptide GO:1901653 133 0.024
multicellular organismal reproductive process GO:0048609 233 0.023
regulation of cellular component organization GO:0051128 368 0.023
tube development GO:0035295 89 0.023
negative regulation of cellular biosynthetic process GO:0031327 161 0.023
regulation of purine nucleotide metabolic process GO:1900542 115 0.023
cell motility GO:0048870 202 0.023
regulation of establishment of protein localization GO:0070201 69 0.023
locomotion GO:0040011 237 0.023
axon development GO:0061564 96 0.023
behavior GO:0007610 205 0.023
nucleoside metabolic process GO:0009116 179 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.022
blood vessel morphogenesis GO:0048514 58 0.022
regulation of carbohydrate metabolic process GO:0006109 41 0.022
protein homooligomerization GO:0051260 91 0.022
regulation of proteolysis GO:0030162 66 0.021
polar body extrusion after meiotic divisions GO:0040038 1 0.021
regulation of cellular protein metabolic process GO:0032268 267 0.021
posttranscriptional regulation of gene expression GO:0010608 37 0.021
response to nutrient GO:0007584 248 0.021
camp catabolic process GO:0006198 13 0.021
neuron development GO:0048666 286 0.020
purine containing compound metabolic process GO:0072521 253 0.020
regulation of protein localization GO:0032880 81 0.020
translational initiation GO:0006413 8 0.020
mitotic cell cycle process GO:1903047 35 0.020
anion transmembrane transport GO:0098656 77 0.019
embryo development GO:0009790 49 0.019
nucleoside phosphate biosynthetic process GO:1901293 102 0.019
cellular response to organonitrogen compound GO:0071417 197 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
secretion GO:0046903 307 0.019
cellular component movement GO:0006928 248 0.019
neuron projection extension GO:1990138 26 0.018
nucleocytoplasmic transport GO:0006913 48 0.018
cellular component assembly GO:0022607 360 0.018
intracellular transport GO:0046907 185 0.018
regulation of metanephros development GO:0072215 4 0.018
positive regulation of multicellular organismal process GO:0051240 387 0.018
purine ribonucleoside metabolic process GO:0046128 168 0.018
positive regulation of protein modification process GO:0031401 142 0.018
regulation of embryonic development GO:0045995 2 0.018
rhythmic process GO:0048511 156 0.018
microtubule cytoskeleton organization GO:0000226 25 0.018
cellular response to external stimulus GO:0071496 118 0.017
protein localization to membrane GO:0072657 36 0.017
cyclic nucleotide metabolic process GO:0009187 80 0.017
negative regulation of developmental process GO:0051093 125 0.017
catabolic process GO:0009056 351 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
ossification GO:0001503 70 0.017
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 4 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.017
regulation of transferase activity GO:0051338 123 0.016
cellular chemical homeostasis GO:0055082 247 0.016
response to peptide GO:1901652 292 0.016
regulation of kinase activity GO:0043549 117 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
tissue morphogenesis GO:0048729 22 0.016
glycogen metabolic process GO:0005977 23 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
jak stat cascade GO:0007259 26 0.016
nuclear transport GO:0051169 49 0.016
regulation of endopeptidase activity GO:0052548 51 0.016
chromatin remodeling GO:0006338 3 0.016
response to monosaccharide GO:0034284 159 0.016
regulation of cellular response to stress GO:0080135 49 0.016
vasculature development GO:0001944 70 0.015
protein transport GO:0015031 132 0.015
regulation of organ morphogenesis GO:2000027 22 0.015
cytoplasmic transport GO:0016482 115 0.015
regulation of rna metabolic process GO:0051252 391 0.015
aging GO:0007568 241 0.015
apoptotic signaling pathway GO:0097190 27 0.015
negative regulation of transcription dna templated GO:0045892 116 0.015
regulation of peptidase activity GO:0052547 55 0.015
cell projection morphogenesis GO:0048858 123 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
digestive system development GO:0055123 41 0.015
regulation of catabolic process GO:0009894 113 0.015
organonitrogen compound catabolic process GO:1901565 179 0.014
regulation of cysteine type endopeptidase activity GO:2000116 32 0.014
nucleoside triphosphate metabolic process GO:0009141 144 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
regeneration GO:0031099 163 0.014
nucleotide biosynthetic process GO:0009165 98 0.014
positive regulation of cellular catabolic process GO:0031331 71 0.014
carbohydrate homeostasis GO:0033500 75 0.014
gtp catabolic process GO:0006184 71 0.014
chemical homeostasis GO:0048878 292 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
negative regulation of signaling GO:0023057 157 0.014
regulation of locomotion GO:0040012 148 0.013
positive regulation of gtpase activity GO:0043547 47 0.013
sex differentiation GO:0007548 113 0.013
cytoskeleton organization GO:0007010 111 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.013
camp metabolic process GO:0046058 63 0.013
growth GO:0040007 165 0.013
response to insulin GO:0032868 133 0.013
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 3 0.013
positive regulation of transport GO:0051050 245 0.013
cell growth GO:0016049 104 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
female gamete generation GO:0007292 25 0.013
digestive tract development GO:0048565 39 0.013
regulation of canonical wnt signaling pathway GO:0060828 4 0.013
regulation of generation of precursor metabolites and energy GO:0043467 18 0.013
cellular protein localization GO:0034613 122 0.013
immune system process GO:0002376 204 0.012
regulation of response to wounding GO:1903034 69 0.012
positive regulation of nucleoside metabolic process GO:0045979 55 0.012
cellular response to lipid GO:0071396 201 0.012
negative regulation of nucleic acid templated transcription GO:1903507 117 0.012
immune response GO:0006955 104 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
peptidyl tyrosine modification GO:0018212 72 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
chemotaxis GO:0006935 66 0.012
multi multicellular organism process GO:0044706 138 0.012
purine ribonucleoside catabolic process GO:0046130 124 0.012
negative regulation of oxidative stress induced neuron death GO:1903204 2 0.012
response to wounding GO:0009611 254 0.012
regulation of cell migration GO:0030334 128 0.012
anion transport GO:0006820 178 0.012
cyclic nucleotide catabolic process GO:0009214 13 0.012
negative regulation of catalytic activity GO:0043086 103 0.011
anatomical structure formation involved in morphogenesis GO:0048646 83 0.011
regulation of mrna 3 end processing GO:0031440 1 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
cell migration GO:0016477 197 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
macromolecule localization GO:0033036 252 0.011
hematopoietic progenitor cell differentiation GO:0002244 2 0.011
lymphocyte chemotaxis GO:0048247 3 0.011
glycogen biosynthetic process GO:0005978 15 0.011
organelle fission GO:0048285 25 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
response to growth factor GO:0070848 189 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
establishment of protein localization GO:0045184 141 0.011
taxis GO:0042330 67 0.011
rna localization GO:0006403 4 0.011
energy reserve metabolic process GO:0006112 25 0.011
reproductive system development GO:0061458 128 0.011
microtubule based process GO:0007017 36 0.011
regulation of oxidative stress induced neuron death GO:1903203 2 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
protein localization to organelle GO:0033365 57 0.010
regulation of purine nucleotide catabolic process GO:0033121 65 0.010
peptidyl tyrosine phosphorylation GO:0018108 72 0.010
brain development GO:0007420 247 0.010
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.010
cellular polysaccharide biosynthetic process GO:0033692 15 0.010
gland development GO:0048732 155 0.010
positive regulation of gtp catabolic process GO:0033126 48 0.010
negative regulation of response to stimulus GO:0048585 155 0.010
ion transmembrane transport GO:0034220 365 0.010
chromatin assembly or disassembly GO:0006333 1 0.010
carbohydrate biosynthetic process GO:0016051 42 0.010

Impdh2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016